This data show the 1,664 genes including the 331 MitoCarta genes curated for the homeostatic process and cancer hallmark.
| Gene | Abstracts | Lvl | MitoCarta | Homeostatic | Cancer Hallmark | Notes |
|---|---|---|---|---|---|---|
| Hs.BCL2 | 310 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: BCL2; Aliases: BCL-2; PPP1R50; Role in Cancer: Overexpression of BCL2 contributes to drug resistance (27748803) and blocks apoptosis signaling, potentially by fine-tuning mitochondrial respiration and keeping reactive oxygen species at optimal levels for survival (20367277). Previous reports showed that the downregulation of BCL2 triggers apoptosis in breast cancer (19440893), colon cancer (19755849), squamous carcinoma (19846952), laryngeal cancer (20202741), lung adenocarcinoma (20372842), among others. BCL2 is also involved in the regulation of autophagy-related pathways, upon sensing abrupt increases in oxidative stress (19451193, 19481070). |
| Hs.BAX | 275 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) | Genomic instability and mutations + Evasion of cell death | Gene Name: BAX; Aliases: BCL2L4; Role in Cancer: Along with BAK, BAX is an essential mediator of apoptosis and its function largely depends on the voltage-dependent anion channel 2 (VDAC2) protein (30478310). Deregulation of BAX at the transcriptional and protein levels following treatment of cancer cells with inducers of oxidative stress / endoplasmic reticulum stress has been related to caspase-dependent apoptosis (19481070, 19846952, 30300626). Accordingly, BAX participates in the formation of the mitochondrial pore and further consolidation of the apoptosome in hepatocellular carcinoma (19711344, 19729910), colon cancer (29587544), prostate cancer (30453545) and lung adenocarcinoma (29658606, 30651744) cell lines treated with anti-tumoral agents. Mutation or low expression of BAX contribute to cancer progression (24842234, 23618872 ,25980443, 28381544). |
| Hs.CYCS | 174 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) + Energy metabolism (respiratory chain) | Evasion of cell death | Gene Name: CYCS; Aliases: CYC; HCS; THC4; Role in Cancer: Suppression of cytochrome C release from the mitochondria diminishes caspase-mediated pro-apoptotic stimulation (23711831, 22932725), and it occurs through the upregulation of cycloxygenase-2 in acute lymphoblastic leukemia (30304948). The effectiveness of a great variety of anti-tumoral strategies relies on disrupting the resistance of cancer cells to apoptosis through the dysfunction of the Bax/Bcl-2/cytochrome c/caspase-3 signaling pathway (29559471, 29215703, 30302629, 30290033, 30651744). |
| Hs.BCL2L1 | 85 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: BCL2L1; Aliases: BCLX; BCL2L; BCL-X; PPP1R52; BCL-XL/S; Role in Cancer: Protein also known as BCL-XL. Overexpression of BCL2L1 is associated with anti-apoptotic activity in some types of cancer (21455989, 22098591, 22552631, 23047795, 23152504, 23519076). |
| Hs.CASP8 | 68 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) | Genomic instability and mutations + Evasion of cell death | Gene Name: CASP8; Aliases: CAP4; MACH; MCH5; FLICE; ALPS2B; CASP-8; Role in Cancer: Caspase 8 (CASP8) is one of the initial effectors of extrinsically activated apoptosis (20086182). Inhibition of caspase-8 is frequently caused by genetic mutations, and it can promote cancer development by blocking external pro-apoptotic signaling (23871247, 20086182). Upregulation / activation of this protein is one of the molecular targets of anti-tumoral agents used for several types of cancer (28537448, 29204990, 30651744, 30754643). |
| Hs.SOD2 | 39 | 9.9 | MitoCarta 2.0:YES | Homeostasis (redox) | Evasion of cell death | Gene Name: SOD2; Aliases: IPOB; IPO-B; MNSOD; MVCD6; MN-SOD; Role in Cancer: Moderate transcriptional upregulation of SOD2 reduces aggressiveness of cancer cells (21150282,22994704) and caveolin-1 loss rate in surrounding stromal cells (21150282). However, exacerbated overexpression of SOD2 seems to have detrimental effects (22994704). SOD2 has also been reported to contribute to the adaptive/delayed response of human colon carcinoma cells to radiotherapy (21175348), and mono- or bi-allelic dimorphisms such as Ala16Vl in SOD have been associated with a higher risk of progression to hepatocellular carcinoma in patients with alcoholic cirrhosis (19731237). |
| Hs.BID | 32 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: BID; Aliases: FP497; Role in Cancer: BID is a caspase-8 substrate involved in the Fas signaling pathway (24957706), and absence of BID activity blocks apoptosis (27053107). Patients with small cell lung cancer cells treated with the histone deacetylase "VPA" have induced cleavage of BID (20451370). Truncation of BID was also induced as a result of treating the hepatocellular carcinoma cell line with the cell growth inhibitor Garcinol (21776480). |
| Hs.SDHB | 32 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle / respiratory chain) | Genomic instability and mutations | Gene Name: SDHB; Aliases: IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP; Role in Cancer: SDHB encodes for a subunit of complex II of the respiratory chain. Mutations have been suggested to partially promote paragangliomas and pheochromocytomas development (20484225, 22323561) and associate with renal tumors (24236567). Dysregulation of this protein potentially underlies oncogenesis in gastrointestinal stromal tumors (21173220). Transcriptional downregulation of SDHB has been found in human colorectal cancer tissues (23645213) and partially underlies the switch of cancer cells to the anaerobic metabolism (26585387). |
| Hs.BAK1 | 30 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: BAK1; Aliases: BAK; CDN1; BCL2L7; BAK-LIKE; Role in Cancer: The upregulation of Bak1 follows the administration of anti-cancer treatments such as Camptothecin or DMU-212 and partially underlies its chemotherapeutic effects (22252650, 24055891). Inhibition of Bak in mice decreases hepatocyte apoptosis and reduces the incidence of liver cancer (22414765). |
| Hs.DIABLO | 29 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: DIABLO; Aliases: SMAC; DFNA64; Role in Cancer: DIABLO (also known as SMAC) is an antagonist of the inhibitors of apoptosis protein (IAPs) family. Inactivation or downregulation of DIABLO disrupts cellular apoptotic signaling by blocking Cas-3 activation and promoting cancer progression (22052903, 22751125, 27166192, 27267809). Reductions in the expression of DIABLO have been suggested as a useful prognostic factor in non-small cell lung cancer (20056675) gastric carcinoma (21947931) and colon cancer (22751125). Targeted activation of DIABLO has been detected as a key event that mediates anti-tumoral activity and that contributes to overcoming chemoresistance in ovarian cancer (25661347, 22052903). |
| Hs.TFAM | 29 | 9.9 | MitoCarta 2.0:YES | Mitochondrial dynamics (biogenesis) + DNA (mtDNA replication / transcription / integrity) | Mitochondrial maintenance and repair systems + Evasion of cell death | Gene Name: TFAM; Aliases: TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; MTDPS15; Role in Cancer: High expression levels of the nuclear-encoded TFAM have been found in tumor tissues in the skin (21514422), prostate (21235219), ovaries (22098591) and pancreas (25108120) and inhibition of this gene has been proposed as a potential anti-cancer strategy (27043285). TFAM overexpression favors cancer cell growth and survival (21453679, 22129993, 25108120), mainly by activating the anti-apoptotic gene BCL2L1 (22098591); additionally, TFAM mediates the maintenance of mitochondrial DNA and mitochondrial biogenesis (21453679, 21514422) and supports the metabolic switch in these cells (25220386). An exception to these findings would be squamous cell carcinoma, where TFAM expression levels have been found to be reduced, relative to normal tissues (27079936). |
| Hs.BAD | 21 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: BAD; Aliases: BBC2; BCL2L8; Role in Cancer: BAD is a BH3-only protein involved in mitochondrial activation of apoptosis (30366984). However, modifications in the phosphorylation patterns of BAD modified its activity to block apoptosis and lead to cancer cell survival and progression (25653146). Moreover, the cooperation of BAD with BID, BCLXL and BCL-2 partially underlies migration of triple-negative breast cancer cells, after stimulation with the cytokine CD95L (27367565). In addition, the upregulation of BAD follows anti-tumor therapy in several cancer types, including colon (25386076), papillary thyroid carcinoma (24583924) and lung cancer (24627125). |
| Hs.IFI27 | 21 | 9.9 | MitoCarta 2.0:YES | Cell cycle regulation | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: IFI27; Aliases: P27; ISG12; FAM14D; ISG12A; Role in Cancer: IFI27 encodes the protein p27 (also known as Kip1), a cell cycle inhibitor that has been considered as an onco-suppressor protein (25386076). Treatment-mediated transcriptional upregulation of IFI27 in cancer cells results in reduced cell proliferation, mainly by promoting cell-cycle arrest (20145152, 20637573, 21462330, 21868525, 22103929, 23840429, 25674801, 26352011). Conversely, p27 seems to play an opposite role in gastric carcinoma cells, given that transcriptional downregulation of IFI27 potentially enhanced MLN4924-induced anti-tumoral effects (26313918). |
| Hs.PMAIP1 | 19 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: PMAIP1; Aliases: APR; NOXA; Role in Cancer: PMAIP1 is also known as one of the pro-apoptotic BH3-only proteins. Induced downregulation of NOXA has shown to prevent apoptosis in cellular models of glioma (28418907) and glioblastoma (28415755). Accordingly, it has been observed that treatment-triggered upregulation of pro-apoptotic proteins (such as NOXA) leads to cell death in gastric adenocarcinoma (29966654), colon cancer (25386076) and glioma cells (25139025). |
| Hs.COX2 | 18 | 3.1 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Genomic instability and mutations + Reprogramming of energy metabolism | Gene Name: COX2; Aliases: COII; MTCO2; COX2; Role in Cancer: This protein is a subunit of complex IV in the respiratory chain. Mutations in COX2 (and in genes that encode other subunits of complex IV) are highly common in patients with head and neck squamous cell carcinoma (26238294) or MUTYH-associated polyposis (23599153, 26138249); and correlates with poor prognosis in acute myeloid leukemia patients (23444869). Impaired expression of COX2 partially compensates the increase in glycolysis that occurs in cancer cells (27231905, 26238294) and indirectly stimulates cell proliferation (21129724, 23696597, 26238294). |
| Hs.SIRT3 | 18 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) + Homeostasis (redox) | Reprogramming of energy metabolism + Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: SIRT3; Aliases: SIR2L3; Role in Cancer: SIRT3 is a mitochondrial stress-responsive deacetylase protein that contributes to both mitochondrial homeostasis and to the modulation of reactive oxygen species (28536275). Low levels of SIRT3 have been found in several cancer types, including breast cancer (29683756, 24746213), head and neck squamous cell carcinoma (26785117), renal cell carcinoma (27114304) and hepatocellular carcinoma (25915842). Loss of SIRT3 has been proposed to contribute to the metabolic reprogramming of cancer cells (28536275) and lead to impaired control of oxidative stress, glycolysis and cellular proliferation (23800187, 21397863). However, upregulation of SIRT3 has been reported to promote cell proliferation and to increase energy production efficiency especially in the intestinal type of gastric cancer (26121691). |
| Hs.ATP6 | 17 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Mitochondrial maintenance and repair systems + Evasion of cell death | Gene Name: ATP6; Aliases: ATPASE6; MTATP6; ATP6; Role in Cancer: Reduced amounts of several mitochondrial proteins, including ATPase6, suggest disruption of mitochondrial gene expression in cancer (21129724). Mutations in the ATP6 gene potentially result from increased exposure to free radicals (25110199, 26138249), they are frequently found in cancerous tissues (21334307, 25896597, 27055661, 27121313, 27187822, 27333991) and have been associated with cancer progression and resistance to anticancer therapy (22533676, 22542792, 26406445, 28986220). |
| Hs.ND1 | 17 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Genomic instability and mutations + Reprogramming of energy metabolism + Metastatic process | Gene Name: ND1; Aliases: MTND1; ND1; Role in Cancer: ND1 (a subunit of Complex I) has been considered a cancer susceptibility locus (21612400, 21926107, 24414975, 27941608), as mutations in this and other genes of the respiratory chain can disrupt aerobic metabolism in cells (24163135, 24643264, 27231905, 28423551), which leads to increased production of ROS and contributes to aggressiveness (20006738, 21329181, 25909222, 27333991). |
| Hs.DNM1L | 16 | 9.9 | MitoCarta 2.0:YES | Mitochondrial dynamics (fission) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Evasion of cell death | Gene Name: DNM1L; Aliases: DLP1; DRP1; DVLP; EMPF; OPA5; EMPF1; DYMPLE; HDYNIV; Role in Cancer: This gene encodes a GTPase that induces mitochondrial fission during mitosis or apoptosis (20683914, 21724752). Increased levels of active DNM1L favor mitochondrial fission over fusion in cancer cells and have been detected in several types of cancer including prostate (21724752) and lung (22321727); however, low expression of DNM1L correlate with apoptosis resistance and bad prognosis in neuroblastoma (26812016). Upregulated DNM1L may have a role in drug resistance (23792636) and promotes cancer stemness (28435473) and proliferation (25658204, 28818497), but over-stimulation of DNM1L-dependent pathways contributes to mitochondrial dysfunction and fragmentation (22595283, 24397920, 28981113). Mechanisms involving this gene are potential therapeutic targets in cancer (26114658, 30471409). |
| Hs.SDHD | 16 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle / respiratory chain) | Genomic instability and mutations | Gene Name: SDHD; Aliases: PGL; CBT1; CWS3; PGL1; QPS3; SDH4; CYBS; CII-4; Role in Cancer: SDHD encodes for one of the two subunits of the mitochondrial complex II of the respiratory chain. Mutations in SDHD have been suggested to partially contribute to the development of several types of cancer, including paragangliomas and pheochromocytomas (20379037, 20484225, 23555188, 23723300), testicular seminoma and pituitary tumors (22170724, 22889736). ROS overproduction causes genomic instability, which affects the integrity of SDHD and the functionality of the protein it encodes throughout tumorigenesis (24465590, 25328978, 29235326). |
| Hs.MFN2 | 14 | 9.9 | MitoCarta 2.0:YES | Mitochondrial dynamics (fusion) | Evasion of cell death | Gene Name: MFN2; Aliases: HSG; MARF; CMT2A; CPRP1; CMT2A2; HMSN6A; CMT2A2A; CMT2A2B; Role in Cancer: Mitofusin 2 is a GTPase involved in mitochondrial fusion (27184078) that is downregulated in several types of cancer including bladder, colon (20803103), lung (22321727), gastric (23797661), liver (24339771, 27389277) and endometrium (28698145). MFN2 anticancer activity is underlaid by its ability to arrest cells in phase G1, inhibiting cell proliferation, and to induce Caspase-3-mediated apoptosis (20803103, 22321727). Thus, the transcriptional induction of MFN2 has been explored as a potential anti-cancer strategy (22510407, 22824300). However, it is still unclear whether this strategy suffices to prevent unbalance of mitochondrial dynamics (22595283), despite MFN2 contribution to mitochondrial integrity (23418303). Conversely, increased levels of MFN2 have been found in thyroid carcinoma, where it potentially regulates calcium signaling to delay apoptosis (25822260) and in prostate cancer patients carrying mtDNA deletions (26530043). |
| Hs.HK2 | 13 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) + Energy metabolism (glycolysis) | Reprogramming of energy metabolism + Evasion of cell death | Gene Name: HK2; Aliases: HKII; HXK2; Role in Cancer: This gene encodes the hexokinase 2 protein and its upregulation is promoted by hypoxic conditions (22382780, 23195224) and RUNX2 (25808624) in most malignant cells, at early stages of cancer development (19690031). HK2 initiates the conversion of glucose to lactic acid in glycolysis and modulates ROS formation to promote cancer cell survival (23799003, 25819414, 26182367). It also forms part of the VDAC-ANT-HKII complex that prevents mitochondrial permeability transition pore opening and apoptosis, by blocking cytochrome c release from mitochondria, and partially underlies chemoresistance (19690031, 24704448, 27231905). Increased levels of HK2 have been useful in cancer detection (26182367, 25998032) and targeting of this protein might contribute to the development of cancer therapies (26378042, 27277143, 28105937). |
| Hs.IDH1 | 13 | 8.3 | MitoCarta 2.0:YES | Energy metabolism (modulation of energy carriers) + Homeostasis (redox) + Biosynthesis (lipogenesis) | Genomic instability and mutations + Evasion of cell death | Gene Name: IDH1; Aliases: IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26; Role in Cancer: Mutations in the cytosolic/peroxisomal enzyme IDH1 occur in several types of cancer, including gliomas, secondary glioblastomas, and leukemia (21213123, 24252742, 24755473, 24995286, 25811801, 26901439, 27935156). Most of IDH1 penetrant mutations occur in arginine residues at the active sites, diverging the conversion of _-ketoglutarate towards the oncometabolite 2-hydroxyglutarate, instead of isocitrate. This compromises the production of acetyl-CoA and modifies the epigenetic landscape, promoting the proliferation of cancer cells and inhibiting apoptosis (22442146, 25811801, 26585387, 26007236, 28720665). |
| Hs.ND5 | 13 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Genomic instability and mutations + Evasion of cell death + Metastatic process | Gene Name: ND5; Aliases: MTND5; ND5; Role in Cancer: This gene encodes the subunit 5 of complex I of the electron transport chain and is located at a highly variable region that controls mtDNA replication and transcription (20552226). Mutations of this gene have been found in hepatocellular carcinoma (20006738), breast (20552226, 24253185, 26305705), pancreatic (22174369, 29378198), oral (27055661) and epithelial-ovarian cancer (26162681), among others. Mutated ND5 has been associated with shorter survival times (29378198) due to impairment of electron transport and exacerbated ROS production (24253185), which in turn promote the expression of anti-apoptotic genes and triggers pro-metastatic signaling (24253185, 28502718). |
| Hs.PINK1 | 13 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) + Homeostasis (mitochondria) + Mitochondrial dynamics (mitophagy) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Evasion of cell death + Metastatic process | Gene Name: PINK1; Aliases: BRPK; PARK6; Role in Cancer: PINK1 is a mitochondrial kinase that contributes to the maintenance of mitochondrial integrity, mainly by keeping a balance between fission and fusion via DRP1 (22076283, 24681957), through mitochondrial repair via the mitochondrion-derived vesicles pathway (28673964) or through mitophagy (23885119, 25217637, 26354775). PINK1 participates in the progression from G2/M to G1 phases during cell cycle (24681957) and regulates cell survival (23519076) targeting TRAP-1 and preventing apoptosis triggered by oxidative stress in mitochondria (20971498, 22319455, 23519076). PINK1 promotes proliferation and migration of cancer cells (24681957). Levels of this gene are increased in carcinomas and reduced in sarcomas (20971498, 26530043). This gene has been identified as an important therapeutic target that could help increase the effectiveness of anti-cancer drugs (22076283, 28673964). |
| Hs.AIFM1 | 12 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: AIFM1; Aliases: AIF; AUNX1; CMT2D; CMTX4; COWCK; DFNX5; NADMR; NAMSD; PDCD8; COXPD6; Role in Cancer: Release of AIF from the mitochondria and its nuclear translocation contributes to caspase-dependent apoptosis of cancer cells, upon treatment with anti-tumoral agents (20202741, 22829880, 26547530, 29501488). Conversely, it has been previously reported that the release of AIF mediates apoptosis per se in a caspase-independent manner (26304929). |
| Hs.BNIP3 | 11 | 9.9 | MitoCarta 2.0:YES | Mitochondrial dynamics (mitophagy) | Mitochondrial maintenance and repair systems + Reprogramming of energy metabolism | Gene Name: BNIP3; Aliases: NIP3; Role in Cancer: This protein belongs to the Bcl-2 family and promotes either apoptosis or mitophagy / autophagy in response to cellular stress (22684298, 25391657, 28653874). BNIP3 is a hypoxia-inducible protein that plays a pro-survival role that partially contributes to both atypical mitochondrial fusion and to the enlarged hypoxic mitochondria phenotypes observed in tumor cells (19957303, 26232272). Accordingly, overexpression of BNIP3 occurs at initial stages of cancer (27035659, 28698145) and correlates with decreased oxidative phosphorylation (23195224). However, loss of BNIP3 expression occurs upon cancer progression and contributes to increased aggressiveness and poor clinical outcomes (22684298, 26232272). However, induced chronic overexpression of BNIP3, Beclin and LC3 has been proven to be an effective strategy to activate autophagic cell death in cancer cells (25232961) and to overcome drug resistance (26298722). |
| Hs.CAT | 11 | 1.3 | MitoCarta 2.0:YES | Homeostasis (redox) | Adaptive modulation of oxidative stress | Gene Name: CAT; Aliases: -; Role in Cancer: Catalase is one of the major antioxidant proteins, and it mediates transformation of hydrogen peroxide to water and oxygen (19731237). Levels of this protein increase upon loss of mtDNA that probably occur at early stages of cancer development (19788937), or because of anti-cancer drugs administration (30411198). Although upregulation of CAT reduces intracellular ROS levels and contributes to the ability of cancer cells to resist oxidative stress (19609211), it can contribute to apoptosis due to insufficient buffering capacity (21181232). With other members of the antioxidant system in the cell, catalase represents an important therapeutic target that can mediate response to cancer treatments (21181232, 22142698, 25127718, 27710854, 30411198). |
| Hs.ND3 | 11 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Genomic instability and mutations | Gene Name: ND3; Aliases: MTND3; ND3; Role in Cancer: Non-synonymous mutations in this component of complex I (CI) of the respiratory chain disrupt energy production (24414975) and lead to increased levels of ROS; which ultimately favors cancer development (24437375). Mutations/polymorphisms in ND3 have been considered as predisposition factors for the development of several types of cancer including bone (25952970), oral (26179426), gastric (30275759), prostate and thyroid (19266278, 27187822), although their association with breast cancer is still under debate (19266278, 23993954, 24414975, 26782384, 29414393). In addition, mutations in ND3 highly contribute to fibrosis following radiotherapy, which triggers early senescence of tissues and compromises the life-quality of cancer survivors (19920115). |
| Hs.TRAP1 | 11 | 9.9 | MitoCarta 2.0:YES | Homeostasis (mitochondria / proteins) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Evasion of cell death | Gene Name: TRAP1; Aliases: HSP75; HSP 75; HSP90L; TRAP-1; Role in Cancer: TRAP-1 is a chaperone protein with ATPase activity (20860785) that belongs to the heat shock protein-90 family (19948822). TRAP1 is upregulated in a variety of cancer tissues, including prostate (19948822), colon (23139614, 27862857), pancreas (22116673) and kidney (30680959), as well as in several cancer cell lines (22076283). TRAP-1 mediates inhibition of SDH, leading to the accumulation of the oncometabolite succinate and favoring the metabolic switch in cancer cells (28099845). In addition, increased levels of TRAP-1 promote neoplastic growth through the establishment of hypoxic conditions that attenuate cell death triggered by oxidative stress (26100518, 23139614). Transcriptional levels of TRAP1 increase even more under metastatic conditions and it has been considered as a biomarker that correlates with cancer aggressiveness and poor prognosis (23139614). |
| Hs.VDAC1 | 11 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis / mtPTP) | Evasion of cell death + Metastatic process | Gene Name: VDAC1; Aliases: PORIN; VDAC-1; Role in Cancer: VDAC1 is a component of the mitochondrial permeability transition pore that associates with members of the Bcl-2 protein family in the presence of the Mps1 protein to modulate the cellular response to apoptosis (25177836, 27383047). Upregulation of VDAC1 occurs in several types of cancer, and it correlates with cancer cells evasion of apoptosis (25177836) and drug resistance (29596470). As well, higher levels of this protein have been implicated in an increase in cancer aggressiveness and metastatic potential that lead to poor clinical prognosis (21297950, 26716410). VDAC1 has been proposed as a highly accurate biomarker in cancer that allows risk stratification of patients, as well as a therapeutic target (25333947, 26409771, 27240826, 27894242, 27589771). |
| Hs.IDH2 | 10 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (modulation of energy carriers) + Homeostasis (redox) | Genomic instability and mutations + Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: IDH2; Aliases: IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; MNADP-IDH; Role in Cancer: IDH2 encodes a mitochondrial isocitrate dehydrogenase that metabolizes isocitrate (ICT) into _-ketoglutarate (_-KG) and supplies NADPH as a by-product to maintain a redox balance in mitochondria (20088709). Heterozygous missense mutations in this locus are present in several types of cancer (24995286) and partially contribute to the conversion of ICT into the oncometabolite 2-hydroxyglutarate, instead of _-KG (23561848). Accumulation of this metabolite contributes to metabolic reprogramming and malignancy of cancer cells (22442146, 26007236, 29235326). In addition, increased levels of IDH2 correlate with increased survival rates in gastric cancer patients (29293500). Given its biological role, this protein is considered as an important target in anti-cancer therapies (20088709, 23500467, 24995286, 28536275). |
| Hs.POLG | 10 | 9.9 | MitoCarta 2.0:YES | DNA (mtDNA replication) | Mitochondrial maintenance and repair systems | Gene Name: POLG; Aliases: PEO; MDP1; SCAE; MIRAS; POLG1; POLGA; SANDO; MTDPS4A; MTDPS4B; Role in Cancer: POLG encodes the only DNA polymerase that functions in human mitochondria in a RAD51C/XRCC3-mediated manner (29158291). Several silent/missense mutations and alterations at the POLG gene have been found in a variety of cancer types (20643228, 22276120, 26468652, 28457473, 29341116). Changes in the POLG locus affect mtDNA integrity (resulting in depletion of mtDNA) and lead to both impairment of energy metabolism and redox homeostasis, promoting tumorigenicity (19629138, 20643228). Conversely, increased levels of POLG correlate with better prognosis in some cancer cases (20643228, 22684821). |
| Hs.SDHA | 10 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle / respiratory chain) | Genomic instability and mutations | Gene Name: SDHA; Aliases: FP; PGL5; SDH1; SDH2; SDHF; CMD1GG; Role in Cancer: SDHA encodes the subunit A of the respiratory complex II; mutations in this gene usually lead to loss-of-function, destabilize the SDH complex and stimulate both hypoxic conditions and angiogenesis in tumors (20484225). Mutant SDHA has been detected in a variety of cancer types, including GIST (23282968), RCC (26722403), paragangliomas and pheochromocytomas (20484225, 24781757). SDHA has been considered as a potential cancer susceptibility locus (22972948, 23282968, 24781757, 28324028, 30680959) and has a role in mediating the response to anti-cancer treatments (26980435). |
| Hs.COX1 | 9 | 1.9 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Genomic instability and mutations | Gene Name: COX1; Aliases: COI; MTCO1; COX1; Role in Cancer: This gene encodes one of the two most important catalytic subunits of complex IV of the respiratory chain (23509693, 23444869). Mutations in COX1 have been found in neoplasia, including MAP-carcinogenesis (23599153, 26138249), AML (23444869), HCC (20006738), pancreas (21389643), breast (27121313) and prostate cancer (23509693). Physiologically, these changes have been associated with chromosomal instability and adverse prognosis (23444869), and they are known to contribute to cancer development, as they cause cellular damage and mitochondrial dysfunction, due to ROS/NOS overproduction and oxidative stress (21389643, 23509693, 23599153). |
| Hs.FH | 9 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) | Genomic instability and mutations + Metastatic process | Gene Name: FH; Aliases: MCL; FMRD; HSFH; LRCC; HLRCC; MCUL1; Role in Cancer: Fumarase is considered as an anti-Warburg enzyme that under homeostasis mediates the reversible conversion of fumarate to malate in the TCA cycle (29293500). Either germline or somatic mutations in this gene impair the functionality of Fumarase, producing accumulation of its substrate fumarate and further upregulation of the pro-angiogenic HIF (20231875, 20660115, 25490448). Altogether, FH-related energetic disruptions contribute to malignant transformation of cells (22867999) and FH has been identified as a cancer susceptibility locus as well as a contributor to metastasis in RCC (19963135, 23203078, 24625422). |
| Hs.MFN1 | 9 | 9.9 | MitoCarta 2.0:YES | Mitochondrial dynamics (fusion) | Evasion of cell death | Gene Name: MFN1; Aliases: HFZO1; HFZO2; Role in Cancer: MFN1 encodes Mitofusin 1, which is a dynamin-related GTPase involved in mitochondrial fusion (19957303, 21724752). Either hypoxia or mtDNA depletion induce upregulation of this gene, which increases fusion over fission, produces enlarged mitochondria (previously observed in some cancer tissues) that contribute to reducing cell sensitivity to apoptotic stimuli (19957303, 22824300, 26530043); however, thyroid cancer tissues have decreased levels of MFN1, as this could delay oxidative stress-induced MMP deregulation (25822260). MFN1 regulates mitochondrial morphogenesis and modulates cell sensitivity to apoptosis; thus, it has been considered for several therapeutic strategies (21724752, 30366984). |
| Hs.ND4 | 9 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Genomic instability and mutations + Reprogramming of energy metabolism | Gene Name: ND4; Aliases: MTND4; ND4; Role in Cancer: This gene encodes one of the core subunits of the respiratory complex I (CI). Indels and non-synonymous mutations in the ND4 locus produce frameshift and amino acid substitutions in the protein, respectively (20006738). ND4 variants are considered as risk factors for cancer (20006738, 22174369, 24253185, 27055661, 29378198), and overexpression of ND4 has been detected in gastric cancer (24812152). Transcriptional and protein modifications in ND4 associate with increased oxidative stress, mitochondrial dysfunction, cellular damage and metabolic switch to glycolysis (20006738, 24253185, 25909222, 29309924). In addition, modifications in ND4 contribute to reduced sensitivity to radiotherapy (20426663). |
| Hs.PDK1 | 9 | 8.1 | MitoCarta 2.0:YES | Energy metabolism (pyruvate dehydrogenase complex cycle) | Reprogramming of energy metabolism + Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: PDK1; Aliases: -; Role in Cancer: PDK1 forms part of the pyruvate dehydrogenase complex, it mediates inhibition of Acetyl-CoA production by blocking the pyruvate dehydrogenase enzyme (23840896, 24825347). Upregulation of PDK1 might result from binding of the KDM4A-E2F complex to its promoter regions (27626669), or through the action of HIF-1 mainly under hypoxic conditions (24788728, 28886081). Increased levels of PDK1 favor glycolysis over mitochondrial respiration and promote proliferation of malignant cells as well as angiogenesis (24825347). Accordingly, overexpression of PDK1 has been observed in several types of cancer and correlates with poor prognosis (23840896, 24788728, 24825347, 28827059, 29117193) and targeting of this protein has been performed as part of anti-cancer strategies (23840896, 24788728, 28349827, 28886081). |
| Hs.SDHC | 9 | 9.5 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle / respiratory chain) | Genomic instability and mutations + Metastatic process | Gene Name: SDHC; Aliases: CYBL; PGL3; QPS1; SDH3; CYB560; Role in Cancer: SDHC encodes a structural subunit of the respiratory complex II that anchors the complex to the IMM (23282968). Mutations in this locus have been found in young individuals with different types of cancer, including paraganglioma, pheochromocytoma, and GIST, among others (2048422, 21173220, 22972948, 23282968, 24781345, 28720665). Disruptions of SDHC are associated with pseudo-hypoxia, ROS induction, promotion of cell aggressivenes and angiogenesis (2048422). |
| Hs.UCP2 | 9 | 8.4 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) + Carrier (ions / signaling molecules) + Homeostasis (redox) | Adaptive modulation of oxidative stress + Evasion of cell death | Gene Name: UCP2; Aliases: UCPH; BMIQ4; SLC25A8; Role in Cancer: UCP2 encodes the mitochondrial inner membrane uncoupling protein 2. Upregulation of this gene has been detected in cancer cells and correlates with tumor progression and aggressiveness in multiple cancer types (21364658, 21935467, 26148070, 27478826, 28423551). Upregulated UCP2 promotes cell survival by attenuating oxidative stress through the dissipation of the protonmotive force at the IMM (i.e. extrusion and intrusion of free-fatty acid (FFA) anions and protonated-FFA, respectively from and intro the mitochondrial matrix) (21054343, 21364658, 21935467, 28533128). Therapeutic interventions involving blockage-mediated inhibition of UCP2 disables its tumor-promoting properties (21935467), and induced overexpression of this gene alleviates primary resistance to anti-tumor responses (30664764). |
| Hs.GAPDH | 8 | 2.7 | MitoCarta 2.0:YES | Energy metabolism (glycolysis) | Reprogramming of energy metabolism | Gene Name: GAPDH; Aliases: G3PD; GAPD; HEL-S-162EP; Role in Cancer: GAPDH encodes the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (23640464). Overexpression of GAPDH favors a glycolytic metabolism in tumor cells, it is associated with cancer progression and contributes to survival of tumor cells following treatment-induced inhibition of glycolysis (23603840, 25107643, 25188891,27582538). Severe cellular stress (potentially induced by hypoxia or chemotherapeutic agents) drives nuclear translocation of GAPDH. There, this protein partially modulates cell death/survival and contributes to glycolysis-mediated death resistance in cancer cells (23646141). |
| Hs.ND6 | 8 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Genomic instability and mutations + Reprogramming of energy metabolism + Metastatic process | Gene Name: ND6; Aliases: MTND6; ND6; Role in Cancer: The ND6 locus encodes a subunit of the respiratory complex I (CI). Frameshift and non -synonymous mutations in ND6 have been identified in breast cancer (24061460, 24414975), renal cell carcinoma (27231905) and pancreatic ductal adenocarcinomas (29378198). In colorectal adenocarcinoma, ND6 is increased and contributes to enhancing ROS production, which in turn promotes deleterious mutations in mtDNA (27333991). Disruption of ND6 partially contributes to defects in the oxidative phosphorylation (24061460), leads to a decrease in oxygen consumption (27231905), contributes to the metabolic switch in cancer cells and promotes invasiveness (25909222). Overall, alterations in ND6 have been found to correlate with decreased survival in cancer patients (29378198). |
| Hs.OPA1 | 8 | 8.7 | MitoCarta 2.0:YES | Mitochondrial dynamics (fusion) | Evasion of cell death | Gene Name: OPA1; Aliases: NPG; NTG; MGM1; BERHS; LARGEG; MTDPS14; Role in Cancer: OPA1 is a GTPase located at the inner mitochondrial membrane that mediates mitochondrial fusion and maintenance of mitochondrial cristae structure (25822260). Upregulation of OPA1 occurs from early stages of cancer development (e.g. in thyroid oncocytomas (25822260) and colorectal carcinoma (28423551)); where it mediates viability of cancer cells through proper retention of cytochrome c within mitochondria (28713989, 30366984). In breast and prostate cancer, levels of OPA1 increase as a result of stimulation of estrogen production and activation of EGFR, respectively (22824300, 25483192). |
| Hs.PDP1 | 8 | 8.7 | MitoCarta 2.0:YES | Energy metabolism (pyruvate dehydrogenase complex cycle) | Reprogramming of energy metabolism | Gene Name: PDP1; Aliases: PDH; PDP; PDPC; PPM2A; PPM2C; Role in Cancer: This gene encodes the pyruvate dehydrogenase phosphatase, which triggers the production of Acetyl-CoA in normoxia and promotes entry to the TCA cycle (26378042). A decrease in the expression levels of PDP1 occurs from early stages in several cancer types including breast cancer (24497069), glioblastomas (25712957), ovarian cancer (26378042) and lung cancer (27409347, 27856334). In general, downregulation of PDP1 supports the metabolic reprogramming of the cell and favors glycolysis over oxidative phosphorylation (24497069, 25712957). PDP1 decrease could result from inhibition or absence of activator proteins such as ING5 (27409347), CTP (27856334) and orexins (28886081). Contrastingly, overexpression of PDP1 has been detected in prostate cancer and it seems to support de novo lipid biosynthesis and further growth of cancer cells (29335542). |
| Hs.PHB | 8 | 9.9 | MitoCarta 2.0:YES | Homeostasis (proteins / redox / mitochondria) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Metastatic process | Gene Name: PHB; Aliases: PHB1; HEL-215; HEL-S-54E; Role in Cancer: PHB encodes an inner mitochondrial membrane chaperone that stabilizes mitochondrial proteins and prevents autophagy by mediating ROS production (22363587). This protein is a therapeutic target (29415747), given that it also regulates cell cycle progression and apoptosis through transcriptional modulation of the E2F and P53 loci (20890892). The role of PHB as a tumor-suppressor gene is controversial (20890892, 22728421). PHB is upregulated at early cancer development and has been considered as a biomarker (22728421, 25344214). Increased transcriptional levels of this gene, in turn, promote cell apoptosis through BAX upregulation (23098474). Further loss of functional PHB (due to deleterious mutations or to decreased PHB expression levels) at later stages of cancer associates with tumor progression, cancer metastasis and adverse prognosis (22728421, 23098474, 23244120, 30523154). |
| Hs.ENDOG | 7 | 9.9 | MitoCarta 2.0:YES | Cell death (apoptosis) + DNA (mtDNA integrity) | Mitochondrial maintenance and repair systems + Evasion of cell death | Gene Name: ENDOG; Aliases: Q14249; Role in Cancer: This gene encodes a mitochondrial endonuclease sensitive to oxidative stress that contributes to maintaining mtDNA integrity (27444971). Nuclear translocation of this protein is triggered by the administration of anti-cancer therapies and activates a caspase-independent apoptotic response in cancer cells (19557855, 19846952, 21617225, 21868525, 22593445, 24140706, 27444971). |
| Hs.HSPD1 | 7 | 2.7 | MitoCarta 2.0:YES | Homeostasis (proteins / mitochondria) | Mitochondrial maintenance and repair systems | Gene Name: HSPD1; Aliases: HLD4; CPN60; GROEL; HSP60; HSP65; SPG13; HSP-60; HUCHA60; Role in Cancer: This gene encodes an ATP-dependent mitochondrial chaperone that plays a relevant role in mitochondrial integrity (20978188, 29293508). Expression of HSPD1 increases throughout cancer development and progression (25107643, 25188891, 29293508), and it is considered as a valuable biomarker for cancers with high diagnostic difficulty (24015183, 25188891). This protein is also an attractive therapeutic target; induced inhibition of HSPD1 triggers apoptosis (through the formation of the mtPTP) in cancer cells (20978188) and depletion of the hyperacetylated HSPD1 pool has shown to greatly affect cancer cell viability and chemoresistance (24015183). |
| Hs.MCU | 7 | 9.9 | MitoCarta 2.0:YES | Carrier (ions) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Evasion of cell death | Gene Name: MCU; Aliases: HSMCU; C10ORF42; CCDC109A; Role in Cancer: The protein encoded by this gene is necessary for mitochondrial calcium uptake. Accumulation of mitochondrial calcium has an anti-proliferative activity and induces senescence of cells (24797322). Accordingly, downregulation of this gene may be involved in survival of cancer cells and tumor progression (25824785). |
| Hs.MPC1 | 7 | 9.9 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Reprogramming of energy metabolism + Metastatic process | Gene Name: MPC1; Aliases: MPYCD; BRP44L; CGI-129; SLC54A1; Role in Cancer: The protein encoded by this gene is a member of the mitochondrial pyruvate carrier, which mediates pyruvate oxidation and promotes an oxidative metabolism in homeostatic cells (26577410). Downregulation of MPC1 (e.g. by COUP-TFII (26895100) or PGC-1_ (29669911)) and reduced deacetylation rates due to disruption of Sirt-3 (26577410) occur in a variety of cancers and correlate with poor prognosis (25458841, 26577410, 26895100). Lower levels of the MPC1 protein hinder transport of pyruvate and induces a metabolic switch that favors glycolysis over oxidative phosphorylation in cancer cells, this increases EMT, as well as the metastatic capacity and therapy-resistance of cancer cells (26895100, 28624784, 29286150). However, active levels of MPC1 in bladder carcinoma cells contribute to a metabolic divergence where pyruvate is turned into cytosolic citrate for its further used in fatty acid synthesis and consequent promotion of cancer cell growth and division (28462847). |
| Hs.OGG1 | 7 | 5.1 | MitoCarta 2.0:YES | DNA (mtDNA integrity / nDNA integrity) | Mitochondrial maintenance and repair systems + Metastatic process | Gene Name: OGG1; Aliases: HMMH; MUTM; OGH1; HOGG1; Role in Cancer: OGG1 encodes a base-excision-repair DNA glycosylase localized at nuclei and mitochondria that repairs DNA upon detection of oxidized purines (21187477, 23677377). Deleterious mutations in this locus (partially derived from exposure of cells to carcinogenic agents) greatly affects mtDNA integrity, leading to copy number variation and elevated transcription of OGG1, which supports cancer development, progression and metastasis (21235219, 22941157, 23677377, 26408804, 26586787, 26785117). Interestingly, some cancer cells exhibit increased OGG1 protein levels in mitochondria only, coupled with decreased enzymatic activity, due to impaired import of this protein (21187477). |
| Hs.SOD1 | 7 | 0.6 | MitoCarta 2.0:YES | Homeostasis (redox) | Mitochondrial maintenance and repair systems | Gene Name: SOD1; Aliases: ALS; ALS1; HEL-S-44; IPOA; SOD; STAHP; HSOD1; HOMODIMER; Role in Cancer: SOD1 is part of the antioxidant enzymes within the cell and is involved in removal of the superoxide anion (23318445). Impairment of SOD1 increases oxidative stress levels, which promotes mitochondrial dysfunction and supports cancer development (23318445, 29695906, 23318445, 24535002). SOD1 is considered a suitable therapeutic target for cancer treatment, and it has been observed that induced upregulation of this gene affects viability of cancer cells and promotes mitochondrial respiration (22142698, 24535002). |
| Hs.ATP5F1B | 6 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism | Gene Name: ATP5F1B; Aliases: ATP5B; Role in Cancer: This gene encodes a component of the mitochondrial ATP synthase and is overexpressed in several types of cancer, including colorectal carcinoma (24583174) and glioblastoma (26526033). ATP5B has been considered a biomarker of oxidative phosphorylation (25107643) that correlates with poor prognosis due to resistance to anti-cancer therapies (24968221). As well, this ATP synthase has been suggested as a potential therapeutic target (28713989). |
| Hs.FIS1 | 6 | 9.2 | MitoCarta 2.0:YES | Mitochondrial dynamics (fission) + Cell death (apoptosis) | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: FIS1; Aliases: TTC11; CGI-135; Role in Cancer: Overexpression of FIS1 has been associated with cancer-related fatigue and with radiotherapy-derived fatigue in cancer patients (23047795, 24786901). Upregulation of this gene has also been associated with the increased presence of mitochondria in malignant tissues, dysfunctional mitochondrial turnover and deregulation of the mitochondrial membrane potential (25822260, 30404157). |
| Hs.GLS | 6 | 8.7 | MitoCarta 2.0:YES | Energy metabolism (glutaminolysis) | Reprogramming of energy metabolism + Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: GLS:GAC(3); Aliases: GAC; GAM; KGA; GLS1; AAD20; GDPAG; CASGID; EIEE71; Role in Cancer: This gene encodes a mitochondrial glutaminase. Levels of glutaminase are elevated in different types of cancer, including breast carcinoma. Overexpression of GLS may provide the bioenergetic elements that are necessary for the progression of cancer (22228304, 30092248). |
| Hs.ND2 | 6 | 7 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Genomic instability and mutations | Gene Name: ND2; Aliases: -; MTND2; ND2; Role in Cancer: The ND2 locus encodes a subunit of the respiratory chain complex I. Mutations in this gene disturb electron transport due to the production of malfunctioning ND2, which leads to increased oxidative stress levels (24253185, 24414975). The presence of mutated ND2 has been proposed as a cancer risk predictor (22174369, 24253185, 26340450) that correlates with an adverse clinical outcome (26179426) and potentially contributes to the development of chemoresistance in cancer cells (22777349). |
| Hs.TSPO | 6 | 4.2 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) + Biosynthesis (lipogenesis) + Homeostasis (mitochondria) + Cell death (apoptosis) | Mitochondrial maintenance and repair systems | Gene Name: TSPO; Aliases: DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; MDRC; PK18; Role in Cancer: Overexpression of this gene is observed in different types of cancer. This gene participates in ROS production, mitochondrial transport of molecules, cell proliferation, ATP production, cell death, etc. Also, this gene is involved in regulating the expression of nuclear genes through mitochondrial-nuclear signaling (28387723). |
| Hs.ACLY | 5 | 6.4 | MitoCarta 2.0:YES | Biosynthesis (lipogenesis) | Reprogramming of energy metabolism + Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: ACLY; Aliases: ACL; ATPCL; CLATP; Role in Cancer: Key enzyme that modulates the balance between glycolytic rates and the synthesis of fatty acids in the cell, through which it contributes to cancer cells maintenance and proliferation (25483192, 27248322). |
| Hs.ATP8 | 5 | 7.9 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism | Gene Name: ATP8; Aliases: ATPASE8; MTATP8; ATP8; Role in Cancer: This gene encodes a mitochondrial ATP synthase, which has high susceptibility to oxidative stress (23088850). The presence of missense mutations and ROS-derived damage to the mtDNA have been correlated with reduced levels of ATP8 in breast carcinoma (19125299, 25110199, 25896597). In fact, this protein has been suggested as a biomarker for breast cancer, given that downregulation of ATP8 can be detected in the blood of cancer patients from initial stages of malignancy (20025731). |
| Hs.CPT1A | 5 | 5.2 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) + Energy metabolism (beta-oxidation) | Reprogramming of energy metabolism + Metastatic process | Gene Name: CPT1A; Aliases: CPT1; CPT1-L; L-CPT1; Role in Cancer: Overexpression of CPT1A promotes fatty-acids oxidation and increased production of ATP, which supports proliferation and metastasis of prostate cancer cells (28671672). Induced downregulation of this gene improves treatment efficiency for patients with nasopharyngeal carcinoma (29721083). However, overexpression of CPT1A exerts anti-tumoral effects in clear cell renal cell carcinoma (29176561). |
| Hs.CYTB | 5 | 1.5 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism + Evasion of cell death | Gene Name: CYTB; Aliases: MTCYB; CYTB; Role in Cancer: This gene encodes a protein that forms part of complex III of the mitochondrial respiratory chain. Mutations in this locus are associated with increased ROS production and further mitochondrial and cellular damage (24253185). Overexpression of this gene contributes to cell proliferation and blocks pro-apoptotic signaling (19569044). |
| Hs.FASN | 5 | 3 | MitoCarta 2.0:YES | Biosynthesis (lipogenesis) | Reprogramming of energy metabolism | Gene Name: FASN; Aliases: FAS; OA-519; SDR27X1; Role in Cancer: Proapoptotic function (21617225). Tumor cells overexpress FASN to increase lipids metabolism (21868525). The transcriptional increase is triggered by hypoxia in prostate carcinoma cells to support adaptation to hypoxia, increase energy production and promote cell survival (23709747). |
| Hs.HK1 | 5 | 2 | MitoCarta 2.0:YES | Energy metabolism (glycolysis) | Reprogramming of energy metabolism + Adaptive modulation of oxidative stress | Gene Name: HK1; Aliases: HK; HKD; HKI; HXK1; RP79; HMSNR; HK1-TA; HK1-TB; HK1-TC; NEDVIBA; HEXOKINASE; Role in Cancer: Overexpression of HK1 in tumor cells may be explained by increases in the glycolytic metabolism of tumor cells; also, this enzyme can protect cancer cells from oxidative stress and apoptosis (28105937). |
| Hs.HSPA9 | 5 | 9.9 | MitoCarta 2.0:YES | Homeostasis (proteins) + Carrier (molecules / protein precursors) + Cell death (apoptosis) | Mitochondrial maintenance and repair systems + Evasion of cell death | Gene Name: HSPA9; Aliases: CSA; MOT; MOT2; SAAN; CRP40; EVPLS; GRP75; PBP74; GRP-75; HSPA9B; SIDBA4; MTHSP75; HEL-S-124M; Role in Cancer: This protein participates in fission (mitochondrial fragmentation), which leads to a decrease in cell viability (22595283, 21297950). |
| Hs.MAVS | 5 | 4.6 | MitoCarta 2.0:YES | Cell death (apoptosis) | Potential anti-cancer activity | Gene Name: MAVS; Aliases: IPS1; VISA; IPS-1; CARDIF; Role in Cancer: This protein is involved in a pathway that triggers a pro-inflammatory response in the cell and finally leads to apoptosis upon sensing the presence of viral dsRNA (23014529, 25645662). |
| Hs.RECQL4 | 5 | 9.9 | MitoCarta 2.0:YES | DNA (nDNA replication / nDNA integrity / mtDNA replication / mtDNA integrity) | Mitochondrial maintenance and repair systems + Reprogramming of energy metabolism | Gene Name: RECQL4; Aliases: RECQ4; Role in Cancer: This gene encodes a DNA helicase that belongs to the RECQ family; it is involved in the synthesis of nuclear/mitochondrial DNAs and contributes to their integrity by interacting with p53 and enzymes of the base-excision repair pathway (22357944, 23161009, 24067899). Mutations in this locus predispose patients to cancer development (especially osteosarcoma and lymphoma), as they deregulate the nucleus-to-mitochondria translocation rates of RECQL4, affect the stability/copy number of mtDNA, lead to mitochondrial dysfunction and to development of cell malignancy (22357944, 24067899, 24746816, 26906415). |
| Hs.SHMT2 | 5 | 9.2 | MitoCarta 2.0:YES | Biosynthesis (nucleotides / aminoacids) | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: SHMT2; Aliases: GLYA; SHMT; HEL-S-51E; Role in Cancer: This enzyme mediates the conversion of serine to glycine (23474074) and participates in folate metabolism and nucleotides biosynthesis through the conversion of tetrahydrofolate (THF) to methylene-THF (24223914). Cancer cells have increased levels of this protein, which contributes to their growth and proliferative capacity (23474074, 24223914, 30035852), as well as to their metabolic reprogramming (27530298). SHMT2 is a biomarker of cancer prognosis (27666119) that has also been considered as a valuable therapeutic target (27530298). |
| Hs.SLC16A1 | 5 | 4.7 | MitoCarta 2.0:YES | Carrier (monocarboxylates) | Reprogramming of energy metabolism | Gene Name: SLC16A1; Aliases: MCT; HHF7; MCT1; MCT1D; Role in Cancer: MCT1 mediates transport of monocarboxylates (such as lactate) into cells to fuel mitochondrial respiration and out of cells to support glycolysis. Hypoxic conditions and increased glycolytic rates in cancer cells lead to upregulation of this protein; which has been associated with adverse clinical outcomes (22184616, 22850421). Targeting of this protein has shown to have effective anti-cancer effects (22850421, 25403912, 26198749). |
| Hs.BCL2L2 | 4 | 5 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: BCL2L2; Aliases: BCLW; BCL-W; PPP1R51; BCL2-L-2; Role in Cancer: This gene encodes an anti-apoptotic member of the BCL2 protein family. Downregulation of BCL2L2 occurs as a primary step of the drug-inducible response of cancer cells (22589275) and contributes to tumor cells apoptosis (20457620). |
| Hs.C1QBP | 4 | 5.2 | MitoCarta 2.0:YES | Homeostasis (proteins) + DNA (mtDNA transcription) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Evasion of cell death + Metastatic process | Gene Name: C1QBP; Aliases: P32; HABP1; GC1QR; GC1QBP; SF2P32; GC1Q-R; COXPD33; SF2AP32; Role in Cancer: This gene encodes a protein of the mitochondrial matrix, it plays a role in proteostasis and is involved in de novo production of respiratory complexes. Upregulation of C1QBP promotes proliferation and migration of cancer cells and contributes to their evasion of mitochondrially-triggered cell death, which has been previously correlated with adverse cancer prognosis (22101277, 23195224); thus, this locus is of therapeutic interest (25288439). |
| Hs.CISD2 | 4 | 8.4 | MitoCarta 2.0:YES | Cell death (autophagy / apoptosis) + Homeostasis (redox / mitochondria) | Adaptive modulation of oxidative stress + Evasion of cell death | Gene Name: CISD2; Aliases: ERIS; WFS2; ZCD2; NAF-1; MINER1; Role in Cancer: Overexpression of the iron-sulfur CISD2 protein (also known as NAF-1) increases the tolerance of cancer cells to oxidative stress and supports aggressiveness of malignant cells (27621439, 28928421). Downregulation of CISD2 could be established as a potentially effective anti-cancer strategy (27621439, 29259115). However, complete depletion of this protein has been related with accumulation of truncated-VDAC1 protein that mediates chemoresistance in cancer cells (29596470). |
| Hs.CS | 4 | 2.3 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) | Unclear role in cancer | Gene Name: CS; Aliases: O75390; Role in Cancer: This gene encodes a member of the TCA cycle whose activity increases upon accumulation of citrate, resulting from dysfunctional activity of other members of the mitochondrial energetic machinery (23723300). In a non-small cell lung carcinoma cell line (A459 cells) treated with an ERRa-agonist, CS is also upregulated and potentially promotes cancer cell death by contributing to restoration of mitochondrial respiration and further increase of ROS (20447055). |
| Hs.FXN | 4 | 2.8 | MitoCarta 2.0:YES | Homeostasis (redox / proteins) | Unclear role in cancer | Gene Name: FXN; Aliases: FA; X25; CYAY; FARR; FRDA; Role in Cancer: Frataxin is involved in iron-sulfur cluster biogenesis and incorporation, as well as in the synthesis of heme groups (20398431, 25158131). FXN expression is promoted by p53 (25158131) and inhibited under hypoxia (29596470). This gene has been previously suggested to exert tumor suppressor functions (25158131); however, experimental evidence produced from human samples and clinical data does not provide a direct association between FXN and tumorigenesis (20398431, 22736457). |
| Hs.HTRA2 | 4 | 5 | MitoCarta 2.0:YES | Cell death (apoptosis) + Homeostasis (mitochondria) | Evasion of cell death | Gene Name: HTRA2; Aliases: OMI; MGCA8; PARK13; PRSS25; Role in Cancer: HTRA2 participates in quality control to promote cell survival under homeostasis (22923201). Under normal conditions, this gene acts as a tumor suppressor; however, impaired release of the HTRA2 protein from the mitochondria to the cytosol under cellular stress disrupts activation of caspases, avoiding apoptosis (22562073, 22923201). In other types of cancer, expression of HTRA2 is inhibited by HIF1-alpha, so it is unable to exert its tumor suppressor function (23581228). |
| Hs.MAOA | 4 | 1.4 | MitoCarta 2.0:YES | Homeostasis (redox) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Evasion of cell death + Metastatic process | Gene Name: MAOA; Aliases: BRNRS; MAO-A; Role in Cancer: This gene encodes a protein of the outer mitochondrial membrane that mediates degradation of some catecholamines (20204405). Despite the homeostatic tumor-suppressor activity of this gene, its overexpression occurs in prostate and lung carcinomas. This leads to increased ROS production and further promotes growth and metastasis of tumor cells (20204405, 28402333, 30021838). MAO-A has been suggested as an attractive therapeutic target (20204405, 28402333) and complete dysfunction of this protein is associated with exacerbated levels of nitrosative/oxidative stress in cancer cells treated with chemotherapeutic agents (21678067). |
| Hs.MDH2 | 4 | 6.6 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) | Reprogramming of energy metabolism | Gene Name: MDH2; Aliases: MDH; MOR1; M-MDH; EIEE51; MGC:3559; Role in Cancer: MDH2 is a susceptibility locus of paragangliomas and pheochromocytomas (28720665). Downregulation of this gene diminishes oxidative respiration and contributes to the metabolic reprogramming that occurs in cancer cells, under hypoxic conditions (29235326). However, inhibition of MDH2 in human colorectal cancer cells has been reported to abolish hypoxia and to trigger apoptosis (27611801). |
| Hs.MRPS30 | 4 | 9.9 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: MRPS30; Aliases: PAP; PDCD9; S30MT; MRP-S30; Role in Cancer: MRPS30 has been previously identified as a risk locus for breast cancer, but the mechanisms through which the encoded protein of this gene might contribute to carcinogenesis have not been fully elucidated (29351903). |
| Hs.PAM16 | 4 | 9.9 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) + Mitochondrial dynamics (biogenesis) | Adaptive modulation of oxidative stress | Gene Name: PAM16:MAGMAS(5); Aliases: TIM16; MAGMAS; SMDMDM; TIMM16; CGI-136; Role in Cancer: Overexpression of this gene has been reported in prostate cancer (23263864) and gliomas (30414099); the PAM16 protein localizes at the inner mitochondrial membrane and has been associated with mitochondria biogenesis, cell tolerance to oxidative stress and promotion of cell survival under hypoxic conditions (20053669, 27330077, 30414099). |
| Hs.PDHA1 | 4 | 6.4 | MitoCarta 2.0:YES | Energy metabolism (pyruvate dehydrogenase complex cycle) | Reprogramming of energy metabolism | Gene Name: PDHA1; Aliases: PDHA; PDHAD; PHE1A; PDHCE1A; Role in Cancer: Overexpression of this gene in prostate cancer cells promotes a metabolic diversion to lipogenesis and lipid-based metabolism in cancer cells, which contributes to fulfill the energy required during tumorigenesis (29335542). Conversely, overexpression of PDHA1 in hepatocellular carcinoma promotes the reestablishment of oxidative respiration and promotes apoptosis of cancer cells (29444744). Functionality of PDHA1 is decreased in breast cancer cells and correlates with an increase in glycolysis over oxidative phosphorylation (25808624). |
| Hs.PRDX3 | 4 | 5.8 | MitoCarta 2.0:YES | Homeostasis (redox / mitochondria) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Evasion of cell death | Gene Name: PRDX3; Aliases: AOP1; MER5; AOP-1; SP-22; HBC189; PRO1748; PRX-III; Role in Cancer: This gene encodes an antioxidant enzyme that mediates the conversion of hydrogen peroxide to water and alcohols. PRDX3 is overexpressed in different types of cancer such as breast and cervical carcinomas, and it has been proposed as a cancer cell proliferation biomarker (20043069, 22496757); conversely, upregulation of this locus has been associated with increased survival of patients with luminal B patients (29545070). |
| Hs.SDHAF2 | 4 | 6.1 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle / respiratory chain) | Reprogramming of energy metabolism + Metastatic process | Gene Name: SDHAF2; Aliases: PGL2; SDH5; C11ORF79; Role in Cancer: SDHAF2 is a tumor suppressor gene that encodes one of the two assembly factors of the succinate dehydrogenase complex (complex II of the respiratory chain) (20398431). SDHAF2 is considered a susceptibility gene for hereditary paragangliomas and pheochromocytomas, given that monoallelic hereditary mutations in this locus ablate activity of complex II, leading to pseudohypoxia and further promoting angiogenesis in tumor tissues (20484225, 22972948). |
| Hs.SLC25A1 | 4 | 7.3 | MitoCarta 2.0:YES | Carrier (tricarboxylates / anaplerotic subtrates) + Energy metabolism (intermediary metabolism) | Reprogramming of energy metabolism + Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: SLC25A1; Aliases: CTP; SEA; CMS23; D2L2AD; SLC20A3; Role in Cancer: SLC25A1 exports citrate from the mitochondria to the cytosol, in exchange of malate; metabolically, it participates in the TCA cycle, promotes lipogenesis and decreases glycolytic rates (23561848). Deleterious genetic alterations generate accumulation of the oncometabolites D-2- and L-2-hydroxyglutarate (23561848). Upregulation of this gene is triggered by inflammation, it occurs in different types of cancer and correlates with poor prognosis (23100451, 25072865, 27856334). |
| Hs.TOMM34 | 4 | 9.8 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) + Homeostasis (proteins) | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: TOMM34; Aliases: TOM34; URCC3; HTOM34P; Role in Cancer: This gene encodes a member of the mitochondrial import machinery that transports cytosolic pre-proteins into the mitochondria and stabilizes them due to its chaperone-like ability (23053644). TOMM34 contributes to the growth of cancer cells (30521791) and its levels increase in breast carcinoma (23053644) and colorectal cancer (25043054, 30521791). In the clinics, TOMM34 has been considered a biomarker for adverse prognosis in BRCA (23053644) and colorectal cancer progress (30521791). |
| Hs.UCP1 | 4 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) + Carrier (ions / signaling molecules) | Reprogramming of energy metabolism | Gene Name: UCP1; Aliases: UCP; SLC25A7; Role in Cancer: This protein promotes oxygen consumption through mitochondrial respiration in cells (19753307). Levels of UCP1 are elevated in different types of cancer (27575944) and targeted inhibition of this protein affects mitochondrial integrity, through dysregulation of the MMP and increase of ROS levels, which inhibits tumor cells growth (21054343). However, exacerbated expression of this gene triggers autophagy in breast cancer cells (23257779). |
| Hs.ATIC | 3 | 3.2 | MitoCarta 2.0:YES | Biosynthesis (nucleotides) | Unclear role in cancer | Gene Name: ATIC:AICAR(3); Aliases: PURH; AICAR; AICARFT; IMPCHASE; HEL-S-70P; Role in Cancer: This gene encodes an activator of the Adenosine Monophosphate Activated Protein Kinase (AMPK). Although exogenous induction of ATIC seems to promote apoptosis of cancer cells (25721362), the evidence consulted during this revision does not support a clear role in cancer of this gene. |
| Hs.BNIP3L | 3 | 4.1 | MitoCarta 2.0:YES | Cell death (apoptosis) | Mitochondrial maintenance and repair systems + Evasion of cell death | Gene Name: BNIP3L; Aliases: NIX; BNIP3A; Role in Cancer: In homeostasis, this gene participates in apoptosis activation via ROS induction (28653874). However, in cancer, hypoxic conditions trigger participation of this gene in unbalancing mitochondrial fission/fusion ratios, which results in enlarged mitochondria and apoptosis resistance (19957303). |
| Hs.COX3 | 3 | 2.2 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism | Gene Name: COX3; Aliases: COIII; MTCO3; COX3; Role in Cancer: Albeit as an individual finding, this protein has been found to be mutated in a prostate cancer case (21129724). In addition, somatic mutations of this locus are present in patients of breast cancer and colorectal carcinoma-predisposing conditions, leading to disruptions in the respiratory chain and promoting both oxidative stress and metabolic reprogramming (24253185, 26138249). |
| Hs.COX5B | 3 | 7.4 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism | Gene Name: COX5B; Aliases: COXVB; Role in Cancer: Part of the respiratory chain_s complex IV. Dysregulation may lead to tumor_s energy metabolism adaptation. Upregulated in breast cancer (29080556, 29107073). |
| Hs.FDXR | 3 | 3.4 | MitoCarta 2.0:YES | Homeostasis (redox / mitochondria) | Mitochondrial maintenance and repair systems + Adaptive modulation of oxidative stress | Gene Name: FDXR; Aliases: ADR; ADXR; ANOA; Role in Cancer: This gene promotes tumorigenesis by maintaining normal mitochondrial function under hypoxic conditions in breast cancer cells (26492917). |
| Hs.GPX1 | 3 | 2.1 | MitoCarta 2.0:YES | Homeostasis (redox) | Genomic instability and mutations | Gene Name: GPX1; Aliases: GPXD; GSHPX1; Role in Cancer: Genetic variation of the GPX1 gene can decrease the antioxidant activity of the resulting protein and further promote oxidative stress; which is a risk factor for breast cancer (24437375). |
| Hs.LETM1 | 3 | 6.2 | MitoCarta 2.0:YES | Carrier (ions) + Homeostasis (mitochondria / redox) | Mitochondrial maintenance and repair systems + Evasion of cell death | Gene Name: LETM1; Aliases: SLC55A1; Role in Cancer: Levels of LETM1 are increased in cancer where it promotes mitochondrial integrity in cancer cells by preventing mitochondrial swelling through the balance of the mitochondrial membrane potential and transmitochondrial ion transport (20197279). Along with MCU, LETM1 regulates mitochondrial calcium homeostasis and prevents calcium overload in cancer cells to evade apoptotic signaling (27606689). |
| Hs.LRPPRC | 3 | 5.9 | MitoCarta 2.0:YES | Homeostasis (mitochondria) + Cell death (apoptosis) | Mitochondrial maintenance and repair systems + Evasion of cell death | Gene Name: LRPPRC; Aliases: LSFC; GP130; LRP130; CLONE-23970; Role in Cancer: Overexpressed in different types of cancers (prostate, breast, etc.) This protein is involved in mitochondrial integrity. It is proposed that under stress conditions, LRPPRC promotes mitochondrial stability and apoptotic signaling. Therefore, aberrant expression could support tumor growth and progression (25379610, 27679555). |
| Hs.ME2 | 3 | 3.2 | MitoCarta 2.0:YES | Energy metabolism (intermediary metabolism / modulation of energy carriers) | Reprogramming of energy metabolism + Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: ME2; Aliases: ODS1; Role in Cancer: The enzyme encoded by this gene is suggested to play a compensatory role for energy production in cells with disrupted cytosolic pyruvate metabolism, which may favor cell malignancy (25202825). Even though expression of ME2 is affected under hypoxic conditions (29235326), its transcriptional levels have been reported to increase throughout cancer progression; which ultimately promotes energy production, growth and invasiveness of cancer cells (25202825, 27114304). |
| Hs.MPC2 | 3 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (glycolysis) | Reprogramming of energy metabolism | Gene Name: MPC2; Aliases: BRP44; SLC54A2; Role in Cancer: Mitochondrial pyruvate carrier. Downregulation of (MCP1/MCP2) promotes aerobic glycolysis needed for cancer cell proliferation (25458841, 26895100). |
| Hs.NNT | 3 | 9.9 | MitoCarta 2.0:YES | Energy metabolism (modulation of energy carriers) + Homeostasis (redox) | Adaptive modulation of oxidative stress | Gene Name: NNT; Aliases: GCCD4; Role in Cancer: NNT encodes the inner mitochondrial membrane NAD(P) transhydrogenase that uses energy from the proton gradient to maintain mitochondrial levels of NADPH; in this way, NNT modulates oxidative stress (25879317). Deleterious mutations in this gene have been found in a patient who developed testicular adrenal rest tumor (25879317). Induced downregulation of this gene in cancer cells reverted the functionality of the NNT protein, which first increased NADH and ROS levels and then greatly affected the viability of cancer cells by promoting a metabolism mainly based in mitochondrial respiration (28478381, 29850793). |
| Hs.PCK2 | 3 | 3 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) | Reprogramming of energy metabolism | Gene Name: PCK2; Aliases: PEPCK; PEPCK2; PEPCK-M; Role in Cancer: High expression of this genes is found in cancer cell lines. This gene participates in bioenergetic processes and its upregulation is associated with growth advantage of cancer cells (24973213). However, opposite effects have been observed in hepatocellular carcinoma where higher levels of this protein associate with increased apoptosis under glucose deprivation (24973213). |
| Hs.PHB2 | 3 | 2.4 | MitoCarta 2.0:YES | Mitochondrial dynamics (fusion) | Mitochondrial maintenance and repair systems | Gene Name: PHB2; Aliases: BAP; REA; P22; HBAP; BAP37; BCAP37; PNAS-141; Role in Cancer: Involved in mitochondria fusion which is associated with cancer cell survival (25483192). |
| Hs.POLRMT | 3 | 6.4 | MitoCarta 2.0:YES | DNA (mtDNA transcription) | Mitochondrial maintenance and repair systems | Gene Name: POLRMT; Aliases: APOLMT; MTRNAP; MTRPOL; H-MTRPOL; Role in Cancer: The protein encoded by this gene mediates expression of mtDNA and indirectly modulates mitochondrial turnover and integrity (27590350). Upregulation and gain-of-function of POLRMT occur in breast cancer patients with adverse prognosis and patients predisposed to oral cancer, respectively (23172368, 26403317). Targeting of this protein leads to increased ROS and apoptosis in cancer cells (26403317). |
| Hs.PPIF | 3 | 3.9 | MitoCarta 2.0:YES | Cell death (mtPTP / mtPTPC-mediated necrosis) + Homeostasis (proteins / mitochondria) | Unclear role in cancer | Gene Name: PPIF:CYCLOPHILIN-D(2); Aliases: CYP3; CYPD; CYP-M; CYP-D; Role in Cancer: PPIF encodes a member of the mitochondrial permeability transition pore (mtPTP). Translocation of this protein from the mitochondrial matrix to the inner membrane can occur upon activation of JNK, as part of a drug-induced response (26427664). Once in the IMM, PPIF associates with ANT-1 and promotes opening of the mtPTP and further cancer cell death (26427664, 27311860). |
| Hs.PRODH | 3 | 4.1 | MitoCarta 2.0:YES | Energy metabolism (proline metabolism) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Evasion of cell death | Gene Name: PRODH; Aliases: POX; PIG6; HSPOX2; PRODH1; PRODH2; TP53I6; Role in Cancer: PRODH is considered as a tumor suppressor gene that regulates cell cycle progression, indirectly promotes ROS production and mediates apoptosis in tumor cells (19654292, 25184115). Downregulation of this gene occurs in several types of cancer, including RCC, and contributes to tumor progression and resistance to apoptosis (19654292, 20562915). |
| Hs.SIRT4 | 3 | 5.2 | MitoCarta 2.0:YES | Energy metabolism (glutaminolysis) | Reprogramming of energy metabolism | Gene Name: SIRT4; Aliases: SIR2L4; Role in Cancer: Regulates glutamine metabolism and thus proliferation of Myc-induced B cell lymphoma. Similar results have been observed in head and neck squamous cell carcinoma (24368766, 26785117). |
| Hs.SIRT5 | 3 | 4.9 | MitoCarta 2.0:YES | Homeostasis (redox) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Evasion of cell death | Gene Name: SIRT5; Aliases: SIR2L5; Role in Cancer: Overexpressed in lung cancer and hepatocellular carcinoma. Its expression is associated with malignant cell progression, proliferation, and drug resistance (25070488, 29115436). However, overexpression of this gene is also associated with tumor suppressor activity (26585387). |
| Hs.SLC25A43 | 3 | 9.9 | MitoCarta 2.0:YES | Cell cycle regulation | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: SLC25A43; Aliases: -; Role in Cancer: In breast cancer cell line BT-474, SLC25A43 knockdown increased proliferation and cell cycle progression. This gene may be involved in cell cycle progression (26721434, 22883974). |
| Hs.SLC25A6 | 3 | 1.9 | MitoCarta 2.0:YES | Carrier (energy carrying molecules) + Cell death (apoptosis) | Reprogramming of energy metabolism + Evasion of cell death | Gene Name: SLC25A6; Aliases: ANT; AAC3; ANT3; ANT 2; ANT 3; ANT3Y; Role in Cancer: This gene encodes a solute carrier protein with pro-apoptotic properties that balances ADP/ATP ratio and oxidative stress in mitochondria (20060930, 23267836).However, other reports state that this gene promotes glycolytic metabolism and proliferation in cancer cells, and this activity has been associated with anti-apoptotic properties and anti-cancer therapy resistance in Non-Small Cell Lung Cancer (26883272). |
| Hs.SSBP1 | 3 | 5.4 | MitoCarta 2.0:YES | DNA (mtDNA replication / mtDNA integrity) + Mitochondrial dynamics (biogenesis) | Mitochondrial maintenance and repair systems | Gene Name: SSBP1; Aliases: SSBP; MTSSB; MT-SSB; SOSS-B1; Role in Cancer: The protein encoded by this gene participates in mtDNA replication and mitochondrial biogenesis. Increased levels of SSBP1 are observed in osteosarcoma and correlate with mitochondrial replication (21536680). |
| Hs.TOMM40 | 3 | 9.9 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) + Cell death (apoptosis) | Potential anti-cancer activity | Gene Name: TOMM40; Aliases: TOM40; PEREC1; C19ORF1; PER-EC1; D19S1177E; Role in Cancer: This gene encodes the translocase of the mitochondrial outer membrane (TOM) complex that mediates import of protein precursors into mitochondria. TOMM40 is also involved in the modulation of mitochondrially-triggered cell death (25177836). Induced upregulation of this gene has been tested as part of therapeutic strategies and results show that it promotes mitochondrial biogenesis and contributes to diminishing the metastatic potential of tumor cells (28713989). |
| Hs.TOP1MT | 3 | 8.3 | MitoCarta 2.0:YES | DNA(mtDNA integrity) | Mitochondrial maintenance and repair systems | Gene Name: TOP1MT; Aliases: -; Role in Cancer: Involved in mitochondrial DNA replication and repair. When dysregulated, this gene may promote cancer progression by increasing mutation rate. Overexpression has been observed in bone marrow neoplastic tissue while in gliomas, lower expression vs normal tissue has been observed (21531700). |
| Hs.UQCRFS1 | 3 | 7.1 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism | Gene Name: UQCRFS1; Aliases: RIP1; RIS1; RISP; UQCR5; Role in Cancer: The encoded protein belongs to complex III of the respiratory chain. Increased expression of this gene is observed in breast cancer and leukemia; in addition, UQCRFS1 may be suitable as a biomarker of impaired mitochondrial oxidative phosphorylation during cancer progression (21901141, 27845902, 29147009). |
| Hs.VDAC2 | 3 | 5.3 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: VDAC2; Aliases: POR; Role in Cancer: Primarily, the protein encoded by this pro-apoptotic gene mediates the function of BAX in apoptosis (25177836, 30478310) and has been suggested as a potentially relevant therapeutic target (26409771). |
| Hs.ACACA | 2 | 2.5 | MitoCarta 2.0:YES | Mitochondrial dynamics (biogenesis) | Mitochondrial maintenance and repair systems | Gene Name: ACACA:ACC1(2); Aliases: ACC; ACAC; ACC1; ACCA; ACACAD; Role in Cancer: This is a key enzyme in fatty acid synthesis and is needed to maintain mitochondrial biogenesis. Expression of this protein is upregulated in tumors and inhibited in prostate cancer cells. The later, leads to cell death (21525791, 28986507). |
| Hs.ACADM | 2 | 1.7 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) | Reprogramming of energy metabolism | Gene Name: ACADM:MCAD(2); Aliases: MCAD; ACAD1; MCADH; Role in Cancer: In breast cancer this gene participates in metabolic adaptations to survive to cellular metabolic stress (25975952). |
| Hs.ACO1 | 2 | 2.2 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) + Homeostasis (iron) | Reprogramming of energy metabolism | Gene Name: ACO1; Aliases: IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1; Role in Cancer: This gene participates in iron homeostasis in the cell. Additionally, it catalyzes the conversion of citrate to isocitrate in the TCA cycle. Inhibition of this gene suppresses proliferation of pancreatic cancer cells (24909164). |
| Hs.ACO2 | 2 | 2.9 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) | Reprogramming of energy metabolism | Gene Name: ACO2:MITOCHONDRIAL ACONITASE(2); Aliases: ICRD; OCA8; OPA9; ACONM; HEL-S-284; Role in Cancer: It is suggested that in malignant cells, this enzyme is actively upregulated to promote energy production and support cancer cell proliferation. This gene is also upregulated under hypoxic conditions in prostate carcinoma cells (23709747, 20607720). |
| Hs.AK4 | 2 | 5 | MitoCarta 2.0:YES | Homeostasis (redox) + Biosynthesis (nucleotides) | Adaptive modulation of oxidative stress + Evasion of cell death | Gene Name: AK4; Aliases: AK3; AK 4; AK3L1; AK3L2; Role in Cancer: This gene participates in ATP regulation and has antioxidant activity. Overexpression of this gene in different types of cancer correlates with cancer cell proliferation and contributes to both tolerance to hypoxia and to drug therapy resistance (24767988, 26980435). |
| Hs.ALDH2 | 2 | 0.9 | MitoCarta 2.0:YES | Energy metabolism (alcohol / intermediary metabolism) | Unclear role in cancer | Gene Name: ALDH2; Aliases: ALDM; ALDHI; ALDH-E2; Role in Cancer: Inactivation of this enzyme promotes accumulation of acetaldehyde, which is considered a carcinogen. Therefore, subjects carrying mutant ALDH2 variants have increased risk of pancreatic cancer. However, the association study reviewed here does not confirm a biological role (20590827). |
| Hs.ATP5F1A | 2 | 3.9 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism | Gene Name: ATP5F1A; Aliases: ATP5A1; ATPM; MOM2; ATP5F1A; AI035633; AL022851; AL023067; D18ERTD206E; Role in Cancer: Elevated expression of ATP5A1 was identified in glioblastoma tumor and may be associated with an elevated demand of ATP by a tumor in a proliferative state (26526033). |
| Hs.ATP5MC1 | 2 | 4.7 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism | Gene Name: ATP5MC1; Aliases: ATP5G1; ATP5A; ATP5MC1; Role in Cancer: This gene is an important element in the synthesis of ATP. Given that proliferation of breast cancer cells decreases upon reduction of ATP levels, this gene has been suggested to participate in tumorigenesis. (28701793) |
| Hs.BCAT2 | 2 | 4.4 | MitoCarta 2.0:YES | Energy metabolism (aminoacids) + Biosynthesis (aminoacids) | Unclear role in cancer | Gene Name: BCAT2; Aliases: BCAM; BCT2; PP18; BCATM; Role in Cancer: The protein encoded by this gene mediates the conversion of branched aminoacids and alpha-ketoglutarate into branched chain alpha-keto acids and glutamate, which contributes to tumor expansion in GBM, due to its neurotoxic properties (28681360). BCAT2 contribution to cancer seems to be indirect and despite it has been suggested that it might underlie chemoresistance in GBM patients (30016590), clear evidence that support a role for this protein in cancer was not found in the literature reviewed. |
| Hs.CDC25C | 2 | 0.8 | MitoCarta 2.0:YES | Cell cycle regulation | Genomic instability and mutations + Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: CDC25C; Aliases: CDC25; PPP1R60; Role in Cancer: The encoded CDC25C phosphatase is a key regulator of the cell cycle. It induces G2/M transition in both meiotic and mitotic cells, through dephosphorylation of Cdc2/cyclinB-Cdk1 (31109596, 27563873). CDC25C is upregulated in several types of cancer, including LUAD and uveal carcinoma, among others, and has been associated with adverse prognosis (31109596, 31213897). Increased levels of this protein support proliferation of malignant cells (28566436). Mutations in CDC25C is a predisposition factor in about 50% of acute myelogenous leukemia (AML) cases (25159113). Targeting of this gene has been considered as a potential anti-cancer strategy (26805039, 28077999). |
| Hs.CHCHD2 | 2 | 4.4 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Evasion of anti-growth signaling and cell sufficiency in growth signals + Metastatic process | Gene Name: CHCHD2; Aliases: MNRR1; NS2TP; MIX17B; PARK22; C7ORF17; Role in Cancer: This gene is overexpressed in non_small cell lung carcinoma and presumably participates in growth cell and migration. This gene also is upregulated under hypoxic conditions (29540477, 25784717). |
| Hs.CISD1 | 2 | 4.1 | MitoCarta 2.0:YES | Carrier (iron) + Biosynthesis (Fe-S clusters) + Homeostasis (redox) | Evasion of cell death | Gene Name: CISD1; Aliases: ZCD1; MDS029; C10ORF70; MITONEET; Role in Cancer: The protein encoded by this gene modulates mitochondrial iron uptake. In hepatocellular carcinoma, this gene regulates mitochondrial iron uptake to avoid lipids peroxidation and then ferroptosis. (27510639) |
| Hs.COX4I1 | 2 | 2.8 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Unclear role in cancer | Gene Name: COX4I1; Aliases: COX4; COXIV; COX4-1; COXIV-1; COX IV-1; Role in Cancer: The revised literature does not support a clear role for this protein in cancer. |
| Hs.COX8A | 2 | 9.9 | MitoCarta 2.0:YES | Annotation error | Annotation error | Gene Name: COX8A; Aliases: COX; COX8; VIII; COX8L; COX8-2; VIII-L; Role in Cancer: Abstracts refer to COX regression and not to the COX8A gene. |
| Hs.CPT1C | 2 | 4.6 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) | Reprogramming of energy metabolism | Gene Name: CPT1C; Aliases: CATL1; CPT1P; CPTIC; SPG73; CPT1-B; CPTI-B; Role in Cancer: In breast cancer, this and other genes participate in energy homeostasis. Particularly in activation of fatty acids oxidation, as a response to metabolic stress conditions (hypoxia and glucose deprivation). With this, this protein contributes to cancer cell proliferation (25975952, 28334197). |
| Hs.CYB5R3 | 2 | 3.4 | MitoCarta 2.0:YES | Homeostasis (redox) + Cell death (apoptosis) | Adaptive modulation of oxidative stress + Evasion of cell death + Metastatic process | Gene Name: CYB5R3; Aliases: B5R; DIA1; Role in Cancer: This protein acts as antioxidant and blocks apoptotic signals. In breast cancer cells, this gene was upregulated and associates with metastasis. (26351264) |
| Hs.CYP11B2 | 2 | 1.2 | MitoCarta 2.0:YES | Biosynthesis (cholesterol / hormones / lipids) | Unclear role in cancer | Gene Name: CYP11B2; Aliases: CPN2; ALDOS; CYP11B; CYP11BL; CYPXIB2; P450C18; P-450C18; P450ALDO; Role in Cancer: Part of the P450 superfamily. They are involved in synthesis of lipids (cholesterol) and drug metabolism. Not clear role in cancer. |
| Hs.DECR1 | 2 | 1.5 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) | Unclear role in cancer | Gene Name: DECR1; Aliases: NADPH; DECR; NADPH; SDR18C1; Role in Cancer: This gene encodes the enzyme that mediates carboxylation of alpha-ketoglutarate to isocitrate. The revised literature does not support a clear role of this protein in cancer. |
| Hs.DHODH | 2 | 3.1 | MitoCarta 2.0:YES | Biosynthesis (nucleotides) | Evasion of cell death | Gene Name: DHODH; Aliases: URA1; POADS; DHODEHASE; Role in Cancer: This enzyme participates in the biosynthesis of pyrimidines and is needed for metabolism and cell proliferation. DHODH is proposed as mediator of resistance to TRAIL signal (resistance to apoptosis) (24013224). In acute promyelocytic leukemia, downregulation of DHODH induced apoptosis. (27374097) |
| Hs.DNAJC15 | 2 | 5.4 | MitoCarta 2.0:YES | Mitochondrial dynamics (biogenesis) | Mitochondrial maintenance and repair systems + Evasion of cell death | Gene Name: DNAJC15; Aliases: MCJ; HSD18; DNAJD1; Role in Cancer: Downregulation of this gene appears to promote tumor chemoresistance (23263864). |
| Hs.DNAJC19 | 2 | 9.9 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Unclear role in cancer | Gene Name: DNAJC19; Aliases: PAM18; TIM14; TIMM14; Role in Cancer: The protein encoded by this gene participates in mitochondrial biogenesis (27330077); however, the information revised does not clearly support its role in cancer. |
| Hs.ECHS1 | 2 | 4.6 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) + Cell death (apoptosis) | Reprogramming of energy metabolism + Evasion of cell death | Gene Name: ECHS1; Aliases: SCEH; ECHS1D; Role in Cancer: It is suggested that overexpression of this gene has anti-apoptotic activity and contributes to proliferation of gastric and colorectal cancer cells (25739098, 25338767). |
| Hs.FDX1 | 2 | 4.1 | MitoCarta 2.0:YES | Energy metabolism (modulation of energy carriers) + Biosynthesis (hormones / Fe-S clusters) | Unclear role in cancer | Gene Name: FDX1; Aliases: ADX; FDX; LOH11CR1D; Role in Cancer: Despite the protein encoded by this gene has been reported as a target of the anti-cancer molecule elesclomol (31133756), none of the reviewed literature clarifies a role of this protein in cancer. |
| Hs.GOLPH3 | 2 | 1.6 | MitoCarta 2.0:YES | Mitochondrial dynamics (biogenesis) | Mitochondrial maintenance and repair systems + Evasion of cell death | Gene Name: GOLPH3; Aliases: GOPP1; GPP34; MIDAS; VPS74; Role in Cancer: The protein product of this gene participates in mitochondrial biogenesis. Overexpression of this gene in cancer promotes resistance of cancer cells to autophagy and contributes to tumor cell growth (22722266). |
| Hs.GOT2 | 2 | 2.3 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) | Genomic instability and mutations + Reprogramming of energy metabolism | Gene Name: GOT2; Aliases: KAT4; KATIV; KYAT4; MITAAT; Role in Cancer: Genetic variants of this gene were found in patients with pheochromocytomas/paragangliomas. Importantly, they increase the activity of this enzyme and lead to increased energy production that favors cancer cell proliferation (28720665). |
| Hs.GPI | 2 | 0.3 | MitoCarta 2.0:YES | Energy metabolism (glycolysis) | Unclear role in cancer | Gene Name: GPI; Aliases: AMF; NLK; PGI; PHI; GNPI; SA36; SA-36; Role in Cancer: Upregulated in breast cancer samples (27582538). Not clear role in cancer |
| Hs.GPX4 | 2 | 2.1 | MitoCarta 2.0:YES | Homeostasis (redox) | Unclear role in cancer | Gene Name: GPX4; Aliases: MCSP; SMDS; GPX-4; PHGPX; SNGPX; GSHPX-4; SNPHGPX; Role in Cancer: This gene has an important antioxidant activity in mammalian cells. Loss-of-function of this protein is related with ROS accumulation, however no relationship with cancer was reported (29144989). |
| Hs.GSTK1 | 2 | 0 | MitoCarta 2.0:YES | Homeostasis (redox) | Unclear role in cancer | Gene Name: GSTK1; Aliases: GST; GST13; HGSTK1; GSTK1-1; GST13-13; GST 13-13; Role in Cancer: This gene participates in regulation of mitosis. Its expression is associated with survival in breast cancer (29545070). |
| Hs.GSTZ1 | 2 | 3.7 | MitoCarta 2.0:YES | Energy metabolism (intermediary metabolism) + Homeostasis (redox) | Unclear role in cancer | Gene Name: GSTZ1; Aliases: MAI; MAAI; MAAID; GSTZ1-1; Role in Cancer: The enzyme encoded by this gene mediates degradation of the potential anti-cancer drug DCA. Expression of this gene in liver increases with age and potentially mediates anti-cancer treatment efficiency (29853471), although a clear role for this protein was not found in the reviewed literature. |
| Hs.HIGD1A | 2 | 5.9 | MitoCarta 2.0:YES | Homeostasis (mitochondria) | Unclear role in cancer | Gene Name: HIGD1A; Aliases: HIG1; RCF1A; Role in Cancer: Given that this protein participates in mitochondrial integrity, it is considered as a marker of metabolic stress, but a specific role in cancer was not deduced from the reviewed literature (22355194, 23646141). |
| Hs.LDHB | 2 | 2.5 | MitoCarta 2.0:YES | Energy metabolism (glycolysis) | Reprogramming of energy metabolism | Gene Name: LDHB; Aliases: LDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281; Role in Cancer: LDHB and LDHA genes participate in activation of aerobic glycolysis during cancer cell proliferation (27732857). |
| Hs.MFF | 2 | 4.4 | MitoCarta 2.0:YES | Mitochondrial dynamics (fission) | Mitochondrial maintenance and repair systems + Reprogramming of energy metabolism | Gene Name: MFF; Aliases: -; EMPF2; GL004; C2ORF33; Role in Cancer: This protein participates in mitochondrial fission. Overexpression of this protein in stromal fibroblasts promotes tumor growth at early stages of cancer. In turn, this supports the characteristic metabolic adaption that promotes glycolysis in tumoral cells (22878233). |
| Hs.MICU1 | 2 | 3.2 | MitoCarta 2.0:YES | Homeostasis (mt-calcium) | Genomic instability and mutations + Evasion of cell death | Gene Name: MICU1; Aliases: CALC; EFHA3; MPXPS; CBARA1; ARA CALC; Role in Cancer: Loss of heterozygosity of this gene was identified in pancreatic cancer (gene expression analysis) and contribute to evasion of pro-apoptotic signal (25824785). |
| Hs.MLH1 | 2 | 0 | MitoCarta 2.0:YES | DNA (mtDNA integrity / nDNA integrity) | Unclear role in cancer | Gene Name: MLH1; Aliases: FCC2; COCA2; HNPCC; HMLH1; HNPCC2; Role in Cancer: A mutation in this gene may be a biomarker of gastric cancer. Not clear role in cancer (29532879). |
| Hs.MRPL58 | 2 | 3.5 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Evasion of anti-growth signaling and cell sufficiency in growth signals | "Gene Name: MRPL58; Aliases: ICT1; DS-1; DS1; MRP-L58; Q14197; Role in Cancer: This gene is overexpressed in human breast cancer subtypes. The role of this genes may be related with cell cycle progression. Its silencing leads to cell cycle arrest and apoptosis (28290601)." |
| Hs.MUL1 | 2 | 4.1 | MitoCarta 2.0:YES | Mitochondrial dynamics (fission / mitophagy) + Cell death (apoptosis) | Unclear role in cancer | Gene Name: MUL1; Aliases: GIDE; MAPL; MULAN; RNF218; C1ORF166; Role in Cancer: This gene encodes an E3 protein ligase of the outer mitochondrial membrane that mediates fission, associates with mitophagy and can trigger degradation of AKT through the UPS (26450902, 29260979). Even though induction of this gene has been explored as an anti-cancer strategy, a causative role in cancer was not found in the reviewed literature. |
| Hs.MUTYH | 2 | 1.6 | MitoCarta 2.0:YES | DNA (mtDNA integrity / nDNA integrity) | Genomic instability and mutations | Gene Name: MUTYH; Aliases: MYH; Role in Cancer: This gene is a DNA-base-excision-repair gene that repairs damage induced by oxidative stress. Mutations of this gene cause inherited polyposis that increase the risk of colorectal cancer (23599153). |
| Hs.NDUFA13 | 2 | 3.8 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: NDUFA13:GRIM-19(4); Aliases: B16.6; CDA016; CGI-39; GRIM19; GRIM-19; MC1DN28; Role in Cancer: This gene was recently described as a tumor suppressor. It induces cell cycle arrest and promotes apoptosis. However, it is downregulated or lost in gastric cancer. Its loss-of-function also promotes the reprogramming of energy metabolism, favoring glycolysis over OXPHOS and giving tumor cells a proliferative advantage (27167343). |
| Hs.NDUFS3 | 2 | 4.8 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Unclear role in cancer | Gene Name: NDUFS3; Aliases: CI-30; MC1DN8; Role in Cancer: This gene participates in the mitochondrial respiratory chain and is downregulated in renal oncocytomas and other types of cancer. However, its role in caner is not clear (20505682). |
| Hs.NFS1 | 2 | 3.4 | MitoCarta 2.0:YES | Biosynthesis (Fe-S clusters) | Unclear role in cancer | Gene Name: NFS1; Aliases: ISCS; NIFS; HUSSY-08; Role in Cancer: The product of this gene belongs to the Fe-S cluster machinery and supplies inorganic sulfide from L-cysteine for synthesis of Fe-S clusters. This protein is downregulated in cancer cells due to hypoxia and, indirectly, prevents activation of caspase-3 (29596470). However, a clear and direct role for this protein in cancer is not described in the reviewed literature. |
| Hs.PARK7 | 2 | 1.2 | MitoCarta 2.0:YES | Homeostasis (redox) | Unclear role in cancer | Gene Name: PARK7:DJ-1(4); Aliases: DJ1; DJ-1; GATD2; HEL-S-67P; Role in Cancer: The encoded protein is involved in maintaining mitochondrial integrity; however, not a clear role in cancer was found. |
| Hs.PDK3 | 2 | 4.9 | MitoCarta 2.0:YES | Energy metabolism (pyruvate dehydrogenase complex cycle) | Reprogramming of energy metabolism | Gene Name: PDK3; Aliases: CMTX6; GS1-358P8.4; Role in Cancer: This gene is expressed in different cancer types. Hypoxic conditions promote transcription of this gene, and its protein product participates in the establishment of aerobic glycolysis in melanoma. (22865452, 27626669) |
| Hs.PRDX5 | 2 | 1.2 | MitoCarta 2.0:YES | Homeostasis (redox) | Adaptive modulation of oxidative stress + Evasion of cell death | Gene Name: PRDX5; Aliases: PLP; ACR1; B166; PRXV; PMP20; PRDX6; PRX-V; SBBI10; AOEB166; HEL-S-55; Role in Cancer: Overexpression of this gene in breast cancer cell lines suggests that its antioxidant activity protects cells from oxidative stress to promote evasion of apoptosis. (22020876) |
| Hs.PRDX6 | 2 | 2.6 | MitoCarta 2.0:YES | Homeostasis (redox) | Unclear role in cancer | Gene Name: PRDX6; Aliases: PRX; P29; AOP2; 1-CYS; NSGPX; AIPLA2; HEL-S-128M; Role in Cancer: This gene protects cells from oxidative damage. Genetic variants in this gene are associated with poor prognosis in breast cancer (23489758). However, a clear role for this gene in cancer progression was not elucidated from the reviewed literature. |
| Hs.PTRH2 | 2 | 5.2 | MitoCarta 2.0:YES | Cell death (anoikis / apoptosis) | Evasion of cell death | Gene Name: PTRH2:BIT1(3); Aliases: PTH; BIT1; PTH2; PTH 2; CFAP37; IMNEPD; CGI-147; Role in Cancer: This gene promotes a type of cell death through anoikis. Functionality of this protein is inhibited in breast cancer cells, by TLE1; which promotes survival of malignant cells. (22952044, 23259782) |
| Hs.REXO2 | 2 | 2.3 | MitoCarta 2.0:YES | Cell cycle regulation | Unclear role in cancer | Gene Name: REXO2:SFN(2); Aliases: RFN; SFN; REX2; CGI-114; Role in Cancer: This gene participates in cell cycle by regulating G1/S transition; however, a clear role in cancer was not described. |
| Hs.SCO1 | 2 | 9.9 | MitoCarta 2.0:YES | Homeostasis (proteins) + Energy metabolism (respiratory chain) | Unclear role in cancer | Gene Name: SCO1; Aliases: SCOD1; Role in Cancer: The protein encoded by this gene is an assembly factor of the respiratory complex IV required for stability and maturation of complex IV. A clear role for this gene in cancer was not elucidated from literature revision. |
| Hs.SDHAF1 | 2 | 6.4 | MitoCarta 2.0:YES | Homeostasis (proteins) + Energy metabolism (respiratory chain) | Unclear role in cancer | Gene Name: SDHAF1; Aliases: LYRM8; Role in Cancer: This gene encodes an assembly factor of the respiratory complex II (20398431). The reviewed literature for this gene did not support a causative role for its protein product in cancer. |
| Hs.SHMT1 | 2 | 2.7 | MitoCarta 2.0:YES | Biosynthesis (nucleotides) | Reprogramming of energy metabolism | Gene Name: SHMT1; Aliases: SHMT; CSHMT; Role in Cancer: This gene encodes an isoenzyme that participates in biosynthesis of purine, pyrimidine and methionine needed to maintain cancer cell proliferation. This gene is overexpressed in cancer cells during initial stages of lung cancer cells (27530298). |
| Hs.SLC25A10 | 2 | 5.1 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Unclear role in cancer | Gene Name: SLC25A10; Aliases: DIC; Role in Cancer: Upregulated in cancer but not clear role of its activity was found. |
| Hs.SLC25A37 | 2 | 5.2 | MitoCarta 2.0:YES | Carrier (iron) + Biosynthesis (Fe-S clusters / heme groups) | Unclear role in cancer | Gene Name: SLC25A37; Aliases: MSC; MFRN; MSCP; HT015; MFRN1; PRO1278; PRO1584; PRO2217; Role in Cancer: The protein encoded by this gene is a mitochondrial iron importer that is essential for synthesis of heme groups and Fe-S clusters (24786901). Despite the biological relevance of this protein, a clear role in cancer was not deduced from the reviewed literature. |
| Hs.SLC25A4 | 2 | 2.9 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Unclear role in cancer | Gene Name: SLC25A4; Aliases: T1; ANT; AAC1; ANT1; PEO2; PEO3; ANT 1; PEOA2; MTDPS12; MTDPS12A; Role in Cancer: Involved in fatigue in response to external beam radiation therapy in prostate cancer patients (23047795). Role in cancer not specified. |
| Hs.TIMM44 | 2 | 4.8 | MitoCarta 2.0:YES | Mitochondrial dynamics (biogenesis) | Unclear role in cancer | Gene Name: TIMM44; Aliases: TIM44; Role in Cancer: The protein encoded by this gene is used as a marker of tumor recurrence in breast cancer. However, no role has been reported for this gene in cancer development (29080556). |
| Hs.TOMM70 | 2 | 4 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Mitochondrial maintenance and repair systems | Gene Name: TOMM70; Aliases: TOMM70A; TOM70; D16IUM22; D16IUM22E; MKIAA0719; D16WSU109E; 2610044B22RIK; Role in Cancer: This gene is upregulated in breast cancer. This may suggest mitochondrial biogenesis as a possible mechanism for cancer cell maintenance. (23172368) |
| Hs.TUFM | 2 | 2.4 | MitoCarta 2.0:YES | Biosynthesis (proteins) + Mitochondrial dynamics (biogenesis) | Mitochondrial maintenance and repair systems | Gene Name: TUFM; Aliases: P43; EFTU; COXPD4; EF-TUMT; Role in Cancer: The protein encoded by this gene participates in translation of mitochondrial proteins and is a regulator of mitochondrial biogenesis (23104437). This protein has been proposed as a therapeutic target in cancer (23104437, 28645610). |
| Hs.TWNK | 2 | 3.1 | MitoCarta 2.0:YES | DNA (mtDNA replication / mtDNA integrity) | Unclear role in cancer | Gene Name: TWNK; Aliases: PEO; PEO1; SCA8; ATXN8; IOSCA; PEOA3; SANDO; TWINL; MTDPS7; PRLTS5; C10ORF2; Role in Cancer: This protein is a helicase needed for mitochondrial DNA replication. Although it controls mtDNA synthesis, a clear role in cancer was not found in the literature reviewed. |
| Hs.TXN2 | 2 | 3.2 | MitoCarta 2.0:YES | Cell death (apoptosis) | Evasion of cell death | Gene Name: TXN2:TRX2(1); Aliases: TXN; MTRX; TRX2; MT-TRX; COXPD29; Role in Cancer: Downregulation of TXN2 inhibits caspase 3 in microglia under a pro-tumoral phenotype (27618552). |
| Hs.TXNRD2 | 2 | 3.2 | MitoCarta 2.0:YES | Homeostasis (redox) | Adaptive modulation of oxidative stress | Gene Name: TXNRD2; Aliases: TR; TR3; SELZ; GCCD5; TRXR2; TR-BETA; Role in Cancer: This protein plays a key role in redox homoeostasis. This gene protects cancer cells from oxidative stress and the cytotoxicity derived from transcriptional silencing of genes with antioxidant activity (21203553). |
| Hs.UQCRB | 2 | 5.7 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) + Homeostasis (proteins) | Adaptive modulation of oxidative stress + Metastatic process | Gene Name: UQCRB; Aliases: QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3; Role in Cancer: The protein encoded by this gene is a component of the respiratory complex III. This gene mediates generation of ROS and promotes both hypoxia and angiogenesis in tumors; which indirectly contribute to metastasis (29115404, 29147009). It has been proposed as a potential therapeutic target in GBM (29115404) and as a biomarker of CRC (29147009). |
| Hs.VDAC3 | 2 | 4.4 | MitoCarta 2.0:YES | Carrier (energy carrying molecules) + Cell death (apoptosis) | Unclear role in cancer | Gene Name: VDAC3; Aliases: VDAC-3; HD-VDAC3; Role in Cancer: The protein product of this gene mediates transport of ATP and ADP across the mitochondrial outer membrane and secondarily mediates apoptosis by interacting with BAX (30478310). The literature reviewed supported a secondary and not a central role for this gene in cancer. |
| Hs.ABCB10 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) + Biosynthesis (Fe-S clusters / heme groups) + Homeostasis (iron / redox) | Mitochondrial maintenance and repair systems | Gene Name: ABCB10; Aliases: M-ABC2; MTABC2; EST20237; Role in Cancer: This gene appears to participate in iron regulation within mitochondria and is needed to form Fe-S clusters. Defects in this protein lead to iron accumulation and oxidative stress that contribute to genomic instability and increased plasticity of tumor-initiating cells (28031527). |
| Hs.ABCB7 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors / ions) | Unclear role in cancer | Gene Name: ABCB7; Aliases: ABC7; ASAT; ATM1P; EST140535; Role in Cancer: Mutations in this gene may disrupt iron homeostasis, leading to accumulation of iron in the mitochondria (19907149). However, a clear role in cancer is not described. |
| Hs.ACAA2 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: ACAA2; Aliases: DSAEC; Role in Cancer: The encoded protein is necessary for beta-oxidation and promotes mitochondrial respiration. In vitro targeted upregulation of this gene mediated by the alpha-lactalbumin-oleic acid complex produces electron leaks due to inhibition of electron acceptor proteins; this has been suggested as a potential anti-cancer strategy (29550120). |
| Hs.ACAD10 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: ACAD10; Aliases: -; Role in Cancer: The protein product of this gene participates in beta-oxidation of fatty acids in mitochondria. It has been involved in metformin-induced growth inhibition in cancer cells (27984722). |
| Hs.ACAT1 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (ketogenesis) | Reprogramming of energy metabolism | Gene Name: ACAT1; Aliases: T2; MAT; ACAT; THIL; Role in Cancer: The enzyme encoded by this gene mediates the production of onco-metabolites that participate in the formation of ketone bodies, which are an important energy source for anabolic metabolism of cancer cells (23082722). |
| Hs.ACSF3 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (lipogenesis) | Unclear role in cancer | Gene Name: ACSF3; Aliases: -; Role in Cancer: This gene encodes the mitochondrial enzyme malonyl-CoA synthetase that participates in synthesis of fatty acids (28986507). However, the reviewed literature does not specify a clear role for this gene in cancer. |
| Hs.ACSS1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle / anaplerosis / intermediary metabolism) + Biosynthesis (lipogenesis) | Reprogramming of energy metabolism | Gene Name: ACSS1; Aliases: ACAS2L; ACECS1; ACECS2L; Role in Cancer: The protein product of this gene mediates fatty-acid biosynthesis from acetate. Increased expression of this protein promotes glycolysis during hypoxic conditions and has been associated with tumor progression (26655911). |
| Hs.ADHFE1 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (lipogenesis) | Reprogramming of energy metabolism | Gene Name: ADHFE1; Aliases: HOT; ADH8; HMFT2263; Role in Cancer: Activity of the encoded protein is triggered via MYC and leads to the production of 2-hydroxyglutarate (2HG), which is considered as an onco-metabolite that promotes metabolic reprogramming and malignancy in cancer cells (29202474). |
| Hs.AGK | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (lipogenesis) + Homeostasis (mitochondria) | Evasion of cell death | Gene Name: AGK; Aliases: MULK; CATC5; CTRCT38; MTDPS10; Role in Cancer: The encoded enzyme catalyzes the synthesis of phospholipids involved that modulate tumor progression. This protein also forms part of the TIMM22 complex and thus contributes to maintain mitochondrial morphogenesis. In HeLa cancer cells, this protein contributes to prevention of apoptosis (28712724). |
| Hs.AGR2 | 1 | 0 | MitoCarta 2.0:YES | Annotation error | Annotation error | Gene Name: AGR2; Aliases: AG2; AG-2; HPC8; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116; Role in Cancer: Abstracts show AG2 as an acronym of "Age Group 2" and not to refer to the AGR2 (or AG2) gene. |
| Hs.AIFM2 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (mitochondria) | Evasion of cell death | Gene Name: AIFM2; Aliases: AMID; PRG3; Role in Cancer: This gene encodes a flavoprotein oxidoreductase whose homeostatic function is believed to be induction of apoptosis in response to ssDNA (from bacteria or virus) and through interaction with P53. Downregulation of this gene occurs in prostate cancer patients that undergo fatigue in response to external beam radiation therapy (23047795)._ |
| Hs.AKAP1 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) + Mitochondrial dynamics (biogenesis) | Unclear role in cancer | Gene Name: AKAP1; Aliases: AKAP; PRKA1; AKAP84; TDRD17; AKAP121; AKAP149; D-AKAP1; PPP1R43; SAKAP84; Role in Cancer: This protein is involved in mitochondrial biogenesis and protein translation and it is overexpressed in breast cancer cells (23172368). The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.ALAS2 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (heme groups) | Unclear role in cancer | Gene Name: ALAS2; Aliases: ASB; ANH1; XLSA; ALASE; XLDPP; XLEPP; ALAS-E; SIDBA1; Role in Cancer: The encoded protein is involved in the first step of heme group biosynthesis (19907149). |
| Hs.ALDH1L1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (one-carbon folate / alcohol / intermediary metabolism) | Unclear role in cancer | Gene Name: ALDH1L1; Aliases: FDH; FTHFD; 10-FTHF; 10-FTHFDH; Role in Cancer: The encoded enzyme catalyzes NADP+-dependent oxidation of formyl group (bound to folate) to carbon dioxide (20498374). Evidence from the reviewed literature does not indicate a clear role for this gene in cancer. |
| Hs.ALDH1L2 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (one-carbon folate / alcohol / intermediary metabolism) | Unclear role in cancer | Gene Name: ALDH1L2; Aliases: MTFDH; Role in Cancer: ALDH1L2 is a mitochondrial enzyme with hydrolase and dehydrogenase catalytic activity involved in energy production. It potentially contributes to energy generation trough folate metabolism (20498374). Lung and prostate cancer cell lines (A549 and PC3, respectively) have a higher expression of the mtFDH than of the cytosolic isoform (20498374). Despite the potential contribution, no clear evidence supporting a role for this gene in cancer was found. |
| Hs.ALDH5A1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (glutaminolysis / intermediary metabolism) | Reprogramming of energy metabolism | Gene Name: ALDH5A1; Aliases: SSDH; SSADH; Role in Cancer: This gene is involved in mitochondrial glutamate metabolism and is overexpressed in breast ductal cancer models. It has been suggested as a potential therapeutic target (23236365). |
| Hs.ATP23 | 1 | 0 | MitoCarta 2.0:YES | DNA (nDNA integrity) | Genomic instability and mutations | Gene Name: ATP23; Aliases: KUB3; XRCC6BP1; Role in Cancer: This gene is involved in double-strand break repair and it is overexpressed in glioblastomas. (20352460) |
| Hs.ATP5F1C | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Potential anti-cancer activity | Gene Name: ATP5F1C; Aliases: ATP5F1C; 1700094F02RIK; Role in Cancer: The protein encoded by this gene forms part of the ATP synthase. Overexpression of this gene has been associated with decreased risk in colorectal cancer and may exert a protective role against tumor progression (22363440). |
| Hs.ATP5F1D | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism | Gene Name: ATP5F1D; Aliases: ATP5D; C85518; ATP5F1D; AA960090; AI876556; AU020773; 0610008F14RIK; 1500000I11RIK; Role in Cancer: This gene encodes a subunit of the ATP synthase. Expression of this gene is enriched in lung adenocarcinoma tissues, potentially to support the energetic demand of malignant cells (26840709)._ |
| Hs.ATP5F1E | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism | Gene Name: ATP5F1E; Aliases: ATP5E; ATPE; MC5DN3; P56381; Role in Cancer: The encoded protein epsilon subunit that forms part of the catalytic core in the mitochondrial ATP synthase. Downregulation of this gene has been suggested as a biomarker for specific diagnosis of papillary thyroid cancer, and this event potentially promotes metabolic reprogramming of cancer cells (26079849). |
| Hs.ATP5IF1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism | Gene Name: ATP5IF1; Aliases: ATPIF1; IF1; ATPI; IF (1); Role in Cancer: The encoded protein promotes proliferation in TAM resistant breast cancer cell lines. (28701793) |
| Hs.ATP5PD | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism | Gene Name: ATP5PD; Aliases: ATP5H; 0610009D10RIK; Role in Cancer: ATP5H (currently ATP5D, according to HGNC) encodes the D subunit of the membrane-spanning component (Fo) of the mitochondrial ATP synthase. This subunit is upregulated in human renal oncocytoma (20440404). ATP5D was found to be differentially upregulated in patients with low- to intermediate- grade lung adenocarcinoma and it was proposed as a potential therapeutic target (26840709). |
| Hs.ATP5PF | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism + Evasion of cell death + Metastatic process | Gene Name: ATP5PF; Aliases: ATP5J; CF6; ATP5PF; Role in Cancer: The protein product forms part of the ATP synthase. Overexpression of this gene has been correlated with metastasis and chemotherapy resistance in CRC cells. Effects of ATP5J might depend on AKT2 (29484395). |
| Hs.BCS1L | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Unclear role in cancer | Gene Name: BCS1L; Aliases: BCS; BJS; PTD; BCS1; FLNMS; H-BCS; MC3DN1; H-BCS1; GRACILE; HS.6719; Role in Cancer: Encodes a chaperon involved in complex 3 assembly. Role in cancer: not specified but was found to be significantly associated with changes in fatigue scores in patients with PCa. (24786901) The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.BDH1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) | Reprogramming of energy metabolism | Gene Name: BDH1; Aliases: BDH; SDR9C1; Role in Cancer: Overexpression of this gene produces ketogenic fibroblasts that promote tumor growth of adjacent cancer cells. (23082722) |
| Hs.CHCHD10 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (mitochondria) + Carrier (molecules / protein precursors) + Energy metabolism (oxidative phosphorylation) | Unclear role in cancer | Gene Name: CHCHD10; Aliases: IMMD; SMAJ; MIX17A; FTDALS2; N27C7-4; C22ORF16; Role in Cancer: The protein product of this gene belongs to the CX9C family and modulates oxidative phosphorylation rates. Genetic disease variants of this gene correlated with decreased rates of cellular respiration (29540477). However, a clear role for this gene in cancer was not deduced from the reviewed literature. |
| Hs.CHCHD4 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (proteins) | Reprogramming of energy metabolism | Gene Name: CHCHD4; Aliases: MIA40; TIMM40; Role in Cancer: CHCHD4 modulates metabolic adaptation of cancer cells and is involved in controlling HIF-1_/hypoxia response. Overexpression of CHCHD4 has been detected in human tumors and correlates with decreased survival rates (22214851). |
| Hs.CHPT1 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (phospholipids) | Unclear role in cancer | Gene Name: CHPT1; Aliases: CPT; CPT1; Role in Cancer: The product of this gene is an enzyme involved in lipid metabolism. It specifically participates in the last step of phosphatidylcholine synthesis by transferring phosphocholine from CDP-choline to DAG. Even though expression levels of this gene are altered as part of oncogene-induced senescence (22178194), a clear causative role for this gene in cancer was not found in the reviewed literature. |
| Hs.CISD3 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (iron / redox) | Mitochondrial maintenance and repair systems | Gene Name: CISD3; Aliases: MINT; MINER2; Role in Cancer: This gene encodes a protein that belongs to the NEET protein family and locates at the mitochondrial matrix. The CISD3 gene is overexpressed in breast cancer cells, lymphomas and liver cancer. Downregulation of MiNT leads to accumulation of iron and ROS at the mitochondria of MDAMB231 cells (29259115). |
| Hs.CKMT1A | 1 | 0 | MitoCarta 2.0:YES | Carrier (phosphate groups) | Unclear role in cancer | Gene Name: CKMT1A; Aliases: CKMT1; U-MTCK; MIA-CK; Role in Cancer: The encoded protein mediates transfer of phosphate groups between energy molecules. Overexpression of this gene is considered a diagnostic/recurrence biomarker of several cancer types and has been correlated with poor prognosis. Potentially, this event is related to high energy turnover and self-sufficiency in cancer cells (26516695). The reviewed literature does not clarify a specific role for this gene in cancer. |
| Hs.CKMT1B | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism | Gene Name: CKMT1B; Aliases: CKMT; CKMT1; UMTCK; Role in Cancer: CKMT1B encodes for the ubiquitous mitochondrial creatine kinase protein, which is a member of the mitochondrial interactome that regulates mitochondrial respiration and energy production. The protein encoded by this gene is upregulated in hepatocellular carcinoma and high serum levels significantly correlates with poor prognosis (24174293). |
| Hs.CLPP | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (proteins) | Mitochondrial maintenance and repair systems | Gene Name: CLPP; Aliases: DFNB81; PRLTS3; Role in Cancer: This gene is upregulated in type I Endometrial Cancer (EC). The encoded protein removes damaged mitochondrial proteins, promoting survival and proliferation of EC cells (28698145). |
| Hs.COX16 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Evasion of cell death | Gene Name: COX16; Aliases: HCOX16; HSPC203; C14ORF112; Role in Cancer: This gene has been validated as an inhibitor of P53 in |
| Hs.COX4I2 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism | Gene Name: COX4I2; Aliases: COX4; COX4B; COX4-2; COX4L2; COXIV-2; DJ857M17.2; Role in Cancer: This gene encodes a subunit of the mitochondrial respiratory complex IV. This complex mediates transfer of electrons from reduced cytochrome c to molecular oxygen. Levels of this protein are significantly increased in cells of Barrett_s esophagus with predisposition to adenocarcinoma (25107643). |
| Hs.COX5A | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism | Gene Name: COX5A; Aliases: VA; COX; COX-VA; Role in Cancer: This gene encodes a respiratory chain enzyme upregulated in renal cell carcinoma. (20440404) |
| Hs.COX6A1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism | Gene Name: COX6A1; Aliases: COX6A; CMTRID; COX6AL; Role in Cancer: COX6A1 is involved in the last step of the electron transport chain. Upregulation of COX6A1 was detected in a variety of human follicular cell-derived thyroid tumors and in follicular adenomas, compared to biopsies from healthy individuals (23569218). |
| Hs.COX6B1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism + Metastatic process | Gene Name: COX6B1; Aliases: COXG; COX6B; COXVIB1; Role in Cancer: COX6B1 is a component of the respiratory complex IV. Colorectal cancer expression profiles revealed that SNPs rs6510502 and rs10420252 in COX6B1 were associated with cancer progression and metastasis to the lymph nodes. Potentially, this association relies in metabolic reprogramming (22545919). |
| Hs.COX6C | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Evasion of cell death | Gene Name: COX6C; Aliases: -; Role in Cancer: COX6C forms part of complex IV and partially mediates the electron transfer from reduced cytochrome c to oxygen. Overexpression of COX6C in MCF7 breast cancer cells treated with the antineoplastic drug mitoxantrone promoted their viability by stabilizing their cell membrane potential and through expression of ROS) and promoted the development of chemoresistance. (28098816). |
| Hs.COX7A1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Evasion of cell death | Gene Name: COX7A1; Aliases: COX7A; COX7AH; COX7AM; Role in Cancer: The encoded protein is a terminal component of the mitochondrial respiratory chain. In patients with lung adenocarcinoma, this gene is downregulated, promoting cell viability and evasion of apoptosis (27866983). |
| Hs.COX8C | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism | Gene Name: COX8C; Aliases: COX8-3; Role in Cancer: Increased expression of this gene was identified in Barrett syndrome. It has been suggested that this gene alters energy metabolism and contributes to tumorigenesis by increasing oxidative phosphorylation rates (25107643). |
| Hs.CPT2 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) | Reprogramming of energy metabolism + Metastatic process | Gene Name: CPT2; Aliases: CPT1; IIAE4; CPTASE; Role in Cancer: The encoded enzyme is a rate-limiting protein for beta-oxidation; which is an usual source of energy in the metastatic type of breast cancer (26923594). |
| Hs.CRAT | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) | Reprogramming of energy metabolism | Gene Name: CRAT; Aliases: CAT; CAT1; NBIA8; Role in Cancer: The encoded protein is part of the carnitine system. Increased activity of this protein is observed in prostate cancer cells. It promotes fatty acids utilization (28671672). |
| Hs.CYC1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism + Evasion of anti-growth signaling and cell sufficiency in growth signals + Metastatic process | Gene Name: CYC1; Aliases: UQCR4; MC3DN6; Role in Cancer: The encoded protein is a subunit of the respiratory complex III. Expression of this gene correlates with aggressive ductal carcinoma and has been suggested that CYC1 promotes proliferation of cancer cells and tumor progression via upregulation of oxidative phosphorylation at early stages (28394473). |
| Hs.CYP11A1 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (cholesterol) | Unclear role in cancer | Gene Name: CYP11A1; Aliases: CYP11A; CYPXIA1; P450SCC; Role in Cancer: The encoded protein is part of the P450 superfamily. They are involved in synthesis of lipids (cholesterol) and drug metabolism. The reviewed literature did not provide a clear role for this protein in cancer, as the abstract is not about cancer (28205173). |
| Hs.CYP24A1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (intermediary metabolism) | Genomic instability and mutations | Gene Name: CYP24A1; Aliases: CP24; HCAI; CYP24; HCINF1; P450-CC24; Role in Cancer: The encoded enzyme participates in catabolism of vitamin D and is suggested to be an oncogene. This enzyme is upregulated in ovarian, breast and lung tumors. In patients with colorectal cancer, splicing variants of this gene were identified and generate enzymes without catalytic activity that may compete for substrate, affecting the antiproliferative role of vitamin D. (20398751) |
| Hs.DBI | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) | Reprogramming of energy metabolism | Gene Name: DBI; Aliases: EP; ACBP; ACBD1; CCK-RP; Role in Cancer: This gene mediates import of fatty acids into the mitochondria for beta-oxidation. This gene is upregulated in esophageal cancer (27452861). |
| Hs.DDX28 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: DDX28; Aliases: MDDX28; Role in Cancer: This gene encodes a DEAD box protein with RNA helicase activity. It participates in cell division. This gene is differentially expressed in CRC tissues (22363440), but the reviewed literature does not state a specific role for this gene in cancer. |
| Hs.DNAJA3 | 1 | 0 | MitoCarta 2.0:YES | Mitochondrial dynamics (fission/fusion) + DNA (nDNA integrity) | Mitochondrial maintenance and repair systems | Gene Name: DNAJA3; Aliases: TID1; HCA57; HTID-1; Role in Cancer: The encoded protein is involved in tumor suppression by interacting with oncogenic proteins like ErbB2 and p53. Dysregulation of this gene induces mitochondrial fragmentation in several cancer cell lines. (22595283) |
| Hs.ERAL1 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (mitochondria) | Mitochondrial maintenance and repair systems | Gene Name: ERAL1; Aliases: ERA; CEGA; ERA-W; H-ERA; ERAL1A; ERAL1B; HERA-A; HERA-B; PRLTS6; Role in Cancer: This protein participates in the assembly of the 28S small mitochondrial ribosomal subunit, which is essential for mitochondrial protein synthesis. Downregulation of this gene leads to accumulation of ROS and further autophagy in HeLa cells (22576012). |
| Hs.ETFB | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (beta-oxidation) | Unclear role in cancer | Gene Name: ETFB; Aliases: MADD; FP585; Role in Cancer: The encoded protein of this gene works as an electron shuttle flavoprotein that participates in fatty acid metabolism. Missense variations of this gene have been found in a cohor of pediatric cancer patients with anthracycline-induced cardiotoxicity (28913729). However, a clear causative role for this gene in cancer was not elucidated from the reviewed literature. |
| Hs.FAM210B | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) | Reprogramming of energy metabolism + Evasion of anti-growth signaling and cell sufficiency in growth signals + Metastatic process | Gene Name: FAM210B; Aliases: 5A3; C20ORF108; DJ1167H4.1; Role in Cancer: FAM210B is considered a tumor suppressor gene found at the external mitochondrial membrane. Although this protein has been related with mitochondrial respiration, the homeostatic pathway to which it directly contributes is not clear yet. In ovarian cancer, low levels of FAM210B contribute to metabolic reprogramming involving increased rates of mitochondrial respiration and decreased glycolysis through downregulation of the pyruvate dehydrogenase kinase 4 protein; which correlate with promotion of metastasis and cancer aggressiveness. (28594398). |
| Hs.FASTKD1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Unclear role in cancer | Gene Name: FASTKD1; Aliases: FAST KINASE DOMAIN-CONTAINING PROTEIN 1; MITOCHONDRIAL 3 4; KIAA1800; Role in Cancer: The protein encoded by this gene down-regulates MT-ND3 leading to a decrease in Complex 1 from the respiratory chain. FASTKD1 is mentioned on the paper, but the study was made on FASTKD2 (25409762) The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.FASTKD2 | 1 | 0 | MitoCarta 2.0:YES | Cell death (apoptosis) | Potential anti-cancer activity | Gene Name: FASTKD2; Aliases: KIAA0971; Role in Cancer: The protein encoded by this gene promotes apoptosis in breast and prostate cancer cells (25409762). |
| Hs.FHIT | 1 | 0 | MitoCarta 2.0:YES | Cell death (apoptosis) + Biosynthesis (nucleotides) | Evasion of cell death | Gene Name: FHIT; Aliases: FRA3B; AP3AASE; Role in Cancer: This gene has tumor suppressor activity and mediated apoptosis in hepatocellular carcinoma cells. The encoded protein is involved in purine metabolism and is considered as a potential therapeutic target (21679157). |
| Hs.FTMT | 1 | 0 | MitoCarta 2.0:YES | Cell cycle regulation | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: FTMT; Aliases: MTF; Role in Cancer: Overexpression of this gene in neuronal tumor cells causes G1/S arrest and disrupts iron homeostasis. (25213357) |
| Hs.FUNDC1 | 1 | 0 | MitoCarta 2.0:YES | Mitochondrial dynamics (mitophagy / fusion) + Homeostasis (mt-calcium) | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: FUNDC1; Aliases: -; Role in Cancer: This gene promotes the proliferative and invasive phenotype of breast cancer cells, via the Ca2+_NFATC1_BMI1 axis (30803933). |
| Hs.GCSH | 1 | 0 | MitoCarta 2.0:YES | Annotation error | Annotation error | Gene Name: GCSH; Aliases: GCE; NKH; Role in Cancer: Abstract refers to gamma_glutamylcysteine synthetase heavy chain abbreviation (_GCSh) instead of the GCSH gene. |
| Hs.GFER | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (oxidative phosphorylation) + Homeostasis (redox) + | Adaptive modulation of oxidative stress + Evasion of cell death | Gene Name: GFER; Aliases: ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1; Role in Cancer: The encoded protein has antioxidant and anti-apoptotic activity. Levels of this protein are increased in tumoral tissues (type I endometrial cancer) (28698145). |
| Hs.GLRX2 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (redox) | Evasion of cell death | Gene Name: GLRX2; Aliases: GRX2; CGI-133; Role in Cancer: There is evidence that this gene has anti-apoptotic activity. Along with NDRG1, this gene apparently contributes to anti-cancer therapy resistance in hepatocellular carcinoma cells (20573444). |
| Hs.GLRX5 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (Fe-S clusters) + Homeostasis (iron / redox) | Genomic instability and mutations | Gene Name: GLRX5; Aliases: GRX5; PRSA; SIDBA3; SPAHGC; FLB4739; PR01238; PRO1238; C14ORF87; Role in Cancer: GLRX5 is a gene involved in iron metabolism and in synthesis of Fe-S clusters. This gene is downregulated in hepatocellular carcinoma cells lines and in breast cancer tumor-initiating cells. On the contrary, transcriptional upregulation is observed in several types of leukemia-initiating cells. Dysfunctionality of the encoded protein correlates with impaired DNA repair and genomic instability (28031527). |
| Hs.GLUD1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (anaplerosis) | Unclear role in cancer | Gene Name: GLUD1; Aliases: GDH; GDH1; GLUD; Role in Cancer: This enzyme mediates the conversion of glutamine to _-ketoglutarate, which is a substrate of the TCA cycle. Silencing of this gene to inhibit glutamine metabolism has been suggested as a potential strategy to treat human pancreatic ductal adenocarcinoma (23535601). However, a clear role for this gene in cancer was not deduced from the reviewed literature. |
| Hs.GLYAT | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (aminoacids) | Unclear role in cancer | Gene Name: GLYAT; Aliases: CAT; GAT; ACGNAT; Role in Cancer: GLYAT is expressed in liver and kidney and its protein localizes exclusively in the mitochondria. GLYAT is downregulated in all hepatocellular carcinomas and has been proposed as a biomarker of the transition from liver disease to several types of liver carcinoma (22475485). A clear role for this gene in cancer was not elucidated from the reviewed literature. |
| Hs.GPAM | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (cholesterol) | Evasion of cell death | Gene Name: GPAM; Aliases: GPAT; GPAT1; Role in Cancer: This enzyme has antiapoptotic activity in MDAMB231 breast cancer cell line. (24967918) |
| Hs.GPAT2 | 1 | 0 | MitoCarta 2.0:YES | Cell cycle regulation | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: GPAT2; Aliases: CT123; Role in Cancer: This gene is expressed in melanomas, testis and breast cancer. Its expression correlates with cell proliferation and with a carcinogenic phenotype. It has been suggested that the encoded protein of this gene promotes cell proliferation through disruption of the cell cycle disruption (24967918). |
| Hs.GPT2 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (aminoacids / anaplerosis / TCA cycle) + Biosynthesis (gluconeogenesis) | Reprogramming of energy metabolism | Gene Name: GPT2; Aliases: ALT2; GPT 2; MRT49; Role in Cancer: The encoded enzyme mediates anaplerosis to fuel the TCA cycle in colon cancer cells and supports the metabolic reprogramming and malignancy of cancer cells (27732857). |
| Hs.GRPEL1 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) + Homeostasis (proteins) | Unclear role in cancer | Gene Name: GRPEL1; Aliases: GRPE; HMGE; MT-GRPE#1; Role in Cancer: This gene encodes a nucleotide exchange factor that interacts with mortalin, which is implicated in apoptosis in cancer (24687350). The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.HCCS | 1 | 0 | MitoCarta 2.0:YES | Annotation error | Annotation error | Gene Name: HCCS; Aliases: MLS; CCHL; MCOPS7; LSDMCA1; Role in Cancer: The abstract refers to the abbreviation of hepatocellular carcinoma and not to the HCCS gene symbol. |
| Hs.HMGCS2 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (ketogenesis) | Reprogramming of energy metabolism | Gene Name: HMGCS2; Aliases: -; Role in Cancer: This gene is considered as a metabolic oncogene. The protein product is an enzyme that participates in synthesis of ketone bodies, which are onco-metabolites that promote growth of cancer cells (23082722). |
| Hs.HSCB | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (Fe-S clusters) + Homeostasis (proteins) + Carrier (molecules / protein precursors) | Unclear role in cancer | Gene Name: HSCB; Aliases: JAC1; HSC20; DNAJC20; Role in Cancer: The protein encoded by this gene plays a role in the synthesis of iron-sulfur clusters, contributes to stabilization of proteins of the respiratory complex II by incorporating the Fe-S clusters appropriately. It promotes mitochondrial homeostasis and is involved in the export of Fe-S-cluster-containing proteins (22595283). Despite its many biological functions, a clear role for this protein in cancer was not elucidated from the reviewed literature. |
| Hs.HSPE1 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (proteins) | Mitochondrial maintenance and repair systems | Gene Name: HSPE1; Aliases: EPF; CPN10; GROES; HSP10; Role in Cancer: The resulting protein of this gene plays an important role in mitochondrial integrity. Deficiency of this protein leads to mitochondrial dysfunction and can contribute to different diseases, including cancer (30341613). |
| Hs.IDH3B | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) | Genomic instability and mutations | Gene Name: IDH3B; Aliases: RP46; Role in Cancer: Some genetic variants of this gene produce truncated proteins previously identified in a patient with paraganglioma. These variations altered the _-ketoglutarate/isocitrate ratio and potentially acts as a risk factor for paraganglioma (28720665). |
| Hs.IMMP2L | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (proteins mitochondria) | Unclear role in cancer | Gene Name: IMMP2L; Aliases: IMP2; IMP2-LIKE; IMMP2L-IT1; Role in Cancer: The encoded protein is involved in signal-peptide processing. It is downregulated in prostate cancer and could be involved in how patients respond (fatigue) to external beam radiation therapy, as this event hampers cell energy production (23047795). A clear role for this gene in cancer was not elucidated from the reviewed literature. |
| Hs.IMMT | 1 | 0 | MitoCarta 2.0:YES | Mitochondrial dynamics (biogenesis) + Homeostasis (mitochondria) | Mitochondrial maintenance and repair systems | Gene Name: IMMT; Aliases: HMP; P87; P89; PIG4; MIC60; PIG52; MINOS2; P87/89; MICOS60; Role in Cancer: IMMT is a member of the MICOS complex, which is involved in cristae biogenesis and stability. IMMT has been detected, along with the respiratory complex I and other proteins, in circulating exosomes of men with benign prostate hyperplasia and progressive prostate cancer cells; furthermore, both IMMT and circulating exosomes co-localize with mitochondria in human prostate cancer cells. Therefore, all these elements have been proposed as potential prostate cancer biomarkers (26530043). |
| Hs.ISCU | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (Fe-S clusters) | Evasion of cell death | Gene Name: ISCU; Aliases: HML; ISU2; NIFU; NIFUN; HNIFU; 2310020H20RIK; Role in Cancer: The encoded protein is part of the Fe-S cluster scaffold. In cancer, hypoxia drives downregulation of this gene, impairing Fe-S cluster biogenesis; which is associated with truncation of VDAC and further tumor chemoresistance (29596470). |
| Hs.KRT5 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (cytoskeletal scaffold) | Unclear role in cancer | Gene Name: KRT5; Aliases: K5; CK5; DDD; DDD1; EBS2; KRT5A; Role in Cancer: The encoded protein has been found to be increased in oncocytoma samples of the salivary glands and has been suggested as a potential biomarker (19796983). However, the evidence reviewed does not clearly support a specific role for this gene in cancer. |
| Hs.LETMD1 | 1 | 0 | MitoCarta 2.0:YES | DNA (mtDNA integrity) + Cell death (apoptosis) | Unclear role in cancer | Gene Name: LETMD1; Aliases: HCCR; HCCR1; HCCR2; HCCR-1; HCCR-2; HCRR-2; SLC55A3; 1110019O13RIK; Role in Cancer: This gene encodes a protein found in the outer membrane of the mitochondria, which is potentially involved in tumorigenesis via p53 (20197279). The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.LONP1 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (mitochondria/proteins) | Adaptive modulation of oxidative stress | Gene Name: LONP1; Aliases: LON; LONP; PIM1; HLON; LONHS; CODASS; PRSS15; Role in Cancer: The encoded protein lessens oxidative stress by breaking down oxidized protein. (30411198) |
| Hs.LYRM4 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (iron) | Unclear role in cancer | Gene Name: LYRM4; Aliases: ISD11; CGI-203; COXPD19; C6ORF149; Role in Cancer: The encoded protein is involved in iron homeostasis within the mitochondria and the cytoplasm. Not related with neuroblastoma. (20398431) The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.MAOB | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (aminoacids) | Unclear role in cancer | Gene Name: MAOB; Aliases: P27338; Role in Cancer: This gene encodes a xenobiotic phase I detoxification enzyme and is upregulated by the anti-cancer molecule methotrexate and has been associated with mitochondrial dysfunction (triggered by increased ROS levels) and with senescence of colorectal cancer cells (21678067). However, the literature reviewed does not state a clear role for this gene in cancer. |
| Hs.MARCHF5 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (proteins / mitochondria) | Unclear role in cancer | Gene Name: MARCHF5; Aliases: MARCH5; MARCH-V; MITOL; RNF153; 43895; Role in Cancer: This gene encodes an E3 ligase that mediates protein homeostasis in the mitochondria and contributes to the overall mitochondrial morphology. This gene might suffer mutations in cancer tissues, but their modified products are removed by the WT version of the protein (26476016). A clear role for this protein in cancer was not evident in the reviewed literature. |
| Hs.MDH1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) | Reprogramming of energy metabolism | Gene Name: MDH1; Aliases: MDHA; MOR2; MDH-S; HEL-S-32; MGC:1375; Role in Cancer: High expression of this gene is found in lung tumors. This gene contributes to the generation of substrates for ATP production and supports a glycolytic metabolism that is necessary for cancer cell growth. Inhibition of this gene contributes to cell death in non-small cell lung carcinomas (29574159). |
| Hs.ME3 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (anaplerosis / modulation of energy carriers) + Homeostasis (redox) | Reprogramming of energy metabolism | Gene Name: ME3; Aliases: NADP-ME; Role in Cancer: ME3 is a malic enzyme related to mitochondrial metabolism, as it mediates pyruvate formation from malate in an NADP+-dependent manner. ME3 was found to be hypomethylated in the highly metastatic breast cancer cell line MDA-MB-231 (28467815). |
| Hs.MIPEP | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (proteins) | Unclear role in cancer | Gene Name: MIPEP; Aliases: MIP; HMIP; COXPD31; Role in Cancer: The encoded protein participates in mitochondrial protein processing and is downregulated in non-metastatic prostate cancer patients undergoing fatigue (23047795). However, a clear role for this gene in cancer was not elucidated from the reviewed literature. |
| Hs.MMUT | 1 | 0 | MitoCarta 2.0:YES | Annotation error | Annotation error | Gene Name: MMUT; Aliases: MUT; MCM; P22033; Role in Cancer: The abstract refers to MUT as an abbreviation of the word _mutation_ and not as a gene symbol. |
| Hs.MPST | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (aminoacids) + Homeostasis (redox) | Evasion of cell death | Gene Name: MPST; Aliases: MST; TST2; TUM1; Role in Cancer: The encoded enzyme modulates the production of hydrogen sulfide, which promotes resistance of cancer cells to oxidative damage and radiotherapy (25278485). |
| Hs.MRM2 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) + Homeostasis (proteins) | Potential anti-cancer activity | Gene Name: MRM2; Aliases: FTSJ2; FJH1; HEL97; MRM2; Q9UI43; Role in Cancer: This gene encodes a mitochondrial heat-shock protein. Overexpression of this gene in human lung adenocarcinoma cells protects against metastasis (24595062). |
| Hs.MRPL12 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Reprogramming of energy metabolism | Gene Name: MRPL12; Aliases: 5C5-2; L12MT; MRPL7; RPML12; MRPL7/L12; MRP-L31/34; Role in Cancer: Silencing of this gene causes increase in glycolysis in pancreatic tumors. (19753307) |
| Hs.MRPL14 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: MRPL14; Aliases: L14MT; L32MT; MRPL32; RMPL32; RPML32; MRP-L14; MRP-L32; Role in Cancer: The encoded protein is a component of the 39S subunit of the mitochondrial ribosome. This gene is significantly overexpressed in papillary thyroid carcinoma and has been suggested as a potential biomarker (23569218). However, the reviewed literature does not state a clear role for this gene in cancer. |
| Hs.MRPL16 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: MRPL16; Aliases: L16MT; MRP-L16; PNAS-111; Role in Cancer: This gene encodes a mitochondrial ribosomal protein, which participates in protein synthesis and has been associated with microsatellite instability in CRC samples in a bioinformatic analysis (30664178). However, the evidence does not show a clear role for this gene in cancer. |
| Hs.MRPL28 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Mitochondrial maintenance and repair systems + Reprogramming of energy metabolism | Gene Name: MRPL28; Aliases: P15; MAAT1; Role in Cancer: MRPL28 is a nuclearly-encoded component of the mitochondrial large ribosomal unit, it contributes to the translation of mitochondrial proteins and its downregulation in pancreatic tumor cells diminished the mitochondrial activity and triggered a compensatory increase in glycolysis, which ultimately promoted tumor growth in vivo. (19753307) |
| Hs.MRPL33 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Reprogramming of energy metabolism + Adaptive modulation of oxidative stress | Gene Name: MRPL33; Aliases: L33MT; C2ORF1; RPL33L; MRP-L33; Role in Cancer: The encoded protein dampens ROS effect and increases ATP production in several cancer cell lines. (28869607)_ |
| Hs.MRPL40 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) + Homeostasis (proteins) | Unclear role in cancer | Gene Name: MRPL40; Aliases: URIM; L40MT; NLVCF; MRPL22; MRP-L22; MRP-L40; Role in Cancer: This gene encodes a 39S subunit protein of the ribosomal mitochondrial proteins. It is overexpressed in human epithelial breast cancer cells (23172368), but the reviewed literature does not specify a clear role for this gene in cancer. |
| Hs.MRPL41 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) + Cell death (apoptosis) | Potential anti-cancer activity | Gene Name: MRPL41; Aliases: BMRP; PIG3; MRPL27; RPML27; MRP-L27; Role in Cancer: This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family, which seems to exert a tumor-suppressor activity in association with P53. Downregulation of this gene occurs in breast and kidney carcinomas (24160266). |
| Hs.MRPL44 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) + Homeostasis (proteins) | Reprogramming of energy metabolism + Metastatic process | Gene Name: MRPL44; Aliases: L44MT; COXPD16; MRP-L44; Role in Cancer: This protein transports various molecules across extra-and intra-cellular membranes. It has been considered as a biomarker of OXPHOS and mitochondrial ribosomal protein expression in papillary thyroid carcinomas. This protein is also considered as a marker of lymph node metastasis (25590838). |
| Hs.MRPS15 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: MRPS15; Aliases: DC37; S15MT; RPMS15; MPR-S15; Role in Cancer: This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. It is a marker of mitochondrial biogenesis and is upregulated in epithelial and not tumoral breast cancer cells (23172368). Therefore, a clear role for this protein in cancer was not supported by evidence in the reviewed literature. |
| Hs.MRPS18C | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: MRPS18C; Aliases: CGI-134; S18MT-C; MRPS18-1; MRPS18-C; MRP-S18-1; MRP-S18-C; Role in Cancer: Differential allelic expression of this gene is associated with breast cancer (27792995). However, a clear role for this gene in cancer was not specified in the reviewed literature. |
| Hs.MRPS2 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: MRPS2; Aliases: S2MT; CGI-91; MRP-S2; COXPD36; Role in Cancer: This gene encodes a mitochondrial ribosomal protein. This gene is overexpressed specifically in a subclass of thyroid tumor called papillary thyroid carcinoma and has been proposed as a potential biomarker (23569218). However, the reviewed literature does not specific a clear role for this gene in cancer. |
| Hs.MRPS22 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) + Homeostasis (proteins) | Unclear role in cancer | Gene Name: MRPS22; Aliases: GIBT; ODG7; GK002; C3ORF5; COXPD5; RPMS22; MRP-S22; Role in Cancer: This gene encodes a mitochondrial ribosomal protein. Overexpressed in human epithelial breast cancer cells but not in tumor breast cancer cells (23172368). The reviewed literature does not specify a clear role for this gene in cancer. |
| Hs.MRPS23 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Mitochondrial maintenance and repair systems + Metastatic process | Gene Name: MRPS23; Aliases: CGI-138; HSPC329; MRP-S23; Role in Cancer: This gene encodes a ribosomal protein of mitochondria. Levels of this protein are overexpressed in several types of cancer, including hepatocellular carcinoma and correlate with increased tumor size and tumor metastasis. Upregulation of this gene has been suggested to promote energy production in cancer cells (28714366). |
| Hs.MRPS28 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) + Homeostasis (proteins) | Mitochondrial maintenance and repair systems | Gene Name: MRPS28; Aliases: MRPS35; HSPC007; MRP-S28; MRP-S35; Role in Cancer: This gene encodes a mitochondrial ribosomal protein that is upregulated in thyroid cancer (23569218). |
| Hs.MRPS5 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: MRPS5; Aliases: S5MT; MRP-S5; Role in Cancer: This gene encodes a mitochondrial ribosomal protein that participates in protein synthesis. Role in cancer: not specified. (25590838) The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.MRPS7 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: MRPS7; Aliases: S7MT; MRP-S; RP-S7; RPMS7; MRP-S7; COXPD34; BMRP27A; Role in Cancer: This gene encodes a mitochondrial ribosomal protein that is upregulated in stromal cells of breast tumors (23172368). However, a clear role for this gene in cancer was not elucidated from the reviewed literature. |
| Hs.MTERF1 | 1 | 0 | MitoCarta 2.0:YES | DNA (mtDNA transcription) | Evasion of cell death | Gene Name: MTERF1; Aliases: MTERF; Role in Cancer: This gene is downregulated in breast cancer patients with lymph node metastases. Loss of the encoded protein occurs in cancer and could promote both tumor development and neovascularization to support anti-apoptotic signaling (26400320). |
| Hs.MTHFD1L | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (one-carbon folate) + Biosynthesis (nucleotides) | Unclear role in cancer | Gene Name: MTHFD1L; Aliases: FTHFSDC1; MTC1THFS; DJ292B18.2; Role in Cancer: Expression of this gene is associated with disease-free survival of stage III colorectal cancer patients treated with a combination of 5-fluorouracil and leucovorin (31223065). However, a clear role for this gene in cancer was not elucidated from the reviewed literature. |
| Hs.MTO1 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Mitochondrial maintenance and repair systems | Gene Name: MTO1; Aliases: CGI-02; COXPD10; Role in Cancer: This gene encodes a mitochondrial tRNA-modifying enzyme that has a key role in translation. Upregulation of this gene occurs in ER-neg breast cancer cell lines (24160266). |
| Hs.MTRF1L | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: MTRF1L; Aliases: MRF1L; HMRF1L; MTRF1A; Role in Cancer: The resulting protein participates in mitochondrial protein synthesis. It has been related with dissociation of the translation process of several proteins in mitochondria (20186120). However, a clear role for this protein in cancer was not deduced from the reviewed literature. |
| Hs.ND4L | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Unclear role in cancer | Gene Name: ND4L; Aliases: MTND4L; ND4L; Role in Cancer: Silent mutations of this gene were reported in breast cancer cells. However, it was not fully clear whether they are related to tumor growth (24061460). |
| Hs.NDUFAF1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) + Homeostasis (proteins) | Unclear role in cancer | Gene Name: NDUFAF1; Aliases: CGI65; CIA30; CGI-65; MC1DN11; Role in Cancer: This gene encodes an assembly factor of the mitochondrial respiratory complex I. Downregulation of this gene derives from mitochondrial dysfunction, contributing to tumor progression. The encoded protein is mentioned in the paper as a downstream effector (lowered expression) of anti_miR-663A (29066618). However, a clear role for this gene in cancer was not determined based on the reviewed literature. |
| Hs.NDUFB9 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism + Metastatic process | Gene Name: NDUFB9; Aliases: B22; LYRM3; CI-B22; UQOR22; MC1DN24; Role in Cancer: Downregulation of this gene is associated with breast cancer cells progression and invasiveness. Dysfunctions in the encoded protein impairs the function of the respiratory complex I, leading to imbalance of the NAD+/NADH ratio and to overproduction of mitochondrial ROS (26641458). |
| Hs.NDUFS1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Unclear role in cancer | Gene Name: NDUFS1; Aliases: CI-75K; MC1DN5; CI-75KD; PRO1304; Role in Cancer: The encoded protein forms part of the respiratory complex I. This gene is downregulated by M4N (26886430), but its role in cancer is not specified. |
| Hs.NDUFV1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Mitochondrial maintenance and repair systems | Gene Name: NDUFV1; Aliases: UQOR1; CI-51K; CI51KD; MC1DN4; Role in Cancer: The protein product of this gene forms part of complex I in the respiratory chain. Levels of this protein are elevated in bladder carcinoma cell lines and contribute to dysfunctions in the metabolism of malignant cells (26722457). |
| Hs.NTHL1 | 1 | 0 | MitoCarta 2.0:YES | DNA (mtDNA integrity) | Mitochondrial maintenance and repair systems | Gene Name: NTHL1; Aliases: FAP3; NTH1; OCTS3; HNTH1; Role in Cancer: The enzyme encoded by this gene have base excision repair (BER) activity. Levels of this protein are upregulated in mitochondria of lung cancer cell lines (21187477). |
| Hs.NUBPL | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) + Homeostasis (proteins) + Energy metabolism (respiratory chain) | Metastatic process | Gene Name: NUBPL; Aliases: IND1; HUIND1; MC1DN21; C14ORF127; Role in Cancer: This protein is required for the assembly of the respiratory complex I. It promotes migration and invasiveness of colorectal cancer cells and greatly contributes to induction of EMT and metastasis (28346728). |
| Hs.OGDH | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) | Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: OGDH; Aliases: E1K; OGDC; AKGDH; Role in Cancer: This gene encodes a subunit of the 2-oxoglutarate dehydrogenase complex and is overexpressed in spheroids of proliferative breast cancer MCF-7 cells (23195224). |
| Hs.OGDHL | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (TCA cycle) + Homeostasis (redox) | Adaptive modulation of oxidative stress + Reprogramming of energy metabolism | Gene Name: OGDHL; Aliases: -; Role in Cancer: The protein product is an enzyme of the TCA cycle that regulates availability of reducing equivalents for the respiratory chain and OXPHOS in order to keep a redox balance. Increased expression of this enzyme contributes to maintain mitochondrial viability in cancer cells (26980435). |
| Hs.OXA1L | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Unclear role in cancer | Gene Name: OXA1L; Aliases: OXA1; Role in Cancer: The encoded protein participates in the import of nuclearly-encoded mitochondrial proteins (28156110). |
| Hs.PDK4 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (pyruvate dehydrogenase complex cycle) | Reprogramming of energy metabolism + Metastatic process | Gene Name: PDK4; Aliases: -; Role in Cancer: The encoded protein participates in the pyruvate dehydrogenase complex. Downregulation of this protein occurs after depletion of FAM210B and is a key event that underlies metabolic reprogramming, EMT and metastasis in ovarian cancer cells (28594398). |
| Hs.PGAM5 | 1 | 0 | MitoCarta 2.0:YES | Cell death (necroptosis) + Mitochondrial dynamics (fission) | Evasion of cell death | Gene Name: PGAM5; Aliases: BXLBV68; Role in Cancer: The protein encoded by this gene plays an important role in necroptosis and contributes to resistance of gastric cancer cells by impairing release of cytochrome c. In detail, PGAM5 promotes mitochondrial elongation and fragmentation in cancer cells, through interaction with SOCS6 (22955947). |
| Hs.PKLR | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (intermediary metabolism / glycolysis) + Biosynthesis (lipogenesis) | Reprogramming of energy metabolism + Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: PKLR; Aliases: PK1; PKL; RPK; PKRL; Role in Cancer: The enzyme encoded by this gene is a driver of non-alcoholic fatty liver disease progression to HCC. It supports the energetic demand of cancer cells by producing pyruvate from PEP in response to hypoxia and contributes to lipid biogenesis by interacting with FASN (30615941). |
| Hs.POLG2 | 1 | 0 | MitoCarta 2.0:YES | DNA (mtDNA replication / mtDNA integrity) | Mitochondrial maintenance and repair systems | Gene Name: POLG2; Aliases: HP55; POLB; PEOA4; POLGB; MTPOLB; MTDPS16; POLG-BETA; Role in Cancer: SNP rs9905016 at the nuclearly-encoded POLG2 was found to correlate with enhanced mitochondrial DNA synthesis and with a risk increase for oral cancer (26403317). |
| Hs.PRDX2 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (redox / mitochondria) | Adaptive modulation of oxidative stress | Gene Name: PRDX2; Aliases: PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2A; Role in Cancer: Encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Increased expression of this gene is associated with better survival prognosis in luminal B breast cancer patients (29545070). |
| Hs.PRELID1 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (redox) | Adaptive modulation of oxidative stress | Gene Name: PRELID1; Aliases: PX19; PRELI; SBBI12; CGI-106; Role in Cancer: This gene encodes a protein of the mitochondrial intermembrane space, which is involved in modulation of ROS production, as a response to cellular stress. It promotes cell growth of breast cancer cells and contributes to specific cellular events, depending on the cancer subtype (28912168). |
| Hs.RARS1 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (mitochondria) | Unclear role in cancer | Gene Name: RARS1; Aliases: RARS; AL033339; AW985894; 2610011N19RIK; 2610037E21RIK; Role in Cancer: This enzyme catalyzes the aminoacylation of tRNA by their cognate amino acid. Paper is a review. (19907149) The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.RMDN1 | 1 | 0 | MitoCarta 2.0:YES | Annotation error | Unclear role in cancer | Gene Name: RMDN1; Aliases: RMD1; RMD-1; CGI-90; FAM82B; Role in Cancer: The abstract does not mention the gene symbol RMDN1 nor any of its gene aliases. Instead, PubTerm highlights MAP as a potential gene symbol, but the article uses MAP as an acronym of _Microtubule-Associated Protein_. |
| Hs.ROMO1 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (redox) | Adaptive modulation of oxidative stress | Gene Name: ROMO1; Aliases: MTGM; MTGMP; C20ORF52; BA353C18.2; Role in Cancer: The encoded protein favors generation of ROS and has been suggested to participate in cancer redox signaling. A genetic polymorphism was associated with gastric cancer. Probably, the production of ROS by ROMO1 promotes gastric cancer malignancy (25374412). |
| Hs.RPIA | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (pentose-phosphate pathway) | Reprogramming of energy metabolism | Gene Name: RPIA; Aliases: RPI; RPIAD; Role in Cancer: The encoded protein participates in the pentose-phosphate pathway and contributes to the production of materials for the reductive biosynthesis reactions. It is upregulated in breast cancer cells that carry mutations in the p53 locus (27582538). |
| Hs.RPS18 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) | Unclear role in cancer | Gene Name: RPS18; Aliases: KE3; S18; HKE3; KE-3; D6S218E; Role in Cancer: This protein is part of the 40S subunit of the ribosome. Role in cancer: not specified. (27489352)_The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.SCO2 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (redox) | Adaptive modulation of oxidative stress | Gene Name: SCO2; Aliases: TP; MYP6; TYMP; ECGF1; SCO1L; CEMCOX1; PD-ECGF; TDRPASE; GLIOSTATIN; Role in Cancer: In Glioma and colon cancer cells with wild type p53, SCO2 protects against tumor hypoxia by skewing the Warburg effect (22120717). |
| Hs.SEPTIN4 | 1 | 0 | MitoCarta 2.0:YES | Cell death (apoptosis) | Unclear role in cancer | Gene Name: SEPTIN4; Aliases: H5; ARTS; MART; SEP4; CE5B3; SEPT4; PNUTL2; HUCEP-7; BRADEION; C17ORF47; HCDCREL-2; Role in Cancer: The product of this gene is a mitochondrial protein that exerts pro-apoptotic activity by binding to XIAP. The use of ARTS-derived peptides induces apoptosis in leukemia cells and has been proposed as a therapeutic strategy (22392914). The reviewed literature does not mention that this gene is naturally overexpressed in cancer; thus, a clear role for this gene in this disease is missing. |
| Hs.SLC25A11 | 1 | 0 | MitoCarta 2.0:YES | Carrier (dicarboxylates) + Energy metabolism (TCA cycle) + Homeostasis (redox) | Reprogramming of energy metabolism + Adaptive modulation of oxidative stress | Gene Name: SLC25A11; Aliases: OGC; PGL6; SLC20A4; Role in Cancer: The encoded protein transports dicarboxylates, including 2-oxoglutarate, and glutathione across the mitochondrial membrane. Levels of this protein are upregulated in hepatocellular carcinoma cells, where the protein exerts a protective role against oxidative stress and further contributes to regulate mitochondrial respiration and glycolysis (28942194). |
| Hs.SLC25A19 | 1 | 0 | MitoCarta 2.0:YES | Annotation error | Annotation error | Gene Name: SLC25A19; Aliases: DNC; TPC; MUP1; MCPHA; THMD3; THMD4; Role in Cancer: SLC25A19 and UCP1 are different genes and pubterm detects them as one. In "gene", SLC25A19 has no alias as "UCP1". The abstract mentions UCP1. |
| Hs.SLC25A20 | 1 | 0 | MitoCarta 2.0:YES | Carrier (signaling molecules) | Reprogramming of energy metabolism | Gene Name: SLC25A20; Aliases: CACT; CAC; O43772; Role in Cancer: The encoded protein mediates the transport of acylcarnitine into mitochondria to supply the fatty acid-oxidation pathway. microRNAs present in prostate cancer cells downregulate expression of this gene and deregulate fatty acid utilization; however, the most aggressive subtypes of this cancer have lower levels of microRNAs and increased expression of this carrier (28671672). |
| Hs.SLC25A21 | 1 | 0 | MitoCarta 2.0:YES | Carrier (dicarboxylates) + Homeostasis (mitochondria) | Unclear role in cancer | Gene Name: SLC25A21; Aliases: ODC; ODC1; Role in Cancer: The encoded protein transports oxo-dicarboxylates within the mitochondria and two intronic SNPs have been found for this locus in breast cancer patients that are administered menopausal hormone replacement therapy (24080446); however, a clear causative role for this protein in cancer was not specified in the reviewed literature._ |
| Hs.SLC25A22 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Adaptive modulation of oxidative stress | Gene Name: SLC25A22; Aliases: GC1; GC-1; EIEE3; NET44; Role in Cancer: This protein works as a mitochondrial-glutamate transporter and as an onco-gene by reducing oxidative stress. (27451147) |
| Hs.SLC25A23 | 1 | 0 | MitoCarta 2.0:YES | Carrier (signaling molecules) | Unclear role in cancer | Gene Name: SLC25A23; Aliases: APC2; MCSC2; SCAMC-3; Role in Cancer: Calcium-dependent mitochondrial solute carrier. This protein mediates the transport of metabolites across the inner mitochondrial membrane and is differentially expressed in prostate cancer (23047795). However, not a clear role for this gene has been shown in the reviewed literature. |
| Hs.SLC25A26 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Genomic instability and mutations + Mitochondrial maintenance and repair systems | Gene Name: SLC25A26; Aliases: SAMC; COXPD28; Role in Cancer: SLC5A26 belongs to the mitochondrial carrier family and mediates import of S-adenosylmethionine (SAM). Mutations in this gene affect several processes in the mitochondria such as stability of RNA, mitochondrial translation and ATP production. SLC5A26 expression was found to be downregulated on several cancer cell lines (i.e. CaSki, SiHa, Caco-2, HepG2 and SY-SY5Y) through the action of FOXD3 (30076902). |
| Hs.SLC25A31 | 1 | 0 | MitoCarta 2.0:YES | Carrier (energy carrying molecules) + Cell death (apoptosis) | Evasion of cell death | Gene Name: SLC25A31; Aliases: AAC4; ANT4; ANT 4; SFEC35KDA; Role in Cancer: Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. The encoded protein is a carrier that mediates exchange of ADP/ATP from the cytosol to the mitochondria; it promotes cell growth and contributes to cancer cell resistance to therapy (20060930). |
| Hs.SLC25A33 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) + DNA (mtDNA integrity) + Mitochondrial dynamics (biogenesis) | Mitochondrial maintenance and repair systems | Gene Name: SLC25A33; Aliases: PNC1; BMSC-MCP; Role in Cancer: This gene encodes a mitochondrial carrier that is essential to maintain integrity of mtDNA and respiration. Downregulation of this gene triggers oxidative stress that further diminishes the production of ATP. Indirectly, this promotes mitochondrial biogenesis. Partial dysfunctionality of this protein promotes an invasive phenotype of cancer cells (20453889). |
| Hs.SUPV3L1 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (proteins) + DNA (mtDNA integrity) | Genomic instability and mutations | Gene Name: SUPV3L1; Aliases: SUV3; Role in Cancer: The encoded protein is a mitochondrial helicase. Promotes mitochondrial genome instability in cancer. (22562243) |
| Hs.TCHP | 1 | 0 | MitoCarta 2.0:YES | Mitochondrial dynamics (mitophagy) | Potential anti-cancer activity | Gene Name: TCHP; Aliases: TPMS; Role in Cancer: The protein product of this gene, along with the protein Decorin, contributes to trigger mitophagy in cancer cells which further attenuates angiostasis in tumors. Therefore, this gene has been considered as an onco-suppressor (24403067). |
| Hs.TFB1M | 1 | 0 | MitoCarta 2.0:YES | DNA (mtDNA transcription) | Unclear role in cancer | Gene Name: TFB1M; Aliases: CGI75; MTTFB; CGI-75; MTTFB1; Role in Cancer: This gene encodes a regulator protein of mtDNA synthesis. Despite levels of this protein are differentially expressed as a result of altered mtDNA copy number in astrocytoma tissues, they have not been identified as a causal factor of cancer in the reviewed literature (20643228). |
| Hs.TFB2M | 1 | 0 | MitoCarta 2.0:YES | DNA (mtDNA replication / mtDNA integrity) | Unclear role in cancer | Gene Name: TFB2M; Aliases: HKP1; MTTFB2; Role in Cancer: The encoded protein is involved in mitochondrial DNA replication. Role in cancer: not specified. (20643228) The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.TIMM22 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Unclear role in cancer | Gene Name: TIMM22; Aliases: TEX4; TIM22; Role in Cancer: The encoded protein forms part of the protein-import complex TIM22. This protein is required for insertion of several mitochondrial proteins into the membrane (28712724). The reviewed literature does not provide a clear role for this gene in cancer. |
| Hs.TIMM23 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Mitochondrial maintenance and repair systems | Gene Name: TIMM23; Aliases: TIM23; Role in Cancer: The encoded protein forms part of the TIM23 complex, which mediates translocation of protein precursors in an ATP-dependent manner; it has been identified as a susceptibility locus that contributes to tumorigenesis (23263864). |
| Hs.TIMM29 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Unclear role in cancer | Gene Name: TIMM29; Aliases: C19ORF52; Role in Cancer: The encoded protein TIMM29 forms part of the protein-import complex TIMM22, and is necessary for biogenesis of TIMM23 (28712724). The reviewed literature does not indicate a specific role for this protein in cancer. |
| Hs.TIMM50 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (mitochondria) | Mitochondrial maintenance and repair systems | Gene Name: TIMM50; Aliases: MGCA9; TIM50; TIM50L; Role in Cancer: The encoded protein promotes growth and chemoresistance in p53 mutated cancer cell lines. (21621504) |
| Hs.TIMM8A | 1 | 0 | MitoCarta 2.0:YES | Annotation error | Annotation error | Gene Name: TIMM8A; Aliases: DDP; MTS; DDP1; DFN1; TIM8; Role in Cancer: Abstract refers to diamminedichloridoplatinum's (Cisplatin) abbreviation (DDP) and not to TIMM8A's gene symbol (also known as DDP). |
| Hs.TIMM9 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) + Mitochondrial dynamics (biogenesis) + Homeostasis (proteins) | Mitochondrial maintenance and repair systems | Gene Name: TIMM9; Aliases: TIM9; TIM9A; Role in Cancer: The protein product of this gene participates in protein import and insertion within the mitochondrial inner membrane, and it is a marker of mitochondrial biogenesis. The TIMM9 gene is upregulated in breast cancer cells (23172368). |
| Hs.TIMMDC1 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (proteins) + Energy metabolism (respiratory chain) + Cell cycle regulation | Evasion of anti-growth signaling and cell sufficiency in growth signals + Metastatic process | Gene Name: TIMMDC1; Aliases: C3ORF1; MC1DN31; Role in Cancer: This gene encodes a mitochondrial protein that contributes to stabilization of the respiratory complex I. Levels of this protein are increased in a lung cancer cell line with a marked migratory capacity. Depletion of this gene inhibits cell cycle, migration and proliferation in lung carcinoma cells (25391042). |
| Hs.TK2 | 1 | 0 | MitoCarta 2.0:YES | Biosynthesis (nucleotides) | Unclear role in cancer | Gene Name: TK2; Aliases: MTTK; PEOB3; SCA31; MTDPS2; Role in Cancer: The encoded enzyme phosphorylates thymidine, deoxycytidine, and deoxyuridine. (24484525) The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.TKT | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (pentose-phosphate pathway / glycolysis) | Reprogramming of energy metabolism | Gene Name: TKT; Aliases: TK; TKT1; SDDHD; HEL107; HEL-S-48; Role in Cancer: The encoded protein plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. It is upregulated in breast cancer, which contributes to support the energetic demands of cancer cells. (27582538). |
| Hs.TOMM20 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / protein precursors) | Unclear role in cancer | Gene Name: TOMM20; Aliases: MAS20; MOM19; TOM20; Role in Cancer: This protein is in charge of importing mitochondrial proteins. It is also involved in mitophagy (25177836)._The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.TOMM22 | 1 | 0 | MitoCarta 2.0:YES | Carrier (molecules / proteins precursors) | Evasion of cell death | Gene Name: TOMM22; Aliases: 1C9-2; TOM22; MST065; MSTP065; Role in Cancer: The encoded protein is a receptor of the pro-apoptotic protein Bax and exerts an anti-apoptotic effect. Although in prostate cancer this protein does not seem to exert a protective role, it does prevent death of glioblastoma cells (25177836). |
| Hs.TPI1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (glycolysis) | Reprogramming of energy metabolism | Gene Name: TPI1; Aliases: TIM; TPI; TPID; HEL-S-49; Role in Cancer: The encoded enzyme catalyzes the isomerization of glyceraldehyde 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Levels of this protein increase in the stroma of human breast tumors and potentially support the energetic switch in cancer cells (20562527). |
| Hs.TXNRD1 | 1 | 0 | MitoCarta 2.0:YES | Homeostasis (redox) | Unclear role in cancer | Gene Name: TXNRD1; Aliases: TR; TR1; TXNR; TRXR1; GRIM-12; Role in Cancer: This enzyme belongs to the pyridine nucleotide-disulfide oxidoreductase family. Role in cancer: not specified. (23543312) The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.UNG | 1 | 0 | MitoCarta 2.0:YES | DNA (mtDNA integrity / nDNA integrity) | Unclear role in cancer | Gene Name: UNG; Aliases: DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15; Role in Cancer: One important function of the encoded uracil-DNA glycosylase is to prevent mutagenesis by eliminating uracil from DNA molecules. To do so, this enzyme cleaves the N-glycosylic bond and initiates the base-excision repair (BER) pathway. Not related with lung cancer cells. (21187477) The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.UQCC2 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) + Homeostasis (proteins) | Unclear role in cancer | Gene Name: UQCC2; Aliases: M19; CBP6; MNF1; MC3DN7; C6ORF125; C6ORF126; BA6B20.2; Role in Cancer: The encoded protein is an assembly factor of the respiratory complex III. Expression of this gene is promoted by miR-663 in breast cancer cell lines, which contributes to ATP production (29066618). The reviewed literature did not provide a clear role for this protein in cancer. |
| Hs.UQCR11 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Unclear role in cancer | Gene Name: UQCR11; Aliases: UQCR; QCR10; 0710008D09RIK; Role in Cancer: UQCR11 was found to be differentially upregulated in patients with low- to intermediate- grade lung adenocarcinoma and it was proposed as a potential therapeutic target. (26840709). However, a clear role for this gene in cancer was not deduced from the reviewed literature. |
| Hs.UQCRC1 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism | Gene Name: UQCRC1; Aliases: QCR1; UQCR1; D3S3191; Role in Cancer: The encoded protein forms part of the respiratory complex III. This gene is downregulated in clear cell renal carcinoma, potentially as part of the metabolic switch that occurs in cancer cells (27845902). |
| Hs.UQCRC2 | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Reprogramming of energy metabolism | Gene Name: UQCRC2; Aliases: QCR2; UQCR2; MC3DN5; Role in Cancer: This protein is a component of the ubiquinol-cytochrome c reductase complex (also known as complex III). Levels of this protein are increased in lung cancer cells, where they potentially support the demand of ATP (26840709)._ |
| Hs.UQCRH | 1 | 0 | MitoCarta 2.0:YES | Energy metabolism (respiratory chain) | Unclear role in cancer | Gene Name: UQCRH; Aliases: QCR6; UQCR8; Role in Cancer: This protein is a subunit of the mitochondrial complex III. This gene is upregulated in breast cancer and other types of cancer such as myeloma, SCLC, renal oncocytoma, among others. (21901141). However, the reviewed literature does not discuss the specific pathological role of this protein in cancer. |
| Hs.YME1L1 | 1 | 0 | MitoCarta 2.0:YES | DNA (mtDNA integrity / nDNA integrity) | Genomic instability and mutations + Evasion of anti-growth signaling and cell sufficiency in growth signals | Gene Name: YME1L1; Aliases: FTSH; MEG4; PAMP; OPA11; YME1L; Role in Cancer: YME1L1 was identified as the first suppressor gene for numtogenesis (i.e. somatic migration of mtDNA into the nucleus) in humans; as inactivating mutations of YME1L1 in colorectal cancer patients lead to increased numtogenesis and correlated with tumor progression (28356157). |
| Hs.TP53 | 315 | 9.9 | Prueba guardar | |||
| Hs.CASP3 | 227 | 9.9 | ||||
| Hs.CASP9 | 120 | 9.9 | ||||
| Hs.AKT1 | 94 | 9.9 | ||||
| Hs.H3P16 | 63 | 9.9 | ||||
| Hs.ANXA5 | 61 | 9.9 | ||||
| Hs.PARP1 | 60 | 9.9 | ||||
| Hs.MTOR | 58 | 9.9 | ||||
| Hs.MCL1 | 45 | 9.9 | ||||
| Hs.MYC | 43 | 9.9 | ||||
| Hs.EGFR | 41 | 3.1 | ||||
| Hs.CCND1 | 39 | 9.9 | ||||
| Hs.MAPK1 | 39 | 9.3 | ||||
| Hs.STAT3 | 39 | 9.9 | ||||
| Hs.KRAS | 37 | 9.9 | ||||
| Hs.COL11A2 | 34 | 9.9 | ||||
| Hs.TNFSF10 | 33 | 9.9 | ||||
| Hs.ERBB2 | 32 | 2.6 | ||||
| Hs.CDKN1A | 31 | 9.9 | ||||
| Hs.PIK3CD | 30 | 9.6 | ||||
| Hs.VEGFA | 30 | 0.6 | ||||
| Hs.DDIT3 | 29 | 9.9 | ||||
| Hs.HIF1A | 29 | 9.8 | ||||
| Hs.MAPK8 | 28 | 9.9 | ||||
| Hs.NFE2L2 | 28 | 9.9 | ||||
| Hs.BECN1 | 27 | 9.9 | ||||
| Hs.PTEN | 25 | 8.9 | ||||
| Hs.XIAP | 25 | 9.9 | ||||
| Hs.CDK1 | 24 | 9.9 | ||||
| Hs.MAPK14 | 24 | 5.3 | ||||
| Hs.SLC2A1 | 24 | 9.9 | ||||
| Hs.HSP90AA1 | 23 | 9.9 | ||||
| Hs.RELA | 23 | 9.9 | ||||
| Hs.FASLG | 21 | 9.7 | ||||
| Hs.HSPA5 | 21 | 9.9 | ||||
| Hs.ESR1 | 20 | 2.1 | ||||
| Hs.ATG5 | 19 | 9.9 | ||||
| Hs.CDK2 | 19 | 9.9 | ||||
| Hs.LDHA | 19 | 9.9 | ||||
| Hs.PPARGC1A | 19 | 9.9 | ||||
| Hs.BRAF | 18 | 4.2 | ||||
| Hs.CDKN2A | 18 | 3.2 | ||||
| Hs.MMP9 | 17 | 1.7 | ||||
| Hs.CCNB1 | 16 | 9.9 | ||||
| Hs.TERT | 16 | 6.8 | ||||
| Hs.APAF1 | 14 | 9.9 | ||||
| Hs.MMP2 | 14 | 1.7 | ||||
| Hs.NRF1 | 14 | 9.9 | ||||
| Hs.SRC | 14 | 9.9 | ||||
| Hs.TNF | 14 | 9.9 | ||||
| Hs.CRMP1 | 13 | 9.9 | ||||
| Hs.MAP1LC3A | 13 | 9.6 | ||||
| Hs.MAP2K7 | 13 | 3.1 | ||||
| Hs.PKM | 13 | 9.9 | ||||
| Hs.RB1 | 13 | 3.8 | ||||
| Hs.ABCB1 | 12 | 0.7 | ||||
| Hs.ATF4 | 12 | 9.9 | ||||
| Hs.ATG7 | 12 | 9.9 | ||||
| Hs.BRCA1 | 12 | 1.3 | ||||
| Hs.EIF2AK3 | 12 | 7.4 | ||||
| Hs.FADD | 12 | 9.9 | ||||
| Hs.MDM2 | 12 | 3.7 | ||||
| Hs.TP73 | 12 | 9.4 | ||||
| Hs.CASP7 | 11 | 9.9 | ||||
| Hs.CDH1 | 11 | 0.4 | ||||
| Hs.CDKN1B | 11 | 4.5 | ||||
| Hs.CFLAR | 11 | 5.5 | ||||
| Hs.JAK2 | 11 | 2.9 | ||||
| Hs.JUN | 11 | 1.7 | ||||
| Hs.SIRT1 | 11 | 4.1 | ||||
| Hs.AR | 10 | 1 | ||||
| Hs.CA9 | 10 | 7.3 | ||||
| Hs.CTNNB1 | 10 | 0.1 | ||||
| Hs.CXCL8 | 10 | 0 | ||||
| Hs.PCSK1 | 10 | 7.3 | ||||
| Hs.POU5F1 | 10 | 3 | ||||
| Hs.PRKAA1 | 10 | 7.5 | ||||
| Hs.SP1 | 10 | 2.4 | ||||
| Hs.TNFRSF10B | 10 | 5.8 | ||||
| Hs.BCL2L11 | 9 | 9.7 | ||||
| Hs.CBX8 | 9 | 9.9 | ||||
| Hs.CDK4 | 9 | 3.1 | ||||
| Hs.FOXO3 | 9 | 6 | ||||
| Hs.HSPA4 | 9 | 1.6 | ||||
| Hs.IL6 | 9 | 0 | ||||
| Hs.MIR7-3HG | 9 | 5.6 | ||||
| Hs.NUP62 | 9 | 5.3 | ||||
| Hs.PCNA | 9 | 1 | ||||
| Hs.PIK3CA | 9 | 3.3 | ||||
| Hs.ATM | 8 | 2.6 | ||||
| Hs.CASP2 | 8 | 8.5 | ||||
| Hs.CCNA2 | 8 | 3.4 | ||||
| Hs.E2F1 | 8 | 4.1 | ||||
| Hs.FAS | 8 | 2.7 | ||||
| Hs.STAT1 | 8 | 2.3 | ||||
| Hs.BIRC2 | 7 | 6.2 | ||||
| Hs.BIRC3 | 7 | 5.6 | ||||
| Hs.BIRC7 | 7 | 9.9 | ||||
| Hs.CCNE1 | 7 | 7.3 | ||||
| Hs.CD44 | 7 | 0.3 | ||||
| Hs.CREB1 | 7 | 1.6 | ||||
| Hs.HDAC9 | 7 | 5.2 | ||||
| Hs.IGF1R | 7 | 9.9 | ||||
| Hs.JAK1 | 7 | 4.6 | ||||
| Hs.KRT7 | 7 | 2.8 | ||||
| Hs.NFKB1 | 7 | 0 | ||||
| Hs.RAF1 | 7 | 2.5 | ||||
| Hs.RET | 7 | 9.9 | ||||
| Hs.SOX2 | 7 | 2.1 | ||||
| Hs.TNFRSF1A | 7 | 2.4 | ||||
| Hs.VHL | 7 | 2.6 | ||||
| Hs.XBP1 | 7 | 5.1 | ||||
| Hs.BIK | 6 | 8.3 | ||||
| Hs.CHEK2 | 6 | 3 | ||||
| Hs.EGR1 | 6 | 2.6 | ||||
| Hs.H2AX | 6 | 3.1 | ||||
| Hs.MAP1LC3B | 6 | 9.9 | ||||
| Hs.NANOG | 6 | 2.6 | ||||
| Hs.NQO1 | 6 | 2.8 | ||||
| Hs.PDGFRA | 6 | 2.5 | ||||
| Hs.RPS6KB1 | 6 | 2.3 | ||||
| Hs.TNFRSF10A | 6 | 4.4 | ||||
| Hs.VIM | 6 | 0 | ||||
| Hs.APEX1 | 5 | 2.7 | ||||
| Hs.BMI1 | 5 | 3.1 | ||||
| Hs.CASP4 | 5 | 5.9 | ||||
| Hs.CD34 | 5 | 0 | ||||
| Hs.DCTN6 | 5 | 3.4 | ||||
| Hs.DNMT1 | 5 | 1.9 | ||||
| Hs.EIF2AK4 | 5 | 6.8 | ||||
| Hs.ESRRA | 5 | 6.2 | ||||
| Hs.FOS | 5 | 0 | ||||
| Hs.HMGA2 | 5 | 4 | ||||
| Hs.HMOX1 | 5 | 0.7 | ||||
| Hs.HRAS | 5 | 1.4 | ||||
| Hs.IGF1 | 5 | 0 | ||||
| Hs.IL24 | 5 | 5.2 | ||||
| Hs.KEAP1 | 5 | 3.2 | ||||
| Hs.MAP3K5 | 5 | 4.3 | ||||
| Hs.MAPK3 | 5 | 1.1 | ||||
| Hs.MMP7 | 5 | 2.5 | ||||
| Hs.NKX2-1 | 5 | 9.9 | ||||
| Hs.NR4A1 | 5 | 1.2 | ||||
| Hs.NRAS | 5 | 1.3 | ||||
| Hs.PGR | 5 | 0 | ||||
| Hs.PPARA | 5 | 0.4 | ||||
| Hs.PPID | 5 | 7.4 | ||||
| Hs.PRKAA2 | 5 | 2.9 | ||||
| Hs.PTGS2 | 5 | 0 | ||||
| Hs.PTK2 | 5 | 1 | ||||
| Hs.RIPK1 | 5 | 3 | ||||
| Hs.SLC16A3 | 5 | 6.2 | ||||
| Hs.SMAD4 | 5 | 1.8 | ||||
| Hs.SNCA | 5 | 0.6 | ||||
| Hs.TP63 | 5 | 1 | ||||
| Hs.ULK1 | 5 | 4.8 | ||||
| Hs.ZHX2 | 5 | 1.3 | ||||
| Hs.ABL1 | 4 | 0 | ||||
| Hs.ATF3 | 4 | 3.6 | ||||
| Hs.ATG16L1 | 4 | 4.6 | ||||
| Hs.BTG2 | 4 | 5 | ||||
| Hs.CDC42 | 4 | 0.9 | ||||
| Hs.CSF2 | 4 | 0 | ||||
| Hs.CXCR4 | 4 | 0 | ||||
| Hs.ERN1 | 4 | 2.4 | ||||
| Hs.FOXO1 | 4 | 1.5 | ||||
| Hs.GADD45A | 4 | 3 | ||||
| Hs.GPT | 4 | 0 | ||||
| Hs.GRN | 4 | 2.1 | ||||
| Hs.HDAC2 | 4 | 2.8 | ||||
| Hs.IFNB1 | 4 | 0 | ||||
| Hs.IGF2 | 4 | 9.9 | ||||
| Hs.KISS1 | 4 | 3.9 | ||||
| Hs.KIT | 4 | 0 | ||||
| Hs.KLK3 | 4 | 0 | ||||
| Hs.LGALS7 | 4 | 7.1 | ||||
| Hs.MIR27A | 4 | 9.9 | ||||
| Hs.MLKL | 4 | 5.1 | ||||
| Hs.MME | 4 | 0.1 | ||||
| Hs.MTDH | 4 | 9.9 | ||||
| Hs.MTUS1 | 4 | 8.3 | ||||
| Hs.MYB | 4 | 1.7 | ||||
| Hs.MYCN | 4 | 1 | ||||
| Hs.NDRG2 | 4 | 6.2 | ||||
| Hs.NOS2 | 4 | 0 | ||||
| Hs.PAX8 | 4 | 3 | ||||
| Hs.PDLIM7 | 4 | 9.9 | ||||
| Hs.PIK3R1 | 4 | 2.7 | ||||
| Hs.PLIN2 | 4 | 4.1 | ||||
| Hs.PRKN | 4 | 3.7 | ||||
| Hs.PTK2B | 4 | 1.4 | ||||
| Hs.PTPA | 4 | 1.2 | ||||
| Hs.RAD51 | 4 | 0.9 | ||||
| Hs.RYR1 | 4 | 2.2 | ||||
| Hs.SLC7A11 | 4 | 4.7 | ||||
| Hs.SNAI1 | 4 | 0.6 | ||||
| Hs.SP3 | 4 | 9.9 | ||||
| Hs.SP4 | 4 | 5.3 | ||||
| Hs.TRNG | 4 | 3 | ||||
| Hs.TSC1 | 4 | 1.8 | ||||
| Hs.UTRN | 4 | 5 | ||||
| Hs.XK | 4 | 2.9 | ||||
| Hs.ABCC1 | 3 | 0.6 | ||||
| Hs.ABCG2 | 3 | 0.3 | ||||
| Hs.ATF2 | 3 | 2.2 | ||||
| Hs.CAV1 | 3 | 0.3 | ||||
| Hs.CCL2 | 3 | 9.9 | ||||
| Hs.CD24 | 3 | 1.1 | ||||
| Hs.CD4 | 3 | 9.9 | ||||
| Hs.CD68 | 3 | 0 | ||||
| Hs.CD8A | 3 | 0 | ||||
| Hs.CDC25A | 3 | 2.5 | ||||
| Hs.CDH2 | 3 | 9.9 | ||||
| Hs.CFL1 | 3 | 1.5 | ||||
| Hs.CHEK1 | 3 | 0.9 | ||||
| Hs.DNER | 3 | 0.7 | ||||
| Hs.DRAM1 | 3 | 5.2 | ||||
| Hs.EIF2S3 | 3 | 6 | ||||
| Hs.EPCAM | 3 | 1 | ||||
| Hs.ETS1 | 3 | 1.6 | ||||
| Hs.FBXW7 | 3 | 2.3 | ||||
| Hs.FGFR1 | 3 | 9.9 | ||||
| Hs.FGFR2 | 3 | 1.2 | ||||
| Hs.FLCN | 3 | 3.9 | ||||
| Hs.FOXM1 | 3 | 1.2 | ||||
| Hs.G6PD | 3 | 0 | ||||
| Hs.GLI1 | 3 | 1.2 | ||||
| Hs.GLI2 | 3 | 0 | ||||
| Hs.GSTM1 | 3 | 0.4 | ||||
| Hs.HDAC1 | 3 | 1 | ||||
| Hs.HMGB1 | 3 | 0.5 | ||||
| Hs.HNF4A | 3 | 0.7 | ||||
| Hs.HSP90B1 | 3 | 9.9 | ||||
| Hs.HSPA2 | 3 | 4.6 | ||||
| Hs.IFNG | 3 | 0 | ||||
| Hs.INS | 3 | 0 | ||||
| Hs.JUNB | 3 | 0.5 | ||||
| Hs.KDR | 3 | 0 | ||||
| Hs.KRT20 | 3 | 9.9 | ||||
| Hs.MAPK9 | 3 | 2.1 | ||||
| Hs.MPO | 3 | 0 | ||||
| Hs.NAMPT | 3 | 1.3 | ||||
| Hs.NDRG1 | 3 | 3.1 | ||||
| Hs.NF1 | 3 | 0 | ||||
| Hs.NFKBIA | 3 | 0 | ||||
| Hs.NOX1 | 3 | 2.7 | ||||
| Hs.NOX4 | 3 | 1.8 | ||||
| Hs.NPC1 | 3 | 2.2 | ||||
| Hs.NUPR1 | 3 | 5.3 | ||||
| Hs.OSCP1 | 3 | 9.9 | ||||
| Hs.PCK1 | 3 | 2.8 | ||||
| Hs.PECAM1 | 3 | 0 | ||||
| Hs.PFKFB3 | 3 | 4 | ||||
| Hs.PRIMA1 | 3 | 3.8 | ||||
| Hs.PROM1 | 3 | 0.3 | ||||
| Hs.PTCH1 | 3 | 1.5 | ||||
| Hs.RNR1 | 3 | 4.4 | ||||
| Hs.RNR2 | 3 | 7.1 | ||||
| Hs.S100A1 | 3 | 9.9 | ||||
| Hs.SERPINB3 | 3 | 0.5 | ||||
| Hs.SESN2 | 3 | 4.8 | ||||
| Hs.SLC17A5 | 3 | 0 | ||||
| Hs.SLC2A4 | 3 | 0.7 | ||||
| Hs.SLC7A1 | 3 | 9.9 | ||||
| Hs.SQSTM1 | 3 | 1.6 | ||||
| Hs.STAT5A | 3 | 0.5 | ||||
| Hs.STK11 | 3 | 1.3 | ||||
| Hs.TFEB | 3 | 9.9 | ||||
| Hs.TFRC | 3 | 0.5 | ||||
| Hs.TGFB1 | 3 | 0 | ||||
| Hs.TLR4 | 3 | 0 | ||||
| Hs.TP53I3 | 3 | 9.9 | ||||
| Hs.TPCN1 | 3 | 3.7 | ||||
| Hs.TRND | 3 | 7.1 | ||||
| Hs.UBIAD1 | 3 | 6.4 | ||||
| Hs.YAP1 | 3 | 0.9 | ||||
| Hs.ZBTB10 | 3 | 7.4 | ||||
| Hs.ABCC3 | 2 | 9.9 | ||||
| Hs.ADGRL1 | 2 | 2.5 | ||||
| Hs.ADIPOQ | 2 | 0 | ||||
| Hs.AFP | 2 | 0 | ||||
| Hs.AKT2 | 2 | 1.3 | ||||
| Hs.ALK | 2 | 0 | ||||
| Hs.ANXA2 | 2 | 0.8 | ||||
| Hs.APOBEC3A | 2 | 3.3 | ||||
| Hs.ARID4B | 2 | 2.1 | ||||
| Hs.ATF6 | 2 | 1.4 | ||||
| Hs.ATG12 | 2 | 9.9 | ||||
| Hs.ATP2B4 | 2 | 3.2 | ||||
| Hs.AURKA | 2 | 0.7 | ||||
| Hs.AURKB | 2 | 9.9 | ||||
| Hs.BBC3 | 2 | 4.2 | ||||
| Hs.BCL2A1 | 2 | 0.9 | ||||
| Hs.BCL2L12 | 2 | 4.1 | ||||
| Hs.BCRP1 | 2 | 1.8 | ||||
| Hs.BEX2 | 2 | 9.9 | ||||
| Hs.BMPR2 | 2 | 1 | ||||
| Hs.CA2 | 2 | 0 | ||||
| Hs.CALR | 2 | 0.5 | ||||
| Hs.CAPN1 | 2 | 2.2 | ||||
| Hs.CASP10 | 2 | 2.3 | ||||
| Hs.CCN2 | 2 | 0.4 | ||||
| Hs.CCNG2 | 2 | 3.8 | ||||
| Hs.CDH16 | 2 | 4.5 | ||||
| Hs.CDK6 | 2 | 0.7 | ||||
| Hs.CDKN2B | 2 | 9.9 | ||||
| Hs.CDO1 | 2 | 4.5 | ||||
| Hs.CHKA | 2 | 2.5 | ||||
| Hs.CHP1 | 2 | 1.1 | ||||
| Hs.CLU | 2 | 0.9 | ||||
| Hs.COPS2 | 2 | 9.9 | ||||
| Hs.CRP | 2 | 0 | ||||
| Hs.CTSK | 2 | 1 | ||||
| Hs.CTSL | 2 | 1 | ||||
| Hs.CYP1B1 | 2 | 0.6 | ||||
| Hs.DAPK1 | 2 | 1.5 | ||||
| Hs.DCN | 2 | 1.7 | ||||
| Hs.DDX58 | 2 | 0.9 | ||||
| Hs.DFFA | 2 | 2.5 | ||||
| Hs.DICER1 | 2 | 0.9 | ||||
| Hs.DKK3 | 2 | 1.5 | ||||
| Hs.DNAH8 | 2 | 0 | ||||
| Hs.DNMT3A | 2 | 0.7 | ||||
| Hs.EGF | 2 | 0 | ||||
| Hs.EGLN3 | 2 | 2.8 | ||||
| Hs.ENO1 | 2 | 1.1 | ||||
| Hs.ENO2 | 2 | 0 | ||||
| Hs.EPAS1 | 2 | 0.7 | ||||
| Hs.EPHB2 | 2 | 1.1 | ||||
| Hs.ESR2 | 2 | 9.9 | ||||
| Hs.EWSR1 | 2 | 9.9 | ||||
| Hs.EZH2 | 2 | 0.3 | ||||
| Hs.FANCD2 | 2 | 1.7 | ||||
| Hs.FANCF | 2 | 3.6 | ||||
| Hs.FBP1 | 2 | 2.8 | ||||
| Hs.FGFR4 | 2 | 1.8 | ||||
| Hs.FLT1 | 2 | 0.1 | ||||
| Hs.FN1 | 2 | 0 | ||||
| Hs.GADD45G | 2 | 4.1 | ||||
| Hs.GATA3 | 2 | 0.5 | ||||
| Hs.GCLC | 2 | 1.4 | ||||
| Hs.GDE1 | 2 | 1.7 | ||||
| Hs.GDF15 | 2 | 1 | ||||
| Hs.GGH | 2 | 3.2 | ||||
| Hs.GJA1 | 2 | 0.1 | ||||
| Hs.GOT1 | 2 | 3.3 | ||||
| Hs.GPC3 | 2 | 1.4 | ||||
| Hs.GPX2 | 2 | 3 | ||||
| Hs.GSTT1 | 2 | 0.3 | ||||
| Hs.GZMB | 2 | 0.2 | ||||
| Hs.HAX1 | 2 | 3 | ||||
| Hs.HFM1 | 2 | 9.9 | ||||
| Hs.HK3 | 2 | 9.9 | ||||
| Hs.HMGA1 | 2 | 1.6 | ||||
| Hs.HSPB1 | 2 | 0.2 | ||||
| Hs.HSPG2 | 2 | 0.8 | ||||
| Hs.HTRA3 | 2 | 9.9 | ||||
| Hs.HUWE1 | 2 | 3.2 | ||||
| Hs.ID1 | 2 | 1.4 | ||||
| Hs.ID2 | 2 | 1.7 | ||||
| Hs.IL13 | 2 | 0 | ||||
| Hs.IL2 | 2 | 0 | ||||
| Hs.INF2 | 2 | 9.9 | ||||
| Hs.INSR | 2 | 0 | ||||
| Hs.IRF1 | 2 | 0.8 | ||||
| Hs.IRS1 | 2 | 0.3 | ||||
| Hs.ITK | 2 | 0.6 | ||||
| Hs.KDM1A | 2 | 1.4 | ||||
| Hs.KDM2B | 2 | 4 | ||||
| Hs.KDM5A | 2 | 3.8 | ||||
| Hs.KLF4 | 2 | 9.9 | ||||
| Hs.KRT18 | 2 | 0.5 | ||||
| Hs.KRT8 | 2 | 0.8 | ||||
| Hs.LGALS3 | 2 | 0.3 | ||||
| Hs.LMNB1 | 2 | 2.5 | ||||
| Hs.LRRK2 | 2 | 0.7 | ||||
| Hs.MAP4K4 | 2 | 3.3 | ||||
| Hs.MAPK7 | 2 | 1.8 | ||||
| Hs.MARCHF8 | 2 | 0.2 | ||||
| Hs.MAU2 | 2 | 2.9 | ||||
| Hs.MB | 2 | 0 | ||||
| Hs.MDM4 | 2 | 1.7 | ||||
| Hs.MET | 2 | 0 | ||||
| Hs.MIF | 2 | 0.3 | ||||
| Hs.MIR100 | 2 | 2.8 | ||||
| Hs.MIR122 | 2 | 1.4 | ||||
| Hs.MIR15A | 2 | 2.2 | ||||
| Hs.MIR17HG | 2 | 1.9 | ||||
| Hs.MIR1825 | 2 | 4.3 | ||||
| Hs.MIR210 | 2 | 1.8 | ||||
| Hs.MIR221 | 2 | 9.9 | ||||
| Hs.MIR29B1 | 2 | 2.1 | ||||
| Hs.MIR34A | 2 | 0.9 | ||||
| Hs.MITF | 2 | 1 | ||||
| Hs.MYD88 | 2 | 0.3 | ||||
| Hs.NDUFA4L2 | 2 | 6.2 | ||||
| Hs.NEFL | 2 | 1.1 | ||||
| Hs.NLRP3 | 2 | 0 | ||||
| Hs.NOTCH1 | 2 | 0 | ||||
| Hs.NPM1 | 2 | 0.5 | ||||
| Hs.NR1I2 | 2 | 0.7 | ||||
| Hs.NR4A3 | 2 | 9.9 | ||||
| Hs.NRP1 | 2 | 1 | ||||
| Hs.OSGIN1 | 2 | 5.7 | ||||
| Hs.PARP2 | 2 | 3 | ||||
| Hs.PC | 2 | 0 | ||||
| Hs.PCSK9 | 2 | 0.3 | ||||
| Hs.PDGFRB | 2 | 0.2 | ||||
| Hs.PDIA6 | 2 | 4 | ||||
| Hs.PFKM | 2 | 3 | ||||
| Hs.PGP | 2 | 0.2 | ||||
| Hs.PHGDH | 2 | 1.7 | ||||
| Hs.PIDD1 | 2 | 4.1 | ||||
| Hs.PIK3R2 | 2 | 1.2 | ||||
| Hs.PIM1 | 2 | 1.2 | ||||
| Hs.PIP | 2 | 0.7 | ||||
| Hs.PLAU | 2 | 0 | ||||
| Hs.PLK1 | 2 | 0.6 | ||||
| Hs.PNPLA2 | 2 | 1.9 | ||||
| Hs.PON1 | 2 | 0.2 | ||||
| Hs.PPARG | 2 | 0 | ||||
| Hs.PPARGC1B | 2 | 2.4 | ||||
| Hs.PPP1R15A | 2 | 2.7 | ||||
| Hs.PRCC | 2 | 2.6 | ||||
| Hs.PRDX1 | 2 | 2 | ||||
| Hs.PTH | 2 | 0 | ||||
| Hs.PTPRC | 2 | 0 | ||||
| Hs.RIPK3 | 2 | 1.8 | ||||
| Hs.RMRP | 2 | 9.9 | ||||
| Hs.RNR2 | 2 | 5.9 | ||||
| Hs.RRM2B | 2 | 3.1 | ||||
| Hs.SDS | 2 | 2.4 | ||||
| Hs.SFRP1 | 2 | 1.5 | ||||
| Hs.SGCG | 2 | 2.2 | ||||
| Hs.SHC1 | 2 | 0.9 | ||||
| Hs.SHH | 2 | 0.3 | ||||
| Hs.SIRT6 | 2 | 2.2 | ||||
| Hs.SKP2 | 2 | 9.9 | ||||
| Hs.SLC2A2 | 2 | 1.5 | ||||
| Hs.SMG1 | 2 | 0.5 | ||||
| Hs.SMN1 | 2 | 0 | ||||
| Hs.SNAI2 | 2 | 0.6 | ||||
| Hs.SOCS3 | 2 | 0.7 | ||||
| Hs.SPATA18 | 2 | 6 | ||||
| Hs.SREBF1 | 2 | 9.9 | ||||
| Hs.STAT5B | 2 | 1.7 | ||||
| Hs.STAT6 | 2 | 0.8 | ||||
| Hs.STING1 | 2 | 2.5 | ||||
| Hs.SYP | 2 | 0 | ||||
| Hs.TAZ | 2 | 1.3 | ||||
| Hs.TBL2 | 2 | 5.6 | ||||
| Hs.TENM1 | 2 | 0 | ||||
| Hs.TIGAR | 2 | 3.7 | ||||
| Hs.TLE1 | 2 | 3.2 | ||||
| Hs.TLR9 | 2 | 0.2 | ||||
| Hs.TNFRSF1B | 2 | 0.4 | ||||
| Hs.TOP2A | 2 | 1.2 | ||||
| Hs.TRAF6 | 2 | 9.9 | ||||
| Hs.TTK | 2 | 2.6 | ||||
| Hs.TWSG1 | 2 | 2.1 | ||||
| Hs.TXN | 2 | 0.1 | ||||
| Hs.TXNIP | 2 | 1.9 | ||||
| Hs.VDR | 2 | 0 | ||||
| Hs.WRN | 2 | 1.6 | ||||
| Hs.WT1 | 2 | 0.1 | ||||
| Hs.XPC | 2 | 1.5 | ||||
| Hs.ZEB1 | 2 | 0.7 | ||||
| Hs.ABCB5 | 1 | 0 | ||||
| Hs.ABCC2 | 1 | 0 | ||||
| Hs.ABL2 | 1 | 0 | ||||
| Hs.ABRAXAS1 | 1 | 0 | ||||
| Hs.ACSL3 | 1 | 0 | ||||
| Hs.ACSL5 | 1 | 0 | ||||
| Hs.ACSS2 | 1 | 0 | ||||
| Hs.ACTR1B | 1 | 0 | ||||
| Hs.ADA2 | 1 | 0 | ||||
| Hs.ADAM17 | 1 | 0 | ||||
| Hs.ADAM8 | 1 | 0 | ||||
| Hs.ADGRL3 | 1 | 0 | ||||
| Hs.ADIPOR1 | 1 | 0 | ||||
| Hs.ADPGK | 1 | 0 | ||||
| Hs.ADRB2 | 1 | 0 | ||||
| Hs.AFAP1 | 1 | 0 | ||||
| Hs.AGFG1 | 1 | 0 | ||||
| Hs.AGO2 | 1 | 0 | ||||
| Hs.AGR3 | 1 | 0 | ||||
| Hs.AHRR | 1 | 0 | ||||
| Hs.AIMP1 | 1 | 0 | ||||
| Hs.AKIP1 | 1 | 0 | ||||
| Hs.AKR1C1 | 1 | 0 | ||||
| Hs.AKT1S1 | 1 | 0 | ||||
| Hs.AKT3 | 1 | 0 | ||||
| Hs.ALCAM | 1 | 0 | ||||
| Hs.ALDH3A1 | 1 | 0 | ||||
| Hs.ALDOA | 1 | 0 | ||||
| Hs.ALOX15 | 1 | 0 | ||||
| Hs.ALOX5 | 1 | 0 | ||||
| Hs.ANGPT1 | 1 | 0 | ||||
| Hs.ANGPTL4 | 1 | 0 | ||||
| Hs.ANO1 | 1 | 0 | ||||
| Hs.ANXA7 | 1 | 0 | ||||
| Hs.APC | 1 | 0 | ||||
| Hs.APOB | 1 | 0 | ||||
| Hs.APP | 1 | 0 | ||||
| Hs.APPL1 | 1 | 0 | ||||
| Hs.ARHGAP26 | 1 | 0 | ||||
| Hs.ARHGAP35 | 1 | 0 | ||||
| Hs.ARHGDIA | 1 | 0 | ||||
| Hs.ARHGEF2 | 1 | 0 | ||||
| Hs.ARID1A | 1 | 0 | ||||
| Hs.ARMCX1 | 1 | 0 | ||||
| Hs.ASB9 | 1 | 0 | ||||
| Hs.ASIC3 | 1 | 0 | ||||
| Hs.ASPSCR1 | 1 | 0 | ||||
| Hs.ASRGL1 | 1 | 0 | ||||
| Hs.ATF1 | 1 | 0 | ||||
| Hs.ATF5 | 1 | 0 | ||||
| Hs.ATG10 | 1 | 0 | ||||
| Hs.ATG13 | 1 | 0 | ||||
| Hs.ATG14 | 1 | 0 | ||||
| Hs.ATG16L2 | 1 | 0 | ||||
| Hs.ATG4A | 1 | 0 | ||||
| Hs.ATL1 | 1 | 0 | ||||
| Hs.ATP12A | 1 | 0 | ||||
| Hs.ATP2B2 | 1 | 0 | ||||
| Hs.ATP2C1 | 1 | 0 | ||||
| Hs.AXL | 1 | 0 | ||||
| Hs.AZU1 | 1 | 0 | ||||
| Hs.B3GALT4 | 1 | 0 | ||||
| Hs.BAG1 | 1 | 0 | ||||
| Hs.BANF1 | 1 | 0 | ||||
| Hs.BCAT1 | 1 | 0 | ||||
| Hs.BCL6 | 1 | 0 | ||||
| Hs.BCO2 | 1 | 0 | ||||
| Hs.BCR | 1 | 0 | ||||
| Hs.BIN1 | 1 | 0 | ||||
| Hs.BIRC5 | 1 | 0 | ||||
| Hs.BMF | 1 | 0 | ||||
| Hs.BMP1 | 1 | 0 | ||||
| Hs.BMP8B | 1 | 0 | ||||
| Hs.BNIP1 | 1 | 0 | ||||
| Hs.BOK | 1 | 0 | ||||
| Hs.BPIFB1 | 1 | 0 | ||||
| Hs.BRCA2 | 1 | 0 | ||||
| Hs.BRIP1 | 1 | 0 | ||||
| Hs.BSG | 1 | 0 | ||||
| Hs.BST2 | 1 | 0 | ||||
| Hs.C19orf53 | 1 | 0 | ||||
| Hs.C1QA | 1 | 0 | ||||
| Hs.C1QL1 | 1 | 0 | ||||
| Hs.C2 | 1 | 0 | ||||
| Hs.C20orf85 | 1 | 0 | ||||
| Hs.CACNA2D2 | 1 | 0 | ||||
| Hs.CACNA2D3 | 1 | 0 | ||||
| Hs.CALCA | 1 | 0 | ||||
| Hs.CALCOCO2 | 1 | 0 | ||||
| Hs.CAMK2N1 | 1 | 0 | ||||
| Hs.CAMK4 | 1 | 0 | ||||
| Hs.CAMKK2 | 1 | 0 | ||||
| Hs.CAPN2 | 1 | 0 | ||||
| Hs.CASP6 | 1 | 0 | ||||
| Hs.CBFA2T3 | 1 | 0 | ||||
| Hs.CBL | 1 | 0 | ||||
| Hs.CBS | 1 | 0 | ||||
| Hs.CCDC40 | 1 | 0 | ||||
| Hs.CCDC9B | 1 | 0 | ||||
| Hs.CCL26 | 1 | 0 | ||||
| Hs.CCL5 | 1 | 0 | ||||
| Hs.CCN1 | 1 | 0 | ||||
| Hs.CCNB2 | 1 | 0 | ||||
| Hs.CCND2 | 1 | 0 | ||||
| Hs.CD14 | 1 | 0 | ||||
| Hs.CD163 | 1 | 0 | ||||
| Hs.CD177 | 1 | 0 | ||||
| Hs.CD276 | 1 | 0 | ||||
| Hs.CD33 | 1 | 0 | ||||
| Hs.CD36 | 1 | 0 | ||||
| Hs.CD38 | 1 | 0 | ||||
| Hs.CD63 | 1 | 0 | ||||
| Hs.CD70 | 1 | 0 | ||||
| Hs.CD74 | 1 | 0 | ||||
| Hs.CD81 | 1 | 0 | ||||
| Hs.CD9 | 1 | 0 | ||||
| Hs.CDK2AP1 | 1 | 0 | ||||
| Hs.CDK5 | 1 | 0 | ||||
| Hs.CDK5R1 | 1 | 0 | ||||
| Hs.CDKN2D | 1 | 0 | ||||
| Hs.CDKN3 | 1 | 0 | ||||
| Hs.CEACAM1 | 1 | 0 | ||||
| Hs.CEBPB | 1 | 0 | ||||
| Hs.CEBPD | 1 | 0 | ||||
| Hs.CENPW | 1 | 0 | ||||
| Hs.CERS2 | 1 | 0 | ||||
| Hs.CES1 | 1 | 0 | ||||
| Hs.CETN2 | 1 | 0 | ||||
| Hs.CFAP65 | 1 | 0 | ||||
| Hs.CHAC1 | 1 | 0 | ||||
| Hs.CHAC2 | 1 | 0 | ||||
| Hs.CHM | 1 | 0 | ||||
| Hs.CHMP1B | 1 | 0 | ||||
| Hs.CIDEB | 1 | 0 | ||||
| Hs.CISH | 1 | 0 | ||||
| Hs.CITED1 | 1 | 0 | ||||
| Hs.CKS2 | 1 | 0 | ||||
| Hs.CLDND1 | 1 | 0 | ||||
| Hs.CLMN | 1 | 0 | ||||
| Hs.CNKSR1 | 1 | 0 | ||||
| Hs.CNKSR2 | 1 | 0 | ||||
| Hs.CNMD | 1 | 0 | ||||
| Hs.COL12A1 | 1 | 0 | ||||
| Hs.COL3A1 | 1 | 0 | ||||
| Hs.COL5A2 | 1 | 0 | ||||
| Hs.COL6A1 | 1 | 0 | ||||
| Hs.COL6A3 | 1 | 0 | ||||
| Hs.COMMD7 | 1 | 0 | ||||
| Hs.COMP | 1 | 0 | ||||
| Hs.COPS3 | 1 | 0 | ||||
| Hs.COPS4 | 1 | 0 | ||||
| Hs.COPS5 | 1 | 0 | ||||
| Hs.COPS6 | 1 | 0 | ||||
| Hs.COPS7A | 1 | 0 | ||||
| Hs.COPS8 | 1 | 0 | ||||
| Hs.CP | 1 | 0 | ||||
| Hs.CPA1 | 1 | 0 | ||||
| Hs.CPB1 | 1 | 0 | ||||
| Hs.CPD | 1 | 0 | ||||
| Hs.CREBBP | 1 | 0 | ||||
| Hs.CRTC1 | 1 | 0 | ||||
| Hs.CSHL1 | 1 | 0 | ||||
| Hs.CSK | 1 | 0 | ||||
| Hs.CSNK1A1 | 1 | 0 | ||||
| Hs.CSPG4 | 1 | 0 | ||||
| Hs.CTRL | 1 | 0 | ||||
| Hs.CTSB | 1 | 0 | ||||
| Hs.CTU1 | 1 | 0 | ||||
| Hs.CUL1 | 1 | 0 | ||||
| Hs.CUL3 | 1 | 0 | ||||
| Hs.CWC22 | 1 | 0 | ||||
| Hs.CXCL12 | 1 | 0 | ||||
| Hs.CXCL14 | 1 | 0 | ||||
| Hs.CXXC5 | 1 | 0 | ||||
| Hs.CYBB | 1 | 0 | ||||
| Hs.CYBRD1 | 1 | 0 | ||||
| Hs.CYCSP51 | 1 | 0 | ||||
| Hs.CYGB | 1 | 0 | ||||
| Hs.CYP11B1 | 1 | 0 | ||||
| Hs.CYP17A1 | 1 | 0 | ||||
| Hs.CYP1A1 | 1 | 0 | ||||
| Hs.CYP1A2 | 1 | 0 | ||||
| Hs.CYP2C19 | 1 | 0 | ||||
| Hs.CYP2D6 | 1 | 0 | ||||
| Hs.CYP2E1 | 1 | 0 | ||||
| Hs.CYP3A4 | 1 | 0 | ||||
| Hs.DAB2IP | 1 | 0 | ||||
| Hs.DAPK2 | 1 | 0 | ||||
| Hs.DAPK3 | 1 | 0 | ||||
| Hs.DAXX | 1 | 0 | ||||
| Hs.DBP | 1 | 0 | ||||
| Hs.DCLK1 | 1 | 0 | ||||
| Hs.DDIT4 | 1 | 0 | ||||
| Hs.DDX11 | 1 | 0 | ||||
| Hs.DDX21 | 1 | 0 | ||||
| Hs.DDX6 | 1 | 0 | ||||
| Hs.DEPDC1 | 1 | 0 | ||||
| Hs.DES | 1 | 0 | ||||
| Hs.DESI2 | 1 | 0 | ||||
| Hs.DHRS2 | 1 | 0 | ||||
| Hs.DLGAP5 | 1 | 0 | ||||
| Hs.DLX2 | 1 | 0 | ||||
| Hs.DNMT3B | 1 | 0 | ||||
| Hs.DNTT | 1 | 0 | ||||
| Hs.DPYSL2 | 1 | 0 | ||||
| Hs.DPYSL4 | 1 | 0 | ||||
| Hs.DROSHA | 1 | 0 | ||||
| Hs.DSTN | 1 | 0 | ||||
| Hs.E2F5 | 1 | 0 | ||||
| Hs.E4F1 | 1 | 0 | ||||
| Hs.EBP | 1 | 0 | ||||
| Hs.EED | 1 | 0 | ||||
| Hs.EEF2 | 1 | 0 | ||||
| Hs.EFS | 1 | 0 | ||||
| Hs.EGLN2 | 1 | 0 | ||||
| Hs.EIF4A1 | 1 | 0 | ||||
| Hs.EIF4EBP1 | 1 | 0 | ||||
| Hs.EIF5A | 1 | 0 | ||||
| Hs.ELAVL1 | 1 | 0 | ||||
| Hs.ENPP2 | 1 | 0 | ||||
| Hs.EP300 | 1 | 0 | ||||
| Hs.EPO | 1 | 0 | ||||
| Hs.ERCC6 | 1 | 0 | ||||
| Hs.ERLIN2 | 1 | 0 | ||||
| Hs.ERRFI1 | 1 | 0 | ||||
| Hs.ERVK-15 | 1 | 0 | ||||
| Hs.ERVW-3 | 1 | 0 | ||||
| Hs.ESRP1 | 1 | 0 | ||||
| Hs.ESS2 | 1 | 0 | ||||
| Hs.F2 | 1 | 0 | ||||
| Hs.F2RL3 | 1 | 0 | ||||
| Hs.FAM215A | 1 | 0 | ||||
| Hs.FANCA | 1 | 0 | ||||
| Hs.FERMT1 | 1 | 0 | ||||
| Hs.FGA | 1 | 0 | ||||
| Hs.FGF1 | 1 | 0 | ||||
| Hs.FGF2 | 1 | 0 | ||||
| Hs.FGF3 | 1 | 0 | ||||
| Hs.FGFR3 | 1 | 0 | ||||
| Hs.FLNB | 1 | 0 | ||||
| Hs.FLT3 | 1 | 0 | ||||
| Hs.FOXD3 | 1 | 0 | ||||
| Hs.FOXH1 | 1 | 0 | ||||
| Hs.FOXO4 | 1 | 0 | ||||
| Hs.FOXP3 | 1 | 0 | ||||
| Hs.FRA16D | 1 | 0 | ||||
| Hs.FTSJ1 | 1 | 0 | ||||
| Hs.FTSJ3 | 1 | 0 | ||||
| Hs.FUT1 | 1 | 0 | ||||
| Hs.FXYD3 | 1 | 0 | ||||
| Hs.G3BP1 | 1 | 0 | ||||
| Hs.G6PC | 1 | 0 | ||||
| Hs.G6PC3 | 1 | 0 | ||||
| Hs.GABARAPL1 | 1 | 0 | ||||
| Hs.GABBR1 | 1 | 0 | ||||
| Hs.GABPA | 1 | 0 | ||||
| Hs.GALNT10 | 1 | 0 | ||||
| Hs.GATA1 | 1 | 0 | ||||
| Hs.GBA | 1 | 0 | ||||
| Hs.GCK | 1 | 0 | ||||
| Hs.GDF10 | 1 | 0 | ||||
| Hs.GFAP | 1 | 0 | ||||
| Hs.GGT1 | 1 | 0 | ||||
| Hs.GH1 | 1 | 0 | ||||
| Hs.GHRH | 1 | 0 | ||||
| Hs.GIT2 | 1 | 0 | ||||
| Hs.GJB6 | 1 | 0 | ||||
| Hs.GLI3 | 1 | 0 | ||||
| Hs.GLO1 | 1 | 0 | ||||
| Hs.GLRX | 1 | 0 | ||||
| Hs.GLYATL1 | 1 | 0 | ||||
| Hs.GLYATL2 | 1 | 0 | ||||
| Hs.GNRH1 | 1 | 0 | ||||
| Hs.GNRH2 | 1 | 0 | ||||
| Hs.GOLPH3L | 1 | 0 | ||||
| Hs.GOSR1 | 1 | 0 | ||||
| Hs.GPX3 | 1 | 0 | ||||
| Hs.GRAMD4 | 1 | 0 | ||||
| Hs.GREM1 | 1 | 0 | ||||
| Hs.GSDMA | 1 | 0 | ||||
| Hs.GSK3B | 1 | 0 | ||||
| Hs.GSR | 1 | 0 | ||||
| Hs.GSTA1 | 1 | 0 | ||||
| Hs.GSTP1 | 1 | 0 | ||||
| Hs.GUCY2C | 1 | 0 | ||||
| Hs.GYPC | 1 | 0 | ||||
| Hs.H19 | 1 | 0 | ||||
| Hs.H2BC21 | 1 | 0 | ||||
| Hs.H3P12 | 1 | 0 | ||||
| Hs.HBEGF | 1 | 0 | ||||
| Hs.HBP1 | 1 | 0 | ||||
| Hs.HCC | 1 | 0 | ||||
| Hs.HCRT | 1 | 0 | ||||
| Hs.HCRTR1 | 1 | 0 | ||||
| Hs.HDAC3 | 1 | 0 | ||||
| Hs.HELB | 1 | 0 | ||||
| Hs.HELQ | 1 | 0 | ||||
| Hs.HEPH | 1 | 0 | ||||
| Hs.HES1 | 1 | 0 | ||||
| Hs.HFE | 1 | 0 | ||||
| Hs.HILPDA | 1 | 0 | ||||
| Hs.HLF | 1 | 0 | ||||
| Hs.HMGCR | 1 | 0 | ||||
| Hs.HNRNPA2B1 | 1 | 0 | ||||
| Hs.HNRNPC | 1 | 0 | ||||
| Hs.HNRNPK | 1 | 0 | ||||
| Hs.HNRNPL | 1 | 0 | ||||
| Hs.HOXA9 | 1 | 0 | ||||
| Hs.HOXC13 | 1 | 0 | ||||
| Hs.HRK | 1 | 0 | ||||
| Hs.HSD17B6 | 1 | 0 | ||||
| Hs.HSP90AB1 | 1 | 0 | ||||
| Hs.HSPA1A | 1 | 0 | ||||
| Hs.HSPA8 | 1 | 0 | ||||
| Hs.HTRA1 | 1 | 0 | ||||
| Hs.IAPP | 1 | 0 | ||||
| Hs.ICAM1 | 1 | 0 | ||||
| Hs.ID3 | 1 | 0 | ||||
| Hs.IDO1 | 1 | 0 | ||||
| Hs.IFI16 | 1 | 0 | ||||
| Hs.IFI27L1 | 1 | 0 | ||||
| Hs.IFI27L2 | 1 | 0 | ||||
| Hs.IFNA1 | 1 | 0 | ||||
| Hs.IFT88 | 1 | 0 | ||||
| Hs.IGFBP3 | 1 | 0 | ||||
| Hs.IGHD5-12 | 1 | 0 | ||||
| Hs.IGLV2-8 | 1 | 0 | ||||
| Hs.IL10 | 1 | 0 | ||||
| Hs.IL12A | 1 | 0 | ||||
| Hs.IL17A | 1 | 0 | ||||
| Hs.IL17C | 1 | 0 | ||||
| Hs.IL17F | 1 | 0 | ||||
| Hs.IL1B | 1 | 0 | ||||
| Hs.IL22 | 1 | 0 | ||||
| Hs.IL23A | 1 | 0 | ||||
| Hs.IL23R | 1 | 0 | ||||
| Hs.IL3 | 1 | 0 | ||||
| Hs.IL4 | 1 | 0 | ||||
| Hs.IL6ST | 1 | 0 | ||||
| Hs.ILK | 1 | 0 | ||||
| Hs.IMP3 | 1 | 0 | ||||
| Hs.IMPDH2 | 1 | 0 | ||||
| Hs.ING1 | 1 | 0 | ||||
| Hs.ING2 | 1 | 0 | ||||
| Hs.ING4 | 1 | 0 | ||||
| Hs.ING5 | 1 | 0 | ||||
| Hs.IREB2 | 1 | 0 | ||||
| Hs.IRF3 | 1 | 0 | ||||
| Hs.IRF5 | 1 | 0 | ||||
| Hs.IRS2 | 1 | 0 | ||||
| Hs.ISYNA1 | 1 | 0 | ||||
| Hs.ITGA1 | 1 | 0 | ||||
| Hs.ITGB3BP | 1 | 0 | ||||
| Hs.ITPA | 1 | 0 | ||||
| Hs.ITPR2 | 1 | 0 | ||||
| Hs.IVNS1ABP | 1 | 0 | ||||
| Hs.JPH3 | 1 | 0 | ||||
| Hs.JTB | 1 | 0 | ||||
| Hs.KAT2A | 1 | 0 | ||||
| Hs.KAT2B | 1 | 0 | ||||
| Hs.KAT5 | 1 | 0 | ||||
| Hs.KCNA3 | 1 | 0 | ||||
| Hs.KCNJ5 | 1 | 0 | ||||
| Hs.KCNK9 | 1 | 0 | ||||
| Hs.KCNN3 | 1 | 0 | ||||
| Hs.KCNN4 | 1 | 0 | ||||
| Hs.KDM4A | 1 | 0 | ||||
| Hs.KDM4B | 1 | 0 | ||||
| Hs.KIF20B | 1 | 0 | ||||
| Hs.KIRREL1 | 1 | 0 | ||||
| Hs.KMT2C | 1 | 0 | ||||
| Hs.KRT126P | 1 | 0 | ||||
| Hs.KRT14 | 1 | 0 | ||||
| Hs.KRT19 | 1 | 0 | ||||
| Hs.KRT6A | 1 | 0 | ||||
| Hs.KSR1 | 1 | 0 | ||||
| Hs.KSR2 | 1 | 0 | ||||
| Hs.KYAT1 | 1 | 0 | ||||
| Hs.LAMP3 | 1 | 0 | ||||
| Hs.LAP | 1 | 0 | ||||
| Hs.LARP1 | 1 | 0 | ||||
| Hs.LBH | 1 | 0 | ||||
| Hs.LEP | 1 | 0 | ||||
| Hs.LGALS1 | 1 | 0 | ||||
| Hs.LGR5 | 1 | 0 | ||||
| Hs.LHX2 | 1 | 0 | ||||
| Hs.LIG3 | 1 | 0 | ||||
| Hs.LIMK1 | 1 | 0 | ||||
| Hs.LINC-PINT | 1 | 0 | ||||
| Hs.LIPG | 1 | 0 | ||||
| Hs.LMO2 | 1 | 0 | ||||
| Hs.LOC100507703 | 1 | 0 | ||||
| Hs.LOX | 1 | 0 | ||||
| Hs.LRIG1 | 1 | 0 | ||||
| Hs.LSM2 | 1 | 0 | ||||
| Hs.LTBR | 1 | 0 | ||||
| Hs.LTF | 1 | 0 | ||||
| Hs.LYN | 1 | 0 | ||||
| Hs.LYPD1 | 1 | 0 | ||||
| Hs.MACC1 | 1 | 0 | ||||
| Hs.MAP2K4 | 1 | 0 | ||||
| Hs.MAP3K1 | 1 | 0 | ||||
| Hs.MAP3K14 | 1 | 0 | ||||
| Hs.MAX | 1 | 0 | ||||
| Hs.MCM10 | 1 | 0 | ||||
| Hs.MCM3 | 1 | 0 | ||||
| Hs.MCM3AP | 1 | 0 | ||||
| Hs.MCPH1 | 1 | 0 | ||||
| Hs.MCTP1 | 1 | 0 | ||||
| Hs.MDC1 | 1 | 0 | ||||
| Hs.MEIS1 | 1 | 0 | ||||
| Hs.MEST | 1 | 0 | ||||
| Hs.MGAT5 | 1 | 0 | ||||
| Hs.MGLL | 1 | 0 | ||||
| Hs.MGMT | 1 | 0 | ||||
| Hs.MIB1 | 1 | 0 | ||||
| Hs.MIR107 | 1 | 0 | ||||
| Hs.MIR124-3 | 1 | 0 | ||||
| Hs.MIR1247 | 1 | 0 | ||||
| Hs.MIR126 | 1 | 0 | ||||
| Hs.MIR1265 | 1 | 0 | ||||
| Hs.MIR1275 | 1 | 0 | ||||
| Hs.MIR1295A | 1 | 0 | ||||
| Hs.MIR146A | 1 | 0 | ||||
| Hs.MIR148A | 1 | 0 | ||||
| Hs.MIR17 | 1 | 0 | ||||
| Hs.MIR199A2 | 1 | 0 | ||||
| Hs.MIR19A | 1 | 0 | ||||
| Hs.MIR200A | 1 | 0 | ||||
| Hs.MIR200C | 1 | 0 | ||||
| Hs.MIR206 | 1 | 0 | ||||
| Hs.MIR20A | 1 | 0 | ||||
| Hs.MIR214 | 1 | 0 | ||||
| Hs.MIR22 | 1 | 0 | ||||
| Hs.MIR223 | 1 | 0 | ||||
| Hs.MIR224 | 1 | 0 | ||||
| Hs.MIR23A | 1 | 0 | ||||
| Hs.MIR23B | 1 | 0 | ||||
| Hs.MIR24-1 | 1 | 0 | ||||
| Hs.MIR29A | 1 | 0 | ||||
| Hs.MIR30C1 | 1 | 0 | ||||
| Hs.MIR31 | 1 | 0 | ||||
| Hs.MIR342 | 1 | 0 | ||||
| Hs.MIR345 | 1 | 0 | ||||
| Hs.MIR369 | 1 | 0 | ||||
| Hs.MIR375 | 1 | 0 | ||||
| Hs.MIR378A | 1 | 0 | ||||
| Hs.MIR4257 | 1 | 0 | ||||
| Hs.MIR4295 | 1 | 0 | ||||
| Hs.MIR448 | 1 | 0 | ||||
| Hs.MIR491 | 1 | 0 | ||||
| Hs.MIR494 | 1 | 0 | ||||
| Hs.MIR5100 | 1 | 0 | ||||
| Hs.MIR519D | 1 | 0 | ||||
| Hs.MIR630 | 1 | 0 | ||||
| Hs.MIR634 | 1 | 0 | ||||
| Hs.MIR663A | 1 | 0 | ||||
| Hs.MIR6733 | 1 | 0 | ||||
| Hs.MIR675 | 1 | 0 | ||||
| Hs.MIR944 | 1 | 0 | ||||
| Hs.MKI67 | 1 | 0 | ||||
| Hs.MLANA | 1 | 0 | ||||
| Hs.MMP1 | 1 | 0 | ||||
| Hs.MMP10 | 1 | 0 | ||||
| Hs.MRC1 | 1 | 0 | ||||
| Hs.MRPL11 | 1 | 0 | ||||
| Hs.MSH2 | 1 | 0 | ||||
| Hs.MSL2 | 1 | 0 | ||||
| Hs.MSR1 | 1 | 0 | ||||
| Hs.MSTN | 1 | 0 | ||||
| Hs.MSTO1 | 1 | 0 | ||||
| Hs.MT1E | 1 | 0 | ||||
| Hs.MT2A | 1 | 0 | ||||
| Hs.MT3 | 1 | 0 | ||||
| Hs.MTF1 | 1 | 0 | ||||
| Hs.MTTP | 1 | 0 | ||||
| Hs.MUC1 | 1 | 0 | ||||
| Hs.MUC2 | 1 | 0 | ||||
| Hs.MUC4 | 1 | 0 | ||||
| Hs.MUC5AC | 1 | 0 | ||||
| Hs.MUC6 | 1 | 0 | ||||
| Hs.MX1 | 1 | 0 | ||||
| Hs.MXD1 | 1 | 0 | ||||
| Hs.MYBL2 | 1 | 0 | ||||
| Hs.MYH14 | 1 | 0 | ||||
| Hs.MYL12A | 1 | 0 | ||||
| Hs.MYL12B | 1 | 0 | ||||
| Hs.MYOCD | 1 | 0 | ||||
| Hs.MYOD1 | 1 | 0 | ||||
| Hs.MYOM2 | 1 | 0 | ||||
| Hs.MZF1 | 1 | 0 | ||||
| Hs.NAA10 | 1 | 0 | ||||
| Hs.NAF1 | 1 | 0 | ||||
| Hs.NAGA | 1 | 0 | ||||
| Hs.NAIP | 1 | 0 | ||||
| Hs.NANOGP8 | 1 | 0 | ||||
| Hs.NBAS | 1 | 0 | ||||
| Hs.NBPF10 | 1 | 0 | ||||
| Hs.NCOA1 | 1 | 0 | ||||
| Hs.NCOR1 | 1 | 0 | ||||
| Hs.NDC80 | 1 | 0 | ||||
| Hs.NDEL1 | 1 | 0 | ||||
| Hs.NDOR1 | 1 | 0 | ||||
| Hs.NDRG4 | 1 | 0 | ||||
| Hs.NF2 | 1 | 0 | ||||
| Hs.NFATC1 | 1 | 0 | ||||
| Hs.NFIB | 1 | 0 | ||||
| Hs.NLK | 1 | 0 | ||||
| Hs.NME1 | 1 | 0 | ||||
| Hs.NMNAT2 | 1 | 0 | ||||
| Hs.NOL3 | 1 | 0 | ||||
| Hs.NOP53 | 1 | 0 | ||||
| Hs.NPEPPS | 1 | 0 | ||||
| Hs.NPRL2 | 1 | 0 | ||||
| Hs.NPTX2 | 1 | 0 | ||||
| Hs.NQO2 | 1 | 0 | ||||
| Hs.NR0B2 | 1 | 0 | ||||
| Hs.NR2F2 | 1 | 0 | ||||
| Hs.NR3C1 | 1 | 0 | ||||
| Hs.NR4A2 | 1 | 0 | ||||
| Hs.NTF4 | 1 | 0 | ||||
| Hs.NUF2 | 1 | 0 | ||||
| Hs.OAS3 | 1 | 0 | ||||
| Hs.OIT3 | 1 | 0 | ||||
| Hs.ONECUT2 | 1 | 0 | ||||
| Hs.P2RX7 | 1 | 0 | ||||
| Hs.P2RY1 | 1 | 0 | ||||
| Hs.PAK1 | 1 | 0 | ||||
| Hs.PAK2 | 1 | 0 | ||||
| Hs.PAK3 | 1 | 0 | ||||
| Hs.PAK4 | 1 | 0 | ||||
| Hs.PAK6 | 1 | 0 | ||||
| Hs.PARP10 | 1 | 0 | ||||
| Hs.PAWR | 1 | 0 | ||||
| Hs.PAX2 | 1 | 0 | ||||
| Hs.PAX4 | 1 | 0 | ||||
| Hs.PBX1 | 1 | 0 | ||||
| Hs.PBX2 | 1 | 0 | ||||
| Hs.PCA3 | 1 | 0 | ||||
| Hs.PCSK6 | 1 | 0 | ||||
| Hs.PDA1 | 1 | 0 | ||||
| Hs.PDCD5 | 1 | 0 | ||||
| Hs.PDCD6IP | 1 | 0 | ||||
| Hs.PDHB | 1 | 0 | ||||
| Hs.PDIA4 | 1 | 0 | ||||
| Hs.PDXP | 1 | 0 | ||||
| Hs.PEBP1 | 1 | 0 | ||||
| Hs.PEG10 | 1 | 0 | ||||
| Hs.PERP | 1 | 0 | ||||
| Hs.PFKFB4 | 1 | 0 | ||||
| Hs.PFN1 | 1 | 0 | ||||
| Hs.PGK1 | 1 | 0 | ||||
| Hs.PHLDA2 | 1 | 0 | ||||
| Hs.PHLPP1 | 1 | 0 | ||||
| Hs.PIAS3 | 1 | 0 | ||||
| Hs.PID1 | 1 | 0 | ||||
| Hs.PIK3C2B | 1 | 0 | ||||
| Hs.PIK3CB | 1 | 0 | ||||
| Hs.PIK3R3 | 1 | 0 | ||||
| Hs.PIN4 | 1 | 0 | ||||
| Hs.PIP4K2B | 1 | 0 | ||||
| Hs.PIP5K1B | 1 | 0 | ||||
| Hs.PIP5K1C | 1 | 0 | ||||
| Hs.PKD1 | 1 | 0 | ||||
| Hs.PLA2G1B | 1 | 0 | ||||
| Hs.PLA2G4A | 1 | 0 | ||||
| Hs.PLAAT4 | 1 | 0 | ||||
| Hs.PLAG1 | 1 | 0 | ||||
| Hs.PLCG2 | 1 | 0 | ||||
| Hs.PLD1 | 1 | 0 | ||||
| Hs.PLD6 | 1 | 0 | ||||
| Hs.PLIN3 | 1 | 0 | ||||
| Hs.PLP2 | 1 | 0 | ||||
| Hs.PNPLA3 | 1 | 0 | ||||
| Hs.PNRC1 | 1 | 0 | ||||
| Hs.POF1B | 1 | 0 | ||||
| Hs.POLE4 | 1 | 0 | ||||
| Hs.POMP | 1 | 0 | ||||
| Hs.PON2 | 1 | 0 | ||||
| Hs.POSTN | 1 | 0 | ||||
| Hs.PPA1 | 1 | 0 | ||||
| Hs.PPIL1 | 1 | 0 | ||||
| Hs.PPP2R1A | 1 | 0 | ||||
| Hs.PPRC1 | 1 | 0 | ||||
| Hs.PRDM16 | 1 | 0 | ||||
| Hs.PRF1 | 1 | 0 | ||||
| Hs.PRIM1 | 1 | 0 | ||||
| Hs.PRKAB1 | 1 | 0 | ||||
| Hs.PRKAR2B | 1 | 0 | ||||
| Hs.PRKCA | 1 | 0 | ||||
| Hs.PRKCB | 1 | 0 | ||||
| Hs.PRKCD | 1 | 0 | ||||
| Hs.PRKCE | 1 | 0 | ||||
| Hs.PRKD1 | 1 | 0 | ||||
| Hs.PRKDC | 1 | 0 | ||||
| Hs.PRPF31 | 1 | 0 | ||||
| Hs.PRRC2A | 1 | 0 | ||||
| Hs.PSCA | 1 | 0 | ||||
| Hs.PSEN1 | 1 | 0 | ||||
| Hs.PSG11 | 1 | 0 | ||||
| Hs.PSMD10 | 1 | 0 | ||||
| Hs.PTHLH | 1 | 0 | ||||
| Hs.PTK6 | 1 | 0 | ||||
| Hs.PTK7 | 1 | 0 | ||||
| Hs.PTMA | 1 | 0 | ||||
| Hs.PTMAP9 | 1 | 0 | ||||
| Hs.PTPN1 | 1 | 0 | ||||
| Hs.PTPN11 | 1 | 0 | ||||
| Hs.PTPRU | 1 | 0 | ||||
| Hs.PTTG1 | 1 | 0 | ||||
| Hs.PXN | 1 | 0 | ||||
| Hs.PYCARD | 1 | 0 | ||||
| Hs.QSOX1 | 1 | 0 | ||||
| Hs.RAB14 | 1 | 0 | ||||
| Hs.RAB3D | 1 | 0 | ||||
| Hs.RAB7A | 1 | 0 | ||||
| Hs.RACK1 | 1 | 0 | ||||
| Hs.RAD51B | 1 | 0 | ||||
| Hs.RAD51C | 1 | 0 | ||||
| Hs.RAPGEF6 | 1 | 0 | ||||
| Hs.RARB | 1 | 0 | ||||
| Hs.RARRES1 | 1 | 0 | ||||
| Hs.RASSF1 | 1 | 0 | ||||
| Hs.RB1CC1 | 1 | 0 | ||||
| Hs.RBBP4 | 1 | 0 | ||||
| Hs.RBM10 | 1 | 0 | ||||
| Hs.RBM47 | 1 | 0 | ||||
| Hs.RBM5 | 1 | 0 | ||||
| Hs.RBMS1 | 1 | 0 | ||||
| Hs.RBMS3 | 1 | 0 | ||||
| Hs.RBP1 | 1 | 0 | ||||
| Hs.RBPJP3 | 1 | 0 | ||||
| Hs.RBX1 | 1 | 0 | ||||
| Hs.RECQL | 1 | 0 | ||||
| Hs.REG3A | 1 | 0 | ||||
| Hs.REST | 1 | 0 | ||||
| Hs.REV1 | 1 | 0 | ||||
| Hs.RFC1 | 1 | 0 | ||||
| Hs.RGN | 1 | 0 | ||||
| Hs.RGS5 | 1 | 0 | ||||
| Hs.RGS6 | 1 | 0 | ||||
| Hs.RHAG | 1 | 0 | ||||
| Hs.RICTOR | 1 | 0 | ||||
| Hs.RIEG2 | 1 | 0 | ||||
| Hs.RIN1 | 1 | 0 | ||||
| Hs.RNASEH2A | 1 | 0 | ||||
| Hs.RNASEH2B | 1 | 0 | ||||
| Hs.RNASEL | 1 | 0 | ||||
| Hs.RNF213 | 1 | 0 | ||||
| Hs.RNF43 | 1 | 0 | ||||
| Hs.ROCK1 | 1 | 0 | ||||
| Hs.ROCK2 | 1 | 0 | ||||
| Hs.RPL10 | 1 | 0 | ||||
| Hs.RPL12 | 1 | 0 | ||||
| Hs.RPL14 | 1 | 0 | ||||
| Hs.RPL18A | 1 | 0 | ||||
| Hs.RPL22 | 1 | 0 | ||||
| Hs.RPL27A | 1 | 0 | ||||
| Hs.RPL28 | 1 | 0 | ||||
| Hs.RPL39 | 1 | 0 | ||||
| Hs.RPL7 | 1 | 0 | ||||
| Hs.RPP14 | 1 | 0 | ||||
| Hs.RPS17 | 1 | 0 | ||||
| Hs.RPS19 | 1 | 0 | ||||
| Hs.RPS3A | 1 | 0 | ||||
| Hs.RPS6KA2 | 1 | 0 | ||||
| Hs.RPS9 | 1 | 0 | ||||
| Hs.RPTOR | 1 | 0 | ||||
| Hs.RRAD | 1 | 0 | ||||
| Hs.RRAGC | 1 | 0 | ||||
| Hs.RTN4 | 1 | 0 | ||||
| Hs.RTP3 | 1 | 0 | ||||
| Hs.RUNX1 | 1 | 0 | ||||
| Hs.RUNX2 | 1 | 0 | ||||
| Hs.RUNX3 | 1 | 0 | ||||
| Hs.S100A10 | 1 | 0 | ||||
| Hs.S100A4 | 1 | 0 | ||||
| Hs.S100B | 1 | 0 | ||||
| Hs.SAA2 | 1 | 0 | ||||
| Hs.SALL4 | 1 | 0 | ||||
| Hs.SARM1 | 1 | 0 | ||||
| Hs.SCD | 1 | 0 | ||||
| Hs.SCFV | 1 | 0 | ||||
| Hs.SEC13 | 1 | 0 | ||||
| Hs.SELE | 1 | 0 | ||||
| Hs.SELENOP | 1 | 0 | ||||
| Hs.SERPINB2 | 1 | 0 | ||||
| Hs.SERPINF1 | 1 | 0 | ||||
| Hs.SF3A3 | 1 | 0 | ||||
| Hs.SF3B1 | 1 | 0 | ||||
| Hs.SF3B6 | 1 | 0 | ||||
| Hs.SGCB | 1 | 0 | ||||
| Hs.SH3BP5 | 1 | 0 | ||||
| Hs.SIAH2 | 1 | 0 | ||||
| Hs.SIPA1 | 1 | 0 | ||||
| Hs.SIRT2 | 1 | 0 | ||||
| Hs.SIX1 | 1 | 0 | ||||
| Hs.SIX4 | 1 | 0 | ||||
| Hs.SKA1 | 1 | 0 | ||||
| Hs.SLC19A1 | 1 | 0 | ||||
| Hs.SLC1A3 | 1 | 0 | ||||
| Hs.SLC22A7 | 1 | 0 | ||||
| Hs.SLC25A52 | 1 | 0 | ||||
| Hs.SLC29A1 | 1 | 0 | ||||
| Hs.SLC2A14 | 1 | 0 | ||||
| Hs.SLC2A3 | 1 | 0 | ||||
| Hs.SLC30A1 | 1 | 0 | ||||
| Hs.SLC35G2 | 1 | 0 | ||||
| Hs.SLC36A1 | 1 | 0 | ||||
| Hs.SLC46A1 | 1 | 0 | ||||
| Hs.SLC48A1 | 1 | 0 | ||||
| Hs.SLC49A4 | 1 | 0 | ||||
| Hs.SLC4A1 | 1 | 0 | ||||
| Hs.SLC4A3 | 1 | 0 | ||||
| Hs.SLC52A3 | 1 | 0 | ||||
| Hs.SLC5A5 | 1 | 0 | ||||
| Hs.SLC7A5 | 1 | 0 | ||||
| Hs.SLC9A3R1 | 1 | 0 | ||||
| Hs.SMAD2 | 1 | 0 | ||||
| Hs.SMAD5 | 1 | 0 | ||||
| Hs.SMO | 1 | 0 | ||||
| Hs.SNORA73A | 1 | 0 | ||||
| Hs.SNRPD3 | 1 | 0 | ||||
| Hs.SOAT2 | 1 | 0 | ||||
| Hs.SOCS1 | 1 | 0 | ||||
| Hs.SOCS6 | 1 | 0 | ||||
| Hs.SOS1 | 1 | 0 | ||||
| Hs.SOX10 | 1 | 0 | ||||
| Hs.SOX9 | 1 | 0 | ||||
| Hs.SPAG17 | 1 | 0 | ||||
| Hs.SPEN | 1 | 0 | ||||
| Hs.SPHK1 | 1 | 0 | ||||
| Hs.SPOP | 1 | 0 | ||||
| Hs.SPP1 | 1 | 0 | ||||
| Hs.SRGAP1 | 1 | 0 | ||||
| Hs.SRSF1 | 1 | 0 | ||||
| Hs.SRXN1 | 1 | 0 | ||||
| Hs.SS18 | 1 | 0 | ||||
| Hs.SSTR5 | 1 | 0 | ||||
| Hs.SSX2B | 1 | 0 | ||||
| Hs.STC2 | 1 | 0 | ||||
| Hs.STIL | 1 | 0 | ||||
| Hs.STIM1 | 1 | 0 | ||||
| Hs.STK38L | 1 | 0 | ||||
| Hs.STK39 | 1 | 0 | ||||
| Hs.STMN1 | 1 | 0 | ||||
| Hs.STMN2 | 1 | 0 | ||||
| Hs.SUCO | 1 | 0 | ||||
| Hs.SUMO1 | 1 | 0 | ||||
| Hs.TAC1 | 1 | 0 | ||||
| Hs.TACC3 | 1 | 0 | ||||
| Hs.TARBP2P1 | 1 | 0 | ||||
| Hs.TAS2R63P | 1 | 0 | ||||
| Hs.TAS2R64P | 1 | 0 | ||||
| Hs.TAT | 1 | 0 | ||||
| Hs.TBCA | 1 | 0 | ||||
| Hs.TBX1 | 1 | 0 | ||||
| Hs.TBX5 | 1 | 0 | ||||
| Hs.TCF3 | 1 | 0 | ||||
| Hs.TCF4 | 1 | 0 | ||||
| Hs.TCL1A | 1 | 0 | ||||
| Hs.TDRG1 | 1 | 0 | ||||
| Hs.TFAP2A | 1 | 0 | ||||
| Hs.TFE3 | 1 | 0 | ||||
| Hs.TFF2 | 1 | 0 | ||||
| Hs.TFF3 | 1 | 0 | ||||
| Hs.TGFB2 | 1 | 0 | ||||
| Hs.TGFBR3 | 1 | 0 | ||||
| Hs.THY1 | 1 | 0 | ||||
| Hs.TIA1 | 1 | 0 | ||||
| Hs.TIMP3 | 1 | 0 | ||||
| Hs.TKTL1 | 1 | 0 | ||||
| Hs.TLR3 | 1 | 0 | ||||
| Hs.TMBIM6 | 1 | 0 | ||||
| Hs.TMEFF2 | 1 | 0 | ||||
| Hs.TMEM106A | 1 | 0 | ||||
| Hs.TMEM116 | 1 | 0 | ||||
| Hs.TMEM127 | 1 | 0 | ||||
| Hs.TMEM132E | 1 | 0 | ||||
| Hs.TMEM207 | 1 | 0 | ||||
| Hs.TMEM213 | 1 | 0 | ||||
| Hs.TMEM30B | 1 | 0 | ||||
| Hs.TMEM45A | 1 | 0 | ||||
| Hs.TMEM45B | 1 | 0 | ||||
| Hs.TMEM51 | 1 | 0 | ||||
| Hs.TMEM59 | 1 | 0 | ||||
| Hs.TMEM61 | 1 | 0 | ||||
| Hs.TMEM72 | 1 | 0 | ||||
| Hs.TMEM97 | 1 | 0 | ||||
| Hs.TMPRSS9 | 1 | 0 | ||||
| Hs.TNFAIP2 | 1 | 0 | ||||
| Hs.TNFAIP8 | 1 | 0 | ||||
| Hs.TNFRSF14 | 1 | 0 | ||||
| Hs.TNFRSF18 | 1 | 0 | ||||
| Hs.TNFSF12 | 1 | 0 | ||||
| Hs.TNFSF14 | 1 | 0 | ||||
| Hs.TNP1 | 1 | 0 | ||||
| Hs.TOP1 | 1 | 0 | ||||
| Hs.TOP2B | 1 | 0 | ||||
| Hs.TOX3 | 1 | 0 | ||||
| Hs.TPD52 | 1 | 0 | ||||
| Hs.TPH1 | 1 | 0 | ||||
| Hs.TPO | 1 | 0 | ||||
| Hs.TPT1 | 1 | 0 | ||||
| Hs.TRAF2 | 1 | 0 | ||||
| Hs.TRIAP1 | 1 | 0 | ||||
| Hs.TRIB3 | 1 | 0 | ||||
| Hs.TRIM63 | 1 | 0 | ||||
| Hs.TRNK | 1 | 0 | ||||
| Hs.TRNL1 | 1 | 0 | ||||
| Hs.TRNS1 | 1 | 0 | ||||
| Hs.TRPM2 | 1 | 0 | ||||
| Hs.TRPM8 | 1 | 0 | ||||
| Hs.TRPV1 | 1 | 0 | ||||
| Hs.TSG101 | 1 | 0 | ||||
| Hs.TSHR | 1 | 0 | ||||
| Hs.TSHZ3 | 1 | 0 | ||||
| Hs.TSPAN31 | 1 | 0 | ||||
| Hs.TSPAN8 | 1 | 0 | ||||
| Hs.TTC21B | 1 | 0 | ||||
| Hs.TTC6 | 1 | 0 | ||||
| Hs.TTC7A | 1 | 0 | ||||
| Hs.TTF1 | 1 | 0 | ||||
| Hs.TUB | 1 | 0 | ||||
| Hs.TYMS | 1 | 0 | ||||
| Hs.TYR | 1 | 0 | ||||
| Hs.UBB | 1 | 0 | ||||
| Hs.UBE2D2 | 1 | 0 | ||||
| Hs.UGCG | 1 | 0 | ||||
| Hs.UGT1A | 1 | 0 | ||||
| Hs.ULK2 | 1 | 0 | ||||
| Hs.UPF1 | 1 | 0 | ||||
| Hs.UPP1 | 1 | 0 | ||||
| Hs.USF2 | 1 | 0 | ||||
| Hs.USP13 | 1 | 0 | ||||
| Hs.USP9X | 1 | 0 | ||||
| Hs.VEZF1 | 1 | 0 | ||||
| Hs.VIPR1 | 1 | 0 | ||||
| Hs.VIPR2 | 1 | 0 | ||||
| Hs.VOPP1 | 1 | 0 | ||||
| Hs.WEE1 | 1 | 0 | ||||
| Hs.WNT1 | 1 | 0 | ||||
| Hs.WNT10A | 1 | 0 | ||||
| Hs.WNT2 | 1 | 0 | ||||
| Hs.WNT5A | 1 | 0 | ||||
| Hs.WNT5B | 1 | 0 | ||||
| Hs.WNT9A | 1 | 0 | ||||
| Hs.WRAP53 | 1 | 0 | ||||
| Hs.WWOX | 1 | 0 | ||||
| Hs.XAB2 | 1 | 0 | ||||
| Hs.XAF1 | 1 | 0 | ||||
| Hs.XIST | 1 | 0 | ||||
| Hs.XPO5 | 1 | 0 | ||||
| Hs.XRCC3 | 1 | 0 | ||||
| Hs.XRCC6 | 1 | 0 | ||||
| Hs.YBX1 | 1 | 0 | ||||
| Hs.YY1 | 1 | 0 | ||||
| Hs.ZBTB7A | 1 | 0 | ||||
| Hs.ZEB2 | 1 | 0 | ||||
| Hs.ZFP36 | 1 | 0 | ||||
| Hs.ZMIZ1 | 1 | 0 | ||||
| Hs.ZMYND10 | 1 | 0 | ||||
| Hs.ZNF320 | 1 | 0 | ||||
| Hs.ZNF426 | 1 | 0 | ||||
| Hs.ZNF573 | 1 | 0 | ||||
| Hs.ZNF611 | 1 | 0 |
This data show the 1130 abstracts referred by the 331 genes curated for the homeostatic process and cancer hallmark.
| PMID | Title | Journal | Date |
|---|---|---|---|
| 24613274 | Swietenia macrophylla King induces mitochondrial-mediated apoptosis through p53 upregulation in HCT116 colorectal carcinoma cells. | J Ethnopharmacol | 2014/03/05 |
| 27131434 | Dillenia suffruticosa dichloromethane root extract induced apoptosis towards MDA-MB-231 triple-negative breast cancer cells. | J Ethnopharmacol | 2016/04/27 |
| 25797115 | Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway. | J Ethnopharmacol | 2015/03/19 |
| 30348269 | Evaluation of cell damage induced by irradiated Zinc-Phthalocyanine-gold dendrimeric nanoparticles in a breast cancer cell line. | Biomed J | 2018/09/06 |
| 25386076 | Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination. | World J Gastroenterol | 2014/03/03 |
| 21078664 | Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. | J Biol Chem | 2010/11/15 |
| 23940521 | Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells. | PLoS One | 2013/08/05 |
| 29200826 | Anticancer effect of dentatin and dentatin-hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line. | Drug Des Devel Ther | 2017/11/23 |
| 25846798 | Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels. | Environ Toxicol | 2015/04/06 |
| 25966046 | Comparative cytotoxic response of nickel ferrite nanoparticles in human liver HepG2 and breast MFC-7 cancer cells. | Chemosphere | 2015/05/15 |
| 28068628 | Epoxy clerodane diterpene inhibits MCF-7 human breast cancer cell growth by regulating the expression of the functional apoptotic genes Cdkn2A, Rb1, mdm2 and p53. | Biomed Pharmacother | 2017/01/06 |
| 23917726 | Galectin-3 inhibition sensitizes human renal cell carcinoma cells to arsenic trioxide treatment. | Cancer Biol Ther | 2013/08/05 |
| 19458629 | Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. | Leukemia | 2009/05/21 |
| 26521020 | Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2. | Exp Toxicol Pathol | 2015/10/28 |
| 24100375 | Suppression of the death gene BIK is a critical factor for resistance to tamoxifen in MCF-7 breast cancer cells. | Int J Oncol | 2013/10/04 |
| 26901182 | New 3-Cyano-2-Substituted Pyridines Induce Apoptosis in MCF 7 Breast Cancer Cells. | Molecules | 2016/02/18 |
| 27847212 | EGFR-dependent signalling reduced and p38 dependent apoptosis required by Gallic acid in Malignant Mesothelioma cells. | Biomed Pharmacother | 2016/11/12 |
| 30366984 | Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74-NF-κB signaling. | J Biol Chem | 2018/10/26 |
| 21716903 | In vitro study on apoptosis induced by strontium-89 in human breast carcinoma cell line. | J Biomed Biotechnol | 2011/06/09 |
| 27245202 | HMGI-C suppressing induces P53/caspase9 axis to regulate apoptosis in breast adenocarcinoma cells. | Cell Cycle | 2016/05/31 |
| 25725141 | Dichloromethane fractions of Scrophularia oxysepala extract induce apoptosis in MCF-7 human breast cancer cells. | Bosn J Basic Med Sci | 2015/01/29 |
| 27596816 | miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1. | Life Sci | 2016/09/03 |
| 25358602 | Low fucose containing bacterial polysaccharide facilitate mitochondria-dependent ROS-induced apoptosis of human lung epithelial carcinoma via controlled regulation of MAPKs-mediated Nrf2/Keap1 homeostasis signaling. | Mol Carcinog | 2014/10/30 |
| 26409225 | Autophagy protein Ulk1 promotes mitochondrial apoptosis through reactive oxygen species. | Free Radic Biol Med | 2015/09/25 |
| 29290491 | Induction of apoptosis by pyrazolo[3,4-d]pyridazine derivative in lung cancer cells via disruption of Bcl-2/Bax expression balance. | Bioorg Med Chem | 2017/12/20 |
| 24495391 | Bithionol inhibits ovarian cancer cell growth in vitro - studies on mechanism(s) of action. | BMC Cancer | 2014/02/04 |
| 20060930 | The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells. | Int J Biochem Cell Biol | 2010/01/10 |
| 29665555 | Hesperidin promotes programmed cell death by downregulation of nongenomic estrogen receptor signalling pathway in endometrial cancer cells. | Biomed Pharmacother | 2018/04/24 |
| 22797074 | SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. | Oncogene | 2012/07/16 |
| 30322886 | Sab concentrations indicate chemotherapeutic susceptibility in ovarian cancer cell lines. | Biochem J | 2018/11/15 |
| 23152504 | Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. | J Biol Chem | 2012/11/14 |
| 23259782 | Pathological implication and function of Bcl2-inhibitor of transcription in ovarian serous papillary adenocarcinomas. | Neoplasma | 2012/12/25 |
| 25891540 | Overexpression of the regulator of G-protein signaling 5 reduces the survival rate and enhances the radiation response of human lung cancer cells. | Oncol Rep | 2015/04/20 |
| 27894242 | Indazolo[3,2-b]quinazolinones Attack Hepatocellular Carcinoma Hep3B Cells by Inducing Mitochondrial-Dependent Apoptosis and Inhibition of Nrf2/ARE Signaling Pathway. | Curr Mol Med | 2016/08/20 |
| 28627168 | Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid. | J Agric Food Chem | 2017/07/05 |
| 28653874 | Invalidation of mitophagy by FBP1-mediated repression promotes apoptosis in breast cancer. | Tumour Biol | 2017/06/28 |
| 23711831 | Mechanism for hepato-protective action of Liangxue Huayu Recipe (LHR): blockade of mitochondrial cytochrome c release and caspase activation. | J Ethnopharmacol | 2013/05/24 |
| 26676220 | Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. | Phytother Res | 2015/12/17 |
| 26707867 | Discovery of a novel anti-cancer agent targeting both topoisomerase I and II in hepatocellular carcinoma Hep 3B cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde. | J Drug Target | 2016/01/21 |
| 23076534 | Upregulation of periostin prevents P53-mediated apoptosis in SGC-7901 gastric cancer cells. | Mol Biol Rep | 2012/10/19 |
| 25715710 | Responses of solid tumor cells in DMEM to reactive oxygen species generated by non-thermal plasma and chemically induced ROS systems. | Sci Rep | 2015/02/26 |
| 30453545 | Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines. | Nutrients | 2018/11/16 |
| 29433671 | Phytochemical-induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis and differentiation in malignant melanoma cells. | Phytomedicine | 2017/12/07 |
| 23660334 | Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction. | Toxicol Lett | 2013/05/06 |
| 20398749 | Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. | Free Radic Biol Med | 2010/04/14 |
| 26252009 | Embelin-Induced Apoptosis of Human Prostate Cancer Cells Is Mediated through Modulation of Akt and β-Catenin Signaling. | PLoS One | 2015/08/07 |
| 24594224 | Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts. | Biochim Biophys Acta | 2014/03/01 |
| 22593445 | Safrole induces G0/G1 phase arrest via inhibition of cyclin E and provokes apoptosis through endoplasmic reticulum stress and mitochondrion-dependent pathways in human leukemia HL-60 cells. | Anticancer Res | 2012/05/18 |
| 21868525 | Gallic acid induces G₀/G₁ phase arrest and apoptosis in human leukemia HL-60 cells through inhibiting cyclin D and E, and activating mitochondria-dependent pathway. | Anticancer Res | 2011/08/27 |
| 21617225 | Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. | Anticancer Res | 2011/05/28 |
| 20651361 | Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways. | Anticancer Res | 2010/07/24 |
| 19846952 | Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells. | Anticancer Res | 2009/10/23 |
| 26923760 | Moringa oleifera Gold Nanoparticles Modulate Oncogenes, Tumor Suppressor Genes, and Caspase-9 Splice Variants in A549 Cells. | J Cell Biochem | 2016/03/11 |
| 20457620 | IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis. | Mol Cancer Ther | 2010/05/12 |
| 20308427 | Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma. | J Cell Biol | 2010/03/24 |
| 19755849 | GHRH antagonist causes DNA damage leading to p21 mediated cell cycle arrest and apoptosis in human colon cancer cells. | Cell Cycle | 2009/10/03 |
| 28381544 | Modulation of Bax and mTOR for Cancer Therapeutics. | Cancer Res | 2017/04/05 |
| 26268226 | Bcl2 inhibition of mitochondrial DNA repair. | BMC Cancer | 2015/08/13 |
| 23959540 | PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status. | Int J Cancer | 2013/09/23 |
| 21367858 | Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha). | J Biol Chem | 2011/03/02 |
| 28937686 | Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. | Cell Death Differ | 2017/09/22 |
| 21878365 | 2,3-Diaryl-2H-1-benzopyran derivatives interfere with classical and non-classical estrogen receptor signaling pathways, inhibit Akt activation and induce apoptosis in human endometrial cancer cells. | Mol Cell Endocrinol | 2011/08/22 |
| 23024798 | Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1. | PLoS One | 2012/09/14 |
| 26658189 | Mitochondrial protection impairs BET bromodomain inhibitor-mediated cell death and provides rationale for combination therapeutic strategies. | Cell Death Dis | 2015/12/10 |
| 22366766 | EBP50 gene transfection promotes 5-fluorouracil-induced apoptosis in gastric cancer cells through Bax- and Bcl-2-triggered mitochondrial pathways. | Mol Med Rep | 2012/02/22 |
| 24957706 | Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer. | J Dig Dis | 2014/06/25 |
| 22050790 | Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway. | J Cell Mol Med | 2011/11/05 |
| 21368886 | WRAP53 promotes cancer cell survival and is a potential target for cancer therapy. | Cell Death Dis | 2011/01/13 |
| 21555592 | Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. | Proc Natl Acad Sci U S A | 2011/05/09 |
| 21041304 | Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity. | J Biol Chem | 2010/11/01 |
| 22932725 | High-mobility group A1 protein inhibits p53-mediated intrinsic apoptosis by interacting with Bcl-2 at mitochondria. | Cell Death Dis | 2012/08/30 |
| 28698145 | Increase in proteins involved in mitochondrial fission, mitophagy, proteolysis and antioxidant response in type I endometrial cancer as an adaptive response to respiratory complex I deficiency. | Biochem Biophys Res Commun | 2017/07/08 |
| 24603988 | Pristimerin, a quinonemethide triterpenoid, induces apoptosis in pancreatic cancer cells through the inhibition of pro-survival Akt/NF-κB/mTOR signaling proteins and anti-apoptotic Bcl-2. | Int J Oncol | 2014/03/05 |
| 27441372 | Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest. | PLoS One | 2016/07/21 |
| 25521557 | AG4, a compound isolated from Radix Ardisiae Gigantifoliae, induces apoptosis in human nasopharyngeal cancer CNE cells through intrinsic and extrinsic apoptosis pathways. | Anticancer Drugs | 2014/12/19 |
| 21462330 | Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells. | Mol Nutr Food Res | 2011/01/05 |
| 25927702 | Characterization of the apoptotic response induced by the cyanine dye D112: a potentially selective anti-cancer compound. | PLoS One | 2015/04/30 |
| 29559471 | Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells. | Cancer Res | 2018/03/20 |
| 26604689 | PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways. | Drug Des Devel Ther | 2015/11/05 |
| 26104578 | Myricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinoma. | Mol Cell Biochem | 2015/06/24 |
| 25613585 | The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells. | BMC Cancer | 2015/01/23 |
| 22829912 | Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to TRAIL-induced apoptosis. | PLoS One | 2012/07/19 |
| 25177836 | Expression of the Bcl-2 family genes and complexes involved in the mitochondrial transport in prostate cancer cells. | Int J Oncol | 2014/03/04 |
| 22589275 | Mitochondrial Bcl-2 family dynamics define therapy response and resistance in neuroblastoma. | Cancer Res | 2012/05/17 |
| 21135115 | Hedgehog signaling drives cellular survival in human colon carcinoma cells. | Cancer Res | 2010/12/06 |
| 25864810 | Is Bax/Bcl-2 ratio considered as a prognostic marker with age and tumor location in colorectal cancer? | Iran Biomed J | 2015/04/14 |
| 24140706 | Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. | Free Radic Biol Med | 2013/10/17 |
| 26367393 | Apoptosis-Promoting Effects of Hematoporphyrin Monomethyl Ether-Sonodynamic Therapy (HMME-SDT) on Endometrial Cancer. | PLoS One | 2015/09/14 |
| 26503209 | Knockdown of miR-221 promotes the cisplatin-inducing apoptosis by targeting the BIM-Bax/Bak axis in breast cancer. | Tumour Biol | 2015/10/26 |
| 27519795 | Tumor suppressor miRNA-204-5p promotes apoptosis by targeting BCL2 in prostate cancer cells. | Asian J Surg | 2016/08/09 |
| 20202741 | Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. | Cancer Lett | 2010/03/03 |
| 27729282 | Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway. | J Ethnopharmacol | 2016/10/08 |
| 23326480 | bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. | PLoS One | 2013/01/11 |
| 28320088 | Flower extract of Allium atroviolaceum triggered apoptosis, activated caspase-3 and down-regulated antiapoptotic Bcl-2 gene in HeLa cancer cell line. | Biomed Pharmacother | 2017/03/17 |
| 26053091 | NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. | Oncotarget | 2015/01/10 |
| 26771233 | The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer. | Oncotarget | 2015/10/02 |
| 27815964 | Anticancer activity of new molecular hybrids combining 1,4-naphthalenedione motif with phosphonic acid moiety in hepatocellular carcinoma HepG2 cells. | Acta Biochim Pol | 2016/11/04 |
| 24034139 | Anticancer Activity of New Synthetic α-Methylene-δ-Lactones on Two Breast Cancer Cell Lines. | Basic Clin Pharmacol Toxicol | 2013/09/18 |
| 22146623 | Harmine induces apoptosis in HepG2 cells via mitochondrial signaling pathway. | Hepatobiliary Pancreat Dis Int | 2011/12/08 |
| 26235743 | New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway. | Acta Pharmacol Sin | 2015/08/03 |
| 24055891 | Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue. | Toxicol In Vitro | 2013/09/19 |
| 27055871 | Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance. | Leukemia | 2016/03/08 |
| 23382857 | Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells. | PLoS One | 2013/01/31 |
| 23201138 | Viability screen on pediatric low grade glioma cell lines unveils a novel anti-cancer drug of the steroid biosynthesis inhibitor family. | Cancer Lett | 2012/11/29 |
| 29133058 | Design and synthesis of thienopyrimidine urea derivatives with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7. | Eur J Med Chem | 2017/10/28 |
| 24702929 | Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions. | Carbohydr Polym | 2014/02/20 |
| 25127718 | Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB. | BMC Complement Altern Med | 2014/08/15 |
| 27376493 | Natural product-inspired rational design, synthesis and biological evaluation of 2,3-dihydropyrano[2,3-f]chromen-4(8H)-one based hybrids as potential mitochondrial apoptosis inducers. | Eur J Med Chem | 2016/06/27 |
| 23510470 | Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug-DNA interaction. | Cell Prolif | 2012/09/24 |
| 22939973 | [6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: drug-DNA interaction and expression of certain signal genes in HeLa cells. | Eur J Pharmacol | 2012/08/24 |
| 28627691 | Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signaling pathways in MCF-7 breast cancer cells. | Mol Med Rep | 2017/06/16 |
| 25243868 | Schizandra chinensis extracts induce apoptosis in human gastric cancer cells via JNK/p38 MAPK activation and the ROS-mediated/mitochondria-dependent pathway. | Pharm Biol | 2014/09/22 |
| 27144558 | Exogenous and Endogeneous Disialosyl Ganglioside GD1b Induces Apoptosis of MCF-7 Human Breast Cancer Cells. | Int J Mol Sci | 2016/04/30 |
| 21843371 | The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1. | Mol Cancer | 2011/08/16 |
| 29538328 | Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum. | Molecules | 2018/03/14 |
| 28319809 | ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer. | Neoplasia | 2017/03/17 |
| 21947931 | Expression of apoptosis-related proteins and its clinical implication in surgically resected gastric carcinoma. | Virchows Arch | 2011/09/27 |
| 27175602 | Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells. | Oncol Rep | 2016/05/05 |
| 26500281 | Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. | Biosci Rep | 2015/10/23 |
| 22527937 | Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells. | Mol Cell Biochem | 2012/04/20 |
| 31048139 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. | Eur J Med Chem | 2019/04/16 |
| 20127709 | Overexpression of Par-4 sensitizes TRAIL-induced apoptosis via inactivation of NF-kappaB and Akt signaling pathways in renal cancer cells. | J Cell Biochem | 2010/02/04 |
| 30842155 | Digital Analysis of BCL2 Expression in Laryngeal Squamous Cell Carcinoma. | Anticancer Res | 2019/01/09 |
| 21455217 | MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. | Cell Death Differ | 2011/04/01 |
| 21289092 | Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells. | Mol Biol Cell | 2011/02/02 |
| 25674801 | HY253, a novel decahydrofluorene analog, induces apoptosis via intrinsic pathway and cell cycle arrest in liver cancer HepG2 cells. | J Microbiol Biotechnol | 2015/02/13 |
| 20823585 | 3α,23-isopropylidenedioxyolean-12-en-27-oic acid, a triterpene isolated from Aceriphyllum rossii, induces apoptosis in human cervical cancer HeLa cells through mitochondrial dysfunction and endoplasmic reticulum stress. | Biol Pharm Bull | 2010/09/09 |
| 26082034 | Differential roles of Bcl2L12 and its short variant in breast cancer lymph node metastasis. | Oncol Rep | 2015/06/16 |
| 27367565 | The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca(2+) flux from the endoplasmic reticulum to mitochondria. | Cell Death Differ | 2016/07/01 |
| 29444163 | The effect of "NutramilTM Complex," food for special medical purpose, on breast and prostate carcinoma cells. | PLoS One | 2018/02/14 |
| 23063124 | Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML. | Cell | 2012/03/26 |
| 24788728 | Expression of oxidored nitro domain-containing protein 1(NOR1) impairs nasopharyngeal carcinoma cells adaptation to hypoxia and inhibits PDK1 expression. | Mol Cell Biochem | 2014/05/01 |
| 20808790 | Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. | PLoS One | 2010/08/23 |
| 23563985 | Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid induces apoptosis and cell cycle arrest in CNE-2Z nasopharyngeal carcinoma cells. | Oncol Rep | 2013/04/03 |
| 21385902 | PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl-2 pathway. | Cancer Res | 2011/03/08 |
| 26061993 | Apoptosis induced by farrerol in human gastric cancer SGC-7901 cells through the mitochondrial-mediated pathway. | Eur J Cancer Prev | 2015/06/11 |
| 27322225 | Two Trichothecene Mycotoxins from Myrothecium roridum Induce Apoptosis of HepG-2 Cells via Caspase Activation and Disruption of Mitochondrial Membrane Potential. | Molecules | 2016/06/17 |
| 22366885 | Antitumor effects of ginsenoside Rg3 on human hepatocellular carcinoma cells. | Mol Med Rep | 2012/02/23 |
| 25214410 | Ursodeoxycholic acid induces apoptosis of hepatocellular carcinoma cells in vitro. | J Dig Dis | 2014/09/13 |
| 28246474 | Molecular mechanisms of apoptosis in hepatocellular carcinoma cells induced by ethanol extracts of | World J Gastroenterol | 2016/09/25 |
| 24411335 | A universal gene carrier platform for treatment of human prostatic carcinoma by p53 transfection. | Biomaterials | 2014/01/09 |
| 23411336 | Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway. | Food Chem | 2012/11/15 |
| 23968395 | The DNA binding domain of p53 is sufficient to trigger a potent apoptotic response at the mitochondria. | Mol Pharm | 2013/09/06 |
| 22729369 | Zoledronic acid inhibits human nasopharyngeal carcinoma cell proliferation by activating mitochondrial apoptotic pathway. | Med Oncol | 2012/06/23 |
| 30754643 | Fluoxetine Induces Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits ERK/NF-κB-Modulated Anti-Apoptotic and Invasive Potential in Hepatocellular Carcinoma Cells In Vitro. | Int J Mol Sci | 2019/02/11 |
| 22159556 | Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro. | Int J Oncol | 2011/12/07 |
| 20632439 | Galangin induces apoptosis of hepatocellular carcinoma cells via the mitochondrial pathway. | World J Gastroenterol | 2010/07/16 |
| 25820747 | The p53-inducible gene 3 involved in flavonoid-induced cytotoxicity through the reactive oxygen species-mediated mitochondrial apoptotic pathway in human hepatoma cells. | Food Funct | 2015/03/31 |
| 26125273 | Underlying mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in SKOV3 human ovarian cancer cells. | Eur Rev Med Pharmacol Sci | 2015/07/01 |
| 26002438 | Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway. | Apoptosis | 2015/05/24 |
| 28673964 | Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response. | J Biol Chem | 2017/07/03 |
| 24869760 | Effects of oxymatrine on the apoptosis and proliferation of gallbladder cancer cells. | Anticancer Drugs | 2014/05/30 |
| 25650185 | FV-429 Induced Apoptosis Through ROS-Mediated ERK2 Nuclear Translocation and p53 Activation in Gastric Cancer Cells. | J Cell Biochem | 2014/01/23 |
| 25045844 | RFT2 is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenesis by sustaining cell proliferation and protecting against cell death. | Cancer Lett | 2014/07/18 |
| 28382170 | Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer. | Theranostics | 2017/02/23 |
| 27447597 | Protocatechualdehyde Induces S-Phase Arrest and Apoptosis by Stimulating the p27(KIP1)-Cyclin A/D1-CDK2 and Mitochondrial Apoptotic Pathways in HT-29 Cells. | Molecules | 2016/07/19 |
| 27852038 | Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming. | Oncotarget | 2016/09/30 |
| 27673746 | Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins. | Biol Cell | 2016/10/26 |
| 28783983 | Mechanisms underlying the cytotoxic effect of propolis on human laryngeal epidermoid carcinoma cells. | Nat Prod Res | 2017/08/08 |
| 28306533 | ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29. | J Complement Integr Med | 2016/10/28 |
| 22552631 | The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. | Oncol Rep | 2012/04/30 |
| 25847773 | Extract of Zuojin Pill ([characters: see text]) induces apoptosis of SGC-7901 cells via mitochondria-dependent pathway. | Chin J Integr Med | 2015/04/06 |
| 27847140 | A novel adamantane thiadiazole derivative induces mitochondria-mediated apoptosis in lung carcinoma cell line. | Bioorg Med Chem | 2016/11/05 |
| 25652758 | Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway. | BMC Complement Altern Med | 2015/02/05 |
| 25946039 | (6E,10E) Isopolycerasoidol and (6E,10E) Isopolycerasoidol Methyl Ester, Prenylated Benzopyran Derivatives from Pseuduvaria monticola Induce Mitochondrial-Mediated Apoptosis in Human Breast Adenocarcinoma Cells. | PLoS One | 2015/05/06 |
| 26916824 | Chalcone derivatives cause accumulation of colon cancer cells in the G2/M phase and induce apoptosis. | Life Sci | 2016/02/23 |
| 19440893 | Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells. | Cancer Invest | 2009/05/15 |
| 28855578 | HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells. | Sci Rep | 2017/08/30 |
| 19711344 | Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. | Int J Cancer | 2009/08/28 |
| 29587544 | Ferula pseudalliacea induces apoptosis in human colorectal cancer HCT-116 cells via mitochondria-dependent pathway. | Arch Physiol Biochem | 2018/03/27 |
| 22142698 | Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study. | Food Chem Toxicol | 2011/11/28 |
| 22583411 | The nuclear orphan receptors NR4A as therapeutic target in cancer therapy. | Anticancer Agents Med Chem | 2011/12/05 |
| 25740140 | BARF1 gene silencing triggers caspase-dependent mitochondrial apoptosis in Epstein-Barr virus-positive malignant cells. | J Biosci | 2015/03/06 |
| 20942963 | The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein. | BMC Cancer | 2010/10/13 |
| 22103929 | The chemoadjuvant potential of grape seed procyanidins on p53-related cell death in oral cancer cells. | J Oral Pathol Med | 2011/11/21 |
| 23581228 | Hypoxia-inducible factor-1alpha suppressed hepatocellular carcinoma cell apoptosis through influencing on Omi/HtrA2 expression and its releasing from the mitochondrion. | Oncol Res | 2013/04/16 |
| 22544066 | Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration. | Nat Cell Biol | 2012/04/29 |
| 22700474 | Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells. | ChemMedChem | 2012/06/14 |
| 24256980 | Potential therapeutic role of Tridham in human hepatocellular carcinoma cell line through induction of p53 independent apoptosis. | BMC Complement Altern Med | 2013/11/21 |
| 21776480 | Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis. | Food Funct | 2010/10/27 |
| 28698525 | Hepatoprotective Role of Hydrangea macrophylla against Sodium Arsenite-Induced Mitochondrial-Dependent Oxidative Stress via the Inhibition of MAPK/Caspase-3 Pathways. | Int J Mol Sci | 2017/07/10 |
| 25435367 | Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells. | Oncogene | 2014/12/01 |
| 27998772 | Zinc induces apoptosis on cervical carcinoma cells by p53-dependent and -independent pathway. | Biochem Biophys Res Commun | 2016/12/18 |
| 23175101 | Induction of apoptosis in A431 skin cancer cells by Cissus quadrangularis Linn stem extract by altering Bax-Bcl-2 ratio, release of cytochrome c from mitochondria and PARP cleavage. | Food Funct | 2012/11/24 |
| 25234615 | Gamma-aminobutyric acid induces tumor cells apoptosis via GABABR1·β-arrestins·JNKs signaling module. | Cell Biochem Biophys | 2014/09/20 |
| 25746954 | Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells. | Eur J Pharm Sci | 2015/03/05 |
| 27687210 | Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1α. | Free Radic Biol Med | 2016/09/26 |
| 24824514 | The expression of genes involved in hepatocellular carcinoma chemoresistance is affected by mitochondrial genome depletion. | Mol Pharm | 2014/05/13 |
| 21785821 | Androgen deprivation therapy affects BCL-2 expression in human prostate cancer. | Int J Oncol | 2011/07/22 |
| 20367277 | Bcl-2 modulates resveratrol-induced ROS production by regulating mitochondrial respiration in tumor cells. | Antioxid Redox Signal | 2010/04/07 |
| 24223914 | Proteomic identification of mitochondrial targets of arginase in human breast cancer. | PLoS One | 2013/11/05 |
| 26538029 | Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death. | Mol Biol Cell | 2015/11/04 |
| 26585571 | Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines. | J Pharmacol Exp Ther | 2015/11/19 |
| 25139025 | Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines. | J Neurooncol | 2014/08/20 |
| 22393246 | ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines. | J Pharmacol Exp Ther | 2012/03/05 |
| 27663504 | BCL-2 system analysis identifies high-risk colorectal cancer patients. | Gut | 2016/09/23 |
| 21127500 | GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria. | Cell Death Differ | 2010/12/03 |
| 20388787 | ID1 enhances docetaxel cytotoxicity in prostate cancer cells through inhibition of p21. | Cancer Res | 2010/04/13 |
| 27552933 | Combined expression of miR-34a and Smac mediated by oncolytic vaccinia virus synergistically promote anti-tumor effects in Multiple Myeloma. | Sci Rep | 2016/08/24 |
| 30651744 | Anti-tumor effects and mechanism of GA-13315, a novel gibberellin derivative, in human lung adenocarcinoma: an in vitro and in vivo study. | Cell Mol Biol Lett | 2019/01/10 |
| 29343765 | Regulation of Signaling Pathways Involved in the Anti-proliferative and Apoptosis-inducing Effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells. | Sci Rep | 2018/01/17 |
| 28931215 | Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways. | Biomed Pharmacother | 2017/09/18 |
| 21109977 | mda-7/IL-24 induces apoptosis in human GBC-SD gallbladder carcinoma cells via mitochondrial apoptotic pathway. | Oncol Rep | 2010/11/27 |
| 26852038 | Marine steroid derived from Acropora formosa enhances mitochondrial-mediated apoptosis in non-small cell lung cancer cells. | Tumour Biol | 2016/02/06 |
| 22071691 | Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure. | Cell Cycle | 2011/11/15 |
| 28958615 | Cellular effect of styrene substituted biscoumarin caused cellular apoptosis and cell cycle arrest in human breast cancer cells. | Int J Biochem Cell Biol | 2017/09/25 |
| 28443516 | Synergistic Effect of Graphene Oxide Coated Nanotised Apigenin with Paclitaxel (GO-NA/PTX): A ROS Dependent Mitochondrial Mediated Apoptosis in Ovarian Cancer. | Anticancer Agents Med Chem | 2016/06/06 |
| 27756602 | Synergistic effect of piperine and paclitaxel on cell fate via cyt-c, Bax/Bcl-2-caspase-3 pathway in ovarian adenocarcinomas SKOV-3 cells. | Eur J Pharmacol | 2016/10/15 |
| 28262615 | Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells. | Biomed Pharmacother | 2017/03/04 |
| 21455989 | The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells. | Int J Cancer | 2011/07/21 |
| 25229655 | Fatty acid esters of phloridzin induce apoptosis of human liver cancer cells through altered gene expression. | PLoS One | 2014/09/17 |
| 21156786 | GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. | Mol Cancer Res | 2010/12/14 |
| 30218747 | Targeting apoptosis by 1,2-diazole through regulation of EGFR, Bcl-2 and CDK-2 mediated signaling pathway in human non-small cell lung carcinoma A549 cells. | Gene | 2018/09/13 |
| 23792636 | Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer. | Cancer Biol Ther | 2013/05/31 |
| 23047795 | Mitochondria-related gene expression changes are associated with fatigue in patients with nonmetastatic prostate cancer receiving external beam radiation therapy. | Cancer Nurs | 2012/10/11 |
| 25374178 | Roles of the Bcl-2/Bax ratio, caspase-8 and 9 in resistance of breast cancer cells to paclitaxel. | Asian Pac J Cancer Prev | 2014/11/07 |
| 23977393 | Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion. | PLoS One | 2013/08/19 |
| 19502594 | Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. | Carcinogenesis | 2009/06/05 |
| 20042497 | GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein. | J Virol | 2009/12/30 |
| 20582416 | Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin. | Cancer Chemother Pharmacol | 2010/06/26 |
| 25143432 | BIRO1, a cell-permeable BH3 peptide, promotes mitochondrial fragmentation and death of retinoblastoma cells. | Mol Cancer Res | 2014/08/20 |
| 21955141 | The Bcl-2/Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma cancer cells. | Ophthalmic Genet | 2011/09/28 |
| 20924970 | Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2. | Nutr Cancer | 2010/10/07 |
| 24480042 | α-Mangostin-induced apoptosis is mediated by estrogen receptor α in human breast cancer cells. | Food Chem Toxicol | 2014/01/28 |
| 24233024 | Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products. | J Mol Med (Berl) | 2013/01/24 |
| 25877700 | Activation of A2b adenosine receptor regulates ovarian cancer cell growth: involvement of Bax/Bcl-2 and caspase-3. | Biochem Cell Biol | 2015/03/16 |
| 23138847 | Involvement of the mitochondrial pathway and Bim/Bcl-2 balance in dihydroartemisinin-induced apoptosis in human breast cancer in vitro. | Int J Mol Med | 2012/11/08 |
| 23167995 | The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo. | Biochem Biophys Res Commun | 2012/11/17 |
| 24716946 | Mitochondria-mediated apoptosis in human lung cancer A549 cells by 4-methylsulfinyl-3-butenyl isothiocyanate from radish seeds. | Asian Pac J Cancer Prev | 2014/04/11 |
| 30599913 | JAK2 regulation by licochalcone H inhibits the cell growth and induces apoptosis in oral squamous cell carcinoma. | Phytomedicine | 2018/09/18 |
| 26352011 | Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma. | Int J Oncol | 2015/09/08 |
| 22710790 | Rapamycin induces p53-independent apoptosis through the mitochondrial pathway in non-small cell lung cancer cells. | Oncol Rep | 2012/06/12 |
| 20154083 | High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines. | J Biol Chem | 2010/02/12 |
| 23725135 | Plumbagin from Plumbago Zeylanica L induces apoptosis in human non-small cell lung cancer cell lines through NF- κB inactivation. | Asian Pac J Cancer Prev | 2013/06/04 |
| 19481070 | [6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells. | Chem Biol Interact | 2009/05/27 |
| 28415755 | Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma. | Oncotarget | 2017/02/15 |
| 26247574 | MicroRNA-345 induces apoptosis in pancreatic cancer cells through potentiation of caspase-dependent and -independent pathways. | Br J Cancer | 2015/08/06 |
| 19826421 | Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells. | Br J Cancer | 2009/10/13 |
| 22673012 | Resveratrol-sensitized UVA induced apoptosis in human keratinocytes through mitochondrial oxidative stress and pore opening. | J Photochem Photobiol B | 2012/05/18 |
| 26665397 | MOLECULAR EFFECTS OF AMINE DERIVATIVES OF PHENOTHIAZINE ON CANCER CELLS C-32 AND SNB-19 IN VITRO. | Acta Pol Pharm | 2015/12/16 |
| 24633962 | The overexpression of MCPH1 inhibits cell growth through regulating cell cycle-related proteins and activating cytochrome c-caspase 3 signaling in cervical cancer. | Mol Cell Biochem | 2014/03/15 |
| 25921134 | ALEX1 Regulates Proliferation and Apoptosis in Breast Cancer Cells. | Asian Pac J Cancer Prev | 2015/04/30 |
| 22564437 | Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis. | Int J Biochem Cell Biol | 2012/05/04 |
| 22902833 | Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. | Biochem Pharmacol | 2012/08/15 |
| 24952138 | Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations. | Free Radic Biol Med | 2014/06/19 |
| 23098474 | Prohibitin induces apoptosis in BGC823 gastric cancer cells through the mitochondrial pathway. | Asian Pac J Cancer Prev | 2012/10/27 |
| 27748803 | ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells. | Int J Oncol | 2016/10/13 |
| 19451193 | Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. | Toxicol Sci | 2009/05/18 |
| 27277143 | SIRT3 participates in glucose metabolism interruption and apoptosis induced by BH3 mimetic S1 in ovarian cancer cells. | Int J Oncol | 2016/06/01 |
| 30001631 | Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells. | J Enzyme Inhib Med Chem | 2018/07/14 |
| 25959910 | Mushroom Extracts Induce Human Colon Cancer Cell (COLO-205) Death by Triggering the Mitochondrial Apoptosis Pathway and Go/G1-Phase Cell Cycle Arrest. | Arch Iran Med | 2015/05/12 |
| 25401123 | Achyranthes aspera root extracts induce human colon cancer cell (COLO-205) death by triggering the mitochondrial apoptosis pathway and S phase cell cycle arrest. | ScientificWorldJournal | 2014/10/27 |
| 29710492 | Shufeng Jiedu Capsule and its active ingredients induce apoptosis, inhibit migration and invasion, and enhances doxorubicin therapeutic efficacy in hepatocellular carcinoma. | Biomed Pharmacother | 2018/02/20 |
| 24887205 | Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells. | J Exp Clin Cancer Res | 2014/05/16 |
| 28737827 | Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. | Oncol Rep | 2017/07/24 |
| 27775704 | PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. | Nat Med | 2016/10/24 |
| 29034805 | In vitro investigation of the effect of matrix molecules on the behavior of colon cancer cells under the effect of geldanamycin derivative. | Tumour Biol | 2017/10/17 |
| 23302226 | Cisplatin hypersensitivity of testicular germ cell tumors is determined by high constitutive Noxa levels mediated by Oct-4. | Cancer Res | 2013/01/09 |
| 19808980 | BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells. | Mol Cancer Ther | 2009/10/06 |
| 28038913 | rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway. | Int J Biol Macromol | 2016/12/27 |
| 27223122 | Small Molecule APY606 Displays Extensive Antitumor Activity in Pancreatic Cancer via Impairing Ras-MAPK Signaling. | PLoS One | 2016/05/25 |
| 28000884 | Thioridazine elicits potent antitumor effects in colorectal cancer stem cells. | Oncol Rep | 2016/12/14 |
| 19539424 | Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo. | Cancer Lett | 2009/06/17 |
| 20587415 | The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma. | J Biol Chem | 2010/06/29 |
| 22505651 | In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolution. | Cancer Res | 2012/04/13 |
| 23494867 | Role of altholactone in inducing type II apoptosis signalling pathway and expression of cancer-related genes in cervical carcinoma HeLa cell line. | Cell Biol Int | 2013/03/13 |
| 22843330 | D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. | Apoptosis | 2012/07/31 |
| 29618179 | Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines. | J Microbiol Biotechnol | 2018/04/06 |
| 26701852 | miR-101 reverses hypomethylation of the PRDM16 promoter to disrupt mitochondrial function in astrocytoma cells. | Oncotarget | 2015/08/16 |
| 29208281 | Overcoming STC2 mediated drug resistance through drug and gene co-delivery by PHB-PDMAEMA cationic polyester in liver cancer cells. | Mater Sci Eng C Mater Biol Appl | 2017/08/18 |
| 28714224 | Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy. | Macromol Biosci | 2017/07/17 |
| 22910913 | BaxΔ2 is a novel bax isoform unique to microsatellite unstable tumors. | J Biol Chem | 2012/08/21 |
| 29787950 | Macroporous silica nanoparticles for delivering Bcl2-function converting peptide to treat multidrug resistant-cancer cells. | J Colloid Interface Sci | 2018/05/15 |
| 25370579 | Epigallocatechin-3-gallate induces the apoptosis of hepatocellular carcinoma LM6 cells but not non-cancerous liver cells. | Int J Mol Med | 2014/10/31 |
| 20659543 | HPV E6 down-regulation and apoptosis induction of human cervical cancer cells by a novel lipid-soluble extract (PE) from Pinellia pedatisecta Schott in vitro. | J Ethnopharmacol | 2010/07/24 |
| 25976678 | Cambogin Induces Caspase-Independent Apoptosis through the ROS/JNK Pathway and Epigenetic Regulation in Breast Cancer Cells. | Mol Cancer Ther | 2015/05/14 |
| 25550789 | Effect of DAPK1 gene on proliferation, migration, and invasion of carcinoma of pancreas BxPC-3 cell line. | Int J Clin Exp Pathol | 2014/10/15 |
| 21271220 | Triptolide-induced cell cycle arrest and apoptosis in human renal cell carcinoma cells. | Oncol Rep | 2011/01/24 |
| 25148076 | Proteomic investigation into betulinic acid-induced apoptosis of human cervical cancer HeLa cells. | PLoS One | 2014/08/22 |
| 28290601 | ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis. | Int J Mol Med | 2017/03/09 |
| 29551681 | Interferon-gamma induces autophagy-associated apoptosis through induction of cPLA2-dependent mitochondrial ROS generation in colorectal cancer cells. | Biochem Biophys Res Commun | 2018/03/19 |
| 20707719 | Tumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo. | Cancer Biother Radiopharm | 2010/08/17 |
| 28423543 | MiR-519d impedes cisplatin-resistance in breast cancer stem cells by down-regulating the expression of MCL-1. | Oncotarget | 2016/12/28 |
| 24854102 | Inhibition of Beclin 1 expression enhances cisplatin-induced apoptosis through a mitochondrial-dependent pathway in human ovarian cancer SKOV3/DDP cells. | Oncol Res | 2014/05/24 |
| 28373424 | Methylsulfonylmethane Induces G | Anticancer Res | 2017/01/20 |
| 27862996 | Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells. | J Cell Mol Med | 2016/11/15 |
| 26202061 | Tannic acid inhibits the Jak2/STAT3 pathway and induces G1/S arrest and mitochondrial apoptosis in YD-38 gingival cancer cells. | Int J Oncol | 2015/07/21 |
| 22665354 | Capsaicin-induced apoptosis of FaDu human pharyngeal squamous carcinoma cells. | Yonsei Med J | 2012/06/06 |
| 23147571 | The targeted inhibition of mitochondrial Hsp90 overcomes the apoptosis resistance conferred by Bcl-2 in Hep3B cells via necroptosis. | Toxicol Appl Pharmacol | 2012/11/09 |
| 22592084 | Luffa echinata Roxb. induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway. | Molecules | 2012/05/16 |
| 25856714 | Leonurine hydrochloride induces apoptosis of H292 lung cancer cell by a mitochondria-dependent pathway. | Pharm Biol | 2015/04/09 |
| 23703817 | BaP-induced DNA damage initiated p53-independent necroptosis via the mitochondrial pathway involving Bax and Bcl-2. | Hum Exp Toxicol | 2013/05/23 |
| 28109089 | Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling. | Oncol Res | 2017/01/20 |
| 22382024 | Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells. | Biochem Biophys Res Commun | 2012/02/21 |
| 27759171 | Chemotherapeutic effect of Zerumbone on melanoma cells through mitochondria-mediated pathways. | Clin Exp Dermatol | 2016/10/19 |
| 29144987 | Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide induces human trophoblast Swan 71 cell dysfunctions due to cell apoptosis through disorder of mitochondrial fission/fusion. | Environ Pollut | 2017/05/12 |
| 26823779 | TFF3 knockout in human pituitary adenoma cell HP75 facilitates cell apoptosis via mitochondrial pathway. | Int J Clin Exp Pathol | 2015/11/01 |
| 25379610 | Downregulation of LRPPRC induces apoptosis in prostate cancer cells through the mitochondria-mediated pathway. | Cancer Biother Radiopharm | 2014/11/08 |
| 24627125 | β-elemene reverses the drug resistance of lung cancer A549/DDP cells via the mitochondrial apoptosis pathway. | Oncol Rep | 2014/03/12 |
| 29533931 | Sepia Ink Oligopeptide Induces Apoptosis of Lung Cancer Cells via Mitochondrial Pathway. | Cell Physiol Biochem | 2018/03/07 |
| 26585387 | NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance. | Mol Cell | 2015/11/12 |
| 27409347 | The down-regulated ING5 expression in lung cancer: a potential target of gene therapy. | Oncotarget | 2016/02/06 |
| 25735224 | Overexpression of a Novel Tumor Metastasis Suppressor Gene TMSG1/LASS2 Induces Apoptosis via a Caspase-dependent Mitochondrial Pathway. | J Cell Biochem | 2014/08/16 |
| 21714853 | Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. | J Exp Clin Cancer Res | 2011/06/29 |
| 26460892 | Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway. | Mol Med Rep | 2015/09/30 |
| 19798105 | Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells. | Cell Death Differ | 2009/10/03 |
| 20372842 | Curcumin induces mitochondria pathway mediated cell apoptosis in A549 lung adenocarcinoma cells. | Oncol Rep | 2010/04/08 |
| 25834401 | The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells. | Drug Des Devel Ther | 2015/03/16 |
| 23893182 | Sodium selenite induces apoptosis in colon cancer cells via Bax-dependent mitochondrial pathway. | Eur Rev Med Pharmacol Sci | 2013/07/30 |
| 29150439 | Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. | Sci Immunol | 2017/04/17 |
| 29303982 | Curcumin Analog DK1 Induces Apoptosis in Human Osteosarcoma Cells In Vitro through Mitochondria-Dependent Signaling Pathway. | Molecules | 2018/01/05 |
| 28537448 | Hesperetin induces an apoptosis-triggered extrinsic pathway and a p53- independent pathway in human lung cancer H522 cells. | J Asian Nat Prod Res | 2017/05/24 |
| 22847135 | Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells. | Food Chem Toxicol | 2012/07/27 |
| 29393444 | Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. | Oncol Rep | 2018/01/31 |
| 23396090 | Overcoming chemotherapy resistance of ovarian cancer cells by liposomal cisplatin: molecular mechanisms unveiled by gene expression profiling. | Biochem Pharmacol | 2013/02/08 |
| 20673369 | Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression. | Mol Cancer | 2010/07/31 |
| 19816523 | Improved nonviral cancer suicide gene therapy using survivin promoter-driven mutant Bax. | Cancer Gene Ther | 2009/10/09 |
| 23088850 | Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation. | Mitochondrion | 2012/10/23 |
| 25451688 | Oncogenic c-Myc and prothymosin-alpha protect hepatocellular carcinoma cells against sorafenib-induced apoptosis. | Biochem Pharmacol | 2014/11/03 |
| 28238784 | Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma. | Biochem Biophys Res Commun | 2017/02/24 |
| 25915842 | Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway. | Oncogene | 2015/04/27 |
| 22955947 | Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation. | Cell Death Differ | 2012/09/07 |
| 30036487 | Bisphenol A suppresses proliferation and induces apoptosis in colonic epithelial cells through mitochondrial and MAPK/AKT pathways. | Life Sci | 2018/07/20 |
| 22552851 | HIV-1 viral protein R (Vpr) induction of apoptosis and cell cycle arrest in multidrug-resistant colorectal cancer cells. | Oncol Rep | 2012/04/23 |
| 23565238 | CG0009, a novel glycogen synthase kinase 3 inhibitor, induces cell death through cyclin D1 depletion in breast cancer cells. | PLoS One | 2013/04/02 |
| 24818581 | Cantharidin induces apoptosis of H460 human lung cancer cells through mitochondria-dependent pathways. | Int J Oncol | 2014/05/09 |
| 20419447 | Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3. | J Mol Med (Berl) | 2010/04/25 |
| 30478310 | VDAC2 enables BAX to mediate apoptosis and limit tumor development. | Nat Commun | 2018/11/26 |
| 26469759 | HMGB1 induction of clusterin creates a chemoresistant niche in human prostate tumor cells. | Sci Rep | 2015/10/15 |
| 20630060 | Gonadotropin-releasing hormone type II antagonist induces apoptosis in MCF-7 and triple-negative MDA-MB-231 human breast cancer cells in vitro and in vivo. | Breast Cancer Res | 2010/07/14 |
| 28356713 | Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells. | Drug Des Devel Ther | 2017/03/20 |
| 21706479 | PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. | J Pathol | 2011/06/27 |
| 28942194 | The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. | Redox Biol | 2017/09/14 |
| 24343129 | NF-κB p65 recruited SHP regulates PDCD5-mediated apoptosis in cancer cells. | Apoptosis | 2013/12/18 |
| 23451189 | Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways. | PLoS One | 2013/02/22 |
| 23285096 | Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. | PLoS One | 2012/12/20 |
| 21693538 | Apoptosis-related protein-2 triggers melanoma cell death by a mechanism including both endoplasmic reticulum stress and mitochondrial dysregulation. | Carcinogenesis | 2011/06/21 |
| 29204990 | Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum. | J Zhejiang Univ Sci B | 2017/12/06 |
| 26531171 | Effect of GnT-V knockdown on the proliferation, migration and invasion of the SMMC7721/R human hepatocellular carcinoma drug-resistant cell line. | Mol Med Rep | 2015/10/29 |
| 26780985 | Overexpression of FOXO4 induces apoptosis of clear-cell renal carcinoma cells through downregulation of Bim. | Mol Med Rep | 2016/01/15 |
| 25242370 | Enhancement of the effects of gemcitabine against pancreatic cancer by oridonin via the mitochondrial caspase-dependent signaling pathway. | Mol Med Rep | 2014/09/19 |
| 29125839 | Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca2 + dyshomeostasis in hepatocarcinoma PLC cells. | PLoS Negl Trop Dis | 2017/11/10 |
| 22076283 | Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1. | Oncol Rep | 2011/11/10 |
| 19729910 | Involvement of the mitochondrial pathway in p53-independent apoptosis induced by p28GANK knockdown in Hep3B cells. | Cytogenet Genome Res | 2009/08/31 |
| 26502806 | Mitochondrial dysfunction rather than mtDNA sequence mutation is responsible for the multi-drug resistance of small cell lung cancer. | Oncol Rep | 2015/04/29 |
| 20807285 | Hsp72 mediates TAp73α anti-apoptotic effects in small cell lung carcinoma cells. | J Cell Mol Med | 2010/09/03 |
| 25823563 | Low-pH-induced apoptosis: role of endoplasmic reticulum stress-induced calcium permeability and mitochondria-dependent signaling. | Cell Stress Chaperones | 2015/04/01 |
| 20145152 | miR-181a and miR-630 regulate cisplatin-induced cancer cell death. | Cancer Res | 2010/02/09 |
| 21545297 | Lentivirus-mediated RNA interference targeting Bax inhibitor-1 suppresses ex vivo cell proliferation and in vivo tumor growth of nasopharyngeal carcinoma. | Hum Gene Ther | 2011/05/05 |
| 23618872 | The retinoblastoma protein induces apoptosis directly at the mitochondria. | Genes Dev | 2013/04/25 |
| 23644847 | Prima-1 induces apoptosis in bladder cancer cell lines by activating p53. | Clinics (Sao Paulo) | 2012/08/20 |
| 29165056 | Citrinin induces apoptosis in human HCT116 colon cancer cells through endoplasmic reticulum stress. | J Toxicol Environ Health A | 2017/11/23 |
| 23831407 | Tumor suppressor gene Oxidored-nitro domain-containing protein 1 regulates nasopharyngeal cancer cell autophagy, metabolism, and apoptosis in vitro. | Int J Biochem Cell Biol | 2013/07/03 |
| 27053107 | Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis. | J Biol Chem | 2016/04/06 |
| 29966654 | l-asparaginase induces intrinsic mitochondrial-mediated apoptosis in human gastric adenocarcinoma cells and impedes tumor progression. | Biochem Biophys Res Commun | 2018/07/06 |
| 28256105 | Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation. | Basic Clin Pharmacol Toxicol | 2017/06/27 |
| 30179714 | HCV non-structural NS4A protein of genotype 3a induces mitochondria mediated death by activating Bax and the caspase cascade. | Microb Pathog | 2018/09/01 |
| 20233581 | Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma. | Biochem Biophys Res Commun | 2010/03/15 |
| 28870896 | Gefitinib Enhances Mitochondrial Biological Functions in NSCLCs with | Anticancer Res | 2017/06/27 |
| 20647320 | Interaction of TAp73 and breast cancer-associated gene 3 enhances the sensitivity of cervical cancer cells in response to irradiation-induced apoptosis. | Cancer Res | 2010/07/20 |
| 22613969 | Apoptosis-related gene transcription in human A549 lung cancer cells via A(3) adenosine receptor. | Cell Physiol Biochem | 2012/05/11 |
| 19701890 | A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production. | Eur J Immunol | 2009/08/25 |
| 25692338 | Tumor suppression by resistant maltodextrin, Fibersol-2. | Cancer Biol Ther | 2015/02/19 |
| 27710854 | Albendazole as a promising molecule for tumor control. | Redox Biol | 2016/09/22 |
| 21071633 | hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. | Cancer Res | 2010/11/11 |
| 22874769 | Colon cancer cell chemosensitisation by fish oil emulsion involves apoptotic mitochondria pathway. | Br J Nutr | 2012/08/08 |
| 27805285 | Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl-xL silenced glioma cell lines. | Mol Carcinog | 2016/11/22 |
| 22086447 | Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage. | Mol Carcinog | 2011/11/15 |
| 25458053 | A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1. | Mol Oncol | 2014/10/17 |
| 21641698 | Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway. | Eur J Med Chem | 2011/05/24 |
| 25528193 | Superoxide mediated photomodification and DNA damage induced apoptosis by Benz(a)anthracene via mitochondrial mediated pathway. | J Photochem Photobiol B | 2014/12/02 |
| 28951871 | Recombinant Vaccinia Viruses Coding Transgenes of Apoptosis-Inducing Proteins Enhance Apoptosis But Not Immunogenicity of Infected Tumor Cells. | Biomed Res Int | 2017/08/30 |
| 27622714 | Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. | Sci Rep | 2016/09/13 |
| 23651852 | RB goes mitochondrial. | Genes Dev | 2013/05/09 |
| 25470234 | Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. | Autophagy | 2014/12/04 |
| 19507249 | Parathyroid hormone-related protein confers chemoresistance by blocking apoptosis signaling via death receptors and mitochondria. | Int J Cancer | 2009/06/10 |
| 24073224 | Secreted human adipose leptin decreases mitochondrial respiration in HCT116 colon cancer cells. | PLoS One | 2013/09/20 |
| 26206395 | Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway. | J Pharm Pharmacol | 2015/07/21 |
| 24216611 | MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX. | Cell Signal | 2013/11/09 |
| 25683251 | Activation of AMP-activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib. | Cancer Sci | 2015/03/09 |
| 25434584 | Anticancer agent icaritin induces apoptosis through caspase-dependent pathways in human hepatocellular carcinoma cells. | Mol Med Rep | 2014/11/26 |
| 19569044 | Forced cytochrome B gene mutation expression induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells. | Int J Cancer | 2009/07/02 |
| 21853114 | Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species. | PLoS One | 2011/08/10 |
| 20571029 | Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells. | J Biol Chem | 2010/06/22 |
| 20197401 | Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. | Mol Cancer Ther | 2010/03/02 |
| 30300626 | Chrysophanol selectively represses breast cancer cell growth by inducing reactive oxygen species production and endoplasmic reticulum stress via AKT and mitogen-activated protein kinase signal pathways. | Toxicol Appl Pharmacol | 2018/10/06 |
| 22913657 | The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways. | Fundam Clin Pharmacol | 2012/08/23 |
| 26398332 | Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways. | Mol Med Rep | 2015/09/14 |
| 20830746 | Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. | J Cell Biochem | 2010/09/11 |
| 21953469 | The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein. | J Biol Chem | 2011/09/27 |
| 29215703 | Design, synthesis, and characterization of α, β-unsaturated carboxylic acid, and its urea based derivatives that explores novel epigenetic modulators in human non-small cell lung cancer A549 cell line. | J Cell Physiol | 2018/01/25 |
| 21852238 | Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL. | J Biol Chem | 2011/08/18 |
| 25220870 | Promotion of p53 expression and reactive oxidative stress production is involved in zerumbone-induced cisplatin sensitization of non-small cell lung cancer cells. | Biochimie | 2014/09/16 |
| 25980443 | Mitochondrial p53 phosphorylation induces Bak-mediated and caspase-independent cell death. | Oncotarget | 2015/01/19 |
| 22052903 | Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101. | J Biol Chem | 2011/11/03 |
| 20451370 | Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy. | Eur J Cancer | 2010/05/05 |
| 24842234 | BaxΔ2 promotes apoptosis through caspase-8 activation in microsatellite-unstable colon cancer. | Mol Cancer Res | 2014/05/19 |
| 20683914 | Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. | J Cell Physiol | 2010/08/05 |
| 23990352 | The effects of silencing of PI3K p85α on 5-FU-induced colorectal cancer cells apoptosis. | Med Oncol | 2013/08/29 |
| 27460082 | The anti-oncogenic influence of ellagic acid on colon cancer cells in leptin-enriched microenvironment. | Tumour Biol | 2016/07/26 |
| 21042755 | Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways. | Oncol Rep | 2010/11/03 |
| 29658606 | Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial‑mediated apoptosis. | Oncol Rep | 2018/04/12 |
| 25721362 | Adenosine monophosphate activated protein kinase (AMPK), a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast cancer cells. | Apoptosis | 2015/02/28 |
| 29030986 | The small molecule AU14022 promotes colorectal cancer cell death via p53-mediated G2/M-phase arrest and mitochondria-mediated apoptosis. | J Cell Physiol | 2018/01/15 |
| 21993600 | The histone deacetylase inhibitor, Trichostatin A, induces G2/M phase arrest and apoptosis in YD-10B oral squamous carcinoma cells. | Oncol Rep | 2011/10/06 |
| 21480800 | Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation. | J Med Food | 2011/04/11 |
| 20046096 | The EphB2 tumor suppressor induces autophagic cell death via concomitant activation of the ERK1/2 and PI3K pathways. | Cell Cycle | 2010/01/02 |
| 23523951 | Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. | Chem Biol Interact | 2013/03/22 |
| 28513634 | Mitochondria-targeted platinum(ii) complexes: dual inhibitory activities on tumor cell proliferation and migration/invasion via intracellular trafficking of β-catenin. | Metallomics | 2017/05/18 |
| 30241032 | Myostatin knockout induces apoptosis in human cervical cancer cells via elevated reactive oxygen species generation. | Redox Biol | 2018/09/13 |
| 27444971 | Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo. | Environ Toxicol | 2016/07/22 |
| 28160167 | Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells. | Cell Oncol (Dordr) | 2017/02/03 |
| 21525791 | TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status. | Cancer Biol Ther | 2011/07/01 |
| 25318378 | Silencing the KCNK9 potassium channel (TASK-3) gene disturbs mitochondrial function, causes mitochondrial depolarization, and induces apoptosis of human melanoma cells. | Arch Dermatol Res | 2014/10/16 |
| 23686572 | p14ARF induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop. | Int J Cancer | 2013/08/01 |
| 19969555 | Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells. | Carcinogenesis | 2009/12/07 |
| 25755712 | Sequential treatment with betulinic acid followed by 5-fluorouracil shows synergistic cytotoxic activity in ovarian cancer cells. | Int J Clin Exp Pathol | 2015/01/01 |
| 30051679 | Exopolysaccharide from Marine Bacillus velezensis MHM3 Induces Apoptosis of Human Breast Cancer MCF-7 Cells through a Mitochondrial Pathway | Asian Pac J Cancer Prev | 2018/07/27 |
| 21121808 | Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria. | J Neurotrauma | 2010/12/03 |
| 22484428 | WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway. | Mol Med Rep | 2012/04/06 |
| 26041471 | Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden. | Mol Cancer | 2015/06/04 |
| 21091652 | Microarray analysis of nemorosone-induced cytotoxic effects on pancreatic cancer cells reveals activation of the unfolded protein response (UPR). | Br J Pharmacol | 2010/11/25 |
| 20530481 | One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity. | J Biol Chem | 2010/06/08 |
| 29353042 | Ginkgolic acid induces interplay between apoptosis and autophagy regulated by ROS generation in colon cancer. | Biochem Biophys Res Commun | 2018/01/17 |
| 26390926 | PK11195-chitosan-graft-polyethylenimine-modified SPION as a mitochondria-targeting gene carrier. | J Drug Target | 2015/09/22 |
| 25590838 | A metabolic phenotype based on mitochondrial ribosomal protein expression as a predictor of lymph node metastasis in papillary thyroid carcinoma. | Medicine (Baltimore) | 2015/01/16 |
| 23046869 | TGF-β suppresses the expression of genes related to mitochondrial function in lung A549 cells. | Cell Mol Biol (Noisy-le-grand) | 2012/10/08 |
| 23142370 | Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction. | Eur J Pharmacol | 2012/11/06 |
| 24190574 | Wilms' tumor gene 1 enhances nutlin-3-induced apoptosis. | Oncol Rep | 2013/11/01 |
| 25788004 | 5-diphenylacetamido-indirubin-3'-oxime as a novel mitochondria-targeting agent with anti-leukemic activities. | Mol Carcinog | 2015/03/18 |
| 26083392 | Down Regulation of CLDND1 Induces Apoptosis in Breast Cancer Cells. | PLoS One | 2015/06/17 |
| 21315590 | HY251, a novel decahydrocyclopenta[a]indene analog, from Aralia continentalis induces apoptosis via down-regulation of AR expression in human prostate cancer LNCaP cells. | Bioorg Med Chem Lett | 2011/01/15 |
| 20219657 | HY253, a novel decahydrofluorene analog, from Aralia continentalis, induces cell cycle arrest at the G1 phase and cytochrome c-mediated apoptosis in human lung cancer A549 cells. | J Ethnopharmacol | 2010/02/26 |
| 24606760 | Interaction of translationally controlled tumor protein with Apaf-1 is involved in the development of chemoresistance in HeLa cells. | BMC Cancer | 2014/03/07 |
| 27720946 | 6-(3,4-Dihydro-1H-isoquinoline-2-yl)-N-(6-methoxypyridine-2-yl) nicotinamide-26 (DIMN-26) decreases cell proliferation by induction of apoptosis and downregulation of androgen receptor signaling in human prostate cancer cells. | Chem Biol Interact | 2016/10/05 |
| 20648695 | Cancer-upregulated gene 2 (CUG2) overexpression induces apoptosis in SKOV-3 cells. | Cell Biochem Funct | 2010/07/22 |
| 26034354 | Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways. | World J Gastroenterol | 2014/09/28 |
| 28337983 | Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells. | Cell Res | 2017/03/24 |
| 26313918 | The novel protective role of P27 in MLN4924-treated gastric cancer cells. | Cell Death Dis | 2015/08/27 |
| 27428374 | Overexpression of Mitochondria Mediator Gene TRIAP1 by miR-320b Loss Is Associated with Progression in Nasopharyngeal Carcinoma. | PLoS Genet | 2016/07/18 |
| 27383047 | Mps1 kinase regulates tumor cell viability via its novel role in mitochondria. | Cell Death Dis | 2016/07/07 |
| 21474236 | Combination of interferon-α and 5-fluorouracil induces apoptosis through mitochondrial pathway in hepatocellular carcinoma in vitro. | Cancer Lett | 2011/04/06 |
| 30290033 | Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis. | Cancer Sci | 2018/11/11 |
| 22745125 | Impairment of the ubiquitin-proteasome pathway by methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate leads to a potent cytotoxic effect in tumor cells: a novel antiproliferative agent with a potential therapeutic implication. | J Biol Chem | 2012/06/28 |
| 27431913 | Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence. | BMC Cancer | 2016/07/19 |
| 26774105 | The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth. | Mol Carcinog | 2016/01/15 |
| 27240826 | Weighted gene co-expression network analysis reveals key genes involved in pancreatic ductal adenocarcinoma development. | Cell Oncol (Dordr) | 2016/05/30 |
| 30304948 | Targeting the mitochondrial apoptosis pathway by a newly synthesized COX-2 inhibitor in pediatric ALL lymphocytes. | Future Med Chem | 2018/10/11 |
| 30302629 | Pantoprazole Induces Mitochondrial Apoptosis and Attenuates NF-κB Signaling in Glioma Cells. | Cell Mol Neurobiol | 2018/10/09 |
| 28771532 | The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells. | PLoS One | 2017/08/03 |
| 21810437 | Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells. | Toxicol Appl Pharmacol | 2011/07/19 |
| 21920417 | Mitochondrial apoptosis contributes to the anti-cancer effect of Smilax glabra Roxb. | Toxicol Lett | 2011/09/03 |
| 19586787 | AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells. | Mol Genet Metab | 2009/06/23 |
| 29975932 | miR-100 Reverses Cisplatin Resistance in Breast Cancer by Suppressing HAX-1. | Cell Physiol Biochem | 2018/07/05 |
| 27865929 | G | J Inorg Biochem | 2016/11/04 |
| 27444183 | CD317 Promotes the survival of cancer cells through apoptosis-inducing factor. | J Exp Clin Cancer Res | 2016/07/22 |
| 22912861 | Interaction of OKL38 and p53 in regulating mitochondrial structure and function. | PLoS One | 2012/08/17 |
| 23322088 | hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells. | Apoptosis | 2013/01/17 |
| 26547530 | Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer. | Phytomedicine | 2015/08/31 |
| 22829880 | Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome C. | PLoS One | 2012/07/19 |
| 23770345 | Proteomic-based identification of multiple pathways underlying n-butylidenephthalide-induced apoptosis in LNCaP human prostate cancer cells. | Food Chem Toxicol | 2013/06/12 |
| 27104982 | TDRG1 regulates chemosensitivity of seminoma TCam-2 cells to cisplatin via PI3K/Akt/mTOR signaling pathway and mitochondria-mediated apoptotic pathway. | Cancer Biol Ther | 2016/04/22 |
| 23201011 | Dihydroartemisinin inhibits the Bcr/Abl oncogene at the mRNA level in chronic myeloid leukemia sensitive or resistant to imatinib. | Biomed Pharmacother | 2012/11/19 |
| 22020078 | Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway. | Biochem Biophys Res Commun | 2011/10/12 |
| 22562073 | Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation. | Autophagy | 2012/05/07 |
| 23525303 | Silencing Bmi-1 expression by RNA interference suppresses the growth of laryngeal carcinoma cells. | Int J Mol Med | 2013/03/20 |
| 25177958 | Inhibitory effect of survivin-targeting small interfering RNA on gastric cancer cells. | Genet Mol Res | 2014/08/28 |
| 19641995 | Simultaneous treatment with camptothecin and valproic acid suppresses induction of Bcl-X(L) and promotes apoptosis of MCF-7 breast cancer cells. | Apoptosis | 2009/07/31 |
| 29300929 | Downregulation of SKP2 in Papillary Thyroid Cancer Acts Synergistically With TRAIL on Inducing Apoptosis via ROS. | J Clin Endocrinol Metab | 2017/10/03 |
| 23686163 | Notch inhibition restores TRAIL-mediated apoptosis via AP1-dependent upregulation of DR4 and DR5 TRAIL receptors in MDA-MB-231 breast cancer cells. | Int J Oncol | 2013/05/17 |
| 28038320 | Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis. | Neoplasia | 2016/12/27 |
| 29940575 | Knockdown of MiR-20a Enhances Sensitivity of Colorectal Cancer Cells to Cisplatin by Increasing ASK1 Expression. | Cell Physiol Biochem | 2018/06/19 |
| 30429221 | Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-X | J Biol Chem | 2018/11/14 |
| 27802904 | Panobinostat induces apoptosis via production of reactive oxygen species and synergizes with topoisomerase inhibitors in cervical cancer cells. | Biomed Pharmacother | 2016/10/29 |
| 20948318 | Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery. | Cancer Biol Ther | 2010/12/15 |
| 20107314 | OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins. | Cancer Biol Ther | 2010/04/01 |
| 23103048 | Cytotoxic effects of polycarbonate-based orthodontic brackets by activation of mitochondrial apoptotic mechanisms. | Dent Mater | 2012/10/24 |
| 21840189 | Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells. | J Nutr Biochem | 2011/08/12 |
| 27460078 | VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway. | Tumour Biol | 2016/07/26 |
| 27757837 | E | Pathol Oncol Res | 2016/10/18 |
| 22098591 | Mitochondrial transcription factor A regulates BCL2L1 gene expression and is a prognostic factor in serous ovarian cancer. | Cancer Sci | 2011/12/23 |
| 26181206 | Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF). | Cell Death Dis | 2015/07/16 |
| 23519249 | MicroRNA miR-491-5p targeting both TP53 and Bcl-XL induces cell apoptosis in SW1990 pancreatic cancer cells through mitochondria mediated pathway. | Molecules | 2012/12/11 |
| 22751348 | MDR1-P-glycoprotein behaves as an oncofetal protein that promotes cell survival in gastric cancer cells. | Lab Invest | 2012/07/02 |
| 21325824 | Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cells. | Cell Physiol Biochem | 2011/02/11 |
| 24786901 | Differential expression of genes related to mitochondrial biogenesis and bioenergetics in fatigued prostate cancer men receiving external beam radiation therapy. | J Pain Symptom Manage | 2014/04/28 |
| 28418907 | BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma. | Oncotarget | 2017/01/09 |
| 27186678 | Biological characteristics of renal cancer cells after CTP-mediated cancer suppressor gene NPRL2 protein treatment. | Biol Chem | 2016/02/23 |
| 23519076 | PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage. | Cell Death Differ | 2013/03/22 |
| 27974663 | PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation. | Sci Transl Med | 2016/07/20 |
| 20590608 | Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells. | Br J Pharmacol | 2010/07/02 |
| 22791147 | Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells. | Biol Pharm Bull | 2012/07/14 |
| 28476895 | Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. | J Exp Med | 2017/05/05 |
| 23329180 | Targeting RET to induce medullary thyroid cancer cell apoptosis: an antagonistic interplay between PI3K/Akt and p38MAPK/caspase-8 pathways. | Apoptosis | 2013/01/19 |
| 25066322 | G226, a novel epipolythiodioxopiperazine derivative, induces autophagy and caspase-dependent apoptosis in human breast cancer cells in vitro. | Acta Pharmacol Sin | 2014/03/21 |
| 27198984 | Effect of PUFAs Oral Administration on the Amount of Apoptotic Caspases Enzymes in Gastric Cancer Patients Undergoing Chemotherapy. | Anticancer Agents Med Chem | 2015/08/09 |
| 23871247 | Sodium nitroprusside (SNP) sensitizes human gastric cancer cells to TRAIL-induced apoptosis. | Int Immunopharmacol | 2013/07/16 |
| 19799997 | Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation. | Cell Signal | 2009/09/30 |
| 23232551 | Ligation of CM1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with EGFR mutation. | Int J Oncol | 2012/12/07 |
| 23337979 | Newcastle disease virus Malaysian strain AF2240 induces apoptosis in MCF-7 human breast carcinoma cells at an early stage of the virus life cycle. | Int J Mol Med | 2013/01/15 |
| 23152563 | Suppressors of cytokine signaling promote Fas-induced apoptosis through downregulation of NF-κB and mitochondrial Bfl-1 in leukemic T cells. | J Immunol | 2012/11/14 |
| 25356873 | Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer. | Cell Death Dis | 2014/10/30 |
| 25829127 | N-Isopropylacrylamide-modified polyethylenimine-mediated p53 gene delivery to prevent the proliferation of cancer cells. | Colloids Surf B Biointerfaces | 2015/03/18 |
| 20551295 | Cellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells. | J Pharmacol Exp Ther | 2010/06/15 |
| 24632851 | Persistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell death. | PLoS One | 2014/03/14 |
| 23874836 | Silencing of Pokemon enhances caspase-dependent apoptosis via fas- and mitochondria-mediated pathways in hepatocellular carcinoma cells. | PLoS One | 2013/07/17 |
| 21850380 | Latent membrane protein 1 mediates the resistance of nasopharyngeal carcinoma cells to TRAIL-induced apoptosis by activation of the PI3K/Akt signaling pathway. | Oncol Rep | 2011/08/17 |
| 20637573 | Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways. | Phytomedicine | 2010/07/16 |
| 20086182 | The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck. | Cancer Prev Res (Phila) | 2010/01/19 |
| 22987598 | Proteomic analysis of mitochondria from infantile hemangioma endothelial cells treated with sodium morrhuate and its liposomal formulation. | J Biochem Mol Toxicol | 2012/09/19 |
| 24799381 | Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo. | Biotechnol J | 2014/04/10 |
| 23315858 | Association between gene polymorphism of manganese superoxide dismutase and prostate cancer risk. | J Biochem Mol Toxicol | 2013/01/11 |
| 26678158 | Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress. | Mitochondrion | 2015/12/08 |
| 19731237 | Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. | Hepatology | 2009/09/05 |
| 29695906 | Silica nanoparticle-induced oxidative stress and mitochondrial damage is followed by activation of intrinsic apoptosis pathway in glioblastoma cells. | Int J Nanomedicine | 2018/04/12 |
| 28414098 | Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells. | Free Radic Biol Med | 2017/04/14 |
| 30411198 | Fumonisin B | Mycotoxin Res | 2018/11/08 |
| 29233736 | Fumonisin B | Toxicon | 2017/12/09 |
| 24437375 | Factors associated with oxidative stress and cancer risk in the Breast and Prostate Cancer Cohort Consortium. | Free Radic Res | 2014/01/23 |
| 22341440 | Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. | Cell | 2011/08/27 |
| 21235219 | Chronic exposure to arsenic causes increased cell survival, DNA damage, and increased expression of mitochondrial transcription factor A (mtTFA) in human prostate epithelial cells. | Chem Res Toxicol | 2011/01/14 |
| 19847642 | Alcohol consumption and breast tumor mitochondrial DNA mutations. | Breast Cancer Res Treat | 2009/10/22 |
| 28368421 | Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR | Oncogene | 2017/04/03 |
| 23319113 | Alterations in mtDNA: a qualitative and quantitative study associated with cervical cancer development. | Gynecol Oncol | 2013/01/11 |
| 21175348 | SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells. | Radiat Res | 2010/11/08 |
| 23463417 | Mitochondrial modulation decreases the bortezomib-resistance in multiple myeloma cells. | Int J Cancer | 2013/04/04 |
| 21697181 | Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides. | Neuro Oncol | 2011/06/22 |
| 26359457 | Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma. | Cancer Res | 2015/09/10 |
| 19706356 | Functional polymorphism in manganese superoxide dismutase and antioxidant status: their interactions on the risk of cervical intraepithelial neoplasia and cervical cancer. | Gynecol Oncol | 2009/08/25 |
| 24055523 | Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD). | Biomaterials | 2013/09/19 |
| 27364630 | Anti-cancer efficacy of nonthermal plasma dissolved in a liquid, liquid plasma in heterogeneous cancer cells. | Sci Rep | 2016/07/01 |
| 24054763 | Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome. | Psychoneuroendocrinology | 2013/09/06 |
| 21150282 | Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts. | Cancer Biol Ther | 2011/02/15 |
| 26121691 | SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells. | PLoS One | 2015/06/29 |
| 26490979 | The roles of mitochondria in radiation-induced autophagic cell death in cervical cancer cells. | Tumour Biol | 2015/10/21 |
| 19687253 | Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. | J Cell Biol | 2009/08/17 |
| 22994704 | Bidirectional regulation of manganese superoxide dismutase (MnSOD) on the radiosensitivity of esophageal cancer cells. | Asian Pac J Cancer Prev | 2012/09/22 |
| 25220386 | Pro-oxidant effect of ALA is implicated in mitochondrial dysfunction of HepG2 cells. | Biochimie | 2014/09/08 |
| 25659582 | Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression. | Oncogene | 2015/02/09 |
| 26846100 | Manganese-superoxide dismutase (Mn-SOD) overexpression is a common event in colorectal cancers with mitochondrial microsatellite instability. | Tumour Biol | 2016/02/04 |
| 25529796 | Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria. | Am J Pathol | 2014/08/15 |
| 19647296 | Association between manganese superoxide dismutase gene polymorphism and risk of prostate cancer: a meta-analysis. | Urology | 2009/07/31 |
| 26906415 | Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion. | J Cell Sci | 2016/02/18 |
| 25684475 | Manganese superoxide dismutase (MnSOD Val-9Ala) gene polymorphism and susceptibility to gastric cancer. | Asian Pac J Cancer Prev | 2015/02/17 |
| 21203553 | miR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes. | PLoS One | 2010/12/22 |
| 22130631 | Oxidative stress-related enzyme gene polymorphisms and susceptibility to breast cancer in non-smoking, non-alcohol-consuming Taiwanese women: a case-control study. | Ann Clin Biochem | 2011/11/30 |
| 23259779 | Expression of NRF2 and NRF2-modulated genes in peripheral blood leukocytes of bladder cancer males. | Neoplasma | 2012/12/25 |
| 23886214 | Predominant genotypes and alleles of two functional polymorphisms in the manganese superoxide dismutase gene are not associated with Thai cervical or breast cancer. | Asian Pac J Cancer Prev | 2013/07/27 |
| 27221200 | Reduced SOD2 expression is associated with mortality of hepatocellular carcinoma patients in a mutant p53-dependent manner. | Aging (Albany NY) | 2016/03/30 |
| 20151177 | Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes. | Biometals | 2010/02/12 |
| 24975047 | Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis. | J Cell Mol Med | 2014/06/28 |
| 27959410 | Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells. | Mol Med Rep | 2016/12/09 |
| 26112407 | Phosphatidylinositol Induces Caspase-Independent Apoptosis of Malignant Pleural Mesothelioma Cells by Accumulating AIF in the Nucleus. | Cell Physiol Biochem | 2015/06/18 |
| 26152738 | Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models. | Clin Cancer Res | 2015/07/07 |
| 27464624 | Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors. | BMC Cancer | 2016/07/27 |
| 23158838 | 3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis. | World J Surg Oncol | 2012/11/16 |
| 19895686 | A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB. | BMC Cancer | 2009/11/06 |
| 30680959 | Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma. | Mol Genet Genomic Med | 2019/01/24 |
| 24236567 | Signalling pathways in succinate dehydrogenase B-associated renal carcinoma. | Histopathology | 2013/11/18 |
| 28204537 | Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes. | Hum Mol Genet | 2016/11/16 |
| 27847310 | Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors. | Metab Eng | 2016/11/12 |
| 28324028 | A Duodenal SDH-Deficient Gastrointestinal Stromal Tumor in a Patient With a Germline SDHB Mutation. | J Clin Endocrinol Metab | 2017/01/18 |
| 20484225 | SDHA is a tumor suppressor gene causing paraganglioma. | Hum Mol Genet | 2010/05/18 |
| 28423651 | Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors. | Oncotarget | 2016/11/02 |
| 24133624 | Gene expression of the IGF pathway family distinguishes subsets of gastrointestinal stromal tumors wild type for KIT and PDGFRA. | Cancer Med | 2013/02/03 |
| 24781345 | Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies. | Fam Cancer | 2014/05/01 |
| 24526120 | Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites. | Cell Cycle | 2014/02/03 |
| 20398431 | Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma. | BMC Cancer | 2010/04/19 |
| 26722403 | A novel germline mutation in SDHA identified in a rare case of gastrointestinal stromal tumor complicated with renal cell carcinoma. | Int J Clin Exp Pathol | 2015/10/01 |
| 22323561 | Mitochondrial function and content in pheochromocytoma/paraganglioma of succinate dehydrogenase mutation carriers. | Endocr Relat Cancer | 2012/05/03 |
| 23282968 | Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation. | Am J Surg Pathol | 2013/01/04 |
| 23550148 | Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor. | Cancer Discov | 2013/04/02 |
| 21059645 | Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II. | J Biol Chem | 2010/11/08 |
| 23555188 | Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas. | Neoplasia | 2012/12/17 |
| 23252569 | Expression of IGF-1 receptor in KIT/PDGF receptor-α wild-type gastrointestinal stromal tumors with succinate dehydrogenase complex dysfunction. | Future Oncol | 2012/12/21 |
| 28099845 | Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1. | Cell Rep | 2016/06/30 |
| 29235326 | Effect of hypoxia on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells. | Ukr Biochem J | 2017/12/14 |
| 24781757 | SDHA mutations causing a multisystem mitochondrial disease: novel mutations and genetic overlap with hereditary tumors. | Eur J Hum Genet | 2014/04/30 |
| 23645213 | Reduced succinate dehydrogenase B expression is associated with growth and de-differentiation of colorectal cancer cells. | Tumour Biol | 2013/05/05 |
| 25808178 | Carney triad, SDH-deficient tumors, and Sdhb+/- mice share abnormal mitochondria. | Endocr Relat Cancer | 2015/03/25 |
| 22170724 | Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH? | J Clin Endocrinol Metab | 2011/12/14 |
| 22889736 | Succinate dehydrogenase (SDHx) mutations in pituitary tumors: could this be a new role for mitochondrial complex II and/or Krebs cycle defects? | Endocr Relat Cancer | 2012/10/30 |
| 21173220 | Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. | Proc Natl Acad Sci U S A | 2010/12/20 |
| 20379037 | A large deletion in the succinate dehydrogenase B gene (SDHB) in a Japanese patient with abdominal paraganglioma and concomitant metastasis. | Endocr J | 2010/04/06 |
| 22972948 | Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency. | J Med Genet | 2012/09/14 |
| 25328978 | Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeast. | Antioxid Redox Signal | 2015/01/13 |
| 23723300 | Genotype-specific abnormalities in mitochondrial function associate with distinct profiles of energy metabolism and catecholamine content in pheochromocytoma and paraganglioma. | Clin Cancer Res | 2013/05/30 |
| 25827535 | Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma. | Hum Pathol | 2015/03/11 |
| 22252650 | Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. | Mol Pharmacol | 2012/01/17 |
| 24633417 | Delivery of a monomeric p53 subdomain with mitochondrial targeting signals from pro-apoptotic Bak or Bax. | Pharm Res | 2014/03/15 |
| 30404157 | The Mitochondrial Genes | Int J Mol Sci | 2018/11/06 |
| 22414765 | Bak deficiency inhibits liver carcinogenesis: a causal link between apoptosis and carcinogenesis. | J Hepatol | 2012/03/10 |
| 20056675 | Survivin and Smac gene expressions but not livin are predictors of prognosis in non-small cell lung cancer patients treated with adjuvant chemotherapy following surgery. | Jpn J Clin Oncol | 2010/01/07 |
| 27166192 | Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy. | Oncotarget | 2015/12/22 |
| 27267809 | Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked. | Cancer Lett | 2016/06/03 |
| 26152356 | Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner. | Neoplasia | 2015/04/08 |
| 20683954 | A smac mimetic reduces TNF related apoptosis inducing ligand (TRAIL)-induced invasion and metastasis of cholangiocarcinoma cells. | Hepatology | 2010/08/05 |
| 21760855 | Progesterone receptor-B induction of BIRC3 protects endometrial cancer cells from AP1-59-mediated apoptosis. | Horm Cancer | 2011/07/16 |
| 29396267 | A New Role for the Mitochondrial Pro-apoptotic Protein SMAC/Diablo in Phospholipid Synthesis Associated with Tumorigenesis. | Mol Ther | 2017/12/24 |
| 28440486 | Synergistic antitumor effects of CDK inhibitor SNS‑032 and an oncolytic adenovirus co‑expressing TRAIL and Smac in pancreatic cancer. | Mol Med Rep | 2017/04/12 |
| 29700304 | Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors. | Nat Commun | 2018/04/26 |
| 21543344 | Lung-cancer chemoprevention by induction of synthetic lethality in mutant KRAS premalignant cells in vitro and in vivo. | Cancer Prev Res (Phila) | 2011/05/06 |
| 25661347 | Smac is another pathway in the anti-tumour activity of Trichosanthin and reverses Trichosanthin resistance in CaSki cervical cancer cells. | Biomed Pharmacother | 2014/11/11 |
| 22751125 | An apoptosis-independent role of SMAC in tumor suppression. | Oncogene | 2012/07/02 |
| 22236877 | PERP gene therapy attenuates lung cancer xenograft via inducing apoptosis and suppressing VEGF. | Cancer Biol Ther | 2011/12/15 |
| 27843028 | Association of a TFAM haplotype with aggressive prostate cancer in overweight or obese Mexican Mestizo men. | Urol Oncol | 2016/11/11 |
| 26530043 | Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression. | J Cell Physiol | 2015/11/24 |
| 28438434 | Connective tissue growth factor decreases mitochondrial metabolism through ubiquitin-mediated degradation of mitochondrial transcription factor A in oral squamous cell carcinoma. | J Formos Med Assoc | 2017/04/21 |
| 24496235 | Stat3 binds to mtDNA and regulates mitochondrial gene expression in keratinocytes. | J Invest Dermatol | 2014/02/04 |
| 24367550 | Expression and methylation of mitochondrial transcription factor a in chronic obstructive pulmonary disease patients with lung cancer. | PLoS One | 2013/12/18 |
| 23104437 | An analogue of resveratrol HS-1793 exhibits anticancer activity against MCF-7 cells via inhibition of mitochondrial biogenesis gene expression. | Mol Cells | 2012/10/18 |
| 30157478 | Down-Regulation of MicroRNA-214 Contributed to the Enhanced Mitochondrial Transcription Factor A and Inhibited Proliferation of Colorectal Cancer Cells. | Cell Physiol Biochem | 2018/08/29 |
| 27043285 | Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. | J Clin Invest | 2016/04/04 |
| 28126676 | MiR-199a-3p enhances breast cancer cell sensitivity to cisplatin by downregulating TFAM (TFAM). | Biomed Pharmacother | 2017/01/23 |
| 25833036 | Distribution of mitochondrial DNA nucleoids inside the linear tubules vs. bulk parts of mitochondrial network as visualized by 4Pi microscopy. | J Bioenerg Biomembr | 2015/04/02 |
| 29259235 | Transcriptomic analysis of mitochondrial TFAM depletion changing cell morphology and proliferation. | Sci Rep | 2017/12/19 |
| 21453679 | Human mitochondrial transcription factor A functions in both nuclei and mitochondria and regulates cancer cell growth. | Biochem Biophys Res Commun | 2011/03/29 |
| 27079936 | Decreased mitochondrial copy numbers in oral squamous cell carcinoma. | Head Neck | 2016/04/15 |
| 22865514 | Downregulation of nuclear respiratory factor-1 contributes to mitochondrial events induced by benzo(a)pyrene. | Environ Toxicol | 2012/08/06 |
| 23172368 | Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. | Cell Cycle | 2012/11/21 |
| 22129993 | Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection. | Cell Cycle | 2011/12/01 |
| 20643228 | Mitochondrial DNA depletion and its correlation with TFAM, TFB1M, TFB2M and POLG in human diffusely infiltrating astrocytomas. | Mitochondrion | 2010/07/17 |
| 28713989 | Effects of proton beam irradiation on mitochondrial biogenesis in a human colorectal adenocarcinoma cell line. | Int J Oncol | 2017/07/05 |
| 25243473 | Expression of mitochondrial regulators PGC1α and TFAM as putative markers of subtype and chemoresistance in epithelial ovarian carcinoma. | PLoS One | 2014/09/22 |
| 26208486 | Chronic oxidative stress causes estrogen-independent aggressive phenotype, and epigenetic inactivation of estrogen receptor alpha in MCF-7 breast cancer cells. | Breast Cancer Res Treat | 2015/07/26 |
| 27231905 | Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma. | Int J Mol Sci | 2016/05/25 |
| 23109849 | High mitochondrial DNA copy number and bioenergetic function are associated with tumor invasion of esophageal squamous cell carcinoma cell lines. | Int J Mol Sci | 2012/09/10 |
| 27206316 | Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. | Cell Death Differ | 2016/05/20 |
| 25108120 | The combination of strong immunohistochemical mtTFA expression and a high survivin index predicts a shorter disease-specific survival in pancreatic ductal adenocarcinoma. | Histol Histopathol | 2014/08/08 |
| 21514422 | Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers. | Am J Pathol | 2009/11/27 |
| 24684598 | microRNA-200a inhibits cell proliferation by targeting mitochondrial transcription factor A in breast cancer. | DNA Cell Biol | 2014/03/31 |
| 23720198 | ERRα metabolic nuclear receptor controls growth of colon cancer cells. | Carcinogenesis | 2013/05/29 |
| 27862857 | Casticin induced apoptotic cell death and altered associated gene expression in human colon cancer colo 205 cells. | Environ Toxicol | 2016/11/14 |
| 23840429 | Chemotherapeutic Potential of 2-[Piperidinoethoxyphenyl]-3-Phenyl-2H-Benzo(b)pyran in Estrogen Receptor- Negative Breast Cancer Cells: Action via Prevention of EGFR Activation and Combined Inhibition of PI-3-K/Akt/FOXO and MEK/Erk/AP-1 Pathways. | PLoS One | 2013/06/19 |
| 27755961 | Marrubium vulgare ethanolic extract induces proliferation block, apoptosis, and cytoprotective autophagy in cancer cells in vitro. | Cell Mol Biol (Noisy-le-grand) | 2016/09/30 |
| 30060617 | Manzamine A Exerts Anticancer Activity against Human Colorectal Cancer Cells. | Mar Drugs | 2018/07/29 |
| 23139833 | L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro. | PLoS One | 2012/11/05 |
| 24583924 | High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma. | Carcinogenesis | 2014/02/28 |
| 24182354 | The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin. | BMC Cancer | 2013/11/04 |
| 28423695 | NDRG2 promotes adriamycin sensitivity through a Bad/p53 complex at the mitochondria in breast cancer. | Oncotarget | 2016/12/05 |
| 24525728 | Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer. | Cell Death Dis | 2014/02/13 |
| 23014529 | TRAIL and Noxa are selectively upregulated in prostate cancer cells downstream of the RIG-I/MAVS signaling pathway by nonreplicating Sendai virus particles. | Clin Cancer Res | 2012/09/26 |
| 21034493 | Gene expression analysis of cell death induction by taurolidine in different malignant cell lines. | BMC Cancer | 2010/10/30 |
| 24746213 | Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer. | Hum Pathol | 2014/01/23 |
| 29683756 | De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment. | Free Radic Res | 2018/04/23 |
| 23800187 | Role of SIRT3 in the regulation of redox balance during oral carcinogenesis. | Mol Cancer | 2013/06/23 |
| 22850421 | Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. | Cancer Res | 2012/07/31 |
| 28536275 | SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth. | Cancer Res | 2017/05/23 |
| 20129246 | SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. | Cancer Cell | 2009/02/20 |
| 24909164 | SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. | Oncogene | 2014/06/09 |
| 21397863 | SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. | Cancer Cell | 2010/10/22 |
| 26785117 | Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study. | PLoS One | 2016/01/19 |
| 27114304 | Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma. | Biochem Biophys Res Commun | 2016/04/23 |
| 26577410 | Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity. | Biochem Biophys Res Commun | 2015/11/11 |
| 24042441 | SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2. | Int J Oncol | 2013/09/16 |
| 19623659 | Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. | Int J Cancer | 2009/07/23 |
| 21268068 | Suppression of the proinflammatory response of metastatic melanoma cells increases TRAIL-induced apoptosis. | J Cell Biochem | 2011/01/27 |
| 26017042 | Mitochondrial intergenic COII/tRNA(Lys) 9-bp deletion, a biomarker for hepatocellular carcinoma? | Mitochondrial DNA A DNA Mapp Seq Anal | 2015/05/28 |
| 24867695 | Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation. | Br J Cancer | 2014/05/27 |
| 26238294 | Impaired mitochondrial protein synthesis in head and neck squamous cell carcinoma. | Mitochondrion | 2015/08/01 |
| 21129724 | Somatic mutations throughout the entire mitochondrial genome are associated with elevated PSA levels in prostate cancer patients. | Am J Hum Genet | 2010/08/09 |
| 29310608 | Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway. | BMC Cancer | 2018/01/08 |
| 28732079 | LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma. | PLoS Pathog | 2017/07/21 |
| 23292149 | Creating a tumor-resistant microenvironment: cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo. | Cell Cycle | 2012/02/01 |
| 23696597 | Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells. | Endocr Relat Cancer | 2013/05/21 |
| 23444869 | Characterization and prognostic significance of mitochondrial DNA variations in acute myeloid leukemia. | Eur J Haematol | 2013/03/22 |
| 23599153 | Oxidative DNA damage drives carcinogenesis in MUTYH-associated-polyposis by specific mutations of mitochondrial and MAPK genes. | Mod Pathol | 2013/04/19 |
| 26138249 | Mitochondrial variants in MT-CO2 and D-loop instability are involved in MUTYH-associated polyposis. | J Mol Med (Berl) | 2015/07/03 |
| 27333991 | Expression of mitochondrial genes MT-ND1, MT-ND6, MT-CYB, MT-COI, MT-ATP6, and 12S/MT-RNR1 in colorectal adenopolyps. | Tumour Biol | 2016/06/22 |
| 29414393 | Complete sequence of the ATP6 and ND3 mitochondrial genes in breast cancer tissue of postmenopausal women with different body mass indexes. | Ann Diagn Pathol | 2017/09/10 |
| 26406445 | Targeted Sequencing of the Mitochondrial Genome of Women at High Risk of Breast Cancer without Detectable Mutations in BRCA1/2. | PLoS One | 2015/09/25 |
| 25110199 | Novel mitochondrial mutations in the ATP6 and ATP8 genes in patients with breast cancer. | Mol Med Rep | 2014/08/08 |
| 22542792 | Mutations in the mitochondrial ATPase6 gene are frequent in human osteosarcoma. | Exp Mol Pathol | 2012/04/19 |
| 22925728 | Heteroplasmic mutations of the mitochondrial genome cause paradoxical effects on mitochondrial functions. | FASEB J | 2012/08/27 |
| 21334307 | Mutational hotspots in the mitochondrial genome of lung cancer. | Biochem Biophys Res Commun | 2011/02/18 |
| 28986220 | Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast. | Biochim Biophys Acta Mol Cell Res | 2017/10/03 |
| 27083309 | Yeast models of mutations in the mitochondrial ATP6 gene found in human cancer cells. | Mitochondrion | 2016/04/12 |
| 27187822 | Genetic variants in ATP6 and ND3 mitochondrial genes are not associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity. | Aging Male | 2016/05/17 |
| 27055661 | Genome-wide mitochondrial DNA sequence variations and lower expression of OXPHOS genes predict mitochondrial dysfunction in oral cancer tissue. | Tumour Biol | 2016/04/07 |
| 25896597 | Mitochondrial complex I and V gene polymorphisms associated with breast cancer in mizo-mongloid population. | Breast Cancer | 2015/04/21 |
| 27121313 | Correlational study on mitochondrial DNA mutations as potential risk factors in breast cancer. | Oncotarget | 2016/01/01 |
| 20426663 | Mitochondrial gene expression changes in normal and mitochondrial mutant cells after exposure to ionizing radiation. | Radiat Res | 2010/04/30 |
| 22533676 | Detection of mitochondrial DNA mutations in nonmuscle invasive bladder cancer. | Genet Test Mol Biomarkers | 2012/04/25 |
| 21612400 | Mutational hotspots in the mitochondrial D-loop region of cancerous and precancerous colorectal lesions in Egyptian patients. | DNA Cell Biol | 2011/05/25 |
| 19487983 | Association of mitochondrial allele 4216C with increased risk for sepsis-related organ dysfunction and shock after burn injury. | Shock | 2009/06/03 |
| 24643264 | Analysis of the mitochondrial proteome of cybrid cells harbouring a truncative mitochondrial DNA mutation in respiratory complex I. | Mol Biosyst | 2014/03/18 |
| 25909222 | Enhanced tumorigenicity by mitochondrial DNA mild mutations. | Oncotarget | 2015/01/14 |
| 20006738 | Somatic mutations of mitochondrial genome in hepatocellular carcinoma. | Mitochondrion | 2009/12/16 |
| 24163135 | Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment. | Hum Mol Genet | 2013/10/24 |
| 21329181 | Mutations in mitochondrial NADH dehydrogenase subunit 1 (mtND1) gene in colorectal carcinoma. | Malays J Pathol | 2011/02/19 |
| 23195224 | Anti-mitochondrial therapy in human breast cancer multi-cellular spheroids. | Biochim Biophys Acta | 2012/11/27 |
| 28423551 | Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis. | Oncotarget | 2016/12/08 |
| 30622675 | Oxid Med Cell Longev | 2018/12/09 | |
| 24414975 | Mitochondrial NADH dehydrogenase polymorphisms are associated with breast cancer in Poland. | J Appl Genet | 2014/01/11 |
| 27941608 | Mutations in the Mitochondrial ND1 Gene Are Associated with Postoperative Prognosis of Localized Renal Cell Carcinoma. | Int J Mol Sci | 2016/12/07 |
| 21926107 | Two distinct thyroid tumours in a patient with Cowden syndrome carrying both a 10q23 and a mitochondrial DNA germline deletion. | J Med Genet | 2011/09/16 |
| 22321727 | Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer. | FASEB J | 2012/02/09 |
| 25658204 | Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors. | Mol Cell | 2014/05/19 |
| 26114658 | A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. | Autophagy | 2015/06/27 |
| 22595283 | Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentation. | Int J Biochem Cell Biol | 2012/05/15 |
| 21724752 | Novel role of androgens in mitochondrial fission and apoptosis. | Mol Cancer Res | 2011/07/01 |
| 28435473 | Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1. | Theranostics | 2017/03/23 |
| 24681957 | The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes. | Oncogene | 2014/03/31 |
| 28981113 | Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission. | Cell Death Dis | 2017/10/05 |
| 26812016 | The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis. | Dev Cell | 2015/07/03 |
| 28818497 | Drp1 regulates mitochondrial morphology and cell proliferation in cutaneous squamous cell carcinoma. | J Dermatol Sci | 2017/08/05 |
| 24397920 | Prolonged exposure to (R)-bicalutamide generates a LNCaP subclone with alteration of mitochondrial genome. | Mol Cell Endocrinol | 2013/10/25 |
| 30471409 | Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway. | Pharmacol Res | 2018/11/22 |
| 20885442 | miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. | Cell Death Differ | 2010/10/01 |
| 24465590 | A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction. | PLoS One | 2014/01/20 |
| 23418303 | The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering. | Hum Mol Genet | 2013/02/14 |
| 25822260 | Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration. | PLoS One | 2015/03/30 |
| 27184078 | Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion. | Mol Cell | 2016/05/12 |
| 22824300 | Mitochondrial dynamics is affected by 17β-estradiol in the MCF-7 breast cancer cell line. Effects on fusion and fission related genes. | Int J Biochem Cell Biol | 2012/07/21 |
| 24339771 | Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis. | PLoS Pathog | 2013/12/05 |
| 23797661 | Anti-tumor effects of Mfn2 in gastric cancer. | Int J Mol Sci | 2013/06/24 |
| 27389277 | Clinical significance of mitofusin-2 and its signaling pathways in hepatocellular carcinoma. | World J Surg Oncol | 2016/07/07 |
| 22510407 | Hepatitis B virus X protein inhibits p53-mediated upregulation of mitofusin-2 in hepatocellular carcinoma cells. | Biochem Biophys Res Commun | 2012/04/09 |
| 20803103 | Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma. | Med Oncol | 2010/08/28 |
| 25998032 | Deregulation of energetic metabolism in the clear cell renal cell carcinoma: A multiple pathway analysis based on microarray profiling. | Int J Oncol | 2015/05/19 |
| 19690031 | Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines. | J Nucl Med | 2009/08/18 |
| 25819414 | Glucose metabolism provide distinct prosurvival benefits to non-small cell lung carcinomas. | Biochem Biophys Res Commun | 2015/03/26 |
| 25808624 | The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells. | J Cell Biochem | 2014/07/28 |
| 22382780 | 3-Bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective "small molecule" anti-cancer agent taken from labside to bedside: introduction to a special issue. | J Bioenerg Biomembr | 2012/03/03 |
| 26182367 | Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II. | Biosci Rep | 2015/04/24 |
| 26378042 | HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer. | Oncotarget | 2015/05/05 |
| 28105937 | Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells. | BMC Genet | 2016/12/22 |
| 23799003 | Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism. | PLoS One | 2013/06/14 |
| 24704448 | mTOR-targeted therapy: differential perturbation to mitochondrial membrane potential and permeability transition pore plays a role in therapeutic response. | Biochem Biophys Res Commun | 2014/04/02 |
| 29202474 | ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming. | J Clin Invest | 2017/11/27 |
| 28720665 | Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer-Predisposing Mutations in Pheochromocytomas and Paragangliomas. | Clin Cancer Res | 2017/07/18 |
| 24995286 | Potential mitochondrial isocitrate dehydrogenase R140Q mutant inhibitor from traditional Chinese medicine against cancers. | Biomed Res Int | 2014/06/05 |
| 27856334 | Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein. | Metab Eng | 2016/11/14 |
| 26007236 | Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. | Int J Biochem Cell Biol | 2015/05/22 |
| 24252742 | Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG. | Acta Neuropathol Commun | 2013/05/29 |
| 24755473 | IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. | Cancer Res | 2014/04/22 |
| 21213123 | High-throughput immunohistochemical profiling of primary brain tumors and non-neoplastic systemic organs with a specific antibody against the mutant isocitrate dehydrogenase 1 R132H protein. | Brain Tumor Pathol | 2011/01/07 |
| 27935156 | CASP9 germline mutation in a family with multiple brain tumors. | Brain Pathol | 2017/04/17 |
| 25811801 | D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH. | Cell Death Dis | 2015/03/26 |
| 22442146 | Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. | J Biol Chem | 2012/03/22 |
| 26901439 | Mitochondrial DNA copy number variation across human cancers. | Elife | 2016/02/22 |
| 20552226 | Evaluating mitochondrial DNA in patients with breast cancer and benign breast disease. | J Cancer Res Clin Oncol | 2010/06/16 |
| 28502718 | Mitochondrial ND5 mutation mediated elevated ROS regulates apoptotic pathway epigenetically in a P53 dependent manner for generating pro-cancerous phenotypes. | Mitochondrion | 2017/05/11 |
| 29378198 | Mutations in Mitochondrial DNA From Pancreatic Ductal Adenocarcinomas Associate With Survival Times of Patients and Accumulate as Tumors Progress. | Gastroenterology | 2018/03/29 |
| 26305705 | Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing. | PLoS One | 2015/08/25 |
| 26162681 | Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells. | Proc Natl Acad Sci U S A | 2015/07/10 |
| 24253185 | Detection of mitochondrial DNA mutations by high-throughput sequencing in the blood of breast cancer patients. | Int J Mol Med | 2013/11/19 |
| 22815783 | Mitochondrial genome variations in advanced stage endometriosis: a study in South Indian population. | PLoS One | 2012/07/17 |
| 22174369 | Mitochondrial DNA sequence variation and risk of pancreatic cancer. | Cancer Res | 2011/12/15 |
| 25217637 | Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy. | J Biol Chem | 2014/09/12 |
| 23885119 | SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria. | Mol Biol Cell | 2013/07/24 |
| 26631731 | Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria. | J Biol Chem | 2015/12/02 |
| 20971498 | PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells. | Hum Pathol | 2010/10/23 |
| 22319455 | The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity. | PLoS Genet | 2012/02/02 |
| 26354775 | Dysregulation of Parkin-mediated mitophagy in thyroid Hürthle cell tumors. | Carcinogenesis | 2015/09/08 |
| 24471704 | Recurrent and fatal akinetic crisis in genetic-mitochondrial parkinsonisms. | Eur J Neurol | 2014/01/28 |
| 24606795 | Mitochondrial biogenesis: pharmacological approaches. | Curr Pharm Des | 2014/03/11 |
| 26304929 | Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. | Oncotarget | 2015/04/20 |
| 22634395 | Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells. | Free Radic Biol Med | 2012/05/25 |
| 29501488 | Overexpression of apoptosis-inducing factor mitochondrion-associated 1 (AIFM1) induces apoptosis by promoting the transcription of caspase3 and DRAM in hepatoma cells. | Biochem Biophys Res Commun | 2018/03/01 |
| 23646141 | Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. | PLoS One | 2013/04/30 |
| 19948822 | Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. | Am J Pathol | 2009/11/30 |
| 22116673 | Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells. | Proteomics | 2011/11/23 |
| 23139614 | Correlation between mitochondrial TRAP-1 expression and lymph node metastasis in colorectal cancer. | World J Gastroenterol | 2011/11/07 |
| 20860785 | Malignant transformation in a defined genetic background: proteome changes displayed by 2D-PAGE. | Mol Cancer | 2010/09/22 |
| 26100518 | N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting. | J Biomed Sci | 2015/06/24 |
| 19920115 | Involvement of mitochondrial DNA sequence variations and respiratory activity in late complications following radiotherapy. | Clin Cancer Res | 2009/11/17 |
| 30275759 | Mitochondrial NADH Dehydrogenase Subunit 3 ( | Int J Med Sci | 2018/08/10 |
| 25952970 | Bone metastasis in prostate cancer: Recurring mitochondrial DNA mutation reveals selective pressure exerted by the bone microenvironment. | Bone | 2015/05/05 |
| 19266278 | Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland. | Breast Cancer Res Treat | 2009/03/06 |
| 26179426 | Quantitative detection of circulating tumor-derived mitochondrial NADH subunit variants as a potential prognostic biomarker for oral cancer. | Int J Oncol | 2015/07/15 |
| 23993954 | A mitochondrial DNA variant 10398G>A in breast cancer among South Indians: an original study with meta-analysis. | Mitochondrion | 2013/08/29 |
| 26782384 | Mitochondrial ND3 G10398A mutation: a biomarker for breast cancer. | Genet Mol Res | 2015/12/21 |
| 26886430 | Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01. | PLoS One | 2016/02/17 |
| 26298722 | MiR-944 functions as a novel oncogene and regulates the chemoresistance in breast cancer. | Tumour Biol | 2015/08/23 |
| 22684298 | Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. | Cell Cycle | 2012/06/15 |
| 26232272 | Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. | EMBO Rep | 2015/07/31 |
| 19957303 | Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli. | J Cell Physiol | 2009/12/04 |
| 25391657 | A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α. | J Biol Chem | 2014/11/12 |
| 27035659 | Oncogene-mediated tumor transformation sensitizes cells to autophagy induction. | Oncol Rep | 2016/03/23 |
| 25232961 | A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. | PLoS One | 2014/09/18 |
| 25333947 | Expression profiling of mitochondrial voltage-dependent anion channel-1 associated genes predicts recurrence-free survival in human carcinomas. | PLoS One | 2014/10/15 |
| 26409771 | Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway. | Free Radic Biol Med | 2015/09/26 |
| 21297950 | Gene expression meta-analysis identifies VDAC1 as a predictor of poor outcome in early stage non-small cell lung cancer. | PLoS One | 2011/01/31 |
| 29596470 | Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation. | PLoS One | 2018/03/29 |
| 27589771 | Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial Activity, and Cell Cycle Genes on HT-29 Colon Adenocarcinoma Cells. | Mar Drugs | 2016/08/31 |
| 26716410 | Clinical implication of voltage-dependent anion channel 1 in uterine cervical cancer and its action on cervical cancer cells. | Oncotarget | 2015/06/23 |
| 21181232 | The curcuminoid CLEFMA selectively induces cell death in H441 lung adenocarcinoma cells via oxidative stress. | Invest New Drugs | 2010/12/22 |
| 30261500 | Catalase Enhances Viability of Human Chondrocytes in Culture by Reducing Reactive Oxygen Species and Counteracting Tumor Necrosis Factor-α-Induced Apoptosis. | Cell Physiol Biochem | 2018/09/27 |
| 21605374 | Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention? | BMC Med | 2011/05/23 |
| 19609211 | Mitochondrial DNA depletion promotes impaired oxidative status and adaptive resistance to apoptosis in T47D breast cancer cells. | Eur J Cancer Prev | 2009/07/18 |
| 24535002 | Selenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration, enhanced apoptosis and Se-Cu bonding. | J Biol Inorg Chem | 2014/02/15 |
| 19788937 | Mitochondrial copy number and risk of breast cancer: a pilot study. | Mitochondrion | 2009/09/27 |
| 29293500 | PARP10 (ARTD10) modulates mitochondrial function. | PLoS One | 2018/01/02 |
| 23500467 | Silencing of mitochondrial NADP(+)-dependent isocitrate dehydrogenase gene enhances glioma radiosensitivity. | Biochem Biophys Res Commun | 2013/03/13 |
| 20088709 | Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase gene enhances selenite-induced apoptosis. | Free Radic Res | 2010/01/22 |
| 23561848 | Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria. | Am J Hum Genet | 2012/12/11 |
| 28457473 | Polymorphisms in POLG were associated with the prognosis and mtDNA content in hepatocellular carcinoma patients. | Bull Cancer | 2017/04/28 |
| 26317126 | Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer. | Acta Biochim Pol | 2015/08/28 |
| 29158291 | RAD51C/XRCC3 Facilitates Mitochondrial DNA Replication and Maintains Integrity of the Mitochondrial Genome. | Mol Cell Biol | 2018/01/16 |
| 29341116 | Rare missense mutations in RECQL and POLG associate with inherited predisposition to breast cancer. | Int J Cancer | 2018/01/31 |
| 22684821 | Germline variants of base excision repair genes and breast cancer: A polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk. | Int J Cancer | 2012/06/26 |
| 22276120 | CAG repeat variants in the POLG1 gene encoding mtDNA polymerase-gamma and risk of breast cancer in African-American women. | PLoS One | 2012/01/20 |
| 26468652 | Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties. | PLoS One | 2015/10/15 |
| 19629138 | Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis. | J Hum Genet | 2009/07/24 |
| 26980435 | Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4. | J Exp Clin Cancer Res | 2016/03/16 |
| 25490448 | Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer. | Cancer Cell | 2014/01/30 |
| 22867999 | A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer. | Cancer Genet | 2011/10/21 |
| 19963135 | UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. | Cancer Genet Cytogenet | 2009/07/29 |
| 24625422 | Hereditary leiomyomatosis and renal cell carcinoma (HLRCC): a rapid autopsy report of metastatic renal cell carcinoma. | Am J Surg Pathol | 2014/03/15 |
| 20231875 | Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response. | PLoS Biol | 2010/03/09 |
| 20660115 | Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. | Hum Mol Genet | 2010/07/21 |
| 23203078 | Protein profiling of blood samples from patients with hereditary leiomyomatosis and renal cell cancer by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. | Int J Mol Sci | 2012/11/08 |
| 26682947 | Plasma Mitochondrial DNA--a Novel DAMP in Pediatric Sepsis. | Shock | 2015/12/20 |
| 27217714 | Association of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans. | Mol Vis | 2016/05/16 |
| 21389643 | Mitochondrial DNA alterations in colorectal cancer cell lines. | J Nippon Med Sch | 2011/03/11 |
| 23509693 | An inherited heteroplasmic mutation in mitochondrial gene COI in a patient with prostate cancer alters reactive oxygen, reactive nitrogen and proliferation. | Biomed Res Int | 2012/12/27 |
| 29309924 | Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects. | Biochim Biophys Acta Mol Basis Dis | 2018/01/05 |
| 24812152 | Identification of novel genes involved in gastric carcinogenesis by suppression subtractive hybridization. | Hum Exp Toxicol | 2014/05/08 |
| 23840896 | The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration. | PLoS One | 2013/07/01 |
| 28349827 | Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway. | Tumour Biol | 2017/03/29 |
| 28886081 | Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1α-dependent and -independent mechanism. | PLoS One | 2017/09/08 |
| 27582538 | TP53 mutation hits energy metabolism and increases glycolysis in breast cancer. | Oncotarget | 2016/05/24 |
| 27626669 | KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis. | Cell Rep | 2016/02/10 |
| 28827059 | Enhanced aerobic glycolysis of nasopharyngeal carcinoma cells by Epstein-Barr virus latent membrane protein 1. | Exp Cell Res | 2017/08/04 |
| 29117193 | Immunohistochemical analysis of PDK1, PHD3 and HIF-1α expression defines the hypoxic status of neuroblastoma tumors. | PLoS One | 2017/11/08 |
| 24825347 | Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. | EMBO J | 2014/05/13 |
| 26351876 | Targeted inhibition of mitochondrial Hsp90 induces mitochondrial elongation in Hep3B hepatocellular carcinoma cells undergoing apoptosis by increasing the ROS level. | Int J Oncol | 2015/09/07 |
| 28533128 | Polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation in an in vitro model of carcinogenesis. | Food Chem Toxicol | 2017/05/19 |
| 26148070 | Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression. | PLoS One | 2015/07/06 |
| 21364658 | Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediate-grade primary breast cancer. | Cell Death Dis | 2010/07/15 |
| 24393106 | Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. | Antioxid Redox Signal | 2014/02/18 |
| 30664764 | Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle. | Nat Immunol | 2019/01/21 |
| 27478826 | Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes. | Biomed Res Int | 2016/07/10 |
| 21935467 | Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. | PLoS One | 2011/09/15 |
| 21054343 | Phosphatidylinositol 3-kinase affects mitochondrial function in part through inducing peroxisome proliferator-activated receptor γ coactivator-1β expression. | Br J Pharmacol | 2010/11/09 |
| 25188891 | Metabolic markers and HSP60 in chemonaive serous solid ovarian cancer versus ascites. | Int J Gynecol Cancer | 2014/09/05 |
| 23603840 | Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene. | Oncotarget | 2013/04/23 |
| 25107643 | Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus. | Cancer Lett | 2014/08/10 |
| 20714864 | MCM3AP, a novel HBV integration site in hepatocellular carcinoma and its implication in hepatocarcinogenesis. | J Huazhong Univ Sci Technolog Med Sci | 2010/08/17 |
| 23640464 | Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells. | Cell Death Dis | 2013/05/02 |
| 20025731 | Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer. | BMC Cancer | 2009/12/21 |
| 24061460 | Mitochondria and tumors: a new perspective. | Indian J Cancer | 2013/09/25 |
| 25483192 | Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells. | Cell Cycle | 2014/12/09 |
| 25344214 | Identification of prohibitin 1 as a potential prognostic biomarker in human pancreatic carcinoma using modified aqueous two-phase partition system combined with 2D-MALDI-TOF-TOF-MS/MS. | Tumour Biol | 2014/10/25 |
| 22728421 | Prohibitin is an important biomarker for nasopharyngeal carcinoma progression and prognosis. | Eur J Cancer Prev | 2012/06/26 |
| 30523154 | The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers. | J Biol Chem | 2018/12/06 |
| 20890892 | Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. | Hepatology | 2010/10/01 |
| 23244120 | Mutational analysis of prohibitin--a highly conserved gene in Indian female breast cancer cases. | Asian Pac J Cancer Prev | 2012/12/19 |
| 22363587 | Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells. | PLoS One | 2012/02/17 |
| 29415747 | Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway. | J Exp Clin Cancer Res | 2018/02/07 |
| 29335542 | Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. | Nat Genet | 2018/01/15 |
| 25712957 | Ras-mediated modulation of pyruvate dehydrogenase activity regulates mitochondrial reserve capacity and contributes to glioblastoma tumorigenesis. | Neuro Oncol | 2015/02/23 |
| 24497069 | Targeting unique metabolic properties of breast tumor initiating cells. | Stem Cells | 2013/07/19 |
| 29444744 | Overexpression of Pyruvate Dehydrogenase E1α Subunit Inhibits Warburg Effect and Induces Cell Apoptosis Through Mitochondria-Mediated Pathway in Hepatocellular Carcinoma. | Oncol Res | 2018/02/14 |
| 19557855 | Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line. | J Orthop Res | 2009/06/27 |
| 20978188 | Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells. | Cancer Res | 2010/10/26 |
| 29293508 | A systematic atlas of chaperome deregulation topologies across the human cancer landscape. | PLoS Comput Biol | 2018/01/02 |
| 30341613 | A Cell Model for HSP60 Deficiencies: Modeling Different Levels of Chaperonopathies Leading to Oxidative Stress and Mitochondrial Dysfunction. | Methods Mol Biol | 2018/10/21 |
| 29080556 | A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis. | Aging (Albany NY) | 2017/09/17 |
| 24015183 | Geldanamycin-induced osteosarcoma cell death is associated with hyperacetylation and loss of mitochondrial pool of heat shock protein 60 (hsp60). | PLoS One | 2013/08/28 |
| 21187477 | Base excision repair activities differ in human lung cancer cells and corresponding normal controls. | Anticancer Res | 2010/12/29 |
| 26408804 | Differential timing of oxidative DNA damage and telomere shortening in hepatitis C and B virus-related liver carcinogenesis. | Transl Res | 2015/09/05 |
| 26586787 | Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis. | Cancer Res | 2015/11/19 |
| 22941157 | Cigarette smoking and hOGG1 Ser326Cys polymorphism are associated with 8-OHdG accumulation on mitochondrial DNA in thoracic esophageal squamous cell carcinoma. | Ann Surg Oncol | 2012/09/01 |
| 23677377 | Decreased mitochondrial OGG1 expression is linked to mitochondrial defects and delayed hepatoma cell growth. | Mol Cells | 2013/05/14 |
| 28462847 | Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness. | J Egypt Natl Canc Inst | 2017/04/24 |
| 29286150 | Mitochondrial pyruvate carrier modulates the epithelial-mesenchymal transition in cholangiocarcinoma. | Oncol Rep | 2017/12/20 |
| 29669911 | MPC1 is essential for PGC-1α-induced mitochondrial respiration and biogenesis. | Biochem J | 2018/05/18 |
| 25458841 | A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. | Mol Cell | 2014/10/21 |
| 28624784 | Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells. | Oncotarget | 2016/11/09 |
| 26895100 | MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer. | Oncotarget | 2015/11/25 |
| 23318445 | Evidence of mitochondrial dysfunction and impaired ROS detoxifying machinery in Fanconi anemia cells. | Oncogene | 2013/01/14 |
| 24802861 | Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival. | PLoS One | 2014/05/06 |
| 24797322 | Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. | Nat Commun | 2014/05/06 |
| 25824785 | Loss of heterozygosity at the calcium regulation gene locus on chromosome 10q in human pancreatic cancer. | Asian Pac J Cancer Prev | 2015/04/01 |
| 27606689 | Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria. | Cell Physiol Biochem | 2016/09/09 |
| 26892273 | Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop. | Sci Rep | 2016/02/19 |
| 22228304 | Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. | Proc Natl Acad Sci U S A | 2012/01/06 |
| 30092248 | N-terminal phosphorylation of glutaminase C decreases its enzymatic activity and cancer cell migration. | Biochimie | 2018/08/06 |
| 28970582 | Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism. | Sci Rep | 2017/10/02 |
| 26575584 | Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer. | Oncotarget | 2015/04/12 |
| 30555042 | Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway. | EBioMedicine | 2018/12/13 |
| 26340450 | Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort. | PLoS One | 2015/09/04 |
| 22777349 | PGC-1β mediates adaptive chemoresistance associated with mitochondrial DNA mutations. | Oncogene | 2012/07/09 |
| 24583174 | Investigation of the association between ATP2B4 and ATP5B genes with colorectal cancer. | Gene | 2014/02/26 |
| 26526033 | ATP5A1 and ATP5B are highly expressed in glioblastoma tumor cells and endothelial cells of microvascular proliferation. | J Neurooncol | 2015/11/02 |
| 24968221 | Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma. | PLoS One | 2014/06/26 |
| 28387723 | Classical and Novel TSPO Ligands for the Mitochondrial TSPO Can Modulate Nuclear Gene Expression: Implications for Mitochondrial Retrograde Signaling. | Int J Mol Sci | 2017/04/07 |
| 20085808 | Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) - In vitro, in vivo, salivary analysis. | Biochim Biophys Acta | 2010/01/18 |
| 28420545 | GQSAR modeling and combinatorial library generation of 4-phenylquinazoline-2-carboxamide derivatives as antiproliferative agents in human Glioblastoma tumors. | Comput Biol Chem | 2017/04/04 |
| 27452861 | Significant up-regulation of 1-ACBP, B-ACBP and PBR genes in immune cells within the oesophageal malignant tissue and a possible link in carcinogenic angiogenesis. | Histol Histopathol | 2016/07/25 |
| 21958735 | Functional characterization of the human translocator protein (18kDa) gene promoter in human breast cancer cell lines. | Biochim Biophys Acta | 2011/09/18 |
| 22645299 | The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress. | J Endocrinol | 2012/05/29 |
| 29721083 | Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy. | Theranostics | 2018/03/22 |
| 26923594 | Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer. | Cell Rep | 2016/02/25 |
| 28076827 | New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity. | Eur J Med Chem | 2016/12/24 |
| 28671672 | Deregulation of MicroRNAs mediated control of carnitine cycle in prostate cancer: molecular basis and pathophysiological consequences. | Oncogene | 2017/07/03 |
| 29176561 | HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism. | Nat Commun | 2017/11/24 |
| 30557378 | Tumor suppressor RARRES1- A novel regulator of fatty acid metabolism in epithelial cells. | PLoS One | 2018/12/17 |
| 23709747 | Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells. | J Mol Endocrinol | 2013/06/29 |
| 24862273 | Methods to monitor and compare mitochondrial and glycolytic ATP production. | Methods Enzymol | 2014/05/28 |
| 29684851 | Mitochondrial DNA content reduction induces aerobic glycolysis and reversible resistance to drug-induced apoptosis in SW480 colorectal cancer cells. | Biomed Pharmacother | 2018/04/24 |
| 24770931 | TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorectal adenocarcinomas. | Cell Tissue Res | 2014/04/29 |
| 23263864 | Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria. | Hum Mol Genet | 2012/12/20 |
| 19125299 | Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancer. | J Cancer Res Clin Oncol | 2009/01/06 |
| 29147009 | Mitochondrial UQCRB as a new molecular prognostic biomarker of human colorectal cancer. | Exp Mol Med | 2017/11/17 |
| 28990096 | High incidence of coding gene mutations in mitochondrial DNA in esophageal cancer. | Mol Med Rep | 2017/09/29 |
| 26477310 | Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells. | Oncogene | 2015/10/19 |
| 27892457 | Amplification of USP13 drives ovarian cancer metabolism. | Nat Commun | 2016/11/28 |
| 26501265 | Knockdown of PKM2 Suppresses Tumor Growth and Invasion in Lung Adenocarcinoma. | Int J Mol Sci | 2015/10/15 |
| 27248322 | Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. | Oncotarget | 2015/12/22 |
| 25645662 | The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. | Gut | 2015/02/02 |
| 28436963 | A STING-activating nanovaccine for cancer immunotherapy. | Nat Nanotechnol | 2017/04/24 |
| 29880736 | Mar Drugs | 2018/06/07 | |
| 27530298 | Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming. | Biochim Biophys Acta | 2016/08/13 |
| 30035852 | The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells. | FEBS J | 2018/08/07 |
| 23474074 | Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection. | Med Hypotheses | 2013/03/06 |
| 27666119 | Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker. | Oncol Rep | 2016/09/20 |
| 22184616 | Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. | Cancer Res | 2011/12/19 |
| 25403912 | Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin. | Cancer Res | 2014/11/17 |
| 26198749 | 3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants. | Mol Cancer | 2015/07/22 |
| 23161009 | DNA helicases associated with genetic instability, cancer, and aging. | Adv Exp Med Biol | 2012/11/20 |
| 24746816 | Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction. | Cell Rep | 2014/04/17 |
| 24067899 | RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome. | Carcinogenesis | 2013/09/25 |
| 22357944 | RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress. | J Cell Sci | 2012/02/22 |
| 24218030 | Replication of breast cancer susceptibility loci in whites and African Americans using a Bayesian approach. | Am J Epidemiol | 2013/11/10 |
| 20095854 | Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. | Radiat Res | 2010/01/26 |
| 29351903 | Integrative Genomic Analysis Predicts Causative | Cancer Res | 2018/01/19 |
| 23221726 | Gene-environment interactions for breast cancer risk among Chinese women: a report from the Shanghai Breast Cancer Genetics Study. | Am J Epidemiol | 2012/12/06 |
| 20043069 | Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer. | Int J Oncol | 2010/01/01 |
| 29958885 | SALL4 suppresses reactive oxygen species in pancreatic ductal adenocarcinoma phenotype via FoxM1/Prx III axis. | Biochem Biophys Res Commun | 2018/06/29 |
| 29545070 | Expression of reactive species related genes is associated with patient survival in luminal B breast cancer. | Free Radic Biol Med | 2018/03/12 |
| 22496757 | Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer. | PLoS One | 2012/04/09 |
| 23053644 | TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome. | Breast Cancer Res Treat | 2012/10/04 |
| 30521791 | Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study. | Clin Biochem | 2018/12/03 |
| 25043054 | Proteogenomic characterization of human colon and rectal cancer. | Nature | 2014/07/20 |
| 26406403 | Clinicopathological significance and prognostic value of Wilms' tumor gene expression in colorectal cancer. | Cancer Biomark | 2015/09/26 |
| 25002036 | Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. | Neurobiol Aging | 2014/06/10 |
| 20447055 | Oestrogen-related receptor alpha inverse agonist XCT-790 arrests A549 lung cancer cell population growth by inducing mitochondrial reactive oxygen species production. | Cell Prolif | 2010/05/08 |
| 22736457 | Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich's ataxia. | Dis Model Mech | 2012/06/26 |
| 25158131 | p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron. | Gene | 2014/08/23 |
| 22923201 | Changes in expression of human serine protease HtrA1, HtrA2 and HtrA3 genes in benign and malignant thyroid tumors. | Oncol Rep | 2012/08/23 |
| 30021838 | Regulation of monoamine oxidase A (MAO-A) expression, activity, and function in IL-13-stimulated monocytes and A549 lung carcinoma cells. | J Biol Chem | 2018/07/18 |
| 28402333 | MAOA-a novel decision maker of apoptosis and autophagy in hormone refractory neuroendocrine prostate cancer cells. | Sci Rep | 2017/04/12 |
| 20204405 | Targeting monoamine oxidase A in advanced prostate cancer. | J Cancer Res Clin Oncol | 2010/03/04 |
| 21678067 | Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. | Tumour Biol | 2011/06/16 |
| 29574159 | miR-126-5p targets Malate Dehydrogenase 1 in non-small cell lung carcinomas. | Biochem Biophys Res Commun | 2018/03/26 |
| 27611801 | A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration. | PLoS One | 2016/09/09 |
| 29259115 | Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells. | Proc Natl Acad Sci U S A | 2017/12/19 |
| 28928421 | Upregulation of CISD2 augments ROS homeostasis and contributes to tumorigenesis and poor prognosis of lung adenocarcinoma. | Sci Rep | 2017/09/19 |
| 27621439 | Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters. | Proc Natl Acad Sci U S A | 2016/09/12 |
| 27330077 | Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase. | J Biol Chem | 2016/06/21 |
| 20053669 | Role of Magmas in protein transport and human mitochondria biogenesis. | Hum Mol Genet | 2010/01/06 |
| 30414099 | Magmas inhibition as a potential treatment strategy in malignant glioma. | J Neurooncol | 2018/11/09 |
| 24810997 | Nanosilver incurs an adaptive shunt of energy metabolism mode to glycolysis in tumor and nontumor cells. | ACS Nano | 2014/05/12 |
| 29066618 | Epigenetic modification of miR-663 controls mitochondria-to-nucleus retrograde signaling and tumor progression. | J Biol Chem | 2017/10/24 |
| 23100451 | The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. | Oncotarget | 2012/10/27 |
| 25072865 | A key role of the mitochondrial citrate carrier (SLC25A1) in TNFα- and IFNγ-triggered inflammation. | Biochim Biophys Acta | 2014/07/27 |
| 22101277 | The mitochondrial protein C1qbp promotes cell proliferation, migration and resistance to cell death. | Cell Cycle | 2011/12/01 |
| 25288439 | The role of the globular heads of the C1q receptor in HPV-16 E2-induced human cervical squamous carcinoma cell apoptosis via a mitochondria-dependent pathway. | J Transl Med | 2014/10/05 |
| 25784717 | CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration. | Mol Cancer Res | 2015/03/17 |
| 19753307 | Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. | PLoS One | 2009/09/15 |
| 27575944 | Adipocyte Browning and Higher Mitochondrial Function in Periadrenal But Not SC Fat in Pheochromocytoma. | J Clin Endocrinol Metab | 2016/08/30 |
| 23257779 | Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin. | Cell Cycle | 2012/12/20 |
| 27311860 | mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat. | Biochem Biophys Res Commun | 2016/06/14 |
| 26427664 | Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells. | Tumour Biol | 2015/10/01 |
| 24375316 | The significance of LRPPRC overexpression in gastric cancer. | Med Oncol | 2013/12/28 |
| 27679555 | Elevated levels of autophagy-related marker ULK1 and mitochondrion-associated autophagy inhibitor LRPPRC are associated with biochemical progression and overall survival after androgen deprivation therapy in patients with metastatic prostate cancer. | J Clin Pathol | 2016/09/27 |
| 27107440 | A bioinformatics approach for precision medicine off-label drug drug selection among triple negative breast cancer patients. | J Am Med Inform Assoc | 2016/04/23 |
| 21531700 | Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC. | Nucleic Acids Res | 2011/04/29 |
| 25285166 | Quantitative proteomics analysis identifies mitochondria as therapeutic targets of multidrug-resistance in ovarian cancer. | Theranostics | 2014/09/18 |
| 20440404 | Analysis of differentially expressed mitochondrial proteins in chromophobe renal cell carcinomas and renal oncocytomas by 2-D gel electrophoresis. | Int J Biol Sci | 2010/04/23 |
| 29107073 | Immunometabolic Determinants of Chemoradiotherapy Response and Survival in Head and Neck Squamous Cell Carcinoma. | Am J Pathol | 2017/10/27 |
| 26721434 | Mitochondrial regulation of cell cycle progression through SLC25A43. | Biochem Biophys Res Commun | 2015/12/23 |
| 23354756 | The mitochondrial transport protein SLC25A43 affects drug efficacy and drug-induced cell cycle arrest in breast cancer cell lines. | Oncol Rep | 2013/01/23 |
| 22883974 | The mitochondrial transporter SLC25A43 is frequently deleted and may influence cell proliferation in HER2-positive breast tumors. | BMC Cancer | 2012/08/10 |
| 24497629 | Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. | J Biol Chem | 2014/02/04 |
| 28205173 | Measurement of Mitochondrial Cholesterol Import Using a Mitochondria-Targeted CYP11A1 Fusion Construct. | Methods Mol Biol | 2017/02/17 |
| 26492917 | EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. | EMBO J | 2015/10/22 |
| 29115436 | SIRT5 promotes cell proliferation and invasion in hepatocellular carcinoma by targeting E2F1. | Mol Med Rep | 2017/10/25 |
| 25070488 | SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer. | Tumour Biol | 2014/07/29 |
| 28820880 | Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans. | PLoS Genet | 2017/08/18 |
| 24368766 | SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma. | J Biol Chem | 2013/12/24 |
| 28478381 | Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation. | Redox Biol | 2017/04/29 |
| 29850793 | Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma. | Endocrinology | 2018/01/03 |
| 25879317 | Combined adrenal failure and testicular adrenal rest tumor in a patient with nicotinamide nucleotide transhydrogenase deficiency. | J Pediatr Endocrinol Metab | 2015/02/09 |
| 23267836 | B-cell translocation gene 2: expression in the rat ovary and potential association with adenine nucleotide translocase 2 in mitochondria. | Mol Cell Endocrinol | 2012/12/23 |
| 26883272 | Targeting Adenine Nucleotide Translocase-2 (ANT2) to Overcome Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Non-Small Cell Lung Cancer. | Mol Cancer Ther | 2016/02/16 |
| 20197279 | Novel components of an active mitochondrial K(+)/H(+) exchange. | J Biol Chem | 2010/03/02 |
| 28156110 | Architecture Mapping of the Inner Mitochondrial Membrane Proteome by Chemical Tools in Live Cells. | J Am Chem Soc | 2017/03/03 |
| 25202825 | Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion. | J Invest Dermatol | 2014/09/09 |
| 30380689 | Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis. | Int J Mol Sci | 2018/10/29 |
| 24973213 | Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability. | J Biol Chem | 2014/06/27 |
| 29335519 | Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. | Oncogene | 2018/01/16 |
| 27590350 | Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. | Oncotarget | 2016/06/08 |
| 26403317 | Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer. | Gene | 2015/09/25 |
| 25184115 | Sources of superoxide/H2O2 during mitochondrial proline oxidation. | Redox Biol | 2014/07/18 |
| 20562915 | miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer. | Oncogene | 2010/06/21 |
| 19654292 | Proline oxidase functions as a mitochondrial tumor suppressor in human cancers. | Cancer Res | 2009/08/04 |
| 21536680 | Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication. | J Biol Chem | 2011/05/02 |
| 30856376 | Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer. | Neoplasia | 2019/03/08 |
| 27845902 | Systematic expression analysis of the mitochondrial complex III subunits identifies UQCRC1 as biomarker in clear cell renal cell carcinoma. | Oncotarget | 2016/09/30 |
| 21901141 | Impaired OXPHOS complex III in breast cancer. | PLoS One | 2011/08/25 |
| 24249144 | The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (-)-epigallocatechin-3-gallate, in oral cells. | Mol Nutr Food Res | 2013/11/18 |
| 28334197 | PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. | Carcinogenesis | 2016/09/22 |
| 25975952 | Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing. | Breast Cancer Res Treat | 2015/05/15 |
| 29237424 | p53R2 as a novel prognostic biomarker in nasopharyngeal carcinoma. | BMC Cancer | 2017/12/13 |
| 30222970 | Metformin downregulates the mitochondrial carrier SLC25A10 in a glucose dependent manner. | Biochem Pharmacol | 2018/09/15 |
| 30354756 | Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma. | Hypertension | 2018/10/26 |
| 27374097 | Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells. | Oncotarget | 2016/02/22 |
| 24013224 | Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis. | Oncogene | 2013/09/09 |
| 26351264 | NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer. | Mol Cell Proteomics | 2015/09/08 |
| 30520388 | miR-342-5p as a Potential Regulator of HER2 Breast Cancer Cell Growth. | Microrna | 2018/06/13 |
| 25338767 | Attenuation of enoyl coenzyme A hydratase short chain 1 expression in gastric cancer cells inhibits cell proliferation and migration in vitro. | Cell Mol Biol Lett | 2014/10/23 |
| 25739098 | Attenuation of enoyl coenzyme A hydratase 1 expression in colorectal cancer cells using small interfering RNA inhibits cell proliferation and migration. | Mol Med Rep | 2015/03/04 |
| 24767988 | A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels. | Cell Rep | 2014/04/24 |
| 20590827 | Association of aldehyde dehydrogenase 2 gene polymorphism with pancreatic cancer but not colon cancer. | Geriatr Gerontol Int | 2010/07/02 |
| 19641380 | Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans. | Exp Mol Med | 2009/07/31 |
| 31133756 | Mitochondrial metabolism promotes adaptation to proteotoxic stress. | Nat Chem Biol | 2019/05/27 |
| 28922540 | APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing. | Mol Oncol | 2017/10/19 |
| 22020876 | GATA-binding protein 1 is a novel transcription regulator of peroxiredoxin 5 in human breast cancer cells. | Int J Oncol | 2011/10/20 |
| 26689287 | PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug. | J Exp Clin Cancer Res | 2015/12/21 |
| 27618552 | Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype. | Nat Immunol | 2016/09/12 |
| 22355194 | HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function. | FASEB J | 2012/02/21 |
| 29144989 | Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells. | Neoplasia | 2017/11/13 |
| 29853471 | Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1. | Drug Metab Dispos | 2018/05/31 |
| 24297161 | Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors. | Invest New Drugs | 2013/12/03 |
| 28986507 | A conserved mammalian mitochondrial isoform of acetyl-CoA carboxylase ACC1 provides the malonyl-CoA essential for mitochondrial biogenesis in tandem with ACSF3. | Biochem J | 2017/11/06 |
| 20186120 | A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. | EMBO J | 2010/02/25 |
| 27732857 | Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells. | Cell Rep | 2016/07/22 |
| 19582509 | Mitochondrial genomic instability in colorectal cancer: no correlation to nuclear microsatellite instability and allelic deletion of hMSH2, hMLH1, and p53 genes, but prediction of better survival for Dukes' stage C disease. | Ann Surg Oncol | 2009/07/07 |
| 29532879 | Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer. | Mol Med Rep | 2018/03/09 |
| 20505682 | Identification of alternatively spliced GRIM-19 mRNA in kidney cancer tissues. | J Hum Genet | 2010/05/27 |
| 28031527 | Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. | Oncotarget | 2016/01/12 |
| 20607720 | p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells. | Prostate | 2010/07/08 |
| 27167343 | Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer. | Oncotarget | 2015/10/17 |
| 29540477 | The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction. | J Biol Chem | 2018/03/14 |
| 28701793 | The miR-29 transcriptome in endocrine-sensitive and resistant breast cancer cells. | Sci Rep | 2017/07/12 |
| 22865452 | Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants. | Cancer Res | 2012/08/03 |
| 22952044 | TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells. | Mol Cancer Res | 2012/09/04 |
| 27510639 | CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation. | Biochem Biophys Res Commun | 2016/08/07 |
| 25193669 | DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase. | J Biol Chem | 2014/09/05 |
| 29496454 | Potential use of TIA-1, MFF, microRNA-200a-3p, and microRNA-27 as a novel marker for hepatocellular carcinoma. | Biochem Biophys Res Commun | 2018/02/26 |
| 22878233 | Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. | Oncotarget | 2012/08/11 |
| 30016590 | Multistage Ultraviolet Photodissociation Mass Spectrometry To Characterize Single Amino Acid Variants of Human Mitochondrial BCAT2. | Anal Chem | 2018/08/01 |
| 28681360 | Intact Protein Analysis at 21 Tesla and X-Ray Crystallography Define Structural Differences in Single Amino Acid Variants of Human Mitochondrial Branched-Chain Amino Acid Aminotransferase 2 (BCAT2). | J Am Soc Mass Spectrom | 2017/07/05 |
| 20683904 | Demethyl fruticulin A (SCO-1) causes apoptosis by inducing reactive oxygen species in mitochondria. | J Cell Biochem | 2010/08/05 |
| 22722266 | Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. | Cell Cycle | 2012/07/01 |
| 28645610 | Inhibition of mitochondrial translation effectively sensitizes renal cell carcinoma to chemotherapy. | Biochem Biophys Res Commun | 2017/06/20 |
| 29115404 | Downregulation of mitochondrial UQCRB inhibits cancer stem cell-like properties in glioblastoma. | Int J Oncol | 2017/11/06 |
| 29260979 | HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer. | Autophagy | 2018/02/21 |
| 26450902 | Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer. | Oncotarget | 2015/06/23 |
| 23489758 | Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy? | Breast | 2013/03/13 |
| 29970196 | 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. | J Exp Clin Cancer Res | 2018/07/03 |
| 22475485 | Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. | Biochem Biophys Res Commun | 2012/03/27 |
| 29550120 | α-Lactalbumin-oleic acid complex kills tumor cells by inducing excess energy metabolism but inhibiting mRNA expression of the related enzymes. | J Dairy Sci | 2018/03/15 |
| 26597277 | Gene-expression signature functional annotation of breast cancer tumours in function of age. | BMC Med Genomics | 2015/11/23 |
| 28356157 | Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma. | Genome Med | 2017/03/29 |
| 20498374 | ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. | J Biol Chem | 2010/05/24 |
| 28467815 | Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A. | Oncotarget | 2016/02/15 |
| 26840709 | Gene expression profiling analysis of lung adenocarcinoma. | Braz J Med Biol Res | 2016/02/02 |
| 30076902 | FOXD3 acts as a repressor of the mitochondrial S-adenosylmethionine carrier (SLC25A26) gene expression in cancer cells. | Biochimie | 2018/08/02 |
| 24174293 | High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential. | Int J Cancer | 2013/10/31 |
| 28594398 | Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming. | Cell Death Dis | 2017/06/08 |
| 22214851 | Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression. | J Clin Invest | 2012/01/03 |
| 23569218 | DNA microarray and miRNA analyses reinforce the classification of follicular thyroid tumors. | J Clin Endocrinol Metab | 2013/04/08 |
| 22545919 | Polymorphisms in the mitochondrial oxidative phosphorylation chain genes as prognostic markers for colorectal cancer. | BMC Med Genet | 2012/04/30 |
| 28098816 | Estrogen Enhances the Expression of the Multidrug Transporter Gene ABCG2-Increasing Drug Resistance of Breast Cancer Cells through Estrogen Receptors. | Int J Mol Sci | 2017/01/14 |
| 27866983 | Downregulation of cytochrome c oxidase subunit 7A1 expression is important in enhancing cell proliferation in adenocarcinoma cells. | Biochem Biophys Res Commun | 2016/11/17 |
| 30803933 | FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis. | EBioMedicine | 2019/02/23 |
| 25374412 | Association of Romo1 gene genetic polymorphisms with risk of gastric cancer in northwestern Chinese population. | Pathol Oncol Res | 2014/11/06 |
| 24967918 | Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line. | PLoS One | 2014/06/26 |
| 28394473 | Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis. | Cancer Sci | 2017/05/19 |
| 20398751 | CYP24A1 splice variants--implications for the antitumorigenic actions of 1,25-(OH)2D3 in colorectal cancer. | J Steroid Biochem Mol Biol | 2010/04/14 |
| 30015875 | ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells. | Int J Oncol | 2018/07/09 |
| 28913729 | Exome array analysis identifies ETFB as a novel susceptibility gene for anthracycline-induced cardiotoxicity in cancer patients. | Breast Cancer Res Treat | 2017/09/14 |
| 19907149 | Mitochondrial iron metabolism and sideroblastic anemia. | Acta Haematol | 2009/11/10 |
| 21679157 | HIV-TAT-fused FHIT protein functions as a potential pro-apoptotic molecule in hepatocellular carcinoma cells. | Biosci Rep | 2011/06/18 |
| 25409762 | Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain. | BMC Cancer | 2014/11/20 |
| 24160266 | Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. | BMC Cancer | 2013/10/27 |
| 31223065 | Folate pathway genes linked to mitochondrial biogenesis and respiration are associated with outcome of patients with stage III colorectal cancer. | Tumour Biol | 2019/06/22 |
| 22576012 | Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition. | Autophagy | 2012/05/11 |
| 29549912 | γ-Glutamylcysteine synthetase (γ-GCS) as a target for overcoming chemo- and radio-resistance of human hepatocellular carcinoma cells. | Life Sci | 2018/02/14 |
| 28912168 | Alternative Polyadenylation of | Mol Cancer Res | 2017/09/14 |
| 23535601 | Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. | Nature | 2013/03/27 |
| 28712724 | Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. | Mol Cell | 2017/07/14 |
| 24595062 | FTSJ2, a heat shock-inducible mitochondrial protein, suppresses cell invasion and migration. | PLoS One | 2014/03/04 |
| 27177758 | Hepatocellular carcinoma repression by TNFα-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization. | Hepatology | 2016/06/11 |
| 23082722 | Ketone body utilization drives tumor growth and metastasis. | Cell Cycle | 2012/09/19 |
| 19796983 | Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. | Oral Oncol | 2009/09/30 |
| 25278485 | Dedifferentiation of cancer cells following recovery from a potentially lethal damage is mediated by H2S-Nampt. | Exp Cell Res | 2014/09/30 |
| 26714745 | Synthetic Lethality of a Novel Small Molecule Against Mutant KRAS-Expressing Cancer Cells Involves AKT-Dependent ROS Production. | Antioxid Redox Signal | 2016/02/26 |
| 26641458 | Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism. | PLoS One | 2015/12/07 |
| 26722457 | Differentially expressed genes and microRNAs in bladder carcinoma cell line 5637 and T24 detected by RNA sequencing. | Int J Clin Exp Pathol | 2015/10/01 |
| 22363440 | cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue. | PLoS One | 2012/02/17 |
| 20573444 | Hypoxia and retinoic acid-inducible NDRG1 expression is responsible for doxorubicin and retinoic acid resistance in hepatocellular carcinoma cells. | Cancer Lett | 2010/06/22 |
| 27792995 | Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21. | Oncotarget | 2016/04/13 |
| 27037627 | A novel approach for targeted elimination of CSPG4-positive triple-negative breast cancer cells using a MAP tau-based fusion protein. | Int J Cancer | 2016/04/15 |
| 28296343 | A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment. | Mol Oncol | 2017/04/11 |
| 25391042 | Depletion of C3orf1/TIMMDC1 inhibits migration and proliferation in 95D lung carcinoma cells. | Int J Mol Sci | 2014/11/10 |
| 26079849 | Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker? | Med Sci Monit | 2015/06/16 |
| 28714366 | High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes. | Tumour Biol | 2017/07/18 |
| 29484395 | Identification of candidate genes and long non-coding RNAs associated with the effect of ATP5J in colorectal cancer. | Int J Oncol | 2018/02/22 |
| 30615941 | Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function. | Metab Eng | 2019/01/04 |
| 22392914 | Peptides mimicking the unique ARTS-XIAP binding site promote apoptotic cell death in cultured cancer cells. | Clin Cancer Res | 2012/03/05 |
| 26476016 | Self-clearance mechanism of mitochondrial E3 ligase MARCH5 contributes to mitochondria quality control. | FEBS J | 2015/11/18 |
| 26516695 | CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma. | Head Neck | 2015/10/30 |
| 30664178 | Identification of key genes and pathways involved in microsatellite instability in colorectal cancer. | Mol Med Rep | 2019/01/11 |
| 22178194 | Glycerophospholipid profile in oncogene-induced senescence. | Biochim Biophys Acta | 2011/12/10 |
| 27489352 | S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma. | Oncotarget | 2016/04/07 |
| 22562243 | Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. | Oncogene | 2012/05/07 |
| 24484525 | Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies. | BMC Genomics | 2014/02/01 |
| 20562527 | Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling. | Cell Cycle | 2010/06/15 |
| 23543312 | Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study. | J Gastroenterol | 2013/03/30 |
| 23236365 | RNA-Seq of human breast ductal carcinoma in situ models reveals aldehyde dehydrogenase isoform 5A1 as a novel potential target. | PLoS One | 2012/12/06 |
| 27451147 | SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate. | Gastroenterology | 2016/07/21 |
| 26400320 | Gene expression profile in breast cancer comprising predictive markers for metastatic risk. | Genet Mol Res | 2015/09/21 |
| 28346728 | NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition. | Cancer Sci | 2017/06/14 |
| 24687350 | Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone. | Protein Sci | 2014/04/17 |
| 27984722 | An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer. | Cell | 2016/06/24 |
| 24403067 | Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin. | J Biol Chem | 2014/01/08 |
| 20453889 | Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells. | Oncogene | 2010/05/10 |
| 26655911 | Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization. | Cell Rep | 2015/11/19 |
| 24080446 | Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study. | Endocr Relat Cancer | 2013/11/04 |
| 20352460 | Mitomycin C modulates DNA-double strand break repair genes in cervical carcinoma cells. | Amino Acids | 2010/03/30 |
| 21621504 | Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance. | Arch Biochem Biophys | 2011/05/20 |
| 25213357 | Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation. | Cell Mol Life Sci | 2014/09/12 |
| 28869607 | MRPL33 and its splicing regulator hnRNPK are required for mitochondria function and implicated in tumor progression. | Oncogene | 2017/09/04 |
| 22120717 | Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. | Oncogene | 2011/11/28 |
This data represent the % of samples per cancer type whose expression values are outside the normal range (between 5%-95% of normal expression).
| Gene | BRCA | COAD | LUAD | PRAD | KIRC | KIRP | LIHC | LUSC | STAD | THCA | ESCA | HNSC | KICH | PAAD | BLCA | GBM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ABCB10 | 49% | 48% | 50% | 20% | 44% | 41% | 44% | 51% | 11% | 44% | 56% | 25% | 45% | 54% | 22% | 66% |
| ACAA2 | 50% | 78% | 74% | 36% | 35% | 42% | 84% | 91% | 24% | 47% | 59% | 4% | 59% | 17% | 28% | 84% |
| ACACA | 15% | 52% | 20% | 62% | 51% | 42% | 55% | 19% | 15% | 43% | 22% | 16% | 23% | 60% | 15% | 88% |
| ACAD10 | 35% | 38% | 59% | 48% | 52% | 44% | 58% | 45% | 13% | 53% | 49% | 30% | 55% | 44% | 47% | 69% |
| ACADM | 43% | 80% | 49% | 18% | 58% | 73% | 71% | 60% | 77% | 77% | 82% | 53% | 76% | 53% | 68% | 81% |
| ACAT1 | 30% | 85% | 72% | 21% | 53% | 41% | 74% | 84% | 66% | 43% | 65% | 64% | 58% | 70% | 36% | 63% |
| ACLY | 13% | 80% | 70% | 24% | 84% | 28% | 81% | 57% | 39% | 23% | 56% | 27% | 83% | 71% | 55% | 87% |
| ACO1 | 44% | 39% | 50% | 34% | 49% | 53% | 73% | 71% | 23% | 54% | 47% | 28% | 11% | 8% | 42% | 83% |
| ACO2 | 23% | 95% | 62% | 21% | 40% | 54% | 53% | 66% | 36% | 56% | 60% | 40% | 97% | 80% | 63% | 97% |
| ACSS1 | 49% | 63% | 68% | 67% | 56% | 68% | 61% | 57% | 30% | 72% | 33% | 35% | 64% | 51% | 57% | 82% |
| ADHFE1 | 68% | 96% | 68% | 40% | 49% | 35% | 64% | 64% | 81% | 37% | 76% | 37% | 24% | 33% | 56% | 86% |
| AGK | 53% | 85% | 81% | 31% | 40% | 73% | 56% | 86% | 26% | 57% | 60% | 52% | 77% | 57% | 74% | 44% |
| AIFM1 | 36% | 55% | 78% | 38% | 38% | 29% | 55% | 57% | 12% | 17% | 6% | 36% | 36% | 71% | 37% | 72% |
| AIFM2 | 32% | 14% | 56% | 60% | 35% | 51% | 53% | 56% | 22% | 57% | 24% | 8% | 91% | 21% | 27% | 75% |
| AK3 | 62% | 58% | 58% | 27% | 91% | 80% | 82% | 70% | 79% | 18% | 74% | 69% | 53% | 36% | 55% | 51% |
| ALDH5A1 | 47% | 39% | 54% | 12% | 63% | 41% | 71% | 48% | 48% | 35% | 27% | 45% | 23% | 22% | 21% | 74% |
| ATP5A1 | 44% | 80% | 45% | 25% | 95% | 80% | 43% | 50% | 62% | 61% | 65% | 78% | 73% | 54% | 58% | 38% |
| ATP5B | 27% | 52% | 61% | 14% | 89% | 60% | 43% | 88% | 39% | 65% | 13% | 49% | 44% | 69% | 51% | 53% |
| ATP5D | 17% | 74% | 39% | 25% | 34% | 50% | 44% | 48% | 45% | 30% | 36% | 52% | 77% | 68% | 37% | 71% |
| ATP5E | 30% | 68% | 29% | 29% | 49% | 61% | 56% | 23% | 18% | 12% | 29% | 32% | 85% | 56% | 38% | 68% |
| ATP5G1 | 49% | 49% | 33% | 27% | 68% | 57% | 45% | 67% | 23% | 38% | 15% | 23% | 12% | 80% | 31% | 72% |
| ATP5H | 33% | 53% | 31% | 23% | 40% | 60% | 52% | 37% | 27% | 16% | 22% | 38% | 26% | 44% | 28% | 67% |
| ATP5J | 17% | 74% | 19% | 10% | 78% | 63% | 63% | 18% | 48% | 41% | 61% | 48% | 21% | 54% | 14% | 83% |
| ATPIF1 | 35% | 51% | 34% | 40% | 50% | 53% | 50% | 27% | 24% | 15% | 17% | 25% | 85% | 81% | 35% | 83% |
| BAD | 31% | 94% | 40% | 10% | 33% | 49% | 40% | 35% | 52% | 49% | 66% | 36% | 17% | 34% | 27% | 87% |
| BAK1 | 79% | 65% | 35% | 19% | 18% | 19% | 44% | 71% | 2% | 10% | 51% | 43% | 30% | 70% | 32% | 83% |
| BAX | 77% | 53% | 15% | 50% | 81% | 93% | 40% | 19% | 15% | 86% | 80% | 30% | 27% | 57% | 39% | 96% |
| BCL2L1 | 39% | 84% | 36% | 15% | 35% | 73% | 40% | 55% | 43% | 79% | 42% | 34% | 77% | 80% | 56% | 63% |
| BCL2L2 | 80% | 66% | 80% | 20% | 56% | 83% | 30% | 62% | 31% | 30% | 87% | 27% | 88% | 43% | 64% | 100% |
| BCL2 | 64% | 88% | 48% | 50% | 82% | 78% | 34% | 51% | 56% | 87% | 44% | 51% | 76% | 76% | 88% | 92% |
| BDH1 | 27% | 63% | 63% | 62% | 93% | 55% | 67% | 86% | 17% | 55% | 19% | 25% | 79% | 63% | 25% | 90% |
| BID | 44% | 55% | 28% | 19% | 82% | 85% | 59% | 52% | 14% | 81% | 83% | 53% | 17% | 72% | 75% | 85% |
| BNIP3L | 38% | 46% | 57% | 70% | 91% | 52% | 70% | 51% | 41% | 32% | 32% | 18% | 94% | 8% | 57% | 38% |
| BNIP3 | 22% | 71% | 77% | 30% | 89% | 30% | 60% | 78% | 62% | 40% | 65% | 19% | 33% | 52% | 37% | 96% |
| BRP44L | 19% | 90% | 63% | 25% | 62% | 44% | 80% | 82% | 62% | 57% | 67% | 82% | 15% | 61% | 59% | 30% |
| BRP44 | 37% | 55% | 25% | 36% | 33% | 47% | 74% | 37% | 13% | 24% | 21% | 26% | 65% | 50% | 25% | 68% |
| C1QBP | 35% | 50% | 30% | 33% | 32% | 65% | 69% | 56% | 38% | 10% | 32% | 28% | 38% | 65% | 39% | 97% |
| C20orf108 | 47% | 62% | 61% | 16% | 53% | 64% | 50% | 68% | 48% | 51% | 47% | 27% | 82% | 41% | 56% | 99% |
| C3orf1 | 39% | 36% | 28% | 10% | 56% | 39% | 42% | 73% | 38% | 13% | 57% | 31% | 30% | 61% | 74% | 46% |
| CASP8 | 61% | 20% | 65% | 46% | 90% | 89% | 42% | 48% | 35% | 18% | 64% | 35% | 27% | 15% | 38% | 99% |
| CAT | 81% | 63% | 96% | 26% | 73% | 79% | 62% | 99% | 25% | 18% | 52% | 26% | 23% | 46% | 43% | 16% |
| CBARA1 | 45% | 67% | 50% | 38% | 31% | 42% | 55% | 65% | 8% | 71% | 11% | 8% | 65% | 45% | 25% | 95% |
| CCDC109A | 51% | 68% | 59% | 9% | 26% | 92% | 49% | 43% | 13% | 55% | 14% | 8% | 35% | 49% | 38% | 28% |
| CDC25C | 94% | 83% | 91% | 36% | 65% | 91% | 90% | 99% | 46% | 9% | 93% | 68% | 97% | 65% | 75% | 99% |
| CHCHD2 | 47% | 48% | 26% | 8% | 26% | 47% | 58% | 45% | 14% | 19% | 57% | 30% | 12% | 61% | 43% | 90% |
| CHCHD4 | 24% | 53% | 51% | 21% | 57% | 42% | 45% | 39% | 32% | 13% | 32% | 31% | 61% | 75% | 28% | 44% |
| CISD1 | 41% | 40% | 43% | 20% | 45% | 65% | 39% | 59% | 15% | 20% | 23% | 23% | 45% | 38% | 28% | 87% |
| CISD2 | 42% | 36% | 55% | 13% | 53% | 53% | 34% | 56% | 8% | 10% | 35% | 40% | 52% | 35% | 28% | 79% |
| CISD3 | 54% | 58% | 29% | 21% | 27% | 27% | 46% | 47% | 9% | 16% | 32% | 24% | 53% | 53% | 31% | 62% |
| CKMT1B | 47% | 65% | 74% | 21% | 93% | 64% | 37% | 95% | 3% | 40% | 26% | 9% | 98% | 71% | 5% | 99% |
| CLPP | 34% | 58% | 28% | 14% | 28% | 44% | 56% | 44% | 38% | 17% | 24% | 46% | 11% | 57% | 56% | 99% |
| COX16 | 33% | 39% | 22% | 40% | 50% | 45% | 44% | 32% | 10% | 17% | 3% | 40% | 39% | 54% | 15% | 90% |
| COX4I2 | 10% | 40% | 87% | 16% | 79% | 38% | 63% | 98% | 17% | 36% | 14% | 6% | 33% | 30% | 43% | 77% |
| COX5A | 20% | 39% | 23% | 34% | 56% | 44% | 49% | 54% | 10% | 8% | 5% | 50% | 89% | 66% | 29% | 61% |
| COX5B | 17% | 46% | 25% | 25% | 25% | 46% | 41% | 50% | 38% | 15% | 23% | 33% | 24% | 60% | 25% | 50% |
| COX6A1 | 43% | 33% | 22% | 22% | 41% | 64% | 53% | 36% | 13% | 20% | 11% | 18% | 74% | 48% | 25% | 65% |
| COX6B1 | 33% | 47% | 26% | 20% | 45% | 45% | 56% | 44% | 17% | 8% | 21% | 48% | 45% | 52% | 30% | 82% |
| COX6C | 71% | 73% | 48% | 33% | 45% | 67% | 70% | 53% | 20% | 18% | 27% | 27% | 97% | 54% | 40% | 61% |
| COX7A1 | 64% | 37% | 86% | 37% | 45% | 82% | 35% | 96% | 39% | 34% | 29% | 22% | 98% | 53% | 84% | 88% |
| COX8C | 6% | 5% | 5% | 9% | 7% | 40% | 7% | 26% | 3% | 7% | 4% | 9% | 5% | 10% | 1% | 36% |
| CPT1A | 40% | 83% | 32% | 24% | 42% | 93% | 42% | 55% | 23% | 33% | 63% | 38% | 42% | 39% | 51% | 68% |
| CPT1C | 33% | 26% | 30% | 12% | 29% | 63% | 25% | 27% | 13% | 61% | 5% | 17% | 17% | 51% | 42% | 87% |
| CPT2 | 28% | 88% | 33% | 39% | 46% | 62% | 81% | 37% | 17% | 30% | 10% | 74% | 15% | 66% | 22% | 50% |
| CRAT | 52% | 80% | 61% | 37% | 21% | 28% | 66% | 64% | 34% | 56% | 74% | 36% | 59% | 44% | 55% | 88% |
| CYB5R3 | 57% | 52% | 85% | 53% | 77% | 50% | 58% | 81% | 34% | 26% | 39% | 23% | 36% | 19% | 65% | 83% |
| CYC1 | 29% | 42% | 39% | 19% | 64% | 59% | 72% | 61% | 35% | 71% | 27% | 11% | 32% | 67% | 46% | 99% |
| CYCS | 55% | 34% | 50% | 14% | 65% | 34% | 59% | 66% | 36% | 34% | 24% | 18% | 92% | 62% | 30% | 31% |
| CYP24A1 | 4% | 27% | 82% | 16% | 43% | 35% | 18% | 68% | 17% | 35% | 7% | 13% | 76% | 65% | 17% | 66% |
| DBI | 48% | 39% | 50% | 13% | 50% | 41% | 43% | 29% | 3% | 38% | 9% | 34% | 50% | 24% | 15% | 98% |
| DHODH | 20% | 77% | 56% | 41% | 35% | 40% | 69% | 50% | 53% | 33% | 67% | 22% | 53% | 28% | 47% | 34% |
| DIABLO | 40% | 45% | 30% | 16% | 36% | 66% | 40% | 54% | 24% | 21% | 59% | 30% | 3% | 51% | 21% | 96% |
| DNAJA3 | 72% | 67% | 75% | 36% | 40% | 72% | 43% | 86% | 49% | 27% | 36% | 12% | 55% | 61% | 43% | 81% |
| DNAJC15 | 32% | 62% | 42% | 40% | 30% | 44% | 36% | 59% | 20% | 13% | 63% | 39% | 42% | 48% | 42% | 94% |
| DNM1L | 63% | 53% | 65% | 22% | 59% | 44% | 63% | 90% | 7% | 35% | 34% | 34% | 67% | 66% | 30% | 96% |
| ECHS1 | 20% | 51% | 37% | 6% | 46% | 48% | 54% | 42% | 31% | 31% | 39% | 73% | 55% | 42% | 47% | 88% |
| ENDOG | 25% | 19% | 23% | 26% | 60% | 37% | 42% | 47% | 13% | 14% | 32% | 21% | 65% | 54% | 19% | 58% |
| ERAL1 | 66% | 82% | 76% | 20% | 40% | 75% | 42% | 86% | 31% | 23% | 53% | 43% | 76% | 85% | 53% | 90% |
| FASN | 19% | 53% | 42% | 28% | 27% | 50% | 46% | 22% | 32% | 8% | 38% | 5% | 44% | 38% | 61% | 91% |
| FDXR | 56% | 51% | 28% | 42% | 83% | 96% | 53% | 64% | 13% | 36% | 9% | 8% | 35% | 48% | 12% | 60% |
| FHIT | 46% | 54% | 39% | 58% | 34% | 48% | 49% | 48% | 45% | 37% | 60% | 65% | 58% | 71% | 58% | 50% |
| FH | 48% | 59% | 64% | 23% | 66% | 45% | 64% | 72% | 53% | 37% | 21% | 26% | 52% | 40% | 18% | 67% |
| FIS1 | 18% | 35% | 45% | 18% | 46% | 53% | 46% | 55% | 42% | 12% | 36% | 36% | 15% | 65% | 39% | 32% |
| FTMT | 3% | 0% | 0% | 0% | 0% | 0% | 0% | 1% | 1% | 0% | 2% | 0% | 0% | 1% | 7% | 0% |
| FUNDC1 | 62% | 71% | 64% | 22% | 27% | 28% | 44% | 82% | 13% | 13% | 5% | 42% | 76% | 77% | 23% | 65% |
| GAPDH | 45% | 88% | 92% | 28% | 89% | 81% | 78% | 99% | 69% | 19% | 72% | 48% | 76% | 66% | 65% | 58% |
| GFER | 74% | 45% | 65% | 35% | 26% | 76% | 44% | 44% | 7% | 26% | 31% | 10% | 95% | 73% | 7% | 50% |
| GLRX2 | 44% | 38% | 24% | 14% | 33% | 86% | 49% | 46% | 20% | 11% | 39% | 12% | 44% | 53% | 51% | 67% |
| GLRX5 | 32% | 62% | 30% | 34% | 92% | 36% | 54% | 74% | 21% | 34% | 14% | 12% | 82% | 58% | 35% | 53% |
| GLS | 59% | 38% | 76% | 13% | 50% | 41% | 58% | 81% | 13% | 23% | 53% | 60% | 74% | 76% | 19% | 98% |
| GOLPH3 | 66% | 49% | 65% | 22% | 41% | 61% | 15% | 70% | 30% | 16% | 40% | 19% | 58% | 22% | 73% | 99% |
| GOT2 | 44% | 55% | 67% | 27% | 88% | 53% | 66% | 89% | 40% | 21% | 26% | 20% | 86% | 30% | 23% | 98% |
| GPAM | 71% | 9% | 18% | 12% | 73% | 39% | 39% | 3% | 17% | 72% | 58% | 7% | 91% | 66% | 8% | 81% |
| GPAT2 | 39% | 53% | 52% | 21% | 41% | 24% | 32% | 42% | 21% | 20% | 17% | 13% | 26% | 44% | 34% | 72% |
| GPT2 | 44% | 86% | 98% | 30% | 46% | 40% | 67% | 98% | 6% | 43% | 16% | 78% | 35% | 75% | 20% | 88% |
| GPX1 | 20% | 26% | 27% | 7% | 32% | 87% | 52% | 56% | 19% | 53% | 37% | 37% | 50% | 35% | 50% | 99% |
| HK1 | 49% | 33% | 50% | 16% | 3% | 38% | 47% | 64% | 4% | 80% | 54% | 17% | 15% | 24% | 15% | 94% |
| HK2 | 13% | 29% | 43% | 25% | 94% | 97% | 40% | 66% | 22% | 51% | 25% | 19% | 35% | 26% | 20% | 84% |
| HMGCS2 | 3% | 57% | 40% | 8% | 76% | 97% | 61% | 52% | 19% | 2% | 50% | 82% | 65% | 39% | 33% | 4% |
| HSPA9 | 49% | 85% | 81% | 31% | 31% | 59% | 57% | 73% | 72% | 43% | 43% | 48% | 85% | 90% | 34% | 73% |
| HSPD1 | 46% | 96% | 94% | 27% | 7% | 31% | 74% | 94% | 84% | 20% | 74% | 51% | 15% | 74% | 55% | 99% |
| HSPE1 | 68% | 79% | 66% | 23% | 23% | 66% | 56% | 86% | 58% | 6% | 80% | 37% | 21% | 65% | 53% | 72% |
| HTRA2 | 23% | 39% | 31% | 26% | 53% | 71% | 41% | 54% | 42% | 44% | 32% | 43% | 71% | 57% | 39% | 88% |
| ICT1 | 45% | 45% | 34% | 38% | 31% | 73% | 48% | 51% | 22% | 5% | 45% | 20% | 9% | 63% | 73% | 87% |
| IDH1 | 33% | 36% | 42% | 12% | 7% | 12% | 50% | 42% | 9% | 73% | 23% | 22% | 20% | 62% | 17% | 100% |
| IDH2 | 52% | 39% | 83% | 14% | 49% | 84% | 48% | 86% | 43% | 18% | 11% | 58% | 38% | 37% | 22% | 80% |
| IDH3B | 35% | 60% | 58% | 28% | 24% | 61% | 47% | 70% | 39% | 59% | 40% | 31% | 59% | 49% | 43% | 70% |
| IFI27 | 40% | 16% | 49% | 18% | 64% | 87% | 27% | 58% | 6% | 23% | 57% | 53% | 61% | 57% | 58% | 87% |
| IMMT | 43% | 42% | 64% | 16% | 68% | 52% | 50% | 86% | 39% | 39% | 16% | 15% | 26% | 70% | 35% | 72% |
| ISCU | 43% | 42% | 43% | 38% | 72% | 59% | 36% | 76% | 23% | 65% | 46% | 24% | 98% | 78% | 32% | 51% |
| LDHB | 79% | 80% | 70% | 53% | 91% | 56% | 58% | 75% | 36% | 69% | 27% | 32% | 12% | 76% | 37% | 44% |
| LETM1 | 33% | 40% | 58% | 61% | 85% | 65% | 53% | 62% | 14% | 22% | 23% | 4% | 97% | 69% | 13% | 83% |
| LONP1 | 27% | 86% | 50% | 34% | 33% | 52% | 51% | 70% | 35% | 33% | 33% | 26% | 92% | 71% | 22% | 87% |
| LRPPRC | 28% | 66% | 77% | 47% | 48% | 54% | 65% | 90% | 72% | 34% | 62% | 30% | 32% | 43% | 32% | 83% |
| MAOA | 79% | 90% | 81% | 38% | 59% | 33% | 61% | 77% | 65% | 48% | 84% | 42% | 76% | 52% | 55% | 67% |
| MDH1 | 13% | 74% | 17% | 19% | 66% | 60% | 52% | 69% | 34% | 24% | 14% | 40% | 45% | 30% | 9% | 97% |
| MDH2 | 44% | 70% | 70% | 44% | 59% | 64% | 59% | 88% | 47% | 44% | 48% | 44% | 88% | 62% | 44% | 76% |
| ME2 | 42% | 62% | 33% | 13% | 39% | 55% | 46% | 39% | 5% | 17% | 37% | 14% | 64% | 81% | 14% | 92% |
| ME3 | 67% | 24% | 60% | 57% | 24% | 31% | 61% | 79% | 8% | 78% | 23% | 56% | 100% | 50% | 26% | 72% |
| MFF | 34% | 42% | 60% | 19% | 42% | 34% | 63% | 58% | 24% | 16% | 51% | 35% | 82% | 56% | 43% | 78% |
| MFN1 | 43% | 49% | 72% | 23% | 61% | 43% | 55% | 98% | 16% | 31% | 52% | 40% | 27% | 21% | 21% | 61% |
| MFN2 | 62% | 81% | 69% | 47% | 90% | 66% | 59% | 54% | 42% | 31% | 47% | 10% | 27% | 61% | 32% | 91% |
| MPST | 21% | 14% | 44% | 35% | 12% | 14% | 40% | 35% | 12% | 17% | 21% | 37% | 36% | 43% | 35% | 19% |
| MRPL12 | 49% | 33% | 51% | 38% | 40% | 57% | 51% | 83% | 24% | 11% | 38% | 34% | 17% | 67% | 45% | 97% |
| MRPL28 | 40% | 40% | 37% | 11% | 51% | 67% | 45% | 49% | 33% | 20% | 53% | 28% | 14% | 87% | 42% | 65% |
| MRPL33 | 16% | 16% | 20% | 18% | 85% | 27% | 40% | 24% | 30% | 7% | 27% | 23% | 88% | 52% | 24% | 85% |
| MRPL44 | 36% | 26% | 26% | 27% | 27% | 47% | 43% | 52% | 5% | 14% | 30% | 43% | 59% | 52% | 21% | 67% |
| MRPS23 | 71% | 72% | 39% | 19% | 34% | 74% | 67% | 53% | 29% | 13% | 7% | 36% | 23% | 74% | 61% | 92% |
| MRPS28 | 37% | 48% | 26% | 52% | 57% | 50% | 46% | 37% | 34% | 12% | 53% | 21% | 24% | 66% | 38% | 77% |
| MTO1 | 39% | 44% | 52% | 24% | 23% | 43% | 41% | 61% | 44% | 37% | 60% | 25% | 82% | 24% | 24% | 69% |
| MUTYH | 44% | 44% | 66% | 16% | 21% | 39% | 44% | 74% | 38% | 27% | 35% | 45% | 39% | 17% | 48% | 52% |
| NDUFA13 | 24% | 56% | 20% | 19% | 36% | 44% | 44% | 32% | 38% | 10% | 29% | 45% | 23% | 31% | 40% | 74% |
| NDUFB9 | 42% | 59% | 28% | 31% | 58% | 47% | 69% | 49% | 20% | 12% | 17% | 16% | 29% | 54% | 32% | 69% |
| NDUFV1 | 29% | 56% | 69% | 20% | 82% | 63% | 59% | 69% | 42% | 72% | 34% | 39% | 50% | 70% | 40% | 88% |
| NNT | 20% | 65% | 71% | 72% | 87% | 51% | 57% | 61% | 29% | 44% | 31% | 33% | 91% | 49% | 23% | 26% |
| NTHL1 | 53% | 69% | 40% | 29% | 29% | 44% | 35% | 31% | 43% | 32% | 44% | 22% | 52% | 53% | 19% | 39% |
| NUBPL | 32% | 46% | 70% | 37% | 70% | 25% | 53% | 63% | 14% | 44% | 33% | 18% | 53% | 46% | 18% | 79% |
| OGDHL | 21% | 67% | 43% | 54% | 83% | 35% | 84% | 64% | 12% | 82% | 33% | 12% | 77% | 26% | 27% | 96% |
| OGDH | 36% | 51% | 73% | 28% | 54% | 63% | 59% | 59% | 20% | 72% | 65% | 14% | 95% | 84% | 20% | 76% |
| OGG1 | 40% | 20% | 24% | 20% | 22% | 22% | 49% | 37% | 9% | 58% | 59% | 37% | 21% | 22% | 35% | 90% |
| OPA1 | 33% | 39% | 73% | 20% | 66% | 50% | 39% | 95% | 31% | 46% | 61% | 35% | 74% | 77% | 35% | 98% |
| PCK2 | 12% | 39% | 38% | 7% | 14% | 12% | 70% | 57% | 0% | 31% | 46% | 19% | 24% | 84% | 58% | 79% |
| PDHA1 | 29% | 56% | 72% | 5% | 90% | 42% | 47% | 79% | 44% | 28% | 23% | 28% | 41% | 65% | 40% | 86% |
| PDK1 | 26% | 24% | 86% | 19% | 94% | 32% | 52% | 84% | 37% | 6% | 61% | 48% | 20% | 25% | 44% | 74% |
| PDK3 | 46% | 35% | 41% | 25% | 19% | 32% | 56% | 65% | 26% | 43% | 10% | 18% | 56% | 40% | 42% | 29% |
| PDK4 | 80% | 94% | 81% | 31% | 32% | 78% | 58% | 97% | 50% | 24% | 79% | 63% | 92% | 26% | 89% | 43% |
| PDP1 | 36% | 69% | 65% | 31% | 84% | 65% | 68% | 78% | 41% | 43% | 70% | 21% | 94% | 42% | 44% | 97% |
| PGAM5 | 61% | 67% | 66% | 45% | 70% | 62% | 34% | 92% | 54% | 27% | 58% | 14% | 62% | 54% | 43% | 51% |
| PHB2 | 31% | 35% | 29% | 31% | 44% | 84% | 50% | 61% | 52% | 40% | 54% | 33% | 12% | 54% | 41% | 99% |
| PHB | 40% | 46% | 33% | 15% | 74% | 45% | 54% | 47% | 35% | 14% | 68% | 25% | 14% | 51% | 52% | 98% |
| PINK1 | 78% | 98% | 65% | 24% | 77% | 92% | 78% | 89% | 69% | 25% | 76% | 33% | 44% | 25% | 46% | 88% |
| PKLR | 16% | 39% | 16% | 25% | 6% | 24% | 37% | 34% | 1% | 4% | 23% | 9% | 97% | 22% | 47% | 76% |
| PMAIP1 | 64% | 96% | 48% | 13% | 6% | 23% | 49% | 81% | 11% | 57% | 29% | 17% | 36% | 72% | 3% | 60% |
| POLG2 | 45% | 90% | 92% | 55% | 82% | 90% | 52% | 79% | 54% | 16% | 72% | 45% | 24% | 14% | 80% | 76% |
| POLG | 39% | 48% | 33% | 41% | 76% | 49% | 39% | 67% | 34% | 28% | 38% | 25% | 77% | 48% | 38% | 81% |
| POLRMT | 22% | 46% | 44% | 19% | 46% | 38% | 65% | 62% | 34% | 30% | 35% | 31% | 62% | 9% | 52% | 71% |
| PRDX2 | 46% | 36% | 36% | 18% | 67% | 55% | 56% | 65% | 60% | 25% | 41% | 62% | 27% | 46% | 51% | 76% |
| PRDX3 | 43% | 14% | 26% | 16% | 73% | 49% | 47% | 28% | 15% | 27% | 36% | 15% | 85% | 21% | 39% | 90% |
| PRDX5 | 28% | 54% | 30% | 17% | 61% | 56% | 42% | 31% | 11% | 49% | 1% | 24% | 79% | 57% | 12% | 56% |
| PRELID1 | 56% | 18% | 30% | 32% | 52% | 34% | 50% | 30% | 10% | 11% | 27% | 8% | 18% | 68% | 52% | 85% |
| PRODH | 55% | 40% | 57% | 53% | 34% | 37% | 31% | 58% | 14% | 28% | 30% | 24% | 95% | 48% | 42% | 78% |
| PTRH2 | 62% | 79% | 65% | 45% | 68% | 89% | 39% | 57% | 43% | 9% | 66% | 23% | 30% | 54% | 37% | 72% |
| RECQL4 | 90% | 89% | 95% | 3% | 53% | 71% | 89% | 99% | 72% | 22% | 87% | 29% | 97% | 47% | 73% | 99% |
| ROMO1 | 38% | 47% | 14% | 32% | 28% | 64% | 46% | 27% | 22% | 8% | 49% | 28% | 3% | 38% | 42% | 99% |
| RPIA | 33% | 86% | 58% | 32% | 54% | 41% | 50% | 76% | 31% | 22% | 42% | 21% | 30% | 30% | 45% | 97% |
| SCO2 | 47% | 56% | 25% | 29% | 26% | 51% | 42% | 31% | 9% | 13% | 53% | 37% | 3% | 46% | 35% | 71% |
| SDHAF2 | 41% | 35% | 21% | 14% | 31% | 43% | 50% | 23% | 14% | 11% | 38% | 28% | 26% | 58% | 19% | 90% |
| SDHA | 20% | 68% | 71% | 18% | 36% | 53% | 74% | 83% | 22% | 55% | 29% | 4% | 85% | 80% | 54% | 96% |
| SDHB | 16% | 60% | 16% | 15% | 48% | 65% | 67% | 28% | 27% | 19% | 14% | 17% | 5% | 62% | 24% | 60% |
| SDHC | 67% | 48% | 40% | 40% | 58% | 38% | 73% | 55% | 30% | 49% | 34% | 27% | 45% | 87% | 51% | 97% |
| SDHD | 54% | 88% | 28% | 63% | 72% | 74% | 64% | 31% | 42% | 68% | 53% | 53% | 32% | 87% | 59% | 97% |
| SHMT1 | 52% | 43% | 59% | 25% | 31% | 18% | 68% | 40% | 4% | 29% | 10% | 50% | 95% | 51% | 24% | 79% |
| SHMT2 | 45% | 96% | 82% | 50% | 91% | 30% | 68% | 97% | 46% | 23% | 34% | 50% | 33% | 65% | 65% | 100% |
| SIRT3 | 40% | 34% | 63% | 24% | 10% | 57% | 56% | 48% | 37% | 25% | 51% | 31% | 32% | 32% | 35% | 59% |
| SIRT4 | 17% | 18% | 19% | 31% | 28% | 34% | 23% | 12% | 20% | 23% | 20% | 20% | 30% | 40% | 7% | 83% |
| SIRT5 | 49% | 40% | 42% | 35% | 32% | 64% | 65% | 67% | 40% | 23% | 32% | 19% | 79% | 15% | 43% | 94% |
| SLC16A1 | 51% | 12% | 39% | 26% | 89% | 36% | 53% | 94% | 25% | 54% | 18% | 49% | 59% | 61% | 38% | 70% |
| SLC25A11 | 32% | 78% | 40% | 25% | 60% | 62% | 66% | 35% | 45% | 21% | 54% | 33% | 6% | 92% | 21% | 58% |
| SLC25A1 | 31% | 67% | 44% | 10% | 17% | 37% | 39% | 66% | 24% | 52% | 40% | 29% | 44% | 57% | 60% | 83% |
| SLC25A20 | 32% | 94% | 57% | 15% | 49% | 48% | 68% | 90% | 11% | 35% | 64% | 62% | 27% | 24% | 22% | 86% |
| SLC25A22 | 67% | 62% | 66% | 61% | 49% | 50% | 46% | 37% | 46% | 30% | 51% | 34% | 65% | 26% | 46% | 98% |
| SLC25A26 | 44% | 40% | 33% | 18% | 68% | 54% | 47% | 35% | 27% | 21% | 66% | 61% | 53% | 92% | 33% | 92% |
| SLC25A31 | 12% | 9% | 3% | 4% | 5% | 8% | 1% | 8% | 22% | 14% | 20% | 10% | 11% | 18% | 14% | 8% |
| SLC25A33 | 11% | 10% | 15% | 52% | 83% | 57% | 39% | 30% | 21% | 69% | 28% | 26% | 44% | 46% | 15% | 72% |
| SLC25A43 | 28% | 29% | 48% | 31% | 88% | 70% | 61% | 56% | 3% | 31% | 17% | 7% | 55% | 34% | 23% | 97% |
| SLC25A6 | 30% | 55% | 51% | 42% | 44% | 84% | 53% | 49% | 56% | 72% | 54% | 35% | 38% | 75% | 40% | 80% |
| SOD1 | 32% | 42% | 36% | 31% | 49% | 61% | 53% | 59% | 26% | 24% | 45% | 23% | 58% | 78% | 16% | 68% |
| SOD2 | 65% | 47% | 29% | 18% | 53% | 56% | 32% | 34% | 44% | 38% | 41% | 4% | 21% | 25% | 51% | 94% |
| SSBP1 | 49% | 85% | 37% | 32% | 58% | 74% | 55% | 70% | 30% | 11% | 41% | 24% | 82% | 63% | 30% | 99% |
| SUPV3L1 | 36% | 60% | 80% | 58% | 28% | 45% | 42% | 93% | 63% | 19% | 58% | 34% | 65% | 16% | 44% | 94% |
| TFAM | 35% | 58% | 61% | 22% | 75% | 56% | 44% | 76% | 37% | 36% | 55% | 38% | 20% | 21% | 70% | 57% |
| TIMM16 | 64% | 84% | 31% | 39% | 25% | 69% | 37% | 38% | 31% | 9% | 49% | 18% | 17% | 61% | 55% | 90% |
| TIMM50 | 43% | 87% | 61% | 21% | 47% | 68% | 61% | 77% | 48% | 11% | 48% | 24% | 67% | 56% | 51% | 75% |
| TIMM9 | 19% | 60% | 53% | 32% | 59% | 52% | 45% | 47% | 24% | 5% | 32% | 25% | 24% | 61% | 24% | 80% |
| TKT | 36% | 91% | 63% | 20% | 15% | 57% | 68% | 72% | 22% | 18% | 24% | 21% | 42% | 69% | 28% | 50% |
| TOMM22 | 27% | 28% | 16% | 21% | 30% | 46% | 51% | 69% | 29% | 18% | 30% | 23% | 15% | 68% | 27% | 85% |
| TOMM34 | 53% | 98% | 42% | 15% | 79% | 69% | 46% | 54% | 75% | 77% | 51% | 37% | 48% | 51% | 22% | 37% |
| TOMM70A | 41% | 73% | 74% | 19% | 59% | 84% | 50% | 88% | 43% | 9% | 55% | 29% | 47% | 83% | 19% | 78% |
| TOP1MT | 25% | 92% | 74% | 29% | 49% | 63% | 57% | 92% | 56% | 24% | 54% | 51% | 33% | 51% | 39% | 79% |
| TPI1 | 70% | 65% | 83% | 28% | 72% | 67% | 46% | 97% | 35% | 20% | 51% | 53% | 45% | 50% | 52% | 51% |
| TRAP1 | 31% | 94% | 95% | 55% | 28% | 53% | 67% | 97% | 55% | 42% | 38% | 25% | 20% | 37% | 51% | 75% |
| TSPO | 27% | 36% | 62% | 8% | 27% | 39% | 51% | 35% | 9% | 23% | 7% | 20% | 29% | 52% | 11% | 88% |
| TUFM | 37% | 49% | 67% | 32% | 74% | 73% | 49% | 68% | 27% | 32% | 15% | 43% | 76% | 43% | 35% | 97% |
| TXN2 | 50% | 53% | 37% | 23% | 63% | 60% | 65% | 45% | 48% | 55% | 44% | 61% | 23% | 88% | 42% | 90% |
| TXNRD2 | 46% | 43% | 47% | 35% | 62% | 38% | 50% | 54% | 14% | 60% | 23% | 18% | 76% | 60% | 55% | 65% |
| UCP1 | 5% | 27% | 3% | 3% | 23% | 23% | 21% | 16% | 6% | 3% | 20% | 9% | 80% | 29% | 23% | 26% |
| UCP2 | 40% | 54% | 43% | 14% | 8% | 28% | 45% | 56% | 6% | 47% | 42% | 6% | 32% | 76% | 42% | 97% |
| UQCRB | 24% | 56% | 41% | 30% | 37% | 40% | 59% | 31% | 25% | 14% | 35% | 33% | 68% | 78% | 39% | 66% |
| UQCRC1 | 30% | 67% | 28% | 18% | 95% | 67% | 62% | 65% | 42% | 17% | 22% | 55% | 76% | 18% | 42% | 56% |
| UQCRC2 | 30% | 62% | 33% | 19% | 42% | 70% | 58% | 50% | 37% | 28% | 39% | 69% | 71% | 82% | 63% | 63% |
| UQCRFS1 | 23% | 74% | 21% | 16% | 90% | 68% | 61% | 35% | 33% | 17% | 38% | 56% | 36% | 66% | 58% | 70% |
| VDAC1 | 60% | 67% | 65% | 22% | 45% | 52% | 70% | 74% | 23% | 24% | 10% | 30% | 89% | 58% | 60% | 36% |
| VDAC2 | 29% | 40% | 50% | 25% | 20% | 43% | 54% | 77% | 54% | 18% | 22% | 26% | 26% | 43% | 30% | 96% |
| XRCC6BP1 | 4% | 35% | 30% | 23% | 31% | 38% | 26% | 76% | 27% | 14% | 36% | 18% | 14% | 63% | 41% | 80% |
| YME1L1 | 65% | 49% | 79% | 28% | 72% | 74% | 59% | 75% | 47% | 24% | 59% | 53% | 92% | 61% | 62% | 58% |
The data shown here is supplementary for the research publication A systematic review of mitochondrial genes affecting metabolic processes in cancer. Maricruz Sepulveda-Villegas, Rocio Rojo, Debora Garza-Hernandez, Mauricio de la Rosa, and Victor Treviño. PMID:XXXXXXXX.
Abstract
Malignant conversion of cells that leads to establishment of cancer results from efficient metabolic reprogramming and adaptation. Most metabolic changes that occur throughout cancer progression are meant to fulfill increased energy demands. Biosynthesis of molecule precursors is continuously active to accelerate cell growth and proliferation; and the cellular mechanisms that modulate the effects of ROS overproduction are enhanced in order to avoid cell death under hypoxic conditions. These adaptive changes that occur in mitochondria confer cancer cells with biological advantages that allow them to survive in a hostile environment. Given the relevance of mitochondrial adaptation for the onset and progression of cancer, it is important to identify which genes from the mitochondrial or nuclear genomes that encode mitochondrial proteins are actually involved in producing the different adaptive events undergone by cancer cells. Here, we systematically analyzed cancer literature mentioning cancer-related genes that give rise to mitochondrial proteins and provide an overview of the alterations that occur in different mitochondrial functions throughout cancer. Through analysis of the literature, we identified 228 genes and generated a database describing their homeostatic function and the pathological transition that ultimately contributes to specific cancer hallmarks. The potential clinical relevance of these genes was validated by detecting differences in their expression levels across 16 different types of cancer. A compendium including the homeostatic functions of the genes, and details about the alterations underpinning cancer progression can be explored in http://victortrevino.bioinformatics.mx/MitoCancer.
Abstract
Malignant conversion of cells that leads to establishment of cancer results from efficient metabolic reprogramming and adaptation. Most metabolic changes that occur throughout cancer progression are meant to fulfill increased energy demands. Biosynthesis of molecule precursors is continuously active to accelerate cell growth and proliferation; and the cellular mechanisms that modulate the effects of ROS overproduction are enhanced in order to avoid cell death under hypoxic conditions. These adaptive changes that occur in mitochondria confer cancer cells with biological advantages that allow them to survive in a hostile environment. Given the relevance of mitochondrial adaptation for the onset and progression of cancer, it is important to identify which genes from the mitochondrial or nuclear genomes that encode mitochondrial proteins are actually involved in producing the different adaptive events undergone by cancer cells. Here, we systematically analyzed cancer literature mentioning cancer-related genes that give rise to mitochondrial proteins and provide an overview of the alterations that occur in different mitochondrial functions throughout cancer. Through analysis of the literature, we identified 228 genes and generated a database describing their homeostatic function and the pathological transition that ultimately contributes to specific cancer hallmarks. The potential clinical relevance of these genes was validated by detecting differences in their expression levels across 16 different types of cancer. A compendium including the homeostatic functions of the genes, and details about the alterations underpinning cancer progression can be explored in http://victortrevino.bioinformatics.mx/MitoCancer.
