Sample Type

Cancer	Type	Gene	Position	HAZARD RATIO	n With Hotspot	n Without Hotspot	Transcript	pValorate	pCoxHotSpot	pCoxExtendido	pCoxClinico	pCoxMutCount	p HS cox	p HS cox Ext	p HS cox Clinic	p HS cox Mutation Count	qValorate	qCoxHotSpot	qCoxExtendido	qCoxClinico	q HS cox	q HS cox Ext	q HS cox Clinic	q HS cox Mutation Count

The information about the colums shown in the Hotspot table are:

Cancer	Official TCGA study abbreviations
Type	Sample type codes from TCGA
Gene	Official gene symbol
Position	Amino acid position
Hazard Ratio	Hazard Ratio from Extended Cox Model
n with Hotspot	Number of patients with Hotspot
N without Hotspot	Number of patients without Hotspot
pValorate	The p value of the VALORATE statistical test
Transcript	Ensembl transcript code
p HS cox	The p value of the hotspot in the cox model
p HS cox Ext	The p value of the hotspot in the extended cox model
p HS cox Clinic	The p value of the hotspot in the clinic cox model
p HS cox Mutation Count	The p value of the hotspot in the Mutation cox model
qValorate	The false discovery rate (FDR) correction of the p-value of pVALORATE
q HS cox	The false discovery rate (FDR) correction of the p-value of pHScox
q HS cox Ext	The false discovery rate (FDR) correction of the p-value of pHScoxExtendido
q HS cox Clinic	The false discovery rate (FDR) correction of the p-value of pHScoxClinico
q HS cox Mutation Count	The false discovery rate (FDR) correction of the p-value of pHScoxMutCount

Test 1:

The hotspot is compared with other hotspots within the same gene per cancer type.

Test 2:

The hotspot is compared with other mutations within the same gene (even though it isn't a hotspot) per cancer type.

The hotspot is compared with other mutations of all patient's mutations per cancer type.

The hotspot is compared with another hotspot of the same gene per cancer type.